6XP5


Conserved Protein Domain Family
Med7

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pfam05983: Med7 
MED7 protein
This family consists of several eukaryotic proteins which are homologs of the yeast MED7 protein. Activation of gene transcription in metazoans is a multi-step process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators such as MED7 to direct transcriptional initiation by the RNA polymerase II apparatus.
Statistics
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PSSM-Id: 461794
Aligned: 134 rows
Threshold Bit Score: 86.1434
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6XP5_G        12 AHLWPDPPAFWKDFTPENIERYNALKQTYAQQHGLssdalv--------------------ripdvpAdli--nlqPPPE 69  Chaetomium ther...
EKC97575       9 nTLFPPPPEYYKAFTPEAVERLAELRSKDEGGEERerlq---------------------------------keqdPPRT 55 
P0CO76        14 nTLFPPPPPYFQAFTDEAIERYETLTGKSLFVNDEkgktkgkekksddrdmsvdiriqdlteeeqneklelegkleKPRA 93  Cryptococcus ne...
XP_007410722   8 SSFFPAPPTRYLQFTKPNLTIAKSIQSKTKPNELQfdsdlqkrlikeslkdlkdieeideeeierineidlrtllePPNL 87 
Q5CSG5        11 VSSFPPPPPYFRLFDHEDKVAKIK----------------------------------------------------PPPC 38  Cryptosporidium...
EEA07886      11 VSAFPPPPPYYKLYNSEETALE------------------------------------------------------SPPC 36 
XP_001610809   5 TSGYPLPPFFYKNYSFRNKNVTSSKVCMPTTSLTSnessedilc-----------------------iidtvsgprYPSP 61 
Q8IB55         7 VSGYPPPPYYYKEYQSVDIKKlmemsnfkstdeksflehmkns--ydviydvdtntyikniesidniKncnfimgrPPPL 84  Plasmodium falc...
XP_651043      3 aEKYLDPPHFIQEWESNDEST-------------------------------------------------------WPKP 27 
XP_001416123   5 aTPYPDPPAFFTLYGAPDVV--------------------------------------------------------PPAP 28 
6XP5_G        70 PV----DGKWKLYGQQEAl----ANSLQSLEDAGIQRLApasettsDSKHFDRGFELKKLAKSLLVNYLELMGIMSIN-- 139 Chaetomium ther...
EKC97575      56 DWil-eDGRWMAFGQQYTa----TPHIPNARDIGLPALVad---pvSQGGDSERSALPTLLHSFLHTLLAFIDVLTGTar 127
P0CO76        94 DWvn-eDGRWMCFGTMYTt----EPIIPTAQSIGLPPFI--------DPAVEPQESLPPLLHSFLHTLLLLLDTLTMTar 160 Cryptococcus ne...
XP_007410722  88 DLik-eRGGWSSFGDWEPw----PGKSSRAMLEGMPKLY--------EEKMERKDALQALLNTLIYSYLKLLNQLGHQg- 153
Q5CSG5        39 I-----EGPFTCFGSQLSs----DISIHPLDSDTI--LY-------NESNVDLPAELMMLNEMFQMEILKLLENSGKGv- 99  Cryptosporidium...
EEA07886      37 I-----IGPFMCFGSILSs----EINIPPLDSDTS--LY-------NQENSDLIQELRCLNSLFQENILNLFKKSGQGs- 97 
XP_001610809  62 P-----NSPWYSFGVEEKl----EFELHELDSETIINIP--------KKDNDLKKHFQILYGDFMDCFMHYLRHLKEV-- 122
Q8IB55        85 PL----RNSYNVFGIDYEl----QRNIEELDSDEI--LY--------DEKKNLKEEFIRLYKIYKETFFLLFDDIVNN-- 144 Plasmodium falc...
XP_651043     28 PAclgdDETYFSFNRTVK-----REETDLFPSEILDRTK------------DVRDQLKQLNHSILVAYLAIISKQMNQ-- 88 
XP_001416123  29 PTpp-tNAAYASFGANHHtapwhDPDHGYAASGGFVYPIcv----dERGKTDAREEMCALTRHATARFVEAMERCVDA-- 101
6XP5_G       140 -P-AH-----ASEK----VQDIKTIVLNFHHILNE-YRPHQAREQLIQLMQDHLDAKRNETAAVRAVVDKAKRLI 202 Chaetomium thermophi...
EKC97575     128 iPgELeaagrASEGdqqyIQHLSNLAATMIVSANQ-LRGVQAEETLVMLMEKQVSERKSQVEKLRAKNREVAEKI 201
P0CO76       161 tPnELaa-agWASEgdqyIQHLTNLSANMMVASNQ-LRSAQSEATLVLLMEKELEERRKQTEKLRSKCKEIASgi 233 Cryptococcus neoform...
XP_007410722 154 -PpSLsnhsnQVSNtdqiISHIELTSFNMHGLCNE-LRPRQARETLKLMMKEQAKEKREKARLVLKTCEDLKNdl 226
Q5CSG5       100 ---------vDTSS----VKKIIKIYNNMNHILEK-LRIIQTYHQICDELEAQVNEKNQLLDQMKQHLEEYKSLL 160 Cryptosporidium parvum
EEA07886      98 ---------iEVSA----IKHIVKIHSNMNHILEK-LRLIQAYYLIMKQLELQIQEKKELIEQMRQLLTKCNEnt 158
XP_001610809 123 -----------DNDsvsdIKKLIKLYMNLQYVLYT-FSERKAEYDVVRMLREQLYRRRHYIDCLKVALLDTERll 185
Q8IB55       145 -RkDD------KSK----IKHLTKIHVNLFHILAK-LRHYQTINNIINVLKIQLKKRQIAIDKMKISLLNVYQYI 207 Plasmodium falciparu...
XP_651043     89 -Ph-------RYEVitpyVYHLRLLISTMHQALNS-YRPYQAKKYYALLFEKQVEHKEKLYEQLKALIDDANNKy 154
XP_001416123 102 -Pt------rAEEA----TGALHALFNNAHKLINEtIRPSQAMTDFEYQIERMIEEKRTSVEALERALERAKAVk 165
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