Conserved Protein Domain Family
AKR_AKR9A3_9B1-4
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cd19147: AKR_AKR9A3_9B1-4 
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins
Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Links
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Statistics
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PSSM-Id: 381373
Aligned: 7 rows
Threshold Bit Score: 599.888
Created: 19-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    ###                                 #    #                       
P25612     17 FLSETAAIKVSPLILGEVSYDgarsdflksmnKNRAFELLDTFYEAGGNFIDAANNCqneQSEEWIGEWIQsrrlRDQIV 96  Saccharomyces cere...
POE51669   20 VLSSTAGIRVSPLVLGGMSIGeawsafmgsmdKAQAFRLLDAYFAAGGNFIDTANTYqdnESEIWIGEWMKqrknRDQVV 99  Quercus suber
C8VQ93     25 ILSPTAGIRVSPLQLGALSIGdawstdlgsmdKDSAMELLDAYAAAGGNFIDTANAYqneQSEMWIGEWMAsrgnRDKMV 104 Aspergillus nidula...
P42884     20 VLSKTAGIRVSPLILGGASIGdawsgfmgsmnKEQAFELLDAFYEAGGNCIDTANSYqneESEIWIGEWMAsrklRDQIV 99  baker's yeast
EKJ71957   19 ILATTAGVRVSPLVLGAMSIGgawef-mgimkEAESHKLLDSYYDFGGNFIDTANNYqdeQSETLIGDWMKlrdnRDMLF 97  Fusarium pseudogra...
GAX70536   20 VLSKTAGIRVSPLILGGMSIGdawsgfmgsmdKEQAFELLDAFYQAGGNFIDTANNYqyeQSETWIGEWMAsrklRDQIV 99  baker's yeast
POF04878   20 VLSKTAGIKVSPLQLGAMSLGdawsstmgpmsKENSFKLLDAFVEAGGNFIDTSNNYqdeQSETWIGEWMKqrhnRDLLV 99  Quercus suber

Feature 1        #                                                 ##                         
P25612     97 IATKFiksdkkyka--gesntanyCGNHKRSLHVSVRDSLRKLqTDWIDILYVHWWDYmSSIEEFMDSLHILVQQGKVLY 174 Saccharomyces cere...
POE51669  100 LATKFsfhykaggnedktpannnfWGNHKRSMMMSLRDSLAKLqTDWIDVFYVHFWDFtTSIEEVMDALHLLVEQGKVLY 179 Quercus suber
C8VQ93    105 IATKFgtdyrahel--gkglavnySGNHKRSLHMSVRDSLQKLrTSWIDILYLHTWDYtTSIPELMDSLHHLVQRGDVLY 182 Aspergillus nidula...
P42884    100 IATKFtgdykkyev--gggksanyCGNHKRSLHVSVRDSLRKLqTDWIDILYIHWWDYmSSIEEVMDSLHILVQQGKVLY 177 baker's yeast
EKJ71957   98 IATKYtinyrryhe--nsgravnyGGNSKKSMFVSLEASLKKLqTSYIDLFYVHLWDWsTSIPEIMDSLDVLVKQGKVLY 175 Fusarium pseudogra...
GAX70536  100 IATKFttdykgydv--gkgksanfCGNHKRSLHVSVRDSLRKLqTDWIDILYVHWWDYmSSIEEVMDSLHILVQQGKVLY 177 baker's yeast
POF04878  100 VATKFstaytsyrq--gkgktvnyAGNHKRALKMSVRDSLAKLqTDWIDLLYVHWWEWtTSIEEVMDSLHELVLQGKVLY 177 Quercus suber

Feature 1        ##                        #                           #######                
P25612    175 LGVSDTPAWVVSAANYYAtsygktpfsIYQGKWNVLNRDFErDIIPMARHFgMALAPWDVMGGGRFQSKKameerrknge 254 Saccharomyces cere...
POE51669  180 LGISDAPAWVVAGANHYAkahgktvfsIYQGQWNVLSRDLErEILPMARYFgMAVAPWNVLGGGKFLSPEqaaqcqasde 259 Quercus suber
C8VQ93    183 LGICNTPAWVVSAANTYAqqqgktqfsVYQGRWNPLRRELErDILPMARHFgMAVTVYDALGSGKFQSRDmlarrkdqge 262 Aspergillus nidula...
P42884    178 LGVSDTPAWVVSAANYYAtshgktpfsVYQGKWNVLNRDFErDIIPMARHFgMALAPWDVMGGGRFQSKKameerkknge 257 baker's yeast
EKJ71957  176 LGVSDTPAWVVSAANEYArahgktpfsVYQGRWNLVDRAFErEIVPMARHYgMALCPWNVLMGGQLQTKAqrearaans- 254 Fusarium pseudogra...
GAX70536  178 LGVSDTPAWVVSAANYYAtshgktpfsIYQGKWNVLNRDFErDIIPMARHFgMALAPWDVMGGGRFQSKKaveerkkkge 257 baker's yeast
POF04878  178 LGVSDTPAYIVAAANTYAkahgktqfsVYQGRWNVMVRDLErEIVPMCRHFgMAIAPWDSVGGGKFQSKRtveeriknne 257 Quercus suber

Feature 1                                       #                ######  #  ##                
P25612    255 girsfvgaseqtDAEIKISEALAKIAEEHGtesVTAIAIAYVRSKaknFFPSVEGGKIEDLKENIKALSIDLTPDNIKYL 334 Saccharomyces cere...
POE51669  260 ---sgrtgteqsPEETSISEALYTVAKAHGeqsVTAVALAYVRAKapnVLPLVGGRKVEHLHDNIAALELSLTHEEVAYL 336 Quercus suber
C8VQ93    263 g-lraiyggqqtALEEAMSKALGVVAAQHGiesVTAVALAYLLAKapyVFPIIGGRKIQHLHDNIEALSLRLSQEEIEYL 341 Aspergillus nidula...
P42884    258 glrtfvggpeqtELEVKISEALTKIAEEHGtesVTAIAIAYVRSKaknVFPLIGGRKIEHLKQNIEALSIKLTPEQIEYL 337 baker's yeast
EKJ71957  255 ---dggrgdnpsPESVAISDALEKIASSHGsatIQQIALAYIRSKapnVFPIIGGRKVSHLEDNIKALDVVLTKEEISSI 331 Fusarium pseudogra...
GAX70536  258 glrsffgtseqtDMEVKISEALLKVAEEHGtesVTAIAIAYVRSKakhVFPLVGGRKIEHLKQNIEALSIKLTPEQIKYL 337 baker's yeast
POF04878  258 plrsfltpteqsEQEVRASAALEDVAREHNltsLTAVALAYVMSKapyVFPLVGGRKVEHLKDNIQSLTIKLTSEQLDKL 337 Quercus suber

Feature 1      
P25612    335 E 335 Saccharomyces cerevisiae S288C
POE51669  337 E 337 Quercus suber
C8VQ93    342 E 342 Aspergillus nidulans FGSC A4
P42884    338 E 338 baker's yeast
EKJ71957  332 D 332 Fusarium pseudograminearum CS3096
GAX70536  338 E 338 baker's yeast
POF04878  338 D 338 Quercus suber

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