6NR9,6NR8


Conserved Protein Domain Family
Prefoldin_6

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cd23161: Prefoldin_6 
Prefoldin subunit 6
Prefoldin subunit 6 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.
Statistics
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PSSM-Id: 467477
Aligned: 211 rows
Threshold Bit Score: 76.3663
Created: 4-Mar-2021
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 29 residues -Click on image for an interactive view with Cn3D
Feature 1:prefoldin oligomer interface [polypeptide binding site]
Evidence:
  • Structure:6NR9; Homo sapiens prefoldin 6 interacts with 3 other subunits in the prefoldin hemaxer complex, contacts at 4A
  • Comment:forms a hexamer composed of two alpha and four beta subunits

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                               #  ## ## ### #   ################  ##      #   #         
6NR9_6         1 VEKYQQLQKDLSKSMSGRQKLEAQLTENNIVKEELALLdGSNVVFKLLGPVLVKQELGEARATVGKRLDYITAEIKRYES 80  human
XP_005837984  43 AKAYQSLQQEHAKMGQTYSKLLAQQNENNMVLDELKLI-DGGAVYKLVGPVLLSQDPEEAKSNVEKRLQYIGDEMKRTQN 121 Guillardia thet...
KAA8497097    15 MNELNAIQKEMGKEMNAVQNLQAQLTENQLVKSELDLLaADTNVFKLVGPILVKQDCVEAQSNVNKRIEFIEAEMQKATD 94  Porphyridium pu...
KAA0156223     9 MDEYKKVRADTQSVVTNITQLQSQLNENSMVKEEIDEVkDGEPVYKLVGPVLVRQDVEEVKSLVTRRIGLIKSELAKAEA 88  Cafeteria roenb...
XP_005710245  18 VGEVKEVQNDLANSVNTMNNLQSQLTENKLVKDELDNLeQGAKIFKLVGPVLIPQQADEAKSTVNTRIEYISKEVKNAKE 97  carragheen
PRP86053      15 LKEFRSLQKQIGNYQNSRAQYLTQVNENDMVKKELELVeADGEIFKLIGPALIKQEKTEALSNVNKRLEFIKGELKKVDT 94  Planoprotosteli...
CUV04973      12 TKEFLETQKKFEQINERRRILVAQESENQMVSKELELLeSDAVIYKLVGSVMVKQSLDDAKSTVSKRLEYITGEIESVNK 91  Cryptosporidium...
PXF48526       9 AHEVQNIQKEYAAAMQGMKGLQSQLTENQLVKQELDQLeEGSKVYKLIGPVLTPQDADDAKSTVQTRIDFISKELANART 88  Gracilariopsis ...
OSX75039      19 MQNMIALQKEASKAMSAVMGLKNQFLENQLVAKELDEVpDGTAVYKLVGPVLLAEELEEARTNVRTRLSKISEQLQAGNN 98  laver
THH28160      16 STELQNIQRDLTNAIVLRRKLEVRRYENEAVQEDMEALpAGSVVYKQVGSGLVQQSVEDIRKNVRTRMEFIMNELNQAEI 95  Antrodiella cit...
Feature 1                             
6NR9_6        81 QLRDLERQSEQQRETLAQLQQ 101 human
XP_005837984 122 HVIDLEKKMEEKRNKLQQLQA 142 Guillardia theta CCMP2712
KAA8497097    95 KLQRLEKTQGEKRVKVSDLQK 115 Porphyridium purpureum
KAA0156223    89 RAEELRKKEDAIKDKVMAHQK 109 Cafeteria roenbergensis
XP_005710245  98 RAQKVEKEQQQRRVTLLTEQQ 118 carragheen
PRP86053      95 TIGDLEKKSEDKKNKVMELQQ 115 Planoprotostelium fungivorum
CUV04973      92 SFESLQSKLVEKSNQLQKLQK 112 Cryptosporidium hominis
PXF48526      89 KLEGLEKTQQTKRVALVTEEK 109 Gracilariopsis chorda
OSX75039      99 RVHAIETEMEQKRASLIAFQT 119 laver
THH28160      96 RAAELRGRWERKKVQVIDVRL 116 Antrodiella citrinella

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