Conserved Protein Domain Family
SLC-NCS1sbd_NRT1-like
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cd11482: SLC-NCS1sbd_NRT1-like 
nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain
This fungal NCS1 subfamily includes various Saccharomyces cerevisiae transporters: nicotinamide riboside transporter 1 (Nrt1p, also called Thi71p), Dal4p (allantoin permease), Fui1p (uridine permease), Fur4p (uracil permease), and Thi7p (thiamine transporter). NCS1s are essential components of salvage pathways for nucleobases and related metabolites. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters, and solute carrier 6 family neurotransmitter transporters.
Links
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Statistics
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PSSM-Id: 271375
Aligned: 71 rows
Threshold Bit Score: 532.861
Created: 4-Aug-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
Na binding siteputative
Feature 1:Na binding site [ion binding site]
Evidence:
  • Comment:based on the structures of Vibrio parahaemolyticus vSGLT (SLC5), Aquifex aeolicus LeuT (SLC6), and the NCS1, Microbacterium liquefaciens Mhp1, bound with Na+, functional studies of Escherichia coli PutP (SLC5) and mammalian NIS (SLC5), and mutational analysis of vSGLT
  • Comment:one of two Na+ binding sites in Aquifex aeolicus LeuT, where it is referred to as the Na binding site 2
  • Comment:Mhp1 may have a flexible cation specificity
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                               #  #                                                  
Q04895     98 LYNRDLKPVEEERRCWSWFNYLYFWLADCFNINTWQIAGTGLQLGLNWWQCWLTVWIGYTFAGIFVVLNSRFGSAYHLSF 177 baker's yeast
EFQ96065   29 WSNRDLIPLPPERRTWGSFSFFGFWAIASLNIANWQTPGTFLAMGLSVPQSMLIIVVSNILIALFSTVIAWVGLKWHIGF 108 Pyrenophora teres ...
EEU41309   23 WVNEDLKPVPLERQTWGWLQFFELWFLVNVNISTYQTGASLLAVGLNWWQAIIVIVAGSLVTGFFTVLNSISGAVSHLGY 102 Nectria haematococ...
EEA21899   27 WINNDIKPVEAGRRKWGFWTFNYYWVLINCNISTYMTGSSLIPLGLSWWQAIIAIVIGNILASVFIVLNSLPGAFYHLGF 106 Penicillium marnef...
EFR04304   22 LLNNDIKPIEKARRTWSWYEYFSFWCVGAFNITNFQLGSALLATGLNWWQTTVATLIGHILAAVLIVITSFPGLEYHISF 101 Arthroderma gypseu...
EEP81167   23 WINDDIRPLPPKRRTWNVYAFLSFWAINQIALSNWQSGSSLVAFGLSVWQTVIAVVVGKLIIALVAVFNGFVGAEWHIGF 102 Uncinocarpus reesi...
EFQ27398   23 WINDDIRPMPPSRRRWTSWTFISFWLTNQVAISNWQLGASLVAAGLSVWQSVIAIIVGKVIIALVAIANGMVGAEWHIGF 102 Glomerella gramini...
EGD88890   30 WINDDIRPLPPSRRTWSTLTFVGWWSVWQFSLTNWQLGAALVASSLSVWQTMIAVILGRIIAAIVAVMIGYIGAEWHIGF 109 Trichophyton rubru...
EFI94089   26 WSNRDLIPLPPSRRTWGLFEYFGYWSLSSLNISAWQMPNSYLTVGLSVGQSMGVIIVSRAIVCLFASLVAWCGLRWHVGF 105 Schizophyllum comm...
CCA39509   25 LLNRDIIPLPPNRRTWTDWDFVGFWAVINLSVFTWQTCSSLLSLGLSVWESMVIVIISKALIFAVALSHGWGGGVWHVGY 104 Pichia pastoris CB...

Feature 1                                                                                     
Q04895    178 PITVRASFGIFFSMWPIINRVVMAIVWYAVQAWLGATPVALMLKSIFGKnlEDRIPNHFG-SPNSTTFEFMCFFIFWVVS 256 baker's yeast
EFQ96065  109 TVQNRYSWGMMGSFIPLSQRILLNFIWNAVQCWNGGRLAAVCLTAIWPS--YARMPNTFSaNFPATTDQFVGFVVFWFLS 186 Pyrenophora teres ...
EEU41309  103 AVISRSVWGVYGAYFPVLNRILLSLVWYGVQAVIGGKMVFVCLRSIWPTl-DQRIPNKLPeNIGITSAEFVGYFIFNVIC 181 Nectria haematococ...
EEA21899  107 PVANRYVWGMWGSQWVICNRIFLSIIWYACQAWIGGECVYVCLQAIWPSl-EDRIPNHMPaSTGMTTAEFVAYIVFMVIS 185 Penicillium marnef...
EFR04304  102 PVAMRISWGFYGSTFVVLNRILLSIVWFGVQSWQGGQMAYVCIRAIWPS--IDRIPNTIPaSTGMTLPMFVGFIIFSLIQ 179 Arthroderma gypseu...
EEP81167  103 PVFSRVVWGIYGSYVALLQRILLSVVWFAVQSWTGGLCVTAILASIFSG--FHNLENSFPeSAHMTTKQFTGWVVYNVLT 180 Uncinocarpus reesi...
EFQ27398  103 PVVSRYIWGVYGQYLILIQRIILSLVWFSVQSWTGGLTVVNCLSAIFPS--FESLGNVFPeSSHLTSKGFIGWILYNILL 180 Glomerella gramini...
EGD88890  110 PVYSRVIWGIFGAIVPTVIRIGLTIVGFAFQSYTGGLCVSAILAAIFPS--FNNLQNTLPeSAHVTTQQIIGWAIFNIIS 187 Trichophyton rubru...
EFI94089  106 TIQNRFSWGMRGSYIPLIQRVMLNFIWNAIQCWNGGKLVCVCITAIFPS--FASMKNTLPsSMPTTTYEMVGFTIFWFCS 183 Schizophyllum comm...
CCA39509  105 PIYGRFSFGIFGSYLAVGQRIVLAIVWYAVQSFTGAMMLTICLSSIFPS--FNTLHNTFPdSLPMTLKQFIGFIIYHVLS 182 Pichia pastoris CB...

Feature 1                                                                                     
Q04895    257 IPFVLVAPHKIRHLFTVKAALIPFAAFGFLIWALKKSHGkieLGTLNDYSPhgs-----efsWIFVRSLMACVANFAALI 331 baker's yeast
EFQ96065  187 TPFLWLRPERFHIPFLVVCTWCGLGMFAWMIWALVTAKG---VGPLWYSGQqvpagsmwstsWLIMSGINQTIGGFAAGI 263 Pyrenophora teres ...
EEU41309  182 CVFIWFKPHQLRLYFHAGAGLSLVAFVALLGWALGTKGPgesLNDAFDDSVvlkg---salgWAICSGMMSVLGAAAAGI 258 Nectria haematococ...
EEA21899  186 LPFVYVRPHKLQLLFYISAAVVLVFEVVLLIWSLATMGDv-gFGDTISSTTss-------sgWMIAYGIISTIGSIAAGI 257 Penicillium marnef...
EFR04304  180 IPFLILGPGRLRYMLHVGAIGGFICQLVLVSWAGGTKGSq-gFGEILDSTNklsg---snagWMFLLGIGSTMSSITAGT 255 Arthroderma gypseu...
EEP81167  181 IPILYLPPEKTKRLFYVMNSISFVTLIGMTIWALATARG---GGPLLTQPAtasss--sdlgWSIVKGITTVVGGIAVGL 255 Uncinocarpus reesi...
EFQ27398  181 IPILYIRPERIQKLLLAFNVISSVTLVSIMIWALATAGD---AGSLVRQGSksmss--selgWQIVHGITTVIGSIAVGL 255 Glomerella gramini...
EGD88890  188 IPMLYRRPERSEKLMIGMNVMSFASLLGIMIWSLSYAKG---AGDLIHQASdlqgs--salgFGILQGTTTVVGTVSIAL 262 Trichophyton rubru...
EFI94089  184 LPFLWLPPEKFRLPFQVICIYCGVAMVCMMIWALAVAKG---VGSTFHTGQnltgs--wsinWVMLKCINSAIGGKAAGM 258 Schizophyllum comm...
CCA39509  183 IPFLYIPPEKLKHPFRFVSIISFVTIFGVSIGCMVKADG---AGSLLQSSGvsmss--adrgMAWMHGINTMFNSIAVGL 257 Pichia pastoris CB...

Feature 1                                                                                     
Q04895    332 INAPDFGRFAKNpQASLWPQLVAIPLFFAITCLIGIIVTAAGYh----LYGVNYWSPLDVLGQFlett----ytrGTRAG 403 baker's yeast
EFQ96065  264 TNGSDFSRYATKrRSYIYGTITSCIITSVLVSLVGLVTAAAGQk----IYGEVYWNPPDLLMKMmdng---ngssGSRAG 336 Pyrenophora teres ...
EEU41309  259 LNQNDYTRFAQRpSQVVSSQFTSFVLTTTFTGICGILVTAATQkr--yGDGAPLWDPYQLLVAMqdsssnkssesGTRAA 336 Nectria haematococ...
EEA21899  258 LNQTDYARFARKpRDAIYGQIISSALCAISCGVIGILVTAATQn----RYGEAMWNLPNLLSAIiet-----ggsRSRAA 328 Penicillium marnef...
EFR04304  256 LSIGDYTRFAKK-PSDGIWSQAMGAFPVWLANVIGMLTIAATQk----RFGSALWSVASLLMAIqdad----pssKTRVG 326 Arthroderma gypseu...
EEP81167  256 TNQPDYSRFATKpGDQVFGQYFSIIVLGSIMPTLGCLVSSATQq----IYGVALWNPPDLALKWlead----ynaKSRAG 327 Uncinocarpus reesi...
EFQ27398  256 TNQPDYCRFARKpGDQVFGQWFSIIFFGAIFPTFGCLAASATGv----IYGEPIWNPPLIVQAWldnd----ynsKSRAG 327 Glomerella gramini...
EGD88890  263 TSQMDFSRFARKpSDQVFGQWFTFIIIGSIMPLFGCLTSSATQk----LYGEPLWNPPTILAMWlqrd----yssTSRAA 334 Trichophyton rubru...
EFI94089  259 TNGSDFSRYGKTaREYIIGTFLCLFCTGTMVSFVGLVTVSATQk----IYGEVYWNPPDLLMRMmedg---qgssKARAG 331 Schizophyllum comm...
CCA39509  258 ANQPDFSRFVQRpGQQVKGQGFSILILGTVVPLFGLLGTSAAAevygdVVELNLWNPPNILDQWlies----ytsRTRAA 333 Pichia pastoris CB...

Feature 1               #  ##                                                                 
Q04895    404 VFLISFVFALAQLGTNISANSLACGADMTALFPRYINIRRGSLFCVAMALCICPWNLMASSSKFTSALGAYAIFLSSIAG 483 baker's yeast
EFQ96065  337 VFFLAAGFGFAAMFENICGNAVSGGIDLAGLFPRYINIRRGAIITFLAAWIVQPWQLINRATTFIQVLSSFSVFLAPIIG 416 Pyrenophora teres ...
EEU41309  337 TFFLAFAFIVAQLSICVPGNVLAGGLDVASLLPKYINLRRGAYILAALSVLPNPWQQLASGSTFLAVLSAYAVFIGPLIG 416 Nectria haematococ...
EEA21899  329 AFFGGVALVVSQIGVNVPGNALSGGFDFAATWPKYINIRRGAYLTVLISIAANPWKLVNTATTFLTVLSSYSVFVGPMVG 408 Penicillium marnef...
EFR04304  327 IFFCAFVFGITQLVLNISGNSFCGGTDMSALFPKYINIRRGQALTAILGTVINPWYLLSGAIVFISVLSSYVVFLQPFVG 406 Arthroderma gypseu...
EEP81167  328 AFFAGTGLVVCQLAINTIDNAFSAGMDLSGLFPKFINIRRGAYIGLIISIALCPWELLYSAGTFISVLSAYSVFLGPMCG 407 Uncinocarpus reesi...
EFQ27398  328 ALFAGLGLLCIQLSINSVDNAFSAGMDLAGLFSQYINIRRGAYIGLVLSIALCPWELLSSASVFISVLSAYSVFLGPVIG 407 Glomerella gramini...
EGD88890  335 AFFAGLGLVSSQLALTVVDNGYSVGMDLSGLLPRYVNIRRGCYVGLILGMALCPWELLASAKTFVSVISSFSIFMAPLCG 414 Trichophyton rubru...
EFI94089  332 VFFLALGFALTAGFENICGNAVAGGIDLAGIFPKYINIKRGAMITFFAAWICMPWQLVNRADTFITVLSSFTVFLAPIMG 411 Schizophyllum comm...
CCA39509  334 AFFAAFGFFVSTLGLNTIDNAISGGIDLASMAPKWITVRRGAYMIMIVSIAMNPWQIVAKASVFLAVLGSYGCFLGPMIG 413 Pichia pastoris CB...

Feature 1                                                                                     
Q04895    484 VICADYFVVRRGYVKLTHLFl-aQKGSFYMfgnkfGANWRAFVAYICGIAPNLPGFIGDVgapkITVSEGAMRLYYLGYP 562 baker's yeast
EFQ96065  417 IMSCDYYLLRKRKIRLSHLYr-tRDSIYYFs---hGFNWRAIVAWICGWAPTIGGLVVTVra-ePHPSRPLVQLYYMAFL 491 Pyrenophora teres ...
EEU41309  417 ILCVNYYIIQKRKFHVPDLFegsSRSLYWYn---rGVNWRTVAAWLIGTAPSLPGFAASVnp-sISVSQGATNFYNLTFI 492 Nectria haematococ...
EEA21899  409 LMISSYLVVNQRKIKVPDLFignKNSIYWYt---yGVNWRAVVAWICGVAPSLPGFIAYVnp-nISVPIGLTHLYYICFL 484 Penicillium marnef...
EFR04304  407 IAAAHYFIIQKRRIKVPDLYitgNQSIYWYd---fGVNWRTVLAWLVGVIPHLPGMVHSVnp-kLPVTDGASHLYYIASI 482 Arthroderma gypseu...
EEP81167  408 MMISEYWIVRSRKIKLSDLYhprRDGIYYFw---yGMNPRAFTAWVFGFAPLLPGFVNAVnp-sISVPEGCVQMYYLAYP 483 Uncinocarpus reesi...
EFQ27398  408 IQICDYFIIRRRRIKLSDLYhphSDGSFYYw---kGINPRTFVAWVCGFATQLPGFAASVtpdsVKVGTAWINLYYLAFP 484 Glomerella gramini...
EGD88890  415 IHISDYWIVRQRRLKLSDLYhsrPDGIYYYt---sGINWRSIIPWLVGWVPLLPGFIHSInp-tIMMPVGVDRLYALGFP 490 Trichophyton rubru...
EFI94089  412 IMTTDYFILRRQRIRLSSLFd--LHGQYYYn---fGFNWRTPLAWVAGWAPLIAGLNATVq--kTTVARPLFQLYYMSFF 484 Schizophyllum comm...
CCA39509  414 VMTCDYYFVRHQKLKLTDLYkadKSSIYWFy---kGFNWRGFVAWICGFTPGITGFPSVNpn-lTGVPTACIKMFYISFI 489 Pichia pastoris CB...

Feature 1                         
Q04895    563 VGFFISAVIYLILCYFFPVP 582 baker's yeast
EFQ96065  492 IGFFISAIVFYMLNLIVPIP 511 Pyrenophora teres f. teres 0-1
EEU41309  493 FGFCISAFVAFALHWFFPVD 512 Nectria haematococca mpVI 77-13-4
EEA21899  485 TGMSISAAVYVALHYAVPDK 504 Penicillium marneffei ATCC 18224
EFR04304  483 TGFFIPFTVSIALDYLVPVK 502 Arthroderma gypseum CBS 118893
EEP81167  484 LGFAISFVVYIVLNKVFPPP 503 Uncinocarpus reesii 1704
EFQ27398  485 LGFAISFLLHLGINTMWPPP 504 Glomerella graminicola M1.001
EGD88890  491 YGLLASMAVHTVINMVFPPP 510 Trichophyton rubrum CBS 118892
EFI94089  485 IGFSISAILFYALNMLFPPP 504 Schizophyllum commune H4-8
CCA39509  490 IGYPIGFLVHLALNKLFPPP 509 Pichia pastoris CBS 7435

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