3QXY


Conserved Protein Domain Family
SET_SETD6
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cd19178: SET_SETD6 
SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins
SETD6 is a lysine N-methyltransferase that monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. It also monomethylates 'Lys-8' of H2AZ (H2AZK8me1).
Links
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Statistics
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PSSM-Id: 380955
Aligned: 23 rows
Threshold Bit Score: 239.9
Created: 11-Jun-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:SAM binding site
Evidence:
  • Structure:3QXY; Homo sapiens SETD6 binds cofactor S-adenosylmethionine, contacts at 4A.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         ###                                                            
3QXY_A        34 LELSPKVAVSRQGt--vAGYGMVAREsVQAGELLFVVPRAALLsqhtcsigglle------------------------- 86  human
EIE21805      15 IECSCCSIDVFDG----SGRGVVATKdISCGEVVVHVPDESVLmpencscsealed------------------------ 66  Coccomyxa subel...
EGD80779      54 IEFSPNVAITRKRv--vHGRGMVATAnIKAGEVLFEIPRSAMFsektckhadvlmanldhgvhsveedsadcheeadacd 131 Salpingoeca ros...
CEO98390      19 LRFVDDDARDPAR----RFRRVVAGErLPSGHVFLRVPKRALLtpattriarqlr------------------------- 69  Plasmodiophora ...
EAA29290      30 ATFHKDIKLVDLRdk-sAGRGIIATApIPADTTLFTIPRASILcattsplakklphlfkgpaeptvaees---------- 98  Neurospora cras...
KIL65864      17 GFLDVKVVDIKKNsapeGGRGMVAVAdIQEGHTLFTIPRHLILstgtsqlpslfg------------------------- 71  Amanita muscari...
PNW84932      50 KVRFPSSHLAVLPa---TGRALVASRnIKMGEVVVEVPDDAVLmaencglrdvleee----------------------- 103 Chlamydomonas r...
ESN94930      46 GFLLFNVSVSKRNv--aSGWGLVADKdITEGDVLFTVPRSVLLhpctvsdelkvai------------------------ 99  Helobdella robusta
XP_003382977  60 IAISDKVYIGVHGs--sHGIGVFAKDrIRKGEVLAVIPRSSTLsagnstlsdl--------------------------- 110 Amphimedon quee...
CEF98036      37 SIELNGVAVGKDRa---SGRGCVATRdLSVGEVVVRVPDEVVLttetssvrtelda------------------------ 89  Ostreococcus tauri

Feature 1                                                                                        
3QXY_A        87 ----------------------------------rervalqsqsgWVPLLLALLHELQa-------PASRWRPYFALWPe 125 human
EIE21805      67 --------------------------------agltnasgdaemeSIGLILALMTEKKl------gKSSKWKGYLDFLPk 108 Coccomyxa subel...
EGD80779     132 gacrttaasnredgggdhggtccgshakehkpttdeqtgdiklsgWSPLLLAMMLDMDa------gEASEFAPYFNILPe 205 Salpingoeca ros...
CEO98390      70 ----------------------------------prkaakyslnaWDRLILALMYEDAh-------RPSPWDAYLDFLPa 108 Plasmodiophora ...
EAA29290      99 ------------------pshtadaddeppspendeeddsqsqdsWTLLILILMHEYLq-------GSSNWSPYLSILPt 153 Neurospora cras...
KIL65864      72 ---------------------------------leewrrmgldkgWSGLILCMMWEQAk------gPYSKWHDYLAILPg 112 Amanita muscari...
PNW84932     104 --------------------------------gmtkdsadeeileVQGLVIAVMWERWr------gPESRWAPYLALLPd 145 Chlamydomonas r...
ESN94930     100 ---------------------------------eaageeldsgssWVPLLLCLLHEYDkmeaaacgFGGRWQPYFNMVPd 146 Helobdella robusta
XP_003382977 111 -----------------------------------isaniitdnsWIPLIITIMNEYSm------kDESYWCTYLNTVPn 149 Amphimedon quee...
CEF98036      90 --------------------------------fvgddgvesprleKELLVIAVMCEMLrg-----eKNSEWGAYLRVVRe 132 Ostreococcus tauri

Feature 1                                                                                        
3QXY_A       126 lgr-lehPMFWPEEERRCLLqg------tGVPEAVEKDLANIRSEYQSIVLPFMEAHPdlfsl----------rvrsLEL 188 human
EIE21805     109 si--pgmPLFWDSEQLQSLEgtsl-iekmNGCKAMPDRPLEPPCKFNSVVLPFLQSNAhlklph--------naastRRL 177 Coccomyxa subel...
EGD80779     206 dde-lhhPHVWTDRERSTLLkd------sRLQEDVARDLTLMKREYDTIAKPFMIRHPkifpqp-------gkkafsFRK 271 Salpingoeca ros...
CEO98390     109 tl---rtPLFWSVEERALLS---------GTAAETQCGFDAIEAGFRDRILPFVTRHRslfpg---------degalRRS 167 Plasmodiophora ...
EAA29290     154 qf---dtPMFWTEAELSELQ---------ASALVAKVGKEEADKMIRTKIVKVVQEHEevfypadtpktqrleegelLKL 221 Neurospora cras...
KIL65864     113 hf---htPMFWNEEDLHELT---------GTAVVEKLGKDDADKEYMETIVPALQSRTdlfppdt------laldysLAT 174 Amanita muscari...
PNW84932     146 dm--thmPLYWKRREFRELRgtaaydkmlGRAQHPSDAPTQVPLLWSEVVGPFIAEHPelglp---------ggergYEL 214 Chlamydomonas r...
ESN94930     147 fdd-lhlPMMWSKEELNEELkg------tNLLGLLDRDLKSLTFEFEHIVVPFVKKHPqlfna----------dnitLHH 209 Helobdella robusta
XP_003382977 150 ntsvcspPLLWSSEERERLLga-----etGLYHLVDSDMKRLRNDYCTIIKPFMETHLprv-------------kisEEK 211 Amphimedon quee...
CEF98036     133 gaenghsILAWDDEQAEALEgtdtwfdayENDDEGLDLPTMTDEHWEHVVRLFFERNPelargm--------dedelREL 204 Ostreococcus tauri

Feature 1                 ##                                                       ######        
3QXY_A       189 YHQLVALVMAYSFQEpleeee-------------------------------dekepnSPVMVPAADILNHLA--NHNAN 235 human
EIE21805     178 YVWATAMVSAYSFTIge---------------------------------------drFQAMVPMWDALNHITg-HANVR 217 Coccomyxa subel...
EGD80779     272 YAQCAAIVMGYSFTDee---------------------------------------dgRVCLVPVADILNHVTg-KNNAR 311 Salpingoeca ros...
CEO98390     168 YERFGSLVMAYSFSIvdvd-----------------------------------ddecAPVMVPVADALNHVTg-ATNAN 211 Plasmodiophora ...
EAA29290     222 GHRMGSAIMAYAFDLanddededeeeeee---------------edgwvedkiagmndSMGMVPMADMLNADA--VFNAH 284 Neurospora cras...
KIL65864     175 YHVMGSLILSRSFHVehwngilsendvikdsdermeeeptsspestdsvdesdgedstEVAMVPMADMLNAKFr-NENSK 253 Amanita muscari...
PNW84932     215 YRWATAAVASYSFILgd---------------------------------------dkYQAMVPVWDLLNHITg-DVNVR 254 Chlamydomonas r...
ESN94930     210 FKKMVSFVMAYSFTEpkkpgkdddd-----------------------dddddeddvhPPMMVPLADILNHAS--ENNAF 264 Helobdella robusta
XP_003382977 212 VIEIASFIMSYSFTDpysn-----------------------------------dvlsETMMIPFVDLLNHNH--CHHAE 254 Amphimedon quee...
CEF98036     205 HFAATAMVAGYSFTLgd---------------------------------------deIQGMVPFWDMLNHAPpcAASVR 245 Ostreococcus tauri

Feature 1                                    #            # #   
3QXY_A       236 LEYSAn---CLRMVATQPIPkGHEIFNTYGq-MANWQLIHMYGFVEP 278 human
EIE21805     218 LHHCArk-gALRMIATCLITkGEQVINSYGd-LPNSELLRRYGFVET 262 Coccomyxa subellipsoidea C-169
EGD80779     312 LFFSDk---TLQMRSIKRIPaGAEIFNTYGd-LDNLQLVQQHGFAEP 354 Salpingoeca rosetta
CEO98390     212 LFDDEddeeTISMATICDVErGDELINTYGdeLGNDTLLVRYGFVDR 258 Plasmodiophora brassicae
EAA29290     285 INHGEa---CLTATSLREIKeGEEILNYYGp-LSSAELLRRYGYVTP 327 Neurospora crassa OR74A
KIL65864     254 LFHEQd---CLKMIATKPIKaGDQIWNTYGd-LPNAELLRRYGHVDL 296 Amanita muscaria Koide BX008
PNW84932     255 LHHCSkr-hVLQMIAMRDIVaGSELVNNYGe-LSNAELLRGYGFVER 299 Chlamydomonas reinhardtii
ESN94930     265 IRFRPq---CLEMLAKRNIKkNEEIFNTYGe-LSNEQLLHMYGYAEH 307 Helobdella robusta
XP_003382977 255 LKFGNk---VLKLIATRSINpGEEIMNTFGtsLPNYSLLHTHGFIDL 298 Amphimedon queenslandica
CEF98036     246 LNHDPk--rGLQMITVREVKkGEEVFNTYGp-LRNAELLRRYGFVLA 289 Ostreococcus tauri

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