Conserved Protein Domain Family
RITA

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pfam17066: RITA 
RBPJ-interacting and tubulin associated protein
RITA is a highly conserved protein that binds to tubulin and shuttles between the cytoplasm and nucleus. It is responsible for export of RBP-J/CBF-1 from the nucleus, which modulates Notch-mediated transcription.
Statistics
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PSSM-Id: 465342
Aligned: 9 rows
Threshold Bit Score: 290.242
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006005493   1 MMSVDLAITGIQASRLQHKGrsnyRVKSETSYVDETLFGSPSRPGRSVSGFDPPWTAASSqlliRSQP--C--------- 69 
XP_001492491   2 KTPVELAVSGMQTLHLRHRC----RVKARPSYVDETLFGSPAGTRPAPPDFDPPWVEKVD----RTRG--V--------- 62 
XP_005336893   2 KTPVELAISGMQTLHLQHRCrggyRVKAKASYVDETLFGSPVSPRPPPPDFDPPWVQKSD----STRGpiT--------- 68 
XP_004843801   2 KAPVQQSARGMQALHPQHRCrvgcRVKARASYVDETLFGSPVGTRPSVPGFDPPWVQKTN----GTRA--V--------- 66 
XP_004999622   2 KIPVEQAIRGMQALQLQHRCrggcRVKARASYVDETLFGSPVGTRPTLPDFDPPWVQKTN----GTRR--V--------- 66 
XP_015442331   2 KTPVELAISGMQTLHHPHRCrrgcQVKATASYVDETLFGSPAGTRPTPPDFDPPWVEKAS----RTKG--V--------- 66 
XP_006106079   2 KTPVELAISGMQTLHRQHRCrggyQVKARASYVDETLFGSPSGTRPTPPDFDPPWVEKAN----RPKG--V--------- 66  little brown bat
XP_008116882   2 KASAEL---GIAALQFQRQArg-pRVKAKASFVDETLFGSSAGRQVPAVEFDPPWAE--------STA--P--------- 58  green anole
XP_001378593   6 KASVELTINGIQALQLQHKGrggyRVKSSTSFVDETLFGTPLGTRPALPEFDPPWAEKAW----PGKT--Vpltpnkkea 79  gray short-tail...
XP_006005493  70 --------------------QASPRElDTGLRTSPLPVPAKSSPPTCVPK-KK-KYRLKSHTPSYCDEMLFGSRQED-LG 126
XP_001492491  63 --------------------GTGISR-ASAVNGSCETASSRGSTPTLTPR-RKnKYRLIGHTPSYCDESLFGSRPES-TS 119
XP_005336893  69 --------------------RASPSQ-TSLSKGSCETTPSRSSTPTLTPK-KKnKYRVVRRSPSYCDESLFGSRP---AG 123
XP_004843801  67 --------------------GTRAIQ-SSPGKGSCETTPSGGSTPALTPG-KKnRYRLINHTPSYCDESLFGSQPKG-TS 123
XP_004999622  67 --------------------GAGGLQ-SSPGKGSCETTPSEGSTPTLTPRrRKnRYRLIGHTPSYCDESLFGCQPEG-VS 124
XP_015442331  67 --------------------GTEASR-ASEANRSSKTTSSRGSTPTLTPR-KKnKYRLISHTPSYCDESLFGSRSKG-TS 123
XP_006106079  67 --------------------GREAPR-ASGANGSCETASSRGSTPTLTPR-KKnKYRLISHTPSYCDESLFGSRPVG-TC 123 little brown bat
XP_008116882  59 --------------------S---PR-PLLWSPEVGASPAKGPPSAGTPR-KRnKYRLKSHTPSYCDETLFGPKPGE-QE 112 green anole
XP_001378593  80 kwtldsypsrgsssihppsrG-------------------NNCISPRTPR-KKnKYRLIGHKSSYCDETLFGTQGKGgSP 139 gray short-tail...
XP_006005493 127 WEAPWTKKKEKVQLRPLLWTPPVSHKvhgqaTSHSSPPKGTPMKAVHPDTagpPSDSfspD---YKEKTDFWKRPRSDLD 203
XP_001492491 120 REAPWTAKGHAAKVHALFWTPPATPR-----GSHSPRPRETPLRAVPPAG---PSKA---G---PGVAADSRKLSSNGLD 185
XP_005336893 124 PEASGMAKGDAAKLRALLWTPPATPR-----GGHSPRPRETPLRAIHPAG---PSKT---G---PGVAADTRELPSGGRG 189
XP_004843801 124 WEASRMAKGDTAKLHTLFWTPPATPR-----GRDSPRPREIPLRAVHPSG---SSMT---R---PQVAADSQGLSLDGPE 189
XP_004999622 125 WESSRLAKAGASKLHSLFWTPPATPR-----DSDSPCPRKAPLRAMHPEN---PSMT---R---PQGAASSPRLSLHSSD 190
XP_015442331 124 WEAPWMAKGDAAKLHTLFWTPPATPR-----GSHSPRPRETPLRAIHPTG---ASET---E---PKVATGSRKLSVDGLD 189
XP_006106079 124 WEAPWMVKGGASKLHTLFWTPPATPR-----G-HPPHPRETPVRTIHPSA---PTKT---E---PREGSEAGKVSKGGLD 188 little brown bat
XP_008116882 113 WAASWMSGSDVAKLCPLLLTPPSALRd---rLALSPRPKETPLRAVHQEK---GKEG---AgalRRREDAFRRPQESGSD 183 green anole
XP_001378593 140 RKVPWIKLEEIPRLEPLFWTPPSVPW-----DSCSPRPKETPLRAIHPMV---SSMP---K---NRSKSDIWHRPLERLD 205 gray short-tail...
XP_006005493 204 p-SRKSLSRERSHSLTRLSGGSGGPGAAgiTAITPRKDWAPcrRPSSAY-ATLTG-LGgdQHRPGSAGLSGTLSAGRPKT 280
XP_001492491 186 --PPRPLRRELAHSLAHLNVPSTGRPPA--GAPHANGPRDP--RPSPSG-VTFRSpLV--TPRAHSVSVSVPAAPRRGGV 256
XP_005336893 190 --APHPPGRGRSQSLTHLNTPSAGFP------AHGEGPQAP--RPSTSG-VTFRSpLV--TPRARSVSTSVPATPRQGGA 256
XP_004843801 190 --VPRPLRRERSHSLTCLSVPSAGHPAS--SAPHTNGPQDP--RPPPAG-MTFRSpLV--NPRAPSVSASVPATPRRGRG 260
XP_004999622 191 --TPRPPRRERSHSLTCLSVPSSGHPAA--SAPHTNGLQDP--RPPPAG-VTFQSpLV--TPRAHSVSASVPPTSRRGRA 261
XP_015442331 190 --SPHPLRQERSHSLTHLNVPSTGRPHT--SDPHTNGPGNP--RPSPSG-VTFRSpLI--TPRAHSVSVSVPATPRRGGA 260
XP_006106079 189 --SPRALN-----------VPSTGRPPT--GGSPTSGPRDP--RPSHPGxA-FRSpLV--TPRARSVSASVPATSQRGGA 248 little brown bat
XP_008116882 184 rtNQADLRRRRSCSLTRLCSASDRAP------PLANNPRTS--TRQDRA-LLVPStGS--FARPCSQGFSVSTKATRSSD 252 green anole
XP_001378593 206 --SLGPLQKGYSQSLTHLNGSSTRHPLTt-NTPHQGRQREA--WVQSAV-VTFRSpLVtpTPRARSISFSEPGTHQKYLA 279 gray short-tail...
XP_006005493 281 tgSIKIKPAWK 291
XP_001492491 257 --AQKPKPPWK 265
XP_005336893 257 --TQKPKPPWK 265
XP_004843801 261 --PQNPKPPWR 269
XP_004999622 262 --PQNPKPPWR 270
XP_015442331 261 --TQKPKPPWK 269
XP_006106079 249 --TPRPKPPWK 257 little brown bat
XP_008116882 253 --SCKPKPPWK 261 green anole
XP_001378593 280 --APKPKPPWK 288 gray short-tailed opossum
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