1A05


Conserved Protein Domain Family
LeuB

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COG0473: LeuB 
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]
Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Statistics
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PSSM-Id: 440241
Aligned: 836 rows
Threshold Bit Score: 328.125
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1A05_A         1 M----KKIAIFAGDGIGPEIVAAARQVLDAVDqaahLGLRCTEGLVGGAALDASDDPLPAASLQLAMAADAVILGAVGGP 76 
WP_015273087   1 M----KKVLVLPGDGIGQDVCTAALPVFDFLK----LPIELLFGDIGWQCWCQNGDPVPEETWKKIKQCDAVLLGAITSK 72 
WP_011148202   2 N----KKILILPGDGIGQEVCDAALPVFQALN----LPVTLEIGDIGWTCWEREGNPVPANTWEKIASVDAVLLGAITSK 73 
WP_116223764   4 T----YRICLLPGDGIGPEVVASAAEVLCALP----LAFEFSQAEIGFGAFQKLGTPLPQETLDAIRAIDAALFGAVTTP 75 
WP_052663725  11 K----RRIAVLPGDGIGSEILDKLIPALDGFG----LPIAFEEGAIGWQQWCEQGDPVPQRTWDLLEKSDSCLLGAVTSK 82 
WP_014431764   4 P----YRIALIPGDGVGKEVVPAARRVLEALP----LPFDFVELEAGWETFMHTGTALPQRTASVIRGCDGAIFGATQSP 75 
YP_236143      7 R----KRICVLPGDGIGIEVMEAALPVIAALN----LPFDLVPADIGWQCWRAEGETVPARTWEIMASCDATLLGAITSK 78 
ABX05940       1 M----TRLCLIAGDGIGREVVQAARQVLEALA----VPAEFVEAEAGWETFQRTGNALPEQTLAAVQAANSTLFGAVSSP 72 
WP_011955819   5 P----YTILVIPGDGIGREVIPAAVAVLRATG----LPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASP 76 
YP_096688      2 KstdpIKIAVLPGDGIGIEVTEATLPVFEVLD----VPVILNYGDIGWEFWKKEGAAIPSRTWQLIASSDTVLLGAITSK 77 
1A05_A        77 RwdayppA---------------KRPEQGLLRLRKGLDLYANLRPAQIFPQLldAS---PLrpelvRDVDILVVRELTGD 138
WP_015273087  73 G------KvaaeqelhpnlqgtgLRYVSPVIQLRQQLELFANIRPVWHLTGP--HK---P--------FHCVVIRENTEG 133
WP_011148202  74 G------KeeaqqalpphlrvktRNYVSPVIQLRQRLGLYANIRPVRYVEGD--RK---P--------FRCCVIRENSEG 134
WP_116223764  76 P------Ni--------------EGYFSPVVRMRQTLDLYTNLRPIKSIPHP--SS----R-----EGIDILIVRENSEG 124
WP_052663725  83 P------LreaeqelapelrdrgLKYVSPVIQLRQRLGLFANVRVSEDLVNQ--R-------------FRFAVIRENSEG 141
WP_014431764  76 S------Qk-------------vEGYNSPILALRKQLDLYANLRPVVSMPVP--GS----R-----PDIDMLIVRENTEC 125
YP_236143     79 P------LaeaeaelpltlqgqnRRYVSPVIQLRQNLDLYANVRPVTDMTGE--NR------------FRFVVIRENTEG 138
ABX05940      73 S------Qr-------------vAGYRSPIVGMRKAIDLYACVRPVQTPPLA--NA----R-----AGVNLVVVRENTEG 122
WP_011955819  77 G------Yp-------------vAGYRSPIVRLRRELDLYANIRPVFDDLPE--NGsnpRR-----RKVDLVVVRENTED 130
YP_096688     78 P------QreakqelsnalkksnPYYVSPVIQLRQGLDLFANVRPCFSIDDQ--SK---P--------FNFCIIRENSEG 138
1A05_A       139 IYFGQPRGLEV-------------------IDGK-RRGFNTMVYDEDEIRRIAHVAFRAAQGR---RK-------Q---- 184
WP_015273087 134 LYAGMDRKGIPpfmqewi-----qhpnierSGND-EAAISVRLQTRFGLKRLFHYAFNYAREHe--LQ-------R---- 194
WP_011148202 135 LYAGFDFKGIPatattwl-----qhpnidkYGPE-EAAWTVRLQTRFGLERLFITAFEYAKENn--YS-------R---- 195
WP_116223764 125 LYIGSERMEE----------------------NG-ERAVTERIITRRGSERILRKAFELARAGg--RQ-------K---- 168
WP_052663725 142 LYAGFDYHQPPeglwelvk----dhpnadvSGRE-RSSASIRLQTESAMDRLFRFSFEYARKHg--HH-------R---- 203
WP_014431764 126 LYVRQERLED----------------------GG-DTAVAQRVITRRASERIARKAFELAQARgvlRQ-------Krqdv 175
YP_236143    139 LYAGLDFGCIPdalvplleerealgaawqrEGQD-DATVTLRLQTRSGLMRIFEYAFEYARKNh--FT-------R---- 204
ABX05940     123 LYSGQETREG-----------------------D-ERATAQRIITRQASERIVQWAVQYAQRTg--RR-------K---- 165
WP_011955819 131 VYAGRERVED-----------------------DgATAIAERVITRRASARIMRVACDLARARrsaRNgsdappgR---- 183
YP_096688    139 LYCGFDYFPLPkaihslla----esqhwqtIPAD-EASCALRLQSKSGLTRLFDFAFKHAMQTg--MP-------R---- 200
1A05_A       185 -------LCSVDKANVLE-TTRLWREVVTEVARDYPDVRLSHMYVDNAAMQLIRAPAQFDVLLTGNMFGDILSDEASQLT 256
WP_015273087 195 -------VTFADKPNVLRdSGQFAADLFHEIAADYPNIHADIQNVDAVALWLVRRPEIFGVIIAENMFGDILSDLAAGVM 267
WP_011148202 196 -------VTFADKPNVMReSGHFAKGIFDTVAAGYPEIKADIHNVDAIALWMVKKPHEFGVIVSENMFGDILSDLAAGVM 268
WP_116223764 169 -------VHVVHKANVLRqTCGLFRAVALEVARDFPDIEMKEMLVDTCAMELVRAPQQFELIVTTNLFGDILSDEACMLV 241
WP_052663725 204 -------VTVADKPNVMRySGNHLRERFELIAAEYPEITADIHNVDAIALWMVRRPEQFGVIVAENMFGDILSDLGAGMM 276
WP_014431764 176 qkarqalVTVVHKANVLSlTDGLFRETCLAVAKEFPDVQAEEQIVDSMIYRMIREPERYDVIVAPNLYGDILSDAAAALV 255
YP_236143    205 -------VTFVDKPMVLRhSSAFARGIFEATAQRYPDVSGVIENVDAVALWMVQRPERFGVIVAENMFGDILSDLGAGVM 277
ABX05940     166 -------ITVVHKANVLReTCGLFRETALRVLSDAPDLQVEEMLVDNAAYQLARAPERFEVLVTTNLFGDILSDVASVWG 238
WP_011955819 184 -------VTVVHKANVLReTCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPERFDVIVTTNLFGDILSDVACAWG 256
YP_096688    201 -------VTLADKPNVLReSGEFTRKIFESTAQRYPKIQADILNVDAVALWLIKSPEKFGVIVAENMFGDILSDVGAGVM 273
1A05_A       257 GSIGMLPSASLGEGrAMYEPIHGSAPDIAGQDKANPLATILSVAMMLRHsL----------NAEPWAQRVEAAVQRVLDQ 326
WP_015273087 268 GGLGVAPSANIGSSmCYFEPVHGSAPTMAGKGRANPAAMFLSIALLLKH-L----------GFQEAAARIDTAVRQTIRI 336
WP_011148202 269 GGLGLAPSANIGSDiAYFEPVHGSAPGMAGKNKANPAAMFYTIALLLEH-L----------GFADAAQQINCAVDNVIRE 337
WP_116223764 242 GGLGVAASGNIGADaAVFEPVHGSAPTLASTGQANPLAAILAAAMLLEH-I----------GEAVQAQRVRAAAEACMAA 310
WP_052663725 277 GGLGLAGSGNYGSStSYFEPVHGSAPQMAGQDKANPLAMALTAAQMLSH-L----------GFADQSAELSRAVVSMVTD 345
WP_014431764 256 GGLGLAPSANVGDHfTLVEPVHGSAPDIAGKGLANPCAAILAAAQLLDS-L----------GESEMAQRVQRAVRNALAD 324
YP_236143    278 GGLGFAPSGNFGNSgAYFEPVHGSAPAHAGLNKANPGAMFMAIALMLEH-L----------GFPTESACISQAVSLVSRT 346
ABX05940     239 GGLGLAASANYGTRtAVFEPVHGSAPDIAGQGIANPLATLSASVLMLEF-V----------GLNSYAERLQTAIQAVLAN 307
WP_011955819 257 GGLGLAPSANLGERhALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDH-LagrapadlasAMRGWSARIQRAIRHVRAA 335
YP_096688    274 GGLGLAPSANIGDKgSYFEPVHGSGPRIR-KNCANPSAMFLTISMLLNH-F----------GYPDRAKKIVNAVMQVIKE 341
1A05_A       327 G-LrTADIAAPgtpvIGTKAMGAAVVNAL 354
WP_015273087 337 GhHlTYDLGGN----ATTEGMAQAILQAI 361
WP_011148202 338 GrTvTYDLGGS----ATTQQMAQAIISTL 362
WP_116223764 311 Ge-vTADMGGT----LSTEEATQAVIHNL 334
WP_052663725 346 RkVlTYDLGGN----ATMSTVVGELRKRL 370
WP_014431764 325 Gi-wTADLGGT----ATTEALTDAIVARV 348
YP_236143    347 S-TrTYDLGGS----HTTAQVGEAIVQQC 370
ABX05940     308 Gp-yTPDLAGA----ATTAEVVQAVIDQF 331
WP_011955819 336 Gp-hTPDLGGS----AVTTDITNAVLSHM 359
YP_096688    342 KrFiTYDLGGH----ATTTDMANAVIEHC 366
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