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Stannin Stannin (SNN) is a monotopic membrane protein containing an N-terminal single transmembrane helix that transverses the lipid bilayer, an unstructured linker which includes a conserved CXC metal-binding motif and a putative 14-3-3zeta binding site, and a C-terminal distorted cytoplasmic helix. It binds and antagonizes 14-3-3zeta and is required for endosomal maturation. It has also been identified as the specific marker for neuronal cell apoptosis induced by trimethyltin (TMT) intoxication. TMT is one of the most toxic organotin compound (or alkyltin), and is known to selectively inflict injury to specific regions of the brain. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",