Conserved Protein Domain Family
Mitoc_mL59

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pfam18126: Mitoc_mL59 
Mitochondrial ribosomal protein mL59
This domain is a protein found in mitochondrial ribosome 54S large sub unit present in species such as Saccharomyces cerevisiae. The domain used to be referred to as MRP25 but is now called mL59 protein. mL59 is known to partially stabilize a change in the rRNA path prior to helix 82-ES1 ultimately leading to the stabilization of the phosphate backbone of the tRNA acceptor stem. It is worth noting that the domain is encoded in the nucleus and imported from the cytoplasm.
Statistics
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PSSM-Id: 436292
Aligned: 121 rows
Threshold Bit Score: 67.0055
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KIY72663      10 RTLKAFRMHELR--GLESHIARfgflptgpartyertriggsgksvlpkgasagvngkaaataanpntaapasaapsaas 87 
KDQ32032       2 QTIQKFRLQQLN--GLQSHIVRygplkkse-------------------------------------------------- 29 
KIK03907       8 EAVKRFRLREFKvkSVSHHVRRfgyppestp------------------------------------------------- 38 
XP_001885554  10 QAVKRFRYREFE--GALSHEKRfgqppeitnp------------------------------------------------ 39 
KIJ99867       9 QAVKRFRFREFE--ASLSHQNRfghppkttpp------------------------------------------------ 38 
KIL62731       6 QAIKKFRLHEIK--GLQKHILRfgplqtqtsv------------------------------------------------ 35 
EFI92968     134 RAVRTFRLHEIHgaKMAlprlgvdltdakqidpelarrm----------------------------------------- 172
KNZ73508      10 KAVRSFRIKQLA--SLQSYVIHngplpapss------------------------------------------------- 38 
RDB30118       5 QAVKAFRFKQLK--SLPKHIQKfgplppptep------------------------------------------------ 34 
KXN81681       8 RAVQKVRLTQLN--GIQSHIRRwgplseettpt----------------------------------------------- 38 
KIY72663      88 ttataaatastpaantttmtatatatatsialrNPFLPFLNPSTGRWAPPKYSLRRQAELVKAAGRLGLGHLLPPGvkgd 167
KDQ32032      30 --------------------------sphpslpNPFLPLLNPHTGKWRPPKYSLRRQAELVKKAKISNTLHLLPPG---- 79 
KIK03907      39 -------------------------pistirlpNPFIPWRNPKNGKWSEPKYSLRHQAELVKKAKLSGTLHLLPPG---- 89 
XP_001885554  40 -----------------------stdwhlwrvpNPFVPWRHPKNGRYHQPKYSLRRQVELVKKARISGTLHLLPPG---- 92 
KIJ99867      39 -----------------------ihreapwrvpNPFVPWCHPKNGKWYQPKYSLRRQVELVKKAGISGTLHLLPPG---- 91 
KIL62731      36 ------------------------dtsaalrlpNPFVPRKNPNTGRWAEPKYSLRRQTELVKKAGAAGLLHLLPPG---- 87 
EFI92968     173 ------------npqllpnaralkpdvrqaqlqNPFLPNKHPVTGKWKGPKYSLRRQADLVKKAKAAGLLHLLPSG---- 236
KNZ73508      39 ------------------------eqstphrlpNPFVPHKNPLTGRWAPPTISLRRQADLVKKAKASNTLYLLPPG---- 90 
RDB30118      35 -----------------------vdsavahrlpNPFLPRLNPRTGRWAPAAISLRRQADLVKRAKESNTLFLLPPG---- 87 
KXN81681      39 ----------------------lppnsevtvlpNPFLPRK-WPSGKTRPPVYSLRRQADLVKAAKAAGLLHLLPPG---- 91 
KIY72663     168 lrvlaggltPKSSSSKSLPGSTTTPQTKESpvteewslntdtpgepwlvridw--------------------------- 220
KDQ32032      80 ---------PKFSAPDSSVPPIADEDHKSNastseapselepsthevaedga---------------------------- 122
KIK03907      90 ---------PKTPEYIPQPVKVLDETPEPTpdgaktsgsvseervvgsrkeledamdealw-----------qepfewfv 149
XP_001885554  93 ---------IKTPKYVVPPPVETPAAPTPEvaetsagatevekqmskkkllvkrldkffdrl---------seapfdwyv 154
KIJ99867      92 ---------LKTPKYVPQPVETPAPTPEVAktsvgvaeedvvkkrmsikkrndndlsqa---------------pfdwyv 147
KIL62731      88 ---------PKNPLPASPPAAEGEETQSSAlkemwalpvaweg------------------------------------- 121
EFI92968     237 ---------PKNPLPLEPKAVPAVQTKTPAaseakadapveaadaaptptpaaaeaapeeeaeptpalpareyrrrqrla 307
KNZ73508      91 ---------PKNPKLSVPSTEIAAKLAHEQfggkegkgvlkgpsskkkwkqslk-------------------------- 135
RDB30118      88 ---------PKAPLPTTMSFKEAAVEAQKQfggkpnrkvttaykkeleavw----------------------------- 129
KXN81681      92 ---------PKTPRLPAVLRWKAKAVQKAReaeqvavteslrvqlkklgdkee--------------------------- 135
KIY72663     221 vgasadlqkrvekaervrdggriTl---ySTRKRMFKGHKWERLAPKKFARRKIMLRDMDARISRWRM 285
KDQ32032     123 --wsaavewqgefkskvvsgaeiGsr-lyAAKKRMFKGHRWERLLEKRKKKRVILMRDMAKRVASYKA 187
KIK03907     150 gpgregseavrekkrlekpgaelGtr-lyAGKKRMFKGHKWERVKAHRKRRQNILMRDMAKRVYNYKN 216
XP_001885554 155 gqgreereearvkkvlekpgaelGtr-lyAGKKRMFKGHKWERVKAHRERRQNILMRDMKKRVYNYKN 221
KIJ99867     148 grgreereeakvkklqekpgaelGtr-lyAGKKHMFKGHKWERVKAHRERRQNILMRDMAKRVYNYKN 214
KIL62731     122 -----------sreykpvpgtelGir-lyAAKKRMFKGHKWERVKGKREARKHILLRDMDKRIFNYKN 177
EFI92968     308 lkdlsgewtgdvhwvgehrardaPvarlySGKRRMFKGKKHERVAHIVRGKRAVRMRDMAKRVREYKE 375
KNZ73508     136 dtwmnpvgwvgepkvkevpgaelGtr-lyAAKKRMFKGHRWERLKEARDNKKKILMRDMARRIRNYKA 202
RDB30118     130 ---mnavewdgkaefkdvagaelGtr-lyAAKKRMFKGHRWERLKEARDSKKSILLRDMARRVRNYKA 193
KXN81681     136 dlkwlkpvawagkmkekargadlGtt-lyAGKKKMFKGHKWERLRNDRRKKQAILLRDMKKRVYNYKN 202
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