Conserved Protein Domain Family
CRT10

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pfam08728: CRT10 
CRT10
CRT10 is a transcriptional regulator of ribonucleotide reductase (RNR) genes. RNR catalyzes the rate limiting step in dNTP synthesis. Mutations in CRT10 have been shown to enhance hydroxyurea resistance.
Statistics
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PSSM-Id: 400874
Aligned: 7 rows
Threshold Bit Score: 542.151
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q759E8    127 ISPAHTLLPQWERLNIkeegiTEDIFDFRH-----GCA------------FDNNLMCTSe----NSVLFIALGYEFRVFD 185  Eremothecium goss...
Q6FWJ3    108 HQPADNLLPSDMKLCV-----NFTVRKYVSrksveGFG------------FKNNLMQIF-----GDYIIIGRSSTVEIHN 165  [Candida] glabrata
Q6CUM3    106 CDPGEILLPNYYQIKVre-igSYPVHVFQHrs------------------gcNNFIILQn----RYALYISSVRTIKIVD 162  Kluyveromyces lactis
Q6CAP7     67 EAPSDFLPSQQMATMFdkeatTrv----------qFMGdstvgvmgeisqFKGNLAVEAt---rWPVLFIACGTHIEMFA 133  Yarrowia lipolytica
EDK39330  502 KDPYRPGLTSVDTISFssvmkDSPSSKFRDglkvsFVDykrinqagaarkYKNNIAGIIkdsdgREFLVTACESCLVFHE 581 
Q6BNR5    282 YDPHRSEFTAIEDSDPtklviLPPAQKFRDliqlePLGvkklmgldnvrkYKNNISATIsdsegNNFLVTCANSDIVIFD 361  Debaryomyces hans...
ABN67500  175 IDAFSKDYTTIENTDPsrilrKPLAEMYKDglrlkHIGirklhalenirrFKNNISTIIndsdgRDYLVLASNSELIIFD 254 
Q759E8    186 LTKVDLSADtkhqs--rafnlLDSYLLYSAIPLPDTgFLSQVP-MDYRIHFI-KACSFYGDEYVAMCCESGYIMMF---- 257  Eremothecium goss...
Q6FWJ3    166 RACLTAASKlfylklsdwsahIDETTMTEQLKIPDA-FISTNL-MDVTINYM-KILEIKGGFYLCLCCDSGIVLFYslat 242  [Candida] glabrata
Q6CUM3    163 LTHLST---------------HNEILDAEQNLLIDD-LFTNSS-NEYTLSLMeRLPSFMGVTVLVFGDSAGNVSFYress 225  Kluyveromyces lactis
Q6CAP7    134 ADGSPDLV-------------GAFYAEPNIVTTEMR-EGAVRPnSPHDINML-SMVILCGHECLVANYDDGRSGLWvvsr 198  Yarrowia lipolytica
EDK39330  582 FDPLTQHPQte--------vcFAFETKPSYTTAWDR-LVSTSPeNPHTINYLkVYDNWLGQQVLAVCIDDGMVLMWytst 652 
Q6BNR5    362 FDSISQLPNhl--------pvFRFDTKPTFTSTTDR-LISTWPyFPHTINFL-KTDTWLGKQILGACLDDGTLMIWyvet 431  Debaryomyces hans...
ABN67500  255 FDDVVALPNkk--------svLRFDTRPPFTSTTDR-LISTWPyFPHTVNFIrTFNNFCGRQVLGACIDDGSLMLWytdt 325 
Q759E8    258 LVrdfkAYd--------aSDDID-H---FGR---PTMQPR---YILEAAG---SCWAFDIYdDH-----PDIKIIAAGHN 311  Eremothecium goss...
Q6FWJ3    243 IV----MF----------IEDNK-Hg--TSR---IEIAPY---MVLRTPV---SCWSADSI-DY-----DGRTYIALGHN 290  [Candida] glabrata
Q6CUM3    226 FItsfsAV------------------------------PDkavLNLRLPSertKVLSCDYV--------DQSSNLTIFSS 267  Kluyveromyces lactis
Q6CAP7    199 IIaevqEG--------------------VSR-----YLPH---VTFKSDA---SVWGTG----------TSGSLLALSDN 237  Yarrowia lipolytica
EDK39330  653 ITeqmsKHrqr----frgSVNLD-Em--ERAiysVKIKPD---FKIRLKK---SAWGIDLS-TYtdslgDTHHVIVTSDN 718 
Q6BNR5    432 ITeqltKFgltknnkvdnESELDnSytdQNRfygIKINPD---FKLKMEA---SLWGLDFL-SYeddggNMHNLIIASDN 504  Debaryomyces hans...
ABN67500  326 IIkyikSMkire--kvgrQDDADsLyrdTNRfhgLRVNPD---FKFKLEA---SVWGLDFL-NYndtfgNSHNLIVASDN 396 
Q759E8    312 AgsapTGITL--FAHYKD--CTRFAIE-----EIT--------------TEHNVPCVNFIKNT--SP-GFdITLAYTCIY 365  Eremothecium goss...
Q6FWJ3    291 G----PGISL--FVISYD--EDNVVVGpvhckEVI--------------TVHNVPCLSFIPGEtnTD-GS-LLLVYASIF 346  [Candida] glabrata
Q6CUM3    268 K----EVLTV--LFFDS---KERTPISd----EIT--------------FPASLSCITFLDCTvnGF-----IVICEDRT 315  Kluyveromyces lactis
Q6CAP7    238 S----RKIDIydLASLADklQEKHYVDrvnlySDEgveqvqlpryrsplMMNNIPSISIVVDEddAF-----YVTAGTIG 308  Yarrowia lipolytica
EDK39330  719 S----QTITL--LYYHVG--DQQFYSEe----SKQ--------------TSHNIPEVSFIRFYdnDG-LHyVFVAAASIS 771 
Q6BNR5    505 S----QSIVL--FYYHVQ--DERFYHIk----SHQ--------------VLHNIPEVSFLSSHiqDE-IHkIKVACASIS 557  Debaryomyces hans...
ABN67500  397 S----QSVTL--FYYHQQ--DSRFYHVk----SHQ--------------ILHNIPEVSFVSHEvsNEgCHlVKVSCACIS 450 
Q759E8    366 GSVGTIRIQpflYMERDGatd----------------------------------------------kiKIPWEYWDEQY 399  Eremothecium goss...
Q6FWJ3    347 GNLTSLAIK---FDQTNN---------------------------------------------------DIDVSMKDTQF 372  [Candida] glabrata
Q6CUM3    316 ATKFTLHFPiktLQSGQIyy-----------------------------------------------elLEDSKAIDSHG 348  Kluyveromyces lactis
Q6CAP7    309 YEVATIKF----FTGERLekwkqsysemdirpfsrslss---------esldsivdaadeswedshiykPFEGGIWIHRN 375  Yarrowia lipolytica
EDK39330  772 AELVTFGFM---FYIQRGplslahdelsgkthitnvqpsy--------hvmgdveaplaprirsslerlDLVAIMLINRT 840 
Q6BNR5    558 GELIIFKFN---FKLNDGpldrdeyeyfrneviyyvdatmaqiesrrenrpseedlretelrmkrfhrvLFNSPTVVSRV 634  Debaryomyces hans...
ABN67500  451 GELLIFQFE---FRIKSGpldqdeyeyfkketiyyidstme------ihnrdpnlensdeiklkkfkriSFLLPRVLTRT 521 
Q759E8    400 F-TSWCWTITPVSRKDFHRTTAYEYLTNTyDQEQKKKDLELIYQGSLILDSFPSiPSHSPIMGIAANMAQLFVPVSRLDP 478  Eremothecium goss...
Q6FWJ3    373 F-GEFCWTVTPLTSADFMEVSAYEFLNLNyQKVSKVSTLSSMCQDSQILGNSPSnCYKTKSFGIGALTTQVKVPVSQLEL 451  [Candida] glabrata
Q6CUM3    349 LcSHDESTLISISKDDFLSVPKYEFLTLSyNTSRNEETVRQIYQNSMILEVLPLyPSESNYLGFGASIAQIEVPIPNFSL 428  Kluyveromyces lactis
Q6CAP7    376 SlGTHVWTVTTVSPRAFKQSPTLYEVHAN-KWANEQQVAAQLQRDSSKAKNIFD---PLRPFYPAVRFTHYDIPTCPLQS 451  Yarrowia lipolytica
EDK39330  841 ElPEDSWTVKVIDPRWFLPVQSLRAMTGD-PSIREEKEITRIMNESRLLNGQCD-PLQTSFLGLAAEYQFYETPVVDI-- 916 
Q6BNR5    635 LlGEDCWTCKPISSNAFKQVQSVRAMTGD-HRINEEQEIQHIMNESEILDFQYD-PLKTSHLGLSARWQFFESPVLTL-- 710  Debaryomyces hans...
ABN67500  522 VfGEDCWTTKPISSTYFNEVDSLAVAIGD-PFLREEKIVKSIMNESAALDL--------DHLGFGANWQFFQSRVVSI-- 590 
Q759E8    479 F--NGYQCMDGimefhfac---------------aqllngdGDIIpyRKARIKSNCMTYN-DEDSCMYFVPR---SDLPL 537  Eremothecium goss...
Q6FWJ3    452 S--CRYGMVNLpvklrfttfdnegfiqearllpnyisgippGGTI--EFFLHNNTEVQYKvDVQSAQKEKVRfnyAFPAL 527  [Candida] glabrata
Q6CUM3    429 LyrNDESLVNCpielry-------------------tayqkYGKHyhEVYVNKKVLNESFsQDPDCYISKRShgyGDSKV 489  Kluyveromyces lactis
Q6CAP7    452 GgiQPSGVQAL------------------------------AGMFpaMGVPTPGFNYKPHyLLPQCKKETRKmtqWYERY 501  Yarrowia lipolytica
EDK39330      --------------------------------------------------------------------------------     
Q6BNR5        --------------------------------------------------------------------------------      Debaryomyces hans...
ABN67500      --------------------------------------------------------------------------------     
Q759E8    538 GDEKL--DkgvqesdlrrnmdfvttsrtiqkeyvdallrlKVKEPSSRSQQEPfylsfdeqpmlekkpnsvhlirhlhgp 615  Eremothecium goss...
Q6FWJ3    528 SSETLyeDierriekvldsttld--nnlnsrqndgfsqlfKVRQKSQIWGEKNglkyqynrnylttiynshdleelsqpf 605  [Candida] glabrata
Q6CUM3    490 GKVHVtsDr------------------------------sDVRQTRIGWEIVSdaeldfckdykdkflslqdqvetlrie 539  Kluyveromyces lactis
Q6CAP7    502 GIERVedNa------------------------------kNSASSAQSWSDEG--------------------------- 524  Yarrowia lipolytica
EDK39330  917 ----------------------------------------EGKEAE---QEDK--------------------------- 926 
Q6BNR5    711 ----------------------------------------TTKLTE---NQDS--------------------------- 720  Debaryomyces hans...
ABN67500  591 ----------------------------------------SSETTA---D------------------------------ 597 
Q759E8    616 eeslnnnlagsslyrnpaiqrlhprevtrywmsndsfwgqkieiepspriepltlQASTPRPSTHGEDSGSNEGAFPlag 695  Eremothecium goss...
Q6FWJ3    606 sqv----------------------sndyvvlcassvfhsgyrgswkdiapyninEITSTENEEIPEDHKFLHPSLSlas 663  [Candida] glabrata
Q6CUM3    540 rkgypcf--------------dlqfidniecsadllrriyfhktwkftqiksselKSGEFSPSNIKDCFTARQLDIPiln 605  Kluyveromyces lactis
Q6CAP7    525 -------------------------------------------------------DSEQTKLSDTDEGAQEPPSDAP--- 546  Yarrowia lipolytica
EDK39330  927 -------------------------------------------------------EKESARVYSIDEEY----------- 940 
Q6BNR5    721 -------------------------------------------------------TLESAKLTGVDDDY----------- 734  Debaryomyces hans...
ABN67500  598 -------------------------------------------------------LYKAGRITGIDDEY----------- 611 
Q759E8    696 ernrtlcddivdASLTNHIKKLYRLFSSLQKESRHKAEGPEFDS------VvsQDYMFVITTNTSVYLVRSDPLIVNALT 769  Eremothecium goss...
Q6FWJ3    664 aqe----gnqrkWGIHNHVKKVHDLLNCIEPNTRNYPMGYKLKE------F--HSGFLLVTTAQKVYLVKTHPMLILSYT 731  [Candida] glabrata
Q6CUM3    606 r--------idkDAVDEYVDKSIIKYLRICDESRFNNDGPKFFSk-----TsgSNFIFEATSTFETSLLGTDPIIMNAFT 672  Kluyveromyces lactis
Q6CAP7    547 ------------NSLYEH---------EVEREKKESPL---------------KDLFVIVTTHRSLYLCRHDDLFVNGAC 590  Yarrowia lipolytica
EDK39330  941 ------------QRIHKSMKKFHDDWAEEPI---QSVNGKWYLKlssflkIgkLAPILAMTTEHRACLFSSQTLICYGAT 1005
Q6BNR5    735 ------------RRIHKGIDNFVCNQQQKYISKKKSLNGKSYWPl-----DepSINMLAVSTSKKLGLFRADTLYCNSST 797  Debaryomyces hans...
ABN67500  612 ------------RRIHKGIQ------------------------------DleSENFLVVSTTKKLALFRADTLFCTCAT 649 
Q759E8    770 MdELFPTKD-VTTCQPAIEh--lNRISIVCYIRELSCIVVASQIGLLSVLRLTEYNGIYSFRQEYVIGwehippekrdti 846  Eremothecium goss...
Q6FWJ3    732 SdEIFPLES-ITLCSFKGTimalNRINFVCHIKEMNCIAVASQVGLISLLRLTKYKGIHSFRQEYILGwntlgpenddef 810  [Candida] glabrata
Q6CUM3    673 R-PIFPL---NFNCVDLSS----NKI-MVCHLREINCIVVANGSGLMFLYRLTEWRGIYAFRFEKILNilriqdicddsd 743  Kluyveromyces lactis
Q6CAP7    591 A-NVFSWED-IYGFGEQQF----DRLSFAHYIPDLCVYICGSPIGAVSVFRLTQKAGVFCMRQEWAFP------------ 652  Yarrowia lipolytica
EDK39330 1006 R-RIFNLSKhPRTHIDDAS----ARLSISHVIPELSCFIVISQQGLASIFRLCKHRGVYGMRQEHILP------------ 1068
Q6BNR5    798 K-KLFNLSI-PFSDESKFS----NRISITHIIPALLCFIAVTQQGLISIMRLCQHRGLFGMRQEHIFP------------ 859  Debaryomyces hans...
ABN67500  650 K-RVFDLAI-PFNEEVKFS----NRMSITCVIPKLSCIIAVSQLGLATIMRLCCSRGVYAMRQEHIFP------------ 711 
Q759E8    847 cms--------qyttgpqddsavpcGHCNTVFPSFLIQGLDYVYV--------------PDDPGNGILEHALLYVAYRNN 904  Eremothecium goss...
Q6FWJ3    811 qc----------iysklhgstnvycGIDDIDFPFLEINGMDYIYC--------------PRDDVKGVAEYAYLIVSFGSD 866  [Candida] glabrata
Q6CUM3    744 deerstfcetnrrftqnnsdfhhtcNECRLVIKYPMVQSMDYIHM--------------PETNA------VLLYVCTTAC 803  Kluyveromyces lactis
Q6CAP7    653 -------------------------DTSQILFFTDRLRLLAGVAVapihtsirenvigsRERQWNEPCLRYRVTLIYGDG 707  Yarrowia lipolytica
EDK39330 1069 -------------------------SARSLSEIYAGGKTICGLAV--------------RRASAAVEDPRYLIYITYTDG 1109
Q6BNR5    860 -------------------------NALSLALGSRGYRTIAGLAI--------------RDMSL-PKFPRYFIYVTYTDG 899  Debaryomyces hans...
ABN67500  712 -------------------------NALGLALGYNGYRTISGLAV--------------REKSILPRVTRYFVYLSYTDG 752 
Q759E8    905 LA-RYSI 910  Eremothecium gossypii
Q6FWJ3    867 IA-KFKI 872  [Candida] glabrata
Q6CUM3    804 LV-VYEI 809  Kluyveromyces lactis
Q6CAP7    708 YRiNYEI 714  Yarrowia lipolytica
EDK39330 1110 LViTYEL 1116
Q6BNR5    900 IIvAYKL 906  Debaryomyces hansenii
ABN67500  753 IVvAYDL 759 
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