Conserved Protein Domain Family
Scramblase
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pfam03803: Scramblase 
Scramblase
Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site. Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury.
Links
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Statistics
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PSSM-Id: 252175
Aligned: 10 rows
Threshold Bit Score: 278.084
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P47140  59 NSNSGIIKVHDPIATTILNE-PTVIIERQIEFMNVFLGFEQANRYAIMDVNGNKIASMMERdf-siTKAIMRQFYRLHRP 136 Saccharomyces cerevis...
Q9NRY6  62 SAAPFLPLPGVPSGLEFLVQiDQILIHQKAERVETFLGWETCNRYELRSGAGQPLGQAAEE-----SNCCARLCCGARRP 136 human
O15162  86 MPAP-QPPLNCPPGLEYLSQiDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAED-----TDCCTRNCCGPSRP 159 human
Q9NRQ2 100 MPGP-TPMANCPPGLEYLVQlDNIHVLQHFEPLEMMTCFETNNRYDIKNNSDQMVYIVTED-----TDDFTRNAYRTLRP 173 human
Q9VZW1  42 MSIPVG-MPNCPQGLEYLTAlDQLLVSQKIEKLELLTGFETKNRFKVKNSLGQNVYFAYEE-----SDCCTRNMLGRSRP 115 fruit fly
O45799  51 MPMP-PAIQGVPTGLEYLTYlDTIMVHQIKELIEIVTDWETKNKYVLKNANGEQCYYAFEE-----SGCCERQCCGPQRG 124 Caenorhabditis elegans
Q9NAE9  48 MTGFNNLPAH--NVLDMISRtNSMMVVQALEPLEIATGIETPNQYVVHDMYCRPIMNCMER-----SNGFARQMQGSHRS 120 Caenorhabditis elegans
Q21318  74 MTGFVQLVAN--NILSAIAHtNSVMVVQCIKPLEIFTGFETPNRYVVHDMYCRPLLYCMER-----SNIFARQYEGNDRN 146 Caenorhabditis elegans
Q9SI32 150 MSGLLKPKTSDEAKIATLLArSNLLVTRDIEWANLVLGFEQENRYIVVDVCYPEAPVGSIRe---qSNLLARQLLRTRRP 226 thale cress
Q9UT84  58 ISSTGAIPLNSPAA--PLLSqDVLIVERQLEMMNVFLGYEQANRYVILNQQGQHLGYIAEQgassiLSSLSRQFFHTHRA 135 Schizosaccharomyces p...

P47140 137 FLVDVFDNWGNVIMTIKRPFSFINshiKtiippSAYVDNGSDSthyhDGKEGTTVGETIQNWHLWRRRYELFQKDGvEG- 215 Saccharomyces cerevis...
Q9NRY6 137 LRVRLADPGDREVLRLLRPLHCGCs--C-----CPCGLQEMEV----QAPPGTTIGHVLQTWHPFLPKFSIQDADR-QTv 204 human
O15162 160 FTLRIIDNMGQEVITLERPLRCSS---Cc----CPCCLQEIEI----QAPPGVPIGYVIQTWHPCLPKFTIQNEKR-EDv 227 human
Q9NRQ2 174 FVLRVTDCMGREIMTMQRPFRCTC---Ccf--cCPSARQELEV----QCPPGVTIGFVAEHWNLCRAVYSIQNEKK-ENv 243 human
Q9VZW1 116 FEMKILDNFQNEVLHLYRPFKCDIl--Cc----FPSCMNAVEV----SAPPGQVIGSVEQVCTFMRPKFNIKNTCG-DTv 184 fruit fly
O45799 125 FVMHIVDNFKREVLTIKREFKCCGggcCgclacIGCCQQECII----ETPSMGVLGIIRQRCGCMSSNYDIMDGDG-NVi 199 Caenorhabditis elegans
Q9NAE9 121 FAMMCTDLFGAHVMQCHRDQPWGS---------FTDHLTTQFL--------GQNIGIMSRTHG--DVNFHLLGAGS-NQs 180 Caenorhabditis elegans
Q21318 147 FGMQIMDTHGAQVMTCFRGRPCCS---------TDDFLSTQFL--------DQQIGMMKK--ECCNPNFELVGSGC-NQp 206 Caenorhabditis elegans
Q9SI32 227 FVASITDALGNELFRVRRPFW------------WLTSSIYAEI-------DGEEIGVVHRRWHLWRRIYDLYLGN--NQf 285 thale cress
Q9UT84 136 FKADVMDSNGQLVLQLNRPFSWIN-----------SRLQIHSId--ySKFSSTLVGEVLQKWHLWRRRYELFLAKR---- 198 Schizosaccharomyces p...

P47140 216 -STFDQFGKIDaPFLSFDFPVTDADG-KIMASVDRNWVGLGREMFTDTGVYVVRFDSqrcfdniy-----------ptem 282 Saccharomyces cerevis...
Q9NRY6 205 lRVVGPCWTCG-CGTDTNFEVKTRDEsRSVGRISKQWGGLVREALTDADDFGLQFPL----------------------- 260 human
O15162 228 lKISGPCVVCS-CCGDVDFEIKSLDEqCVVGKISKHWTGILREAFTDADNFGIQFPL----------------------- 283 human
Q9NRQ2 244 mRVRGPCSTYG-CGSDSVFEVKSLDGiSNIGSIIRKWNGLLS-AMADADHFDIHFPL----------------------- 298 human
Q9VZW1 185 lQIEGPVCPCK-CFSDTNFKVLSANN-EEIGKISKQWSGLGRELFTDADYFSVTFPL----------------------- 239 fruit fly
O45799 200 fQIDGPCCCMLcGCQDKEFPIKTANNgTVVGAITKKWGGCFREAFTDADTFAVNFPG----------------------- 256 Caenorhabditis elegans
Q9NAE9 181 lLIRSPLFAAS--GGTRSFPVMTYNG-MRVGEIVRLYPGYMQEMYSDADTYIVHFPM----------------------- 234 Caenorhabditis elegans
Q21318 207 lLIQSP--GCAgCGGTQKFPVMTFNG-VLVGEIVRLYPGFMQEMFTDADTYIVHFPM----------------------- 260 Caenorhabditis elegans
Q9SI32 286 aVVENPGF------WNWTFTVKDADG-EVLAQIDRDWRGFGFEIFTDAGQYVIRFGKadaaaktgpa-------tlveel 351 thale cress
Q9UT84 199 -SMFEQFAKIDeRVLSWEFLLRN-EQdRILGSVSRNFMGLPREFFTDTGNYVLRFTStsaangsvnenqllqaahgiand 276 Schizosaccharomyces p...

P47140 283 lssqVLTLDQRAVLLANAVSIDFDYFSR 310 Saccharomyces cerevisiae S288C
Q9NRY6 261 ----DLDVRVKAVLLGATFLIDYMFFEK 284 human
O15162 284 ----DLDVKMKAVMIGACFLIDFMFFES 307 human
Q9NRQ2 299 ----DLDVKMKAMIFGACFLIDFMYFER 322 human
Q9VZW1 240 ----NLDVRMKALIFAALFLIDAVYYEQ 263 fruit fly
O45799 257 ----DLDVKLKGVLIGATFLIDFMEFEQ 280 Caenorhabditis elegans
Q9NAE9 235 ----DLPPILKLLLISSVFLIDFTFFEN 258 Caenorhabditis elegans
Q21318 261 ----DMPPILKLLLVTSVFLIDFTYFED 284 Caenorhabditis elegans
Q9SI32 352 evkrPLTLSERAVVLTLAISLDNDYFSR 379 thale cress
Q9UT84 277 vcarDMSLEERAVMLGSAVTIDFDYFSR 304 Schizosaccharomyces pombe 972h-
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