1NDD,1BT0,4F8C,1NDD,2BKR,2N7K,2NVU,3DBH,3DBL,3DQV,3GZN,4HCP


Conserved Protein Domain Family
Ubl_NEDD8

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cd01806: Ubl_NEDD8 
Click on image for an interactive view with Cn3D
ubiquitin-like (Ubl) domain found in neural precursor cell expressed developmentally down-regulated protein 8 (NEDD8) and similar proteins
NEDD8, also termed Neddylin, or RELATED TO UBIQUITIN (RUB/Rub1p) in plant and yeast, is a ubiquitin-like protein that conjugates to nuclear proteins in a manner analogous to ubiquitination and sentrinization. It modifies a family of molecular scaffold proteins called cullins that are responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. NEDD8 deamidation and its inhibition of Cullin-RING ubiquitin ligases (CRLs) activity are responsible for Cycle-inhibiting factor (Cif)/Cif homolog in Burkholderia pseudomallei (CHBP)-induced cytopathic effect. NEDD8 contains a single conserved ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions. Polyubiquitination, signals for a diverse set of cellular events via different isopeptide linkages formed between the C terminus of one ubiquitin (Ub) and the epsilon-amine of K6, K11, K27, K29, K33, K48, or K63 of a second Ub. Ubl NEDD8, contains many of the same lysines (K6, K11, K27, K33, K48) as Ub, where K27 has an role (other than conjugation) in the mechanism of protein neddylation.
Statistics
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PSSM-Id: 340504
Aligned: 44 rows
Threshold Bit Score: 118.645
Created: 9-Jun-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:E1/E2/E3 interaction site [polypeptide binding site]
Evidence:
  • Comment:Ubl-E1/E2/E3 interaction site
  • Comment:Human NEDD8 Ubiquitin-like protein (Ubl) is covalently conjugated to targets by actions of E1-E2-E3 enzyme cascades
  • Structure:2NVU; Homo sapiens Ubl domain of NEDD8 in complex with E1-E2-E3 enzyme cascades, contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #####                 ## ## ####  # # #  ###                  # #######
1NDD_A          3 IKVKTLTGKEIEIDIEPtDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGG 76   human
2NVU_I          8 IKVKTLTGKEIEIDIEPtDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGG 81   human
O14399          3 IKVKTLTGKEIELDIDPnDKVSRIKERVEEKEGIPPSQQRLIYAGKQMADDKNAESYHLEGGSVLHLVLALRGG 76   Schizosaccharomyces...
Q54XV3          3 IKVKTLTGKEIEIDIDPtDKIQRIKERVEEKEGIPPSQQRLIFGGKQMGDDKPASEYSIEGGSVLHLVLALRGG 76   Dictyostelium disco...
CCA72539       57 IKVKTLTGKEIELDIDPdDKISRIKEKVEEQSGVPPPQQRLIFSGRQMVDEKTAAELNIVAGSVLHLVLALRGG 130  Piriformospora indi...
XP_004995350    3 IKVKTLTGREIELDVEPdDTMLQVKEKLEEKQGIPPEQQRLIYAGKPLNDSKTLKDCKIESGCTIHLVLALRGG 76   Salpingoeca rosetta
XP_005707894 1250 VKVKTLTGKEIEIDIEPgDKIERIKERVEEKEGIPPAQQRLIFGGKQLADEKSARDYHIEGGSVLHLVLALRGG 1323 Galdieria sulphuraria
XP_005824956    3 IKVKTLTGKEIEFDIEPtDTVKRIKERVEEKEGIPPPQQRLIFGGKQMHDDKTASDYNLEGGSTLHLVLALRGG 76   Guillardia theta CC...
CEG00300        3 IKVKTLTGKEIEIDIEPtDSVERIKERVEEKEGIPPVQQRLIFGGKQMNDEKIAKDYNIEGGSVLHLVLALRGG 76   Ostreococcus tauri
KTW29842        3 IKVKTLTGKEIELDIDPsDKVFRIKERMEEKEGIPPIQQRLIFGGKQMSDERTASEYNLEGGSVLHLVLALRGG 76   Pneumocystis carini...

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