Conserved Protein Domain Family
CAF20

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pfam17052: CAF20 
Cap associated factor
In eukaryotes, the translation of mRNA is initiated by the binding of eIF4F complex, which is composed of eIF4E, eIF4A and eIF4G proteins. elF4E-binding proteins (4E-BPs) are involved in translational regulation through their interaction with eIF4E. There are two elF4E-binding proteins (4E-BPs) found in S. cerevisiae, Caf20 and Eap1. This entry represents Caf20 (also known as p20), which competes with elF4G for binding to elF4E and interferes with the formation of the elF4F complex, hence inhibiting translation. It is needed for the induction of pseudohyphal growth in response to nitrogen limitation.
Statistics
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PSSM-Id: 407224
Aligned: 24 rows
Threshold Bit Score: 125.63
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
A5DTJ3         3 KYTEEQLFAIKEEtS---YVPQPQILSAFNELIEQVKEhahqqqlqyqQQQQQQQgfsgigsgvsgpgaqkwrngdtyid 79  Lodderomyces el...
XP_004178710   5 RYSIEELLQLKPSeI---Q-PVDFDAVEFRAIIEKIKQ----------VQLLKDE------------------------- 45 
CCF55850       3 RYTIEELFQLKPSeP---VQQVDFDAVEFKAIIEKVKK----------IQALREE------------------------- 44 
CCK71344       8 SYTIDELFQLKPAaApaeL-AVNFDAVEFCALVAKVKE----------IQAAREE------------------------- 51 
Q6FKJ9         3 KYSIDELIQLKPSeT---L-KVSFDHVEFRNIIEKVVE----------LQKLKEE------------------------- 43  [Candida] glabr...
XP_003670147   3 KYTIDELLQLKPSeT---L-VANFDAVDFRAIIEKVKQ----------LQSLKEE------------------------- 43 
XP_003674513   3 KYTIDELLHLKPSeT---M-TPNFDAVEFRSIIEKVKQ----------LLALREE------------------------- 43 
A7TRH1         3 RYTVDELFHLKPTeS---L-PVQFDAEEFKAIIEKVKQ----------IQALKEE------------------------- 43  Vanderwaltozyma...
CCE63976       3 KYTAEELLHLKPEeT---L-PVDFDAEEFRAIIENIKQ----------IQALKEE------------------------- 43 
Q756C2         3 KYTEEELLQLKPTyD---V-AVNFDVDAFKAMIAEVAE------------------------------------------ 36  Eremothecium go...
A5DTJ3        80 EHGHERSYHHMNRRRPSRSNNgekKPFF---NKKkteVVVDEDGWETFTPVQHahrgsigEDGsEEKSKFRDsvsgssgs 156 Lodderomyces el...
XP_004178710  46 EFAHG---GHFNRRRSSHHYHnmmKPKIkhnKPK---FKTDENGWSTLDTSAK-------DESsAIEDDEQSskskkes- 111
CCF55850      45 EFLTS------NRRRSSHHHPt--RPKIkhnKPK---VTTDEDGWSTFEPKSAt-----tNDEsAIEDDdtnvk------ 102
CCK71344      52 EYMAH----NGGRRRSSHHFAh-tRPKVkhmKPK---VKTDEDGWSTFEPKMPs-----eTDLtEGNKQKSsdsl----- 113
Q6FKJ9        44 EFHSH----HGNRRRSSHHHm---KPKIkhnKPK---VKTDADGWSTLEPATAg-----hEEEsSSSATpaaaatt---- 104 [Candida] glabr...
XP_003670147  44 EFAHHGGHGHFNRRRSSHHHAg--RPKVkhnKPK---VTTDSEGWSTLDNKKDv------AEEsEVVDGATTtaagttsn 112
XP_003674513  44 EFHSAHPLGY--RRRSSHHHg---RPKVkhnKPK---VTTDEDGWSTLETKKSe-----dEEGaIAVDGEKPfiatats- 109
A7TRH1        44 EFNAHG--GHFNRRRSSHHHHg--RPKVkhtKPK---VTTDSDGWSTFEAANKk-----vNEDeESENVsva-------- 103 Vanderwaltozyma...
CCE63976      44 EYAAH---GFTNRRRSSHHYHt--RPKVkhnKPK---VTTDADGWSTLETAKGe-----eGEAgEESDEEDsapfv---- 106
Q756C2        37 HHEIADLFHQKARRRSSHHHGv--KPKIkahKPR---ITTDDDGWCTSTRKTSvv---avGDDgEPSPAfv--------- 99  Eremothecium go...
A5DTJ3       157 gagagagagaasgsaGGVRARPNNKNLGSSKQVDPRQIASTKQTRTFNAFEALE 210 Lodderomyces elongisporus NRRL YB-4239
XP_004178710 112 ---------spgsfhEVVKVKPNNKNISSSRPADTKDIVADKQTLNFNAFAALE 156
CCF55850     103 -----------sraqETVRVKPNNKNIASSRPADARDIIVDKQVHGFNAFAALE 145
CCK71344     114 -----------taaqENVRVRPNNKNMGSSRPADAKDIIADKQILGFNAFAALE 156
Q6FKJ9       105 ---------ktgapqETIRVKPNNKNISSSRPADNSDIIADKQTHGFNAFAALE 149 [Candida] glabrata CBS 138
XP_003670147 113 gntrsspvpsatiaqETLKVRPNNKNIGSSRPADTKDIVADKQIHGFNAFAALE 166
XP_003674513 110 ---------assiaqETMKVKPNNKNISSSRPADTKDIVADKQIHGFNTFAALE 154
A7TRH1       104 ------------vvpETLKVKPNNKNISSSRPADNKDIIADKQTHSFNAFAALE 145 Vanderwaltozyma polyspora DSM 70294
CCE63976     107 ----------atistETIRVKPNNKNISSSRPADNRDIILDKQTNTFNAFAALE 150
Q756C2       100 -------------aqETLRVKPNNKNIASSRPADTRDIVADKPTMSFNAFAALE 140 Eremothecium gossypii ATCC 10895
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