Conserved Protein Domain Family
HRXXH

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pfam13933: HRXXH 
Putative peptidase family
This family of putative peptidases are closely related to the M35 family pfam02102. In this family the metal binding HEXXH motif is replaced with HRXXH. The exact function of these proteins is unknown. Members of this family are found to be fungal allergens.
Statistics
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PSSM-Id: 404766
Aligned: 24 rows
Threshold Bit Score: 321.554
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6CQ42         8 SNILLTLYLALIAQASIvvkradssSTSSASSTSSSPATISKPASANLttenqalapfqdgvfeffgwtNPTFPqYHNSC 87  Kluyveromyces l...
EDU41535       5 LSALMLFGASAAIAGPIvp-----rQNGLTTAAPVAATPVATTWNAGA---------------------VQNFP-IHASC 57 
Q00746         3 LLALTLALCASIAALPT--------------------QQTPLPLEDPI---------------------KSPFP-IHHSC 40  Aspergillus nid...
XP_002562292   3 FFSLILSSAAIAAALPTr-------ETSEGNQSQPFSQNGLAPWDAGA---------------------VTQFP-IHSSC 53 
XP_001271840   5 LRLLCLLPVVLALPTAH-------------VQRESPDKPALSPWNAGA---------------------TTSFA-IHSSC 49 
EED57494       4 LISFLLLSTVTAIPAPI-----------SLTTRDQATPHAPSPWDAGA---------------------TTQYP-IHQSC 50 
Q6CV33         6 SNIVGCISIISSIAGAT--------PLKNHDFHSNSSLELIEFGESGEsg-----------------wgSPVFPyFHQSC 60  Kluyveromyces l...
Q12512         7 KSIIFATIASLALSAPV-------------TYDTNSTAELQSPSSQEIlg-----------------wsHATFPtIYQTC 56  Saccharomyces c...
XP_002552246  11 NGLVLLTSIVCIGTLIAgfv--laiIAERDAVNIKNTRKTFTTVATGEw-------------------aNAQFPrLHKSC 69 
XP_002542986   6 LPLLVIASPLLAAPLAG---------------RELQPGNDLPPCDQGA---------------------VQKYP-IPKSC 48 
Q6CQ42        88 NITNQRMINGALIDTLEVSSFARDRLLANGTSDEIYKRWFGDAPLFTVAGVIENTIQGVKDDLLFRCDDPQGGCAaNPTs 167 Kluyveromyces l...
EDU41535      58 NATQRTMLQKGLNEAITIVSHARDHILRWGNSSEIYTKYFGNAPTGEPIGWYTKLADGDKADILFRCDNIDGNCG-QSG- 135
Q00746        41 NATEQRQLATALQETVTLAEHAKDHILRWGNESAIYRKYFGDRPSLTAIGAYDIIVNGNPDNILFRCDNPDGNCA-LEG- 118 Aspergillus nid...
XP_002562292  54 NATQRRQIELGLNETITLAQHAQDHILRWRNESAIYRKYFGDRPSMEAIGAFDVVVNGDKKDILFRCDNPDGNCD-LEG- 131
XP_001271840  50 NATQRRQIEAGLNEAVALADHAKAHLLRWGNSSDIYRKYFGDRPSMEAIGAYDVIISGDKRDMLFRCDNPDGNC------ 123
EED57494      51 NATQRRQIEAGLNETIALVDHAKAHILRWGNESTIYRKYFGNRPSFEAIGAYDIVSNGDKGSVLFRCDNPDGNCE-NEG- 128
Q6CV33        61 NATNQRMLSSGLKDTLEVTAVARDKLLANGT-DKFFKRWFGNSSVFTVIGTLEYVIESGKSDVLYRCDDPSGDCAvHSTd 139 Kluyveromyces l...
Q12512        57 NETNARMLNAAFKDTAEITAYGKDRLLNYGVDDVYYKRWFGNGSIFTVMGVFEQLMEASKGAMLMRCDDIDGLCAaNPNy 136 Saccharomyces c...
XP_002552246  70 NATDVDFLTRTMNETMEVASYAKEQLLVKGANDTIYKRWFGDGELYDVLGVVDGIANMTKTDVLLRCDDVDGLCAaNPNy 149
XP_002542986  49 NATERRLIPPGLDDAMTLSKRAKEHGLCFGNTSALDRKCFGNAPSGEVIGNLYRIVNADKGNTLFRCDDPDGNCQ-IPT- 126
Q6CQ42       168 WWGYHV-LNTTGETNFCDLFYSGKKPLTHICFEG-TIVEVGPTLYAGIDLFHRYFHLDQMSsEGYIGEY----TEELDDI 241 Kluyveromyces l...
EDU41535     136 WAGHWRgSNASQETVICDLSYEIRKPLEAMCMHGyNVANGPTNYFWASDLVHRLLHVPSVG-EGVVEHYigesGEKYPGV 214
Q00746       119 WGGHWRgENASDETVICELSYTTRRSLSTMCSQGyTISEWETNTFWAGDLLHRLYHMPAIG-QGLVEHY----ADGYEGV 193 Aspergillus nid...
XP_002562292 132 YAGHWRgENGTDETVICDLSYETRRSLSTMCGLGyTVSESETNTFWAADLLHRLYHVSAIG-QGWIDHF----ADGYEEV 206
XP_001271840 124 WGGHWRgNNATGETVICDRSYTTRRSLLTMCAQGyTVSASDTNTFWAADLMHRLYHMPAVG-QGRIEHF----ADGHEEV 198
EED57494     129 WAGHWRgENATAETVICDLSYSTRRSLTSMCALGyTISGSETNTFWAADLLHRLFHMPPIG-QNWVEHF----ADGYGEV 203
Q6CV33       140 WPGYHV-TNTTGETNICDLFYQTKKPLSTICFEG-DIVELGPKHYSGIDLFHRFLHLDNLNgNGFISEW----TETLPEV 213 Kluyveromyces l...
Q12512       137 YAGHHR-QSAPAETVICDYFYTSKKPLSTICFEG-TIVDVGPKHYAGIDMLHRYLHVPTMSmDGYVGEY----AETLEEV 210 Saccharomyces c...
XP_002552246 150 YAGHHR-EKADAETVICDYFYESRAWLSDICANG-TLKDFPPPRYAGIDMIHRYFHVSFINlDEYIGEY----TEEVEDV 223
XP_002542986 127 YGGHWRgSNATGETVICPLSYKTRLFLEYFCTGGyTVSGSPLKTYFGTDLLHRLYHMPAIG-EGHVEHF----SNTYEDV 201
Q6CQ42       242 LALAQNNATYAVRNVDNYLYYLADVYAEAV-IPG-GCLGD 279 Kluyveromyces lactis
EDU41535     215 MNLAKNNATFAVRDSDALQYFALEAYAHDIaVPGiGCSGT 254
Q00746       194 LELAEGNRTEAVHDSETLQYFALEVYAYDVaVPGiGCVGG 233 Aspergillus nidulans FGSC A4
XP_002562292 207 VDLAKTNATLTTRDSETLQYFALEAYAYDIsVPGvGCPGV 246
XP_001271840 199 LTLAKGEGDEPTHDSETLQYFALEAYAFDVaVPGvGCPGE 238
EED57494     204 LELAAGNESTSTRDSETLQYFALEAYAYDIaAPGvGCAGE 243
Q6CV33       214 LYLAENNATFAARNTDNYLYYLADVYAATV-NPG-GCLGE 251 Kluyveromyces lactis
Q12512       211 VDYTQNNATYAVRNTDNYLYYLADVYSASV-IPG-GCLGN 248 Saccharomyces cerevisiae S288C
XP_002552246 224 LDLAKSNSTFAVRNVDNYLYYLADVYSSDK-ISG-GCLGL 261
XP_002542986 202 LQLGAHNSSFAVRDSDTLQYFAADVYGFDIaIPGvGCAGE 241
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