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Get2-like Calcium signal-modulating cyclophilin ligand (CAML) was originally identified in a screen for cyclophilin B-interacting proteins. It is involved in calcium signalling and in other signalling pathways as it interacts with many other signalling molecules including proto-oncogene tyrosine-protein kinase LCK, tumor necrosis factor receptor superfamily member 13B and EGFR. It also mediates the membrane insertion of tail-anchored proteins (TA), acting as a TRC40 receptor (the homolog of yeast Get3). Although CAML shows no sequence similarity to yeast Get2, they share similar biochemical properties and topology, thus resulting in the Get2 homolog in mammals, playing the same essential role in the membrane insertion as that of Get2. It also shows similarity with ER membrane protein complex subunit 6 (EMC6). |
Jiyao W et al.(2023). "The conserved domain database in 2023.",