Conserved Protein Domain Family
EMP24_GP25L
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pfam01105: EMP24_GP25L 
emp24/gp25L/p24 family/GOLD
Members of this family are implicated in bringing cargo forward from the ER and binding to coat proteins by their cytoplasmic domains. This domain corresponds closely to the beta-strand rich GOLD domain described in. The GOLD domain is always found combined with lipid- or membrane-association domains.
Links
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Statistics
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PSSM-Id: 426051
Aligned: 208 rows
Threshold Bit Score: 39.9772
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CAM43991      40 ALTFHFVDSKPLCFSETIenVKESQITGVYDWKasatsPASQVQLRLSVK--DST--GN-----VYYDKAMMEGEhsfAV 110
A0CNR3         2 QFGYEVDKGQQICFQDYF--SQNDVFDLKIRAN-----TSN-YAVKLE----EAV--AK-----RYAILYEKSGSwehNY 62  Paramecium tetr...
A0CKN2        14 QFGYEVERGQSICFEDYF--SQDDVFDLRVRAN-----SSN-YSVKLE----ESE--QK-----KYVPLYERSGAwehNY 74  Paramecium tetr...
A0DT41        16 ILKFKVPPGQQQCIKDSV--SQNTLIYGNYDTT-----SLH-YSFTLSIInqQDQ--ES-----IIIQHANDINQ---QF 77  Paramecium tetr...
A0CX19        16 SLKFKIPPGHQQCIKDNV--AQNTLIYGQYESS-----TLL-YIFTLNVInqQEI--EN-----TIIEYSSQAVS---QF 77  Paramecium tetr...
Q5CYL7        23 ALYFILNPGYTECIHFHA--KKADHIVGSFEID-----SAY-EGVRVSLF--ENKesSK-----ILDKIENSG-----DF 82  Cryptosporidium...
XP_001617072  23 CTHFIVGPLEKDCLHFRV--DKNNIIVGSYEII-----DKN-ALCLMYIVnrNDK--KK-----EKLFKSERVQD---KF 84 
Q8I6T5        24 CTHFNIGPYEKDCIQLKP--EKNNMIVGSYEFM-----DR-KASCIISIFnrSDK--KK-----EPVFKSTKIQD---KF 85  Plasmodium falc...
XP_001610572  21 AMQITLEGQETRCFIAGA--NNREKITGSVESLpe--eNAA-RPLLYKVAgpTSE--PVglplyIVTNN---------QF 84 
XP_001025950  25 ELAIKLEGRQEHCFFDSL----GERILVRLTIVc----DKG-EFLEFKVS--NQD--GT-----YSETQAELKTQ---NF 83  Tetrahymena the...

CAM43991     111 QLNPnVLNGEQLICFTASSNFVASekdpVKVRIELDQalkNefKARKEliktiqkrrqvdgldvytYQEvggelkDILqp 190
A0CNR3        63 QHQSsHKTSHLKYCFINLEDEI------VLFNVTYKT---G--SELAD------------------MQK------VAK-- 105 Paramecium tetr...
A0CKN2        75 QHQSnHKTSHMKYCFINLENDG------ILFNITYKT---G--SELAD------------------MQK------VAK-- 117 Paramecium tetr...
A0DT41        78 HYVM-EESGEISMCFEVEDYADV-----TIFNLFYES---G--AEIYD------------------QDL------LAK-- 120 Paramecium tetr...
A0CX19        78 HHVM-QESGEISMCFEVDDYSDI-----ATFHLFYES---G--AEIYD------------------QDQ------LPK-- 120 Paramecium tetr...
Q5CYL7        83 SINA-PKDTEYQLCFKNLMNSVQ-----QTVNFSIKN--------------------------------------MAY-- 116 Cryptosporidium...
XP_001617072  85 EIKV-TKPGAYSFCYANHKKTEIT----VMFTLRVKE------SHDAA------------------DAE------LGT-- 127
Q8I6T5        86 EIQV-PAAAVYSFCYDNRKNSDVT----IMFTLRVKE------SHNVN------------------DSE------LST-- 128 Plasmodium falc...
XP_001610572  85 EHIV-EETGHYAFCITNTSTKSNT----FLFNYRVET---GfnKDLSS---------------------------LST-- 127
XP_001025950  84 QIIT-EFEGEYQFCFHNTDLKED-----LTVYFDYKT---G--VEAKD------------------YAD------LIK-- 126 Tetrahymena the...

CAM43991     191 RAYLET-IER--------ELNAMEELLDQLVMGLTTSVTREFRMRETSESTFTRVWVCALLLIGIISGVLWMQFRFLKST 261
A0CNR3       106 ISDLNQ-MGD--------NMKKLNGLLDDIKRERSFLISKYDYMDKMQGSISKKQVVFGLLCLGLSFIITAITLNLIKRI 176 Paramecium tetr...
A0CKN2       118 ISDLNQ-MGG--------HMKKLNSMLDDIKRERSFLIAKYDFLSRMQGSISKKQIVFGLMCLGISLIITAITVNLIKRI 188 Paramecium tetr...
A0DT41       121 KQHVLN-LNE--------TLETMEQLQQDISREQLLIVDRENKRKHSFTDIQTKIIGFAGITFGLLIIVGACQVIYVRRF 191 Paramecium tetr...
A0CX19       121 KQHVQN-INE--------TLEQMEQLQQEISREQLLIVDREHIRKISFVDFQQQIVEFTAITLSILIIVAVLQAIYIRRY 191 Paramecium tetr...
Q5CYL7       117 NSNINNvMSNieskklieSMEKLYERITVASEKQRYALTRKRFQMEAIESSRKKAAIWSILELLLSFGLVAIQVYYIKSY 196 Cryptosporidium...
XP_001617072 128 ADDVQK-ISN--------EASQLYEQFFEVFEEQEKMMETADLYKQFNEKMNSKLILWSEVQIILLILLTLIHIFYIKSF 198
Q8I6T5       129 IDDVKQ-INE--------KTSELFDQFLEVFDEQERMMEKSDLYKQFNEKMNSKLILWLEIQIILLVVLTLVHIYYIKSF 199 Plasmodium falc...
XP_001610572 128 IEDANS-VLK--------FAEQLLENTHIIVDRTETYSSREALYSEILDYMNTRIIRWSTCQMIFLICICFFQIYYISSF 198
XP_001025950 127 KEDGVK-FEL--------SAKRLEDTLKDISLEKRFIYRHQQYNSALQNDLTFKIQGFSIITLVLLIALAIFQSYYLRQF 197 Tetrahymena the...

CAM43991     262 LR 263
A0CNR3       177 LQ 178 Paramecium tetraurelia
A0CKN2       189 LQ 190 Paramecium tetraurelia
A0DT41       192 IV 193 Paramecium tetraurelia
A0CX19       192 AK 193 Paramecium tetraurelia
Q5CYL7       197 FQ 198 Cryptosporidium parvum
XP_001617072 199 FE 200
Q8I6T5       200 FE 201 Plasmodium falciparum 3D7
XP_001610572 199 FE 200
XP_001025950 198 FK 199 Tetrahymena thermophila SB210
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