Conserved Protein Domain Family
SHR3_chaperone

?
pfam08229: SHR3_chaperone 
ER membrane protein SH3
This family of proteins are membrane localized chaperones that are required for correct plasma membrane localization of amino acid permeases (AAPs). SH3 prevents AAPs proteins from aggregating and assists in their correct folding. In the absence of SH3, AAPs are retained in the ER.
Statistics
?
PSSM-Id: 369769
Aligned: 52 rows
Threshold Bit Score: 168.886
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_016757972   5 GTAPFATFLIIGPTCFFLGVLFALFPYDYNVLWSTPPTIDpavnpreiYFQLQENHLK-FLHASPPLISRILHIVIGTGL 83 
XP_011110552   3 gaASFWTYLIVCPTSFILGILFTNWSYDFPLLWTSKRLTPe-------MIKAIEAHYV-MLYDSPPLIGRVLHAIILIAL 74 
CAP69338       7 gsGSFATFLIIGR------ILFASFPYDFPLLWSPNPITPl-------HISQIETHLR-FMHAAPPLISRLLHMIIAVGF 72 
Q7S1L1        20 GSGSFSTFIIIGPVCFFLGILFAQFPYDFPLLWTSEPVQAt-------YYDFLETHVK-FLHASPLIISRILNIVIFVGL 91  Neurospora crassa
XP_003005070   6 pSSPFGTFLIVGCVCFFLGILFASFPYDYPLLWTSAPVPEa-------YYAQLETHLR-FIYAAPPLIGRLLTSIILVGF 77 
Q9Y876        14 GLKVAARYGVLMSTSFIFALLFHSSVADVNTLW-SPGPES--------AFDAAETYYT-LVAGSHFIVKYTVYTIMGLNM 83  Schizosaccharom...
EST08811       1 --mglRTGLIIGTTSFLLGTLAMHWTADHLILWQSPVTYD--------SVVTAYTYYQdTMVDMPLVFQRLLHGSGTLVA 70 
XP_007326481   1 --mgarAGIVVCITSFLLGALFTHWIADSLTLWKSPVTDE--------HLWTAASYYS-IVTKGPREILYLLFALVILGG 69 
EPB92454       5 ymqtakVALILCSCFFSYGTYWSDWAFDYYLLWANPSEYPe-------AITRATFYYA-NQGHIPNILKYVPIANLCIAA 76 
XP_007400657   1 --mgfrqAAVLSSVCFFLGVLFICMNVDYRVLF-TPLTED--------VVRDGLEFYT-TFFHSPPAIKALMHAIMGVGI 68 
XP_016757972  84 LGFLIKLFKPTEANLLFDGASLVLYMCGITVYIANIVKGLRTVTAGAYGTkvldeaageslvdkalenregdyIGREDS- 162
XP_011110552  75 AAFIAKLYKPSESNALFDGASLVLFMVAVIVYGSNTIKGMQIIKGGDYGEd----------------------IPQAQS- 131
CAP69338      73 LGFFTKLYRAAESNFLFDGGSLLLYLIAAGVYITNVVTPMNALAEQLEGEggekyavhn------gpltgeveLTREES- 145
Q7S1L1        92 LGFFMKLFRPAESNVLFDGASLILYVIGVGVYTSNIVKGMRTITAGIWDMedfagikhd------gpvsgeviLGREDT- 164 Neurospora crassa
XP_003005070  78 IGFFVKLFKASEANVLFDGASLVLYFIGVGVYLTNIVRGLRAVGEGIWDDpdweakang-----nagegdglvLGKEDS- 151
Q9Y876        84 IFHLIQATGAKGDDKLFFYSSTLLYLTALILFIVNVAPSMLVVKLQNYVQ-----------------------FPRNMH- 139 Schizosaccharom...
EST08811      71 LLIISKALGGRESNWLFDGASLFLFGAAGLVYYHKIVPSLATLPPKAPSPgs-------------------aaVDARDAv 131
XP_007326481  70 STILWSFGDGQAGNLMFDGGSIFLFGMTAVMYVYAVLPNLLTHFENLPPHglkd----------------pfpRTLRQS- 132
EPB92454      77 AGFVTGLLTMTDGNLLFDGASLVLMMFGITTYLSSVKPAITVVSESADVN------------------------EITTS- 131
XP_007400657  69 IGLVGKLVRMDEGAKWFDGSSLAAYIFALSVYLSVGLPASRTIATPVEG------------------------VDTREDq 124
XP_016757972 163 ---LRVLAASDTILALVLVGVLVLQAGQ---WYAQRKEQEEMEM-MDAKRDEKIAAKAEKKAEGK 220
XP_011110552 132 ---LQVVAASNTIMALVLIGVLLLQAGQ---WYAERKEKEELDAmSEGLNNADSPTVSKKELKEK 190
CAP69338     146 ---LRVLSASHTILAFVLVGVLVLQAGQ---WYAEKREREDYAAwVARGEPVEVMDSDEEQEKEE 204
Q7S1L1       165 ---MKVLSASNTILAMVLVGVLVLQAGQ---WYAESKEKDDYAK-GDKKEKKNDGQQQQQQQQQP 222 Neurospora crassa
XP_003005070 152 ---LKVLSASNTILALVLVGVLVLQVGQ---AYAERKEREEIEA-LDKKDKEAAAAAAAGKGGAA 209
Q9Y876       140 ---LSVLAASHVLVEFLLAGVILIQLGYvfgYHVQSIQQREYAEdMREQELAEKAKLESESATTQ 201 Schizosaccharomyces pombe 972h-
EST08811     132 fapLREIATSHTVLAVALVGVIILQSGQ---YYSERLEERER---IEEDEARIRRRQRRREQEEK 190
XP_007326481 133 ---TLDLASNNLICSVALTGVLALQAGR---FWAETPDSDDEEFvLVEAPSAEEQQQQQQQRQQE 191
EPB92454     132 ---LKNIAAAHFIIVLAITGIIGLQITH---YFVMKRSNKDREDgGNQETDQEEDEEDEEEEQEQ 190
XP_007400657 125 ieaLRLLSAGNTIVIALLGGVLFLQAGE---EYARRTEAKELAR-LAELDKKDRSATATSAAGEN 185
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap