Conserved Protein Domain Family
HUL4

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COG5021: HUL4 
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
Statistics
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PSSM-Id: 227354
Aligned: 14 rows
Threshold Bit Score: 676.87
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6320665  2385 DIREGILDTEAEEQRMFGRIGSSADVIRADDDVSNNDEEVENGLDHGNSNDRNNADPEKK--KPARIYFAPLIDRAGIAS 2462 baker's yeast
19074126    1 ----------------------------------------------------------------MNSCLKDEYKQQMTGC 16   Encephalitozoon c...
19074747 1514 ANDVQGNMLCELDNPTVLWRDPENYFNKKSEDRSCVESPGRKAWDFGPAMEGGGEEDSGAgvGGQGPPNNGDVEEENEDI 1593 Encephalitozoon c...
19115545      --------------------------------------------------------------------------------      fission yeast
19114290  155 SNSNDSWLWQRFSSLLLNCLVSSINSHRIEGTDTSAETSLLHCLAYVAPYLKSSELSTYY--DSVMTFYAQIYPKQNMTN 232  fission yeast
19114838    1 -----------------------------------------------------MENIR----FEVQLTILHVEGLWKNGL 23   fission yeast
19115814 2314 DLRDELLFQEAVQMRLFDHATRNNNSVDHEVEMEEIDQGGTVSEHREKSVKPVKKIPVPN--LLDRQGLYSLIRLIFISQ 2391 fission yeast
19112585    1 -----------------------------------------------------MEQG--A--KRVRFYIVAADGLSKRDL 23   fission yeast
19113326    1 ---------------------------------------------------------------MSRPIEIANVSSGNRRT 17   fission yeast
1176337     1 MVSLFDKLNAKKDGRDGSVSKELLSHSVAHTKNRLPKSGRRTSERSLAASVKDGSCSNSK--SNKRNSSASVSGEEDKSC 78   baker's yeast
6320665  2463 LMKSVFISKPYIQREIYHELFYRLCSSKQNRNDLMNTFL---FILSEGIIDQHSLEKVYNIISSRAMGHAKTTTVRQLPs 2539 baker's yeast
19074126   17 CSQIPCYKVFCRDGLEDEAAETLSELFSRYGDVFLCRN----IRRTIEQTSSISVDASGSVILDFFFRLGTMGPRRGTS- 91   Encephalitozoon c...
19074747 1594 GSSESEVGSLNGEMPPLDPDVLNSMAAEELEDALKAYFDe--RRALSLTYVPLHISFYDRLSPDVRPVFEEMERMYREGf 1671 Encephalitozoon c...
19115545      --------------------------------------------------------------------------------      fission yeast
19114290  233 LEDIMSLSLLTPVSSKTDENANSSSAFLFHVLASDCFSSienCIPPDLIIDKVFSSSLQLSEEACISSLLNLGMIKVFS- 311  fission yeast
19114838   24 LRSLKPYLLISVDDDQFIKTNVASGTLRLSWGFTQKLT----VSPQSIILLQLFDEKQKNETSDGFVGLGAAVVNSFL-- 97   fission yeast
19115814 2392 HNGKNPYYDLIVNISENKQHRADIVGLLLYILQEASINDrasEKCYRDLTVKSLNNSQQKEVKKSTGLLESLCKVPVVNg 2471 fission yeast
19112585   24 FRQPDPFAILTVDGEQTHTTKVIKKSVNPYWNEGFEVT----VKPSSVISIRLFDQKKFKKKDQGFLGLVSFRMREVG-- 97   fission yeast
19113326   18 LPALHGSSFSSRSELDNNTNSKISRRLRELVCQRMGENP---LRLRQSFHETISNDSYGNSEKLVIRPCICCNSVLRYP- 93   fission yeast
1176337    79 LISLNCLCCGVPLRFPASITKFRCSACQVTVIVKEPEIN---SNLESSTHISCTLEGLQMVVRRCHDDLQRLKKTGILD- 154  baker's yeast
6320665  2540 dctplTVANQTIEILQSLIDADSRLKYFLIAEHDNLIVNKANNKSRKEALPDKKLRWPLWHLFSLLDRKLITDESVLMDL 2619 baker's yeast
19074126   92 -------------------VEESRFGPDSGPELYVKDRESRGVLRMENGMQSVEWAKRMFRKKGTPLSKGHRSDDRFGCL 152  Encephalitozoon c...
19074747 1672 fydikTESTKESDDETIGIKENFLEMDLSIFGDFIRKSITEKDFPFAKSWKLVDALSKDAKMKGVVFKEADSMISSIASS 1751 Encephalitozoon c...
19115545      --------------------------------------------------------------------------------      fission yeast
19114290  312 ------LAGNCLHLLHTEYKNSSLWKFCSYILDALYVFSGESVNSRIQVVSDVDDDEDDENAFSQNYYSHLQMVAKHFSK 385  fission yeast
19114838   98 ------------------------------------------------PFNN----PKD------DYKTRITLRSP---- 115  fission yeast
19115814 2472 isapaLILQQGIDLLSHLATWADHFASFFLSMHDFSGIASKKSAGRKNRESNVYKIAPINVLLGLLAREELFGNTLVMNT 2551 fission yeast
19112585   98 -----SFRSNR----EVSLTRPLKKSSTTNLSVLGNLVLKVAPSKIRAPAGNHSSTTANRTTSTPTTTTARTTRTTPRPT 168  fission yeast
19113326   94 -----------------AQAMCFRCSLCMTVNDVYFCLSGSQIKTKASTDGSQFISVEHFVETIHQTRSALQLAKQR--- 153  fission yeast
1176337   155 -----KERKGLIFQPVITYLLDRFHDVSILNRSFLVHDGGKNIKMLNYEVLQRFYSILSNLPTRKPYYSMLCCCNDLLKR 229  baker's yeast
6320665  2620 LTRILQVCTKTLAVLSTSSNGKENlsKK----FHLPSFDEDDLMKILSIIMLDSCTTRVFQQTLNIIYNLSKLQGC--MS 2693 baker's yeast
19074126  153 KINEMRGEFDATTRLDHSICGLIS----------GKEEITVEDRYILIGVLQLLLKKYEGSLHFTLGMIILRIYCT--IS 220  Encephalitozoon c...
19074747 1752 QLGNLSAHDAVKFRRTLCLLLSVVksSLryydYFRENPEIIDRIFSLLGRIKLTNDLLRLVTDFSVVFRKDKDLVFgrNI 1831 Encephalitozoon c...
19115545      --------------------------------------------------------------------------------      fission yeast
19114290  386 NYANQSGIVQRSFAECISSTFITKafKL----VSSNTLQAMSHFYATMIKLFPSNRTSILMYISLVETNEGSLTRS--FS 459  fission yeast
19114838  116 -SGSYRGSVVCLFKRSKFLP--------------EELPADKSQICTD--------------------IIDDASG-----C 155  fission yeast
19115814 2552 FSELLSTLTKPLLSFYKSEKLQKD--SA----TTGYTNDQDSRGSTVPKQDPGTTASRKDKKILSPPNILDENLRL--AA 2623 fission yeast
19112585  169 ATTNTSNQSTSNSTRNGTSAATSN--GT----GTGAGTGASHRSSPVTNRQTNNTSALSNSNAHIMSSFEDQYGRL--PP 240  fission yeast
19113326  154 -TGNVQAIVAAGLPLRELISLVFG----------SPPILNKLFSVKNGCSIQSSGLNYKLIYQLYHDITNLDILIT--NE 220  fission yeast
1176337   230 ITINKGENLQILQYRWLLIILNIPtiRT----CLIRDRKSKNVFETQQIRAVSYELAKRCIGYLSNLSTKTSQQLI--QS 303  baker's yeast
6320665  2694 IFTKHLVSLAISIMSKLKSALDGLSREVGTITTGMEINSELLQKf-----------tLPSSDQAKLLKILTTVDFLYTHK 2762 baker's yeast
19074126  221 KYGDVDETYYPTLYKTFDSIRSLYSEMLKKTTLSEGITCRGE----------------RIDSRGDMPICIYLPKFTKVD- 283  Encephalitozoon c...
19074747 1832 DLKSILDCFGRMVDSERFNLLEEFIESTADHFHTRFLDVILAEIk-----------kQFSALHKGIGAAFPSDGFLESQK 1900 Encephalitozoon c...
19115545      --------------------------------------------------------------------------------      fission yeast
19114290  460 RFSWDMFSESPVYQLFHKKFDVQNVLKNDSGYWFQLQLLIDVYSr------------MLFTMIDDEFHNDKQNPLYPVMA 527  fission yeast
19114838  156 AWETRIDEFGHVYYLKS---------P-------Q----LSV-----------------ISAISHEKLENLT-------- 190  fission yeast
19115814 2624 SLITTDSCSSRTFQNALSVMFHLSSIPKAKILIGKELLRHGQEYgnsitndlsrlcaDVKSGKNESELQVALAPFCPASS 2703 fission yeast
19112585  241 GWERRADSLGRTYYVDHNTRTTTWTRP------ASSTNPVHN----------------TSSDSQRLNHQNRH---LPDD- 294  fission yeast
19113326  221 LLRAIESLLRRPMLYCHDPADYQYLLILLENPLLNSKSKNIVN---------------KSSSILKRILGVLSNLNEKTHH 285  fission yeast
1176337   304 LRRTPTDNFSYQVEILNLYINFQFSRLLSNELSNRTAKNNVKPE--------------DEMRSRLRRHHTTGHEFLSTRP 369  baker's yeast
6320665  2763 RKEEERNVKDLQSLYDKMNGGPVWSSLSECLSQFEKSQAINTSATILLPLIESLMVVCRRSDLSQNRNTAVK-------- 2834 baker's yeast
19074126  284 -LSMLVDN----------ITCILNSSEVVDSRESKRIDNLLSILHLLYLVNEECGLLSYKKFYLVSFCSRMN-------- 344  Encephalitozoon c...
19074747 1901 IFLRLWKMLGRITGRDGKSSGEGNSLVMELMMDSFWHVFFENQKGKESIEDLINVSDIYEAFFIAGKVFESRfe------ 1974 Encephalitozoon c...
19115545      --------------------------------------------------------------------------------      fission yeast
19114290  528 EFCTVLKNLVLGLYWDVQAAKDVDCKSVVDISQLRVSSTSLLQQLYRINSRKQFLPEDFFLMSEYFNLNEFEan------ 601  fission yeast
19114838  191 --------------------PKQLKEVFS---QFLFNNQ-SKSSLKINLEY-KVIKHLLEHYPLALSVRQQVa------- 238  fission yeast
19115814 2704 NQAKLLRCLKALDYIFERRPKGQEQSPGNIIQLLEFYDNLKFSSLWEVLSECLSALRDHTSITHVSTVLLPLieslmvic 2783 fission yeast
19112585  295 --SNPSLMQS---DSG-NDLPFGWEMRYTDTGRPYFVDHNTRTTTWVDPRN-PLVRPNGGSSTVGSLMQPQSl------- 360  fission yeast
19113326  286 FFISCFKKQPYNNPKFFRRKVDLINKFIG--QRLMETYSRNKRKHYYNNDWQIKSAAITMALLYSANSQMRL-------- 355  fission yeast
1176337   370 ISAQSNDKQGSGFTHPVNNKMKFKFFQYEEDWHIHSAAKLTFIYYVANTRRNGRGALSIQSFYNITLDFIDYk------- 442  baker's yeast
6320665  2835 --------YEDAKLLDFSKTRVENLFFPFTDAHKKLLNQMIRSNpklmSGPFALLVKNPKVLDFDNKRYFFNAKLK--SD 2904 baker's yeast
19074126  345 --------FREEFKHFRAKSKTPLNFQFILPVHIKAELIKYEN----------------NDRMKTSLQDSFFKSLFe--- 397  Encephalitozoon c...
19074747 1975 -------nGGEDTDEKEQCSEFKAFYRKTIEGQAKQINLLVDERpeklFRNFNGLVN-RSILTFGNKKKYLSRMLSveGA 2046 Encephalitozoon c...
19115545    1 --------------------------SVSFLLSRNPELSKNES--------------SSILQFVSLHRQKIRISRK--K- 37   fission yeast
19114290  602 -------aLQESELASHAEAEINITYKFDNFSESRPRLNILNN-------CSFFLP--FHFRIHLLQQLLLLDKQAngYA 665  fission yeast
19114838  239 --------VEKGPLPAGWEMRLSEDYHVYFVDHSTKTTTWSDPRdnvvASDSVSENTDSIQQINDEYQRKIAYMYDrpEM 310  fission yeast
19115814 2784 rlvfielpEDVGKHISPILERFKTLFISFTEEHRKIINMMVFTTpslmSGSFSLLVKNPKVLEFENKRNYFNRQLHeeAA 2863 fission yeast
19112585  361 --------SHLGPLPSGWEMRLTNSARVYFVDHNTKTTTWDDPR----LPSALDQD---VPQYKCDFRRKLIYFRSqpGM 425  fission yeast
19113326  356 --------IDRSSFYCIMADFINLYHDFELWEQKINCFCFCQYPfllsMGAKISILQLDARRKMEIKAREAFFSSIl-SK 426  fission yeast
1176337   443 -------qDFDHWRGVAQKTKMNQLIEEWGNSTTKKCFSFCKYPfilsLGIKISIMEYEIRRIMEHEAEQAFLISLd-KG 514  baker's yeast
6320665  2905 NQERPKLPITVRREQVFLDSYRALFFKTNDEIKNs---KLEITFKGESGVDAGGVTREWYQVLSRQMFNPDYALFLPVPS 2981 baker's yeast
19074126  398 gHVDPYLFITVSRETVYRDSIEIFKKINVLDARK----QLRITFRNEEGVDSGGIRKEYFQLLSQEIKE-DERLFEHTEN 472  Encephalitozoon c...
19074747 2047 DKSSSFYRVYVDRSDVLRSSYFQVMAKSPEEFRTr---RLEIKLTGEEGLDYGGLTREWLVLLAKDLLDPNFALFEFATE 2123 Encephalitozoon c...
19115545   38 -IFNYALHLLATYAASENILEIEYEDEVGSGLGP----TLEFYTSVSKEFTLNSLDIWR-NDQP-------NSKFVYQAS 104  fission yeast
19114290  666 QPFGHLKHAVIRRNRIFDDGFDAFYNFGKLLKGPiritFVDEHGVVEEGIDGGGLTKEFLTSICKTVFDINYGLFSETKA 745  fission yeast
19114838  311 AVNDAQLQLKVSRATTFEDAYDIISKLSVSDMKK----KLLIRFRNEDGLDYGGVSREFFYILSHAIFNPGYSLFEYATD 386  fission yeast
19115814 2864 KEQYPPLNITVRRDHVFLDSYRALHFKDADEVKFs---KLNIHFRDEEGVDAGGVTREWLQVLARQMFNPDYALFLPVTG 2940 fission yeast
19112585  426 RPLPGQCNVKVRRDHIFEDSYAEIMRYSAHDLKK----RLMIRFDGEDGLDYGGLSREFFFLLSHKMFDPIYCLFEYSAV 501  fission yeast
19113326  427 MNVEPYLMIRVRRDRLLEDSLRQINDRNKDFRKA-----LKVEFLGEEGIDAGGLKREWLLLLTRKVFSPEFGLFVNCEE 501  fission yeast
1176337   515 KSVDVYFKIKVRRDVISHDSLRCIKEHQGDLLKS-----LRIEFVNEPGIDAGGLRKEWFFLLTKSLFNPMNGLFIYIKE 589  baker's yeast
6320665  2982 DKTTFHPNRTSG-----INPEHLSFFKFIGMIIGKAIRDQCFLDCHFSREVYKNILGRPVSLKDMESLDPDYYKSLVWIL 3056 baker's yeast
19074126  473 RIWIRPHEGDGE------------GYEAIGRIIAIALYNNVVLNIPFPSLFFKKLLDRRPTLDDLREISSGIATSLRNLR 540  Encephalitozoon c...
19074747 2124 DKTTVVPCKNSY-----VNPEHLSYFKFVGRIIAKAIMDGNFINLHLSKFIYQYILGKSCDLQDLESADPEFHKSLVWIR 2198 Encephalitozoon c...
19115545  105 GLFPSPIPLLGSs---pENERKISLFFALGQFVARSIYDSRIISIQFNPLFFARNIPLTISSVAKVDKGLANSLRYLEKL 181  fission yeast
19114290  746 HLLYPNTHAYAQ------DVERLRCYEFLGMLIGKCIYEGIQIDAAFASFFVAKWLGHPSYFDDLTSLDPNLYEGLVFLK 819  fission yeast
19114838  387 DNYGLQISPLSS-----VNPDFRSYFRFVGRVMGLAIYHRRYLDVQFVLPFYKRILQKPLCLEDVKDVDEVYYESLKWIK 461  fission yeast
19115814 2941 DATTFHPNRDSS-----VNPDHLSFFKFTGRIIGKALYDGRLLDCHFSRAVYKHMLHRSVSVKDIESLDPDYYKSLVWML 3015 fission yeast
19112585  502 DNYTLQINPHSS-----INPEHLNYFRFIGRVIGLAIFHRRFLDAFFVVSLYKKLLRKKVSLADMESIDAEFYRSLKWVL 576  fission yeast
19113326  502 SSNYLWFNYSHR-------SKEIDYYHMSGILMGIAIHNSINLDVQMPRAFYKKLLQLPLSFNDLDDFQPSLYRGLKELL 574  fission yeast
1176337   590 SSRSWFAIDPPNfdkskGKNSQLELYYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPLSFEDYSELFPETSRNLIKML 669  baker's yeast
6320665  3057 ENDITD-------IIEETFSVETDDYGEHKV------INLIEGGKDIIVTEANKQDYVKKVVEYKLQTSVKEQMDNFLVG 3123 baker's yeast
19074126  541 RLSRDEv-----dSLDLRFVVEHSVDGIPRS------YPLVKNGEDIKLTSENMRLFIEKYVEFHTDALIKPQFESIKRG 609  Encephalitozoon c...
19074747 2199 DNPVDK-------SLGITFSFDDVSFGVHRT------VELVEGGAHVFVDDSNKAEYVKLATQYRLFNGIELQLSALKSG 2265 Encephalitozoon c...
19115545  182 IPGKNPt------NAETDIKLEDLHLDFTLPgf--psIELIPDGASTPVTTFNVSDYLNYVIDYTVGKGVQQQLEAFQNG 253  fission yeast
19114290  820 NYDGDVe-----nDMALNFTVVHEEFGVRNV------IDLIPNGSNISVTNENRLQYIHLVSNYYLNARLSRQCRAFTNG 888  fission yeast
19114838  462 NNDVDE-------SLCLNFSVEENRFGESVT------VDLIPNGRNIAVNNQNKMNYLKALTEHKLVTSTEEQFNALKGG 528  fission yeast
19115814 3016 NNDITD-------IITEEFAVEKDVFGEKTV------VDLIPNGRNIPVTELNKQNYVNRMVDYKLRESVKDQLKSLLDG 3082 fission yeast
19112585  577 ENDITG-------ILDLTFSVEEDHFGEVRT------VELITNGENIEVTEENKKKYVDLVTEWRVSKRVEQQFNAFYSG 643  fission yeast
19113326  575 LFEGDVk-----nTYGLNFTINLKAVEGFRT------VELKEGGSELSVDNENRKEYVLRYVDYLLNTTVKKQFSAFFDG 643  fission yeast
1176337   670 NYTEDNfedvfslTFETTYRNNNWILNDSKSskeyvtVELCENGRNVPITQSNKHEFVMKWVEFYLEKSIEPQYNKFVSG 749  baker's yeast
6320665  3124 FYALISKD-LITIFDEQELELLISGLPD---IDVDDWKNNTTYVN--------------------------YTATCKEVS 3173 baker's yeast
19074126  610 FYSIIDKD-KLAYLDPKELEKIMMGSNT---FDIKAIRSTTTYSG--------------------------FREDSPIIV 659  Encephalitozoon c...
19074747 2266 LFEILGSK-ALEMFDESELELLICGIPD---IDVDDWKNNTLYYG--------------------------YAENSKTVI 2315 Encephalitozoon c...
19115545  254 FSSVFPYT-SLQVLTEHELVTLFGTVDEd-wSYATLMKSIVADHG--------------------------YTMESPTIQ 305  fission yeast
19114290  889 FTQIIDPH-WLAMFHESEIQILVGGDPVp--IDIDDLRRHTVYAGg-------------------------YEPNSPTIV 940  fission yeast
19114838  529 LNELIPDS-VLQIFNENELDTLLNGKRD---IDVQDWKRFTDYRS--------------------------YTETDDIVI 578  fission yeast
19115814 3083 FSDIIPSH-LIQIFNEQELELLISGLPE---IDIDDWKNNTEYHG--------------------------YNVSSPQVQ 3132 fission yeast
19112585  644 FVELVSPD-LVNVFDERELELLIGGISD---VDVEDWKSHTEYRT--------------------------YIATDPVIK 693  fission yeast
19113326  644 FMKVCGGN-AISLFQDNEISKLIRGSEEv--IDWELLKNVCVYDFydqnaisnsisesepsmtaskylchsFVSKRKIIL 720  fission yeast
1176337   750 FKRVFAECnSIKLFNSEELERLVCGDEEqtkFDFKSLRSVTKYVGg-------------------------FSDDSRAVC 804  baker's yeast
6320665  3174 YFWRAVRSFDAEERAKLLQFVTGTSKVPLNGFKELSGVNGVCKFSIHRDFGSSERLPSSHTCFNQLNLPPYESYETLRGS 3253 baker's yeast
19074126  660 YFWEIFEAFNRKKRKKLLQFITGNDRIPVSGPASLKL-------VIMRNGCDTDRLPSSQTCFNTLLLPEYSSKDKLEGK 732  Encephalitozoon c...
19074747 2316 WFWRAVKSLDSVSRAKLLQFVTGTSTLPFEGFSHLQGNNEVQKFSIHKVSDRIDSLPTAHTCFNQLVLPEYSSYENLLKY 2395 Encephalitozoon c...
19115545  306 RLLTLMSQMNFQEQRDFLQFITGSRKLPIGGFAGLNPPLTVVRRLNEPPYVPDDYLPSVMTCVNYLKLPEYSSSEVLGSR 385  fission yeast
19114290  941 LFWEVLREFEEEDKRSFVKFVTSVARPPILGFKALMP-----SFCIRVNGEDETRLPTASTCVNLLKLPMYSTKQTLRDK 1015 fission yeast
19114838  579 WFWELLSEWSPEKKAKLLQFATGTSRLPLSGFKDMHGSDGPRKFTIEKVGHISQ-LPKAHTCFNRLDIPPYNSKEELEQK 657  fission yeast
19115814 3133 WFWRAVRSFDEEERAKLLQFATGTSKVPLNGFKELEGMSGFQRFNIHKSYGSLNRLPQSHTCFNQLDLPEYDTYEQLRSM 3212 fission yeast
19112585  694 WFWEIIAGWKNEDRSKLLQFATGTSRIPVNGFRDLQGSDGPRKFTIEKAGTPDQ-LPVAHTCFNRLDLPDYPSKDTLHEK 772  fission yeast
19113326  721 WFWDLISHYSLKMQKLFLIFVTGSDRIPATGAHNFQLR------ISVLGPDSDQ-LPISHTCFNHLCIWEYSSREKLKKK 793  fission yeast
1176337   805 WFWEIIESWDYPLQKKLLQFVTASDRIPATGISTIPFK------ISLLGSHDSDDLPLAHTCFNEICLWNYSSKKKLELK 878  baker's yeast
6320665  3254 LLLAINEGHeGFGLA 3268 baker's yeast
19074126  733 LETALELTA-GFFLL 746  Encephalitozoon cuniculi
19074747 2396 LTLAINECStGFGFI 2410 Encephalitozoon cuniculi
19115545  386 LSKAILEGQ-GSFHL 399  fission yeast
19114290 1016 LLTAVRSGV-GFGFS 1029 fission yeast
19114838  658 LTIAIQETA-GFGTE 671  fission yeast
19115814 3213 LLTAINEGSeGFGFA 3227 fission yeast
19112585  773 LSLAVENTV-GFGNE 786  fission yeast
19113326  794 LDTALLETN-GFNIR 807  fission yeast
1176337   879 LLWAINESE-GYGFR 892  baker's yeast
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