1PBV,1BC9


Conserved Protein Domain Family
Sec7

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cd00171: Sec7 
Click on image for an interactive view with Cn3D
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.
Statistics
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PSSM-Id: 238100
Aligned: 34 rows
Threshold Bit Score: 137.354
Created: 24-May-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:active site/putative ARF binding site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
1PBV        10 RNRKMAMGRKKFNM---------------------DPKKGIQFLVENell--qntPEEIARFLYKg--eGLNKTAIGDYL 64   human
Q9NRD0     133 RKLYMQLDEGSLTFn-------------------aNPDEGVNYFMSKgil--ddsPKEIAKFIFCt--rTLNWKKLRIYL 189  human
XP_031193  536 IHLTSAEHENLRTPmnsswlpgspmpqaqspeegqRPPAGDKLANGVrnn---kvAWNLASRLYRl--eGFRKSEVAAYL 610  human
NP_115665  266 TDKLLNSASDPSLKdglsdsds-----elssseglEPGSADPLANGCqgv--seaAHRLARRLYHl--eGFQRCDVARQL 336  human
AAF56027   378 VVTLTDEPLGTMTVgmrdasp-------pvsddgsDVESLHSYHYSPkavd-mpsAIRLAKRLHSl--dGFKKSDVSRHL 447  fruit fly
4506161    144 SQLVSDSDSELDSTd--------------------RLALGSTDTLSNgqkadleaAQRLAKRLYRl--dGFRKADVARHL 201  human
7467935      6 DSLLKNEVIKLFND---------------------KPKSGIARIKKWctdnnqdfIAETAKIFYEek-sNLNLEFVGDYL 63   Rickettsia prowa...
465519      48 SPTMVNMCDILQNKeaandekp-----vipttdtaTAGTGTEDISSTqseetdqnSHLIASEILEgtfkDVSYKEYANFL 122  Saccharomyces ce...
7510216    341 SLHATSESRGATGGvslrsa----------essnlNQTAVPSTSTNSvgg--ereAAQIARNLYEl--kNCTSTQVADRL 406  Caenorhabditis e...
2132277    433 HLQQQQQLQQKLDV---------------------SLEDLPPVPAPEfs----dsCKDFLIKLAPy--gKFIGIILTEKD 485  baker's yeast
Feature 1                                         ####### #                                    
1PBV        65 GEreelNLAVLHAFVdlHEFTDLNLVQALRQFLWSFRLPGEA-QKIDRMMEAFAQRYCLCNPGVFq---------STDTC 134  human
Q9NRD0     190 DE----RRDVLDDLVtlHNFRNQFLPNALREFFRHIHAPEERgEYLETLITKFSHRFCACNPDLMrel-----glSPDAV 260  human
XP_031193  611 QKnndfSRAVAEEYLsfFQFGGQSLDRALRSFLQALVLSGET-QERERILYQFSRRFHHCNPGIFp---------SVDSV 680  human
NP_115665  337 GKnnefSRLVAGEYLsfFDFSGLTLDGALRTFLKAFPLMGET-QERERVLTHFSRRYCQCNPDDSt---------SEDGI 406  human
AAF56027   448 SKnndfSRAVADEYLkhFTFEKKSLDQALREFLQQFSLSGET-QERERVLVHFSKRFLDCNPGTFn---------SQDAV 517  fruit fly
4506161    202 GKnndfSKLVAGEYLkfFVFTGMTLDQALRVFLKELALMGET-QERERVLAHFSQRYFQCNPEALs---------SEDGA 271  human
7467935     64 GTdgvdNQKVLESFTkqFDFKEKDYLESLRRFLQSFKLPGEA-QKIDRLVESFGTHYYEQNLNIDi--------nSKDAA 134  Rickettsia prowa...
465519     123 GNd--nNNQVLTEFVklLSPLPSSLLETLFNLSKSIYFIAEA-QNIDRILECLSIEWIACHPNTHwk-------sGYKSC 192  Saccharomyces ce...
7510216    407 NEqnefSFLILVKYLelFQFSTTRIDAALREFLSRVELRGES-SARERLLRVFSARYLECNPAIFd---------SLDEV 476  Caenorhabditis e...
2132277    486 DEf--kKNCLNYLLTncFEFKNDPLDIALRKLLMFLELPKET-QQIDRLIMAFSFAYYKAQKSYSkkkgiecpwsNADQV 562  baker's yeast
Feature 1       ##############                                                           
1PBV       135 YVLSFAVIMLNTSLHNPNV----RDKPGLERFVAMNRGINeg------------gDLPEELLRNLYDSIRNEPF 192  human
Q9NRD0     261 YVLCYSLILLSIDLTSPHV----KNKMSKREFIRNTRRAAq--------------NISEDFVGHLYDNIYLIGH 316  human
XP_031193  681 HTLTCAIMLLNTDLHGQNI----GKSMSCQEFITNLNGLRdg------------gNFPKELLKALYWSIRSEKL 738  human
NP_115665  407 HTLTCALMLLNTDLHGHNI----GKKMSCQQFIANLDQLNdg------------qDFAKDLLKTLYNSIKNEKL 464  human
AAF56027   518 HTLTCAIMLLNTDLHGQNI----NRKMSCAEFVDNLADLNdg------------eNFPKDVLKSLYQAIKTKPL 575  fruit fly
4506161    272 HTLTCALMLLNTDLHGHNI----GKRMTCGDFIGNLEGLNdg------------gDFPRELLKALYSSIKNEKL 329  human
7467935    135 YILAYQTIMLNTDLHNPSIa--kSKKMTFEQLKNNLKGTNes------------kNFNDNFLKKIYDEIEAKPF 194  Rickettsia prowazekii
465519     193 HIVLFSLLILNSDLHNNFQvdhkKIKFSMVAFINNTLRALreeneyeelkiysreHLIIEELSEYYKTLNETPL 266  Saccharomyces cerevisiae
7510216    477 HTLTCALLLLNSDLHGPNM----GKKMTARDFITNIAHTGc--------------TFKREMLKTLFQSIKDNAI 532  Caenorhabditis elegans
2132277    563 YFIAFSLLMLHTDYFNPNN----KSKMTKHDFVDLVHNDKysg----------gnEIPMAVLTYFYENVTAKES 622  baker's yeast

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