4DYO,2GLF,2IJZ,5JM9


Conserved Protein Domain Family
M18
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cd05639: M18 
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M18 peptidase aminopeptidase family
Peptidase M18 aminopeptidase family is widely distributed in bacteria and eukaryotes, but only the yeast aminopeptidase I and mammalian aspartyl aminopeptidase have been characterized to date. Yeast aminopeptidase I is active only in its dodecameric form with broad substrate specificity, acting on N-terminal leucine and most other amino acids. In contrast, the mammalian aspartyl aminopeptidase is highly selective for hydrolysis of N-terminal Asp or Glu residues from peptides. These enzymes have two catalytic zinc ions at the active site.
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Statistics
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PSSM-Id: 349892
Aligned: 4 rows
Threshold Bit Score: 606.839
Created: 16-Mar-2007
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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metal bindingactive site
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1: metal binding site [ion binding site], 6 residue positions
Conserved feature residue pattern:H D E E D HClick to see conserved feature residue pattern help
Evidence:
  • Comment:Thermotoga maritima aminopeptidase has two manganese ions bound rather than zinc ions, and may be active as a multimer.
  • Structure:2GLF: Thermotoga maritima aminopeptidase bind stwo Mn(II) ions
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                    #
4DYO_A     28 AKELLKFVNRSPspFHAVAECRNRLLQAGFselkete---kwnikpESKYFMTRnssTIIAFAVGgqyvpgnGFSLIGAH 104 human
2GLF_D     20 SKEYXEFXSKAKteRXTVKEIKRILDESGFvpledf-----agdpxNXTVYAVNrgkAIAAFRVVddl--krGLNLVVAH 92  Thermotoga maritima
2IJZ_A      5 NQGLIDFLKASPtpFHATASLARRLEAAGYrrlderd---awhtetGGRYYVTRndsSLIAIRLGrrsplesGFRLVGAH 81  Pseudomonas aerugi...
5JM9_A     53 AQEFIDFIYKNPttYHVVSFFAELLDKHNFkylseksnwqdsigedGGKFYTIRngtNLSAFILGknwraekGVGVIGSH 132 Saccharomyces cere...

Feature 1                                                                                     
4DYO_A    105 TDSPCLRVKRRSRRSqv-gfQQVGVETYGGGiwsTWFDRDLTLAGRVIVkcptsgrleQQLVHVEr----PILRIPHLAI 179 human
2GLF_D     93 IDSPRLDFKPNPLIEde-qiALFKTHYYGGIkkyHWLSIPLEIHGVLFKnd-----gtEIEIHIGdkpedPVFTIPDLLP 166 Thermotoga maritima
2IJZ_A     82 TDSPCLRVKPNPEIArn-gfLQLGVEVYGGAlfaPWFDRDLSLAGRVTFrang--kleSRLVDFRk----AIAVIPNLNI 154 Pseudomonas aerugi...
5JM9_A    133 VDALTVKLKPVSFKDtaegyGRIAVAPYGGTlneLWLDRDLGIGGRLLYkkkgtneikSALVDSTp---lPVCRIPSLAP 209 Saccharomyces cere...

Feature 1                                                                                     
4DYO_A    180 HLQRNinenfgpnteMHLVPILATAiqeelekgtpe-pgplnavderhHSVLMSLlcahlglspkDIVEMELCLADtQPA 258 human
2GLF_D    167 HLDKEdakisekfkgENLXLIAGTIplsgeek---------eavktnvLKILNEXygi----teeDFVSGEIEVVPaFSP 233 Thermotoga maritima
2IJZ_A    155 HLNRAanegwpinaqNELPPIIAQLapge---------------aadfRLLLDEQllrehgitadVVLDYELSFYDtQSA 219 Pseudomonas aerugi...
5JM9_A    210 HFGKPaegp--fdkeDQTIPVIGFPtpdeegnepptddekksplfgkhCIHLLRYvaklagvevsELIQMDLDLFDvQKG 287 Saccharomyces cere...

Feature 1                    #                                    ##                          
4DYO_A    259 VLGgaYDEFIFAPrlDNLHSCFCALQALIDScagpgslatephVRMVTLYDNEEvGSEsaqgaqSLLTELVLRRIsasc- 337 human
2GLF_D    234 REVgxDRSLIGAYgqDDRICAYTALRALLSAnp--------ekSIGVIFFDKEEiGSDgntgakARFYLKALRQIlkxqg 305 Thermotoga maritima
2IJZ_A    220 AVVglNDEFIAGArlDNLLSCHAGLEALLNAeg--------deNCILVCTDHEEvGSCshcgadGPFLEQVLRRLlpe-- 289 Pseudomonas aerugi...
5JM9_A    288 TIGgiGKHFLFAPrlDDRLCSFAAMIALICYakdvnt-eesdlFSTVTLYDNEEiGSLtrqgakGGLLESVVERSssaft 366 Saccharomyces cere...

Feature 1                         #                                                           
4DYO_A    338 --qhptAFEEAIPKSFMISADMAHAVHPNYLdkheenHRPLfhKGPVIKVNs-----kQRYASNAVSEALIREVAnkVKV 410 human
2GLF_D    306 akdsefVLDEVLENTSVISGDVCAAVNPPYKdvhdlhNAPKlgYGVALVKYtgargkySTNDAHAEFVARVRKVLneQGV 385 Thermotoga maritima
2IJZ_A    290 ----gdAFSRAIQRSLLVSADNAHGVHPNYAdrhdanHGPAlnGGPVIKINs-----nQRYATNSETAGFFRHLCqdSEV 360 Pseudomonas aerugi...
5JM9_A    367 --kkpvDLHTVWANSIILSADVNHLYNPNFPevylknHFPVpnVGITLSLDp-----nGHMATDVVGTALVEELArrNGD 439 Saccharomyces cere...

Feature 1                                             #                       
4DYO_A    411 PLQDLMVRNDt-pCGTTIGPILAsrlGLRVLDLGSPqLAMHSiREMAcTTGVLQTLTLFKGFFE 473 human
2GLF_D    386 IWQVATLGKVdqgGGGTIAKFFAe-rGSDVIDXGPAlLGXHSpFEISsKADLFETYVAYRSLXE 448 Thermotoga maritima
2IJZ_A    361 PVQSFVTRSDm-gCGSTIGPITAsqvGVRTVDIGLPtFAMHSiRELAgSHDLAHLVKVLGAFYA 423 Pseudomonas aeruginosa
5JM9_A    440 KVQYFQIKNNs-rSGGTIGPSLAsqtGARTIDLGIAqLSMHSiRAATgSKDVGLGVKFFNGFFK 502 Saccharomyces cerevisiae

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