1TLJ


Conserved Protein Domain Family
TYW3

?
pfam02676: TYW3 
Methyltransferase TYW3
The methyltransferase TYW3 (tRNA-yW- synthesising protein 3) has been identified in yeast to be involved in wybutosine (yW) biosynthesis. yW is a complexly modified guanosine residue that contains a tricyclic base and is found at the 3' position adjacent the anticodon of phenylalanine tRNA. TYW3 is an N-4 methylase that methylates yW-86 to yield yW-72 in an Ado-Met-dependent manner.
Statistics
?
PSSM-Id: 460649
Aligned: 137 rows
Threshold Bit Score: 125.373
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1TLJ_A          9 LREKALNKIYHDKEIGYLDPDILGFLLAFYRnRNDVYTQSSCSGRITIV-DAEMPWDRKNsTIIFKNHLRITEQDLEDVL 87  Saccharolobus ...
Q5JES6          3 AKREALQSLFTAMRDGKVDGDIIDLLLLINS-IKGIYTTSSCSGRIGII-EEPALGAKPLsRWLIKVHRPIEFEEAKEAL 80  Thermococcus k...
Q8TZG0          3 AKREALLSLFQAIKENKVDEDIVELLLLINS-IKGVYTTSSCSGRIGII-EEPSLGAKPLsRWLIKVHRPIKFEEAKKAL 80  Pyrococcus fur...
Q5JFK6         11 QKEKAMEGLRKALEEDKVDHDIIPLLEKINA-LQNYFTTSSCSGRISVM-EMPHFGDKVNsVWLGKWHREVRLEEVLEAV 88  Thermococcus k...
Q8U1V7         10 AKKEALISLEIALRKGEVDEDIIPLLKKINS-LDNYFTTSSCSGRISVM-EMPHFGDKVNaKWLGKWHREVSLDEVLGAI 87  Pyrococcus fur...
jgi:Aboo_1247   3 NKKEALEKYERAKSKGEVDKDIISLLEKINS-LPYFYTTSSCSGRIVLL-NIPEIGDKKDaKFVCKWHREVDKKELVNCL 80 
Q58905          6 DKKRTLMNLELAIREGLVDEEIIPILNKINE-IDNYYTTSSCIGRVGIMeIPKDKNPKLYsRWLGKWHHYASYDELFNAL 84  Methanocaldoco...
WP_011973767    5 DKKRTLNKLNEAIKNNFVDKGVMYIVDKINE-KENYYTTSSCIGRCGIMeFPKNKTPKIFsKWLGKWHHYATNEELFDAM 83  Methanococcus ...
jgi:Mvol_1232   5 aKYNKMKKLQYAVDNNLVDKEIMYFVDRINE-EDEYYTTSSCIGRCGIMeFPKNVNTKIYsRWLGKWHHYATTDEMNIAI 83 
Q6M0G1          5 DKEFTLKKLQEALDNDFVDLEVMYLVDKINE-FKDYYTTSSCIGRCGIIeFPKDKNPKINsRWLGKWHHYANYDEIDEAL 83  Methanococcus ...
1TLJ_A         88 SKNQ--VRRLWLIVQGPIIHIYAKNIETGWDILKIAREAGFKHSGILATNQKGVLVELRTGIRMVHLLREsntERVDKDK 165 Saccharolobus ...
Q5JES6         81 KNAK--EGIIFLKSQPPIFHVVAEDLEKARKLHELGLASGFKYTTFKVISK-RYLVEINATEYLTAPLGRdgrVLVDDGY 157 Thermococcus k...
Q8TZG0         81 KNAQ--KGLIFLKSQPPIFHVVTESLELARKIHEIGLSSGFKYTTYKVISR-RYLVEINGTEYLTVPLGKdgkVFVTDEY 157 Pyrococcus fur...
Q5JFK6         89 GKHR--SGQLWFLVRSPILHVGARTLEDAVRLLNLAIGLGFKYSNIKSVSHKKLVVEIRSTERMDVPLGEngeLWVDEAY 166 Thermococcus k...
Q8U1V7         88 KKHR--SGQLWFLVRSPILHVGAKTLEDAIRLVNLAVSCGFKYSNIKSISNKKLIVEIRSTERMDVLLGEngrILVGEEY 165 Pyrococcus fur...
jgi:Aboo_1247  81 KDYK--EHYLFFIMQSPIIHIVASETEWANKLIKISLECGFKYTSIKKIESKKILVEVLSTENLHIPIGRegkIIVKEEQ 158
Q58905         85 KNKK--EGYIVFVMNSPILHIACKDIESAKKMLELAIHSGLKASSIKSISDKRVIVEILTTYKVDTPIGEdgeIFVDNNY 162 Methanocaldoco...
WP_011973767   84 ANKSeeFKNIIFIMNSPILHIASKDMECAKKLLECAYHNGLKASSIKSINKRRIIVEIMTTNKVDAPIGIdgkIVVDDEY 163 Methanococcus ...
jgi:Mvol_1232  84 ESASpdYDRLYFVLNSPIMHIACKDAFSAKKLLEIAYHNGLKASSIKSLSEKRYIVEFLTTMKLDAPIGFdgkLVVDDNY 163
Q6M0G1         84 LKKSenFEKISFVLNSPILHVASRNADTSKKLLELAYHNGLKASSIKSISSKRYIVEIMTTAKMDAPIAYdgkMVVNREY 163 Methanococcus ...
1TLJ_A        166 IKTLVNVCNEVLARGKQKMNLLKDLLSS 193 Saccharolobus solfataricus
Q5JES6        158 LRFAVEIGNEMLRRSKGRLPRLEENFRR 185 Thermococcus kodakarensis KOD1
Q8TZG0        158 LEFVIEIGNQMLMRGKSRLPRLREKFEE 185 Pyrococcus furiosus DSM 3638
Q5JFK6        167 IEKIVNLANAQVRRFKGKLKRLEEEIEK 194 Thermococcus kodakarensis KOD1
Q8U1V7        166 LRKIVEIANAQVRRFKEKLKRLESNIDA 193 Pyrococcus furiosus DSM 3638
jgi:Aboo_1247 159 LTFFLEMANKLLIRAKGKLKCLEEKINS 186
Q58905        163 LKFLLDYSNSKLKRAREILMRWANRLDE 190 Methanocaldococcus jannaschii DSM 2661
WP_011973767  164 LKVLLKIGNEKLKLSRDGIYRFYEKLDT 191 Methanococcus aeolicus
jgi:Mvol_1232 164 LNILLNESNLKLMKAREMLHRVYLKFDE 191
Q6M0G1        164 LDILLDEGNLKLKHARKSLKRFYEKLNE 191 Methanococcus maripaludis
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap