1M9H,4IJC,1SM9,3KRB,1AE4,1EKO,2IPF,1ZGD,5JGW,1QWK,3WCZ,3WG6,3BUR,2WZM,3D3F,1VP5,4HBK,4Q3M,3WBW


Conserved Protein Domain Family
AKR_AKR1-5-like
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cd19071: AKR_AKR1-5-like 
Click on image for an interactive view with Cn3D
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins
Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Links
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Statistics
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PSSM-Id: 381297
Aligned: 220 rows
Threshold Bit Score: 167.273
Created: 24-Apr-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:3BUR: Homo sapiens delta(4)-3-ketosteroid 5-beta-reductase (AKR1D1) in complex with cofactor NADP and testosterone, contacts at 4A.
  • Structure:1AE4: Sus scrofa aldehyde reductase holoenzyme in complex with inhibitor and cofactor NADP; contacts at 4A.
  • Citation:PMID 7552731
  • Citation:PMID 9329083
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            ###                          #    #                                       
1M9H_A      14 IPQLGYGVYkvpp----adtQRAVEEALEVgYRHIDTAAIYg--nEEGVGAAIAasg-------------------iaRD 68   Corynebacterium sp.
3BUR_A      18 IPIIGLGTYsepkstpkgacATSVKVAIDTgYRHIDGAYIYq--nEHEVGEAIRekiae---------------gkvrRE 80   human
ACI64648    88 MPQQGLGMCcrptayddvlvYRTILWYLLSgGRHIDGAHLYl--nHKAIGKGIAeaik----------------rgvpRE 149  Thalassiosira ps...
OLQ04817    81 LPILGYIGCclqrdldsanvRPAAARYLEAgGRHVMTAPIYg--nDQALGQAIRdsg-------------------vpRE 139  Symbiodinium mic...
OLP88567   496 MPMIAFGSYrgslt--ncsvQEGIQQWLQLgGRHIDTAHDYg--tEPDVGAAIKasg-------------------veRK 552  Symbiodinium mic...
KOO35949    36 MPKVAFAANvwdp----dtcKYATLAALSSgFRFVWSSVLIgnscQAAQAQAIAaarnd--------------sggipRQ 97   Chrysochromulina...
EEC45777    95 IPRIGYSMYktta----dqiEAGIQLALQAgARHFDVATQYg--tNPVVGETLRsyihqglsseytptsiipkspqerRR 168  Phaeodactylum tr...
EED93264    77 FPLASFGLQiysd----dvaYDLTLTALEVgYRNFFASVLAg--nQKGFAKAVRasg-------------------ipRE 131  Thalassiosira ps...
EGB06819    10 MPANGLGTCcrkta-kgppiVAATKAYLELgGRLLDTAMAYg--nHADIGRGLResg-------------------vpRD 67   Aureococcus anop...
EGB11320    83 VPRVGFGLYktkp----eetAAAVALALEAgVRHFDAAAAYg--nEAALGEALRg-----------------------GP 133  Aureococcus anop...

Feature 1            #                                        ##                               
1M9H_A      69 DLFITTKLwndr-----hdgdEPAAAIAESLAKLa---lDQVDLYLVHWPtpaad------------------nyvhAWE 122  Corynebacterium sp.
3BUR_A      81 DIFYCGKLwatn-----hvpeMVRPTLERTLRVLq---lDYVDLYIIEVPmafkpgdeiyprdengkwlyhksnlcaTWE 152  human
ACI64648   150 EIFVTTKVfpte-----fgyeSTLKWVVIYLQDLg---lEYIDLVLLHFPslpplmsspcst----egkdattcrkeTWK 217  Thalassiosira ps...
OLQ04817   140 QIWVTTALepigvp-kqnirsWVADQVAGSLQRLn---vTYADDIYIHWGvtnvrrqdpng-----rsnvtqemnleLYR 210  Symbiodinium mic...
OLP88567   553 EIFLTTKIpgpi-----grgaVKDMVMNETLQKLg---vDYIDLVLIHFPcvnmsdfpnkc------geqhqqerldTWR 618  Symbiodinium mic...
KOO35949    98 ELFVSGTVntgscggyddcvaQTRSGAENQFQVLg----EPLEMLMLDYPsrsgc-----------------dairgQWK 156  Chrysochromulina...
EEC45777   169 EIFLTHKIsndeq---stkprEVKNAIISQQRGPlk--gIDVDLAMLHSPltdks------------------rrlaSYE 225  Phaeodactylum tr...
EED93264   132 ELYICGTVlsnrvngevaayrKTKQGCLENMAAMangdiTKLDMIMLDYPgpnde------------------siqgQWR 193  Thalassiosira ps...
EGB06819    68 EVWITSKIspsra----anykQCAKATADLLEELg---vAFVDLLLIHTPklgee------------------ktveLWR 122  Aureococcus anop...
EGB11320   134 KCFVATKVap---------srGARDAVKAAADRLg----FAPDCVYVHSPlapra------------------erlaAYE 182  Aureococcus anop...

Feature 1                      ##                      #                             #######   
1M9H_A     123 KMIELRAAgLTRSIGVSNHlvPHLERIVAatg--vvPAVNQIELHPAy--qQREITDWAAAh--dVKIESWGPLGQGkyd 196  Corynebacterium sp.
3BUR_A     153 AMEACKDAgLVKSLGVSNFnrRQLELILNkpglkhkPVSNQVECHPYf--tQPKLLKFCQQh--dIVITAYSPLGTSrnp 228  human
ACI64648   218 ALSELREKgLIRNAGVSNFalQHVKDLEGvg---apVANNQIQFNPFvpahVMETVEYCHEn--nITITAHSPLGGLtdk 292  Thalassiosira ps...
OLQ04817   211 GLIDMQRAgKTRHIAVGLHtrKEIEYLINstg--vkPDIMWGWITPFmpqkQIDLAMWAKGq--gMAVAAWGPFNWMrld 286  Symbiodinium mic...
OLP88567   619 GLSELRAMgKVRAIGVSNYnaEQVAEVVAefk--eaPAVNQVQWHLAy---HNETLRLAMRkl-gTTIEAWASLAGPtsa 692  Symbiodinium mic...
KOO35949   157 VLSDLYQAkRVKSIAVSNFgsDELDCLKNtt---vaPASNQLLACVScg-dPVPIVQQNAAag-gVVVQAYSPLGSGsl- 230  Chrysochromulina...
EEC45777   226 ALLDLEAKsKIKAVGVCHFgvAALQELVDagl--paPSVIQLIISPFn--qHKDIVEWASKhdsvVSCSAWSKLSSVegp 301  Phaeodactylum tr...
EED93264   194 AFEEMKSDlTVSDLAVSNFspTQLDAILAing-atkPAVNQLPFSVAy--hPQGILEYNAKr--dILVQSWSPLSRVlp- 267  Thalassiosira ps...
EGB06819   123 CLVDAKARgQVRAIGVSNFngPEIDALEKatg--vqPEVNQIQYHPWsskeWHATVAALKAr--gVVTTAYNSLGGSrfp 198  Aureococcus anop...
EGB11320   183 QLLDARRDgLCGAVGVANFgvRHLGELPEp------PALVQLELSPYn--qRRAEAAWATKngavVTCAAWSKLSGAynw 254  Aureococcus anop...

Feature 1                                 #              ####         #  ##                    
1M9H_A     197 ---------lfGAEPVTAAAAAHGktPAQAVLRWHLQkGFVVFPGSv-----rREHLEENLDvfd--------fdLTDTE 254  Corynebacterium sp.
3BUR_A     229 iwvnvssppllKDALLNSLGKRYNktAAQIVLRFNIQrGVVVIPKSf-----nLERIKENFQifd--------fsLTEEE 295  human
ACI64648   293 s-------rafSLAQLNQMAAKYNkrVASIMLRWAIQrGFVVIPGTg-----nPEHMKENMAvyq--------feLSDED 352  Thalassiosira ps...
OLQ04817   287 ep----tqleeHRSITDELARKYNasVHQIINRWYLDmDIAVVTSLr-----kPSFVEEDLHclr--------tpLSPED 349  Symbiodinium mic...
OLP88567   693 gv----paislGDARLKALAQRYNrsSAQVELRWETQnGIVPVTASc-----sKDHVVGDLEsfs--------faLSDED 755  Symbiodinium mic...
KOO35949   231 ----------vKDPLLISIGGAHNksAAQVALRWLLQhNVTIATQSt-----nPTYLAEDLDifd--------fvLAASE 287  Chrysochromulina...
EEC45777   302 ---------qiGWSVLGEIAKEKSmtKQQVLIQWTLQkGFICTPRGsskfnieRMAIQENSWdavq------dfrLTETE 366  Phaeodactylum tr...
EED93264   268 ----------kYGSVLASIGKQYGksAAQVGLRWIVQsGAAFSTQSk-----sKSHFEEDLAvfd--------fsLTEEE 324  Thalassiosira ps...
EGB06819   199 ---------gsHGDALATLAAAHGatVPQLLLRWALQkGCAVIPGSs-----tPAHIAENLAapa--------faLSADE 256  Aureococcus anop...
EGB11320   255 g-------sdaAFKALNACCKAHAatKAQVLVRWAVQrGFAPLPRStaadaaqRLAIAQNAAagvedgdfwrggpLSRAE 327  Aureococcus anop...

Feature 1           
1M9H_A     255 IAAID 259  Corynebacterium sp.
3BUR_A     296 MKDIE 300  human
ACI64648   353 MKIIN 357  Thalassiosira pseudonana CCMP1335
OLQ04817   350 RARLE 354  Symbiodinium microadriaticum
OLP88567   756 IKYLD 760  Symbiodinium microadriaticum
KOO35949   288 MAQLD 292  Chrysochromulina sp. CCMP291
EEC45777   367 MDILD 371  Phaeodactylum tricornutum CCAP 1055/1
EED93264   325 MNKIT 329  Thalassiosira pseudonana CCMP1335
EGB06819   257 MRRIE 261  Aureococcus anophagefferens
EGB11320   328 MKALD 332  Aureococcus anophagefferens

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