Conserved Protein Domain Family
ICMT
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pfam04140: ICMT 
Isoprenylcysteine carboxyl methyltransferase (ICMT) family
The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.
Links
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Statistics
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PSSM-Id: 427740
Aligned: 11 rows
Threshold Bit Score: 95.8849
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P91402   171 WIGTlgCIIGEIFRKVGMVHAGLAFTHRLAMtkRSDHRLVKDGIYAYLRHPGYFGwFLWAVSTQIILCNP--ICCVVYAY 248 Caenorhabditis elegans
Q9EWQ7    75 MLAL--ALSAQALRWWCIATLGPYWNTRVIV--VPGTRPVGAGPYRFLRHPNYLA-VVVEVAALPLVHSAwlTAAVFTAA 149 Streptomyces coelic...
Q9RTL5    91 ALLL--FLALQPLRYWVMHTLGRYWNTRILI--VPGGQRVTSGPFRFLGHPNYTV-VALELAAAPLAVGAwrTAVAFSLL 165 Deinococcus radiodu...
ACI98676  72 LLAL--FVLLQAGRVWVVASLGPYWTTRIIT--LPGAPLIRRGPFRHVRHPNYLV-VTGEIAVLPLAFGAweIALVFSFL 146
Q9KF68    72 AIPFawFLFAQILRLWALSSLGRFWNTRIMI--LPDANVIASGPYRYIKHPNYAV-VIIEIAMLPLFFKAyvTAFLFSLL 148 Bacillus halodurans
OCA29401 169 GLIM--VLFGELLRKCAMLTAGSNFNHIVQNekSDSHTLVTSGVYSWFRHPSYVGwFYWSIGTQVLLCNP--LCLFGYTF 244
O60725   161 VTGLlmVVFGECLRKAAMFTAGSNFNHVVQNekSDTHTLVTSGVYAWFRHPSYVGwFYWSIGTQVMLCNP--ICGVSYAL 238 human
P87014   121 ALGFl--CLGQYLRSSAMVQAGQSFSHIVASkrNKDHLLVTDGIYAYVRHPSYVGfFIWALGTQMLLGNF--VSTLLFSL 196 Schizosaccharomyces...
P32584   123 VLGCllVILGQYTRTIAMHTAGHSFSHIVKTkkESDHVLVKTGVYSWSRHPSYLGfFWWAIGTQLLLLNP--LSLVIFIF 200 Saccharomyces cerev...
Q9CM58    75 LAIL---VFAIAMLFYVIYELKEIWTVKLYI--LPEHHINRSFLFKYVRHPNYFLnIIPELIGLSLFCQAkyTALIGLPI 149 Pasteurella multocida
Q2G1E3    99 LV-I--LIFAYIMLFMVIKTLGGIWTLKLFI--LPNHPIIKSGLYKITKHPNYFLnIIPELIGVLLLTHAtyTTILLVP- 172 Staphylococcus aure...

P91402   249 VTWHFFaSRIYDEEKDLIS 267 Caenorhabditis elegans
Q9EWQ7   150 NAMLLT-VRLRCENTALAQ 167 Streptomyces coelicolor
Q9RTL5   166 NAALLLgVRIPAEDRALAE 184 Deinococcus radiodurans
ACI98676 147 NAALLF-HRIRQEERALAP 164
Q9KF68   149 NAIVLY-IRIHTEEEALQA 166 Bacillus halodurans
OCA29401 245 ASWRFFrERIEEEEFSLIH 263
O60725   239 TVWRFFrDRTEEEEISLIH 257 human
P87014   197 VLWKFFsQRITTEEAYLVS 215 Schizosaccharomyces pombe 972h-
P32584   201 VLWKFFsDRIRVEEKYLIE 219 Saccharomyces cerevisiae S288C
Q9CM58   150 YLLILG-VRIKQEESAMAH 167 Pasteurella multocida
Q2G1E3   173 YAYFLY-VRIKQEEKLMNI 190 Staphylococcus aureus subsp. aureus NCTC 8325
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