Conserved Protein Domain Family
gidA

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TIGR00136: gidA 
glucose-inhibited division protein A
GidA, the longer of two forms of GidA-related proteins, appears to be present in all complete eubacterial genomes so far, as well as Saccharomyces cerevisiae. A subset of these organisms have a closely related protein. GidA is absent in the Archaea. It appears to act with MnmE, in an alpha2/beta2 heterotetramer, in the 5-carboxymethylaminomethyl modification of uridine 34 in certain tRNAs. The shorter, related protein, previously called gid or gidA(S), is now called TrmFO (see model TIGR00137). [Protein synthesis, tRNA and rRNA base modification]
Statistics
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PSSM-Id: 272927
Aligned: 9 rows
Threshold Bit Score: 1033.47
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P53070        37 TQVVVIGAGHAGCEAAAASSRTGAHTTLITPSLTDIGKCSCNPSIGGVGKGILVKEIDALDGLMGKVTDLAGVQFKMLNR 116 Saccharomyces c...
P17112         7 FDVIIIGGGHAGTEAAMAAARMGQQTLLLTHNIDTLGQMSCNPAIGGIGKGHLVKEVDALGGLMAKAIDQAGIQFRILNA 86  Escherichia coli
P44763         7 YDVIVIGGGHAGTEAALAPARMGFKTLLLTHNVDTLGQMSCNPAIGGIGKGHLVKEVDAMGGLMAHAADKAGIQFRTLNS 86  Haemophilus inf...
P25812         8 YDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVAFMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNT 87  Bacillus subtil...
Q55694        13 FDVIVVGAGHAGCEAALATARLGCRTLLLTLNLDRIAWQPCNPAVGGPAKSQLTHEVDALGGEIGKMADRTYLQKRVLNI 92  Synechocystis s...
P56138         5 SDILVVGGGHAGIEASLIAAKMGARVHLITMLIDTIGLASCNPAIGGLGKGHLTKEVDVLGGAMGIITDHSGLQYRVLNA 84  Helicobacter py...
P47619         3 FIITVIGAGHAGLEAAFIVSKFNIKVNLLVLDINHLGSCPCNPSIGGPAKGIVTREIDVLGGMQAIAADNNALQYKLLNS 82  Mycoplasma geni...
P75221         3 FTLTVIGGGHAGLEAAFIASKLGLKVNLLVLDPNHVGSCPCNPAIGGPAKGIVTREIDVLGGMQGKAADATALQYKLLNS 82  Mycoplasma pneu...
WP_002657592   3 FDAIVIGGGHAGIEAALALSRLNFKTLMITQNLDTIGKLSCNPAIGGLAKGNMVREIDALGGEMGRIIDFSMIQFRVLNK 82  Lyme disease sp...
P53070       117 SKGPAVWGPRAQIDRELYKKYMQRELSDKkahPNLSLLQNKVADLILYDpgcgHkVIKGVVLDDGTQVGADQVIITTGTF 196 Saccharomyces c...
P17112        87 SKGPAVRATRAQADRVLYRQAVRTALENQ---PNLMIFQQAVEDLIVEN----D-RVVGAVTQMGLKFRAKAVVLTVGTF 158 Escherichia coli
P44763        87 SKGPAVRATRAQSDRVLYRQAVRTALENQ---PNLDIFQQEATDILIEQ----D-RVTGVSTKMGLTFRAKSVILTAGTF 158 Haemophilus inf...
P25812        88 GKGPAVRALRAQADKFQYQHEMKNTLEKE---PNLTLLQGIVERLIVED----G-ECRGVITQTGAHYRAKAVVMTTGTY 159 Bacillus subtil...
Q55694        93 SRGPAVWALRAQTDKREYAAVMKNIVENQ---PNLSIREGMVTDLVLGD----NdEIQGVQTYFGACFGAQSVVITTGTF 165 Synechocystis s...
P56138        85 SKGPAVRGTRAQIDMDTYRILARNLVLNT---PNLSVSQEMTESLILE-----NdEVVGVTTNINNTYRAKKVIITTGTF 156 Helicobacter py...
P47619        83 SKGPAVQAIRAQIDKIGYKNWFQSQVKLN---KNINLIQSEAINLIVR-----NeKIKGVILKDGSELLSDAVIITTGTY 154 Mycoplasma geni...
P75221        83 SKGPAVQAIRAQIDKIAYQKWFRQQIDQT---PNIELIAGEAVDILES-----NgKVKGVVLADGSELASDAVIVTTGTY 154 Mycoplasma pneu...
WP_002657592  83 SRGPAVQAPRAQADKLMYQTKAKETLERQ---DNLDLFQDTVVDFLLNSm---RnEIEGVVTERGNKFRSSVVVLTTGTF 156 Lyme disease sp...
P53070       197 LSAEIHIGDKRIAAGRIGEQPTYGISNTLQnEVGFQLGRLKTGTPARLAKESIDFSALEVQKGDALPVPMSFLNETVSVe 276 Saccharomyces c...
P17112       159 LDGKIHIGLDNYSGGRAGDPPSIPLSRRLR-ELPLRVGRLKTGTPPRIDARTIDFSVLAQQHGDNPMPVFSFMGNASQHp 237 Escherichia coli
P44763       159 LAGKIHIGLENYEGGRAGDSASVNLSHRLR-DLGLRVDRLKTGTPPRIDARTINFDILAKQHGDEVLPVFSFMGSVDDHp 237 Haemophilus inf...
P25812       160 LRGRIILGDLSYSSGPNNQQPSIKLSEHLE-ELGFDLVRFKTGTPPRVKSDTIDYSKTEIQPGDDVPRAFSYETVEYIT- 237 Bacillus subtil...
Q55694       166 LGGKIWIGNKSMPAGRAGEFAAVGLTETLN-ELGFETGRLKTGTPARVDRRSVDYDKLEPQPPDEQVSWFSFDPEVWVEr 244 Synechocystis s...
P56138       157 LKGVVHIGEHQNQNGRFGENASNSLALNLR-ELGFKVDRLKTGTCPRVAGNSIDFEGLEEHFGDTNPPYFSYKTKDFNP- 234 Helicobacter py...
P47619       155 LRSKTYCGNTVKNQGPDQSKNSEKLSTNLI-NRGFKTIRLKTGTPPRILKTSLDYNQMELEINNNQNLAFSTTNKNFLPl 233 Mycoplasma geni...
P75221       155 LKAKTYCGSLSKEEGPDRAKRSEYLSTNLI-KRGFKTLRLKTGTPPRILRESLDFSQMAVEANTTPHLAFSFTTKNYLPl 233 Mycoplasma pneu...
WP_002657592 157 LRGKIFIGEYRADMGRLAEFSAYGLDKTLL-GLGFEMGRLKTGTPARIHKKSVDFSKTEVQFGDSDIIPFSFSNGKLDK- 234 Lyme disease sp...
P53070       277 ptKQLDCFGTHTTPQMHDFLRNNLHQSIHIQDTTIK-GPRYCPSIEAKILRFPDRSSHKIWLEPEGFNSDVIYPNGISNS 355 Saccharomyces c...
P17112       238 --QQVPCYITHTNEKTHDVIRSNLDRSPMYAGVIEGvGPRYCPSIEDKVMRFADRNQHQIFLEPEGLTSNEIYPNGISTS 315 Escherichia coli
P44763       238 --QQIPCYITHTNEQTHEVIRNNLDRSPMYTGVIEGiGPRYCPSIEDKVMRFADRNSHQIYLEPEGLTSNEVYPNGISTS 315 Haemophilus inf...
P25812       238 --DQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGtGPRYCPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTS 315 Bacillus subtil...
Q55694       245 --EQMNCYLTRTTAKTHQLIKDNLHLSPIYGGFIDSkGPRYCPSIEDKIVRFADKESHQIFIEPEGRDIPELYIQGFSTG 322 Synechocystis s...
P56138       235 --TQLSCFITYTNPITHQIIRDNFHRAPLFSGQIEGiGPRYCPSIEDKINRFSEKERHQLFLEPQTIHKSEYYINGLSTS 312 Helicobacter py...
P47619       234 -eKQIPCYLVHTNQKIHDLILKNLKKSAMFNGSISAqGPLYCPSIEDKVFKFSQKPRHQIFVEPESLSLDTIYLAGLSTS 312 Mycoplasma geni...
P75221       234 -eQQVICHLIHTNPQIHQLILANLKQSAVFNGSIKAnGPLYCPSIEDKVFRFQDKERHQIFVEPESLSLETVYLAGFSTS 312 Mycoplasma pneu...
WP_002657592 235 --SQLSCYVTYTNKKTHEIISENMHLSPLYSGEIVGnGPRYCPSIEDKIVKFKDKDRHQIFIEPEGFNTEEMYLNGLSSS 312 Lyme disease sp...
P53070       356 MPEDVQLQMMRLIPGMANVEILQPAYGVEYDYVDPRQLKPSLETKLVDGLFLAGQINGTTGYEEAAAQGIIAGINAGLLS 435 Saccharomyces c...
P17112       316 LPFDVQMQIVRSMQGMENAKIVRPGYAIEYDFFDPRDLKPTLESKFIQGLFFAGQINGTTGYEEAAAQGLLAGLNAARLS 395 Escherichia coli
P44763       316 LPFDVQMGIVNSMKGLENARIVKPGYAIEYDYFDPRDLKPTLETKSISGLFFAGQINGTTGYEEAAAQGLLAGINAGLYV 395 Haemophilus inf...
P25812       316 LPEDVQQRMLATIPGLENVQMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAGRKA 395 Bacillus subtil...
Q55694       323 LPENVQLAMLQTLPGLENCVMLRPAYAVEYDFLPATQCYPSLMTKKVAGLFCAGQINGTTGYEEAAAQGLVAGINAARHC 402 Synechocystis s...
P56138       313 LPLDVQEKVIHSIKGLENALITRYGYAIEYDFIQPTELTHTLETKKIKGLYLAGQINGTTGYEEAAAQGLMAGINAVLAL 392 Helicobacter py...
P47619       313 FTPEIQKEIIQLLPGFQNAEIKKFGYAIEYDAFLSNQLKPTLETKLIENLYFAGQINGTSGYEEAAGQGLMAGINAALKL 392 Mycoplasma geni...
P75221       313 FPPEVQEHIVRLLPGFKNARFQKYGYAIEYDAFSSIQLKSTLETKLIQNLYFAGQINGTSGYEEAAGQGLIAGINAALKL 392 Mycoplasma pneu...
WP_002657592 313 LPENIQQKLINSIEGLEHAVITRPGYAVEYDYINPIELYPNLESKRVKGLFIAGQTNGSSGYEEAAAQGLMAGINAALRL 392 Lyme disease sp...
P53070       436 RqEREQLVLKRSEAYIGVLIDDLINNGVIEPYRMFTSRSEFRISVRADNADFRLTPIGAQLGIISPVRLSQYSRDKHLYD 515 Saccharomyces c...
P17112       396 A-DKEGWAPARSQAYLGVLVDDLCTLGTKEPYRMFTSRAEYRLMLREDNADLRLTEIGRELGLVDDERWARFNEKLENIE 474 Escherichia coli
P44763       396 Q-EKDAWYPRRDQSYTGVLVDDLCTLGTKEPYRVFTSRAEYRLLLREDNADIRLTPIAHELGLIDEARWARFNQKMENIE 474 Haemophilus inf...
P25812       396 L-GKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTEIGHRIGLISDERYAAFEKKKAAIE 474 Bacillus subtil...
Q55694       403 Q-GKSLIIFSREGSYLGTLIDDLCTKDLREPYRMLTSRSEYRLILRSDNADQRLTPLGREIGLIDDRRWDLFQTKQANIT 481 Synechocystis s...
P56138       393 K-NQAPFILKRNEAYIGVLIDDLITKGTNEPYRMFTSRAEYRLLLREDNTLFRLGEHAYRLGLMEEDFYKELKKDKQEIQ 471 Helicobacter py...
P47619       393 L-KKPPFILQRNEAYIGVMINDLVTKTISDPYRLLTSRAEYRLWLRNDNVQERLIKKSFELGLTDKKTYELFLKKEKKKQ 471 Mycoplasma geni...
P75221       393 Q-RKPEFVLQRNEAYLGVMINDLVTKEISDPYRLLTSRAEHRLWLRNDNLQERLIEKSRALGLVEADVYANYLEQQQKKK 471 Mycoplasma pneu...
WP_002657592 393 Q-NKKPMILTRTSSYIGVLIDDLVTKGTKEPYRMFTSRAEHRLNLRHDTSDKRLIKIGYDLGLVDEKRYSRYLFKESRVE 471 Lyme disease sp...
P53070       516 ETIRALQNFKLSSQK--WSSLLQANIAPQAENRSAWEIFRFKDMDLHKLYECIPDLPInlLDipMHVVTKINIQGKYEPY 593 Saccharomyces c...
P17112       475 RERQRLKSTWVTPSAeaAAEVNAHLTAPLSREASGEDLLRRPEMTYEKLTTLTPFAPA--LTd-EQAAEQVEIQVKYEGY 551 Escherichia coli
P44763       475 QERQRLRSIWLHPRSeyLEEANKVLGSPLVREASGEDLLRRPEMTYDILTSLTPYKPA--MEd-KEAVEQVEIAIKYQGY 551 Haemophilus inf...
P25812       475 AEKKRLHSVIIKPSPenQEYIRSLGGSELKDGVRGTDLMKRPEMNYETVTKLAPPEVP--VP--QDVAEQVEIQVKYEGY 550 Bacillus subtil...
Q55694       482 AEKERLYSTRIKEQDavGKEIVDYTQQKIKGSIVLAELLRRPGFHYPDLEKFQLGNEE--LK--PEEKTSVEIEIKYSGY 557 Synechocystis s...
P56138       472 DNLKRLKEYILTPSKevLKRLDELDENPINDKVDGVSLLARDSFNAEKMRSFFSFLAP--LN--ERVLEQIKIECKYNIY 547 Helicobacter py...
P47619       472 ELISFLKNTQVGKVKalKFTNKNTAQS-------LYDFNKRSEINLDKLIKDLPEKYQ--LD--SETLKQIEIEIKYEGY 540 Mycoplasma geni...
P75221       472 QLIDYLQTTTVGQIAalKLNFKNTAQT-------LFDFTKRAEIKLVDLVQLLPKRFD--LD--VQSLNQIDIDIKYAGY 540 Mycoplasma pneu...
WP_002657592 472 EIKELLKQRRLSLKDvvDEQLKKHVSK------DFYHILKDPSISLDNLIKIDPSLS---DS--KVILEQVELDVKYEGY 540 Lyme disease sp...
P53070       594 IVKQNQFVKAFQADENMLLPQDYDYRQLPTLSTECKLLLNRVQPLTIGQARRIQGITAAALFELYRVARKPS 665 Saccharomyces cerevisia...
P17112       552 IARQQDEIEKQLRNENTLLPATLDYRQVSGLSNEVIAKLNDHKPASIGQASRISGVTPAAISILLVWLKKQG 623 Escherichia coli
P44763       552 IEHQQEEIEKQKRHENTAIPANFDYSKVSGLSNEVRAKLEQHRPVSIGQASRISGITPAAISIILVNLKKQG 623 Haemophilus influenzae ...
P25812       551 IEKSLQQVEKLKKMENKKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGR 622 Bacillus subtilis subsp...
Q55694       558 IKRQQTQIEQVSRHSQKRLPPGLNYMAIETLSMEAREKLTQFQPLTIGQAGRIGGVNPADINALLVYLETQL 629 Synechocystis sp. PCC 6...
P56138       548 IEKQHENIAKMDSMLKVSIPKGFVFKGIPGLSLEAVEKLEKFRPKSLFEASEISGITPANLDVLHLYIHLRK 619 Helicobacter pylori 26695
P47619       541 IKKNEKYFKGLDKLSKIKIPHTFDYHKVKNLASEAIFKLSNFKPSNLAIASQIAGVNFNDIIAIKHFLKTYE 612 Mycoplasma genitalium G37
P75221       541 IKKSEKYFKSLNNLSSVKIPLKLNYHKVPNLASEAIVKLSKIRPTDLSVASQVAGINFNDILAIKHFLDNHE 612 Mycoplasma pneumoniae M129
WP_002657592 541 INRQKDLIKRLDNLELVKLPFDFNYEIIEGLSREAREKFSKIQPATLAQASRIPGIRSTDITVLLIYFSNPK 612 Lyme disease spirochete
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