Conserved Protein Domain Family
Mso1_Sec1_bdg
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pfam14475: Mso1_Sec1_bdg 
Sec1-binding region of Mso1
Mso1p is a component of the secretory vesicle docking complex whose function is closely associated with that of Sec1p. It is a small hydrophilic protein that is enriched in the microsomal membrane fraction, and this binding domain is towards the N-terminus of Mso1. The yeast Sec1p protein functions in the docking of secretory transport vesicles to the plasma membrane. Mso1p and Sec1p interact at sites of exocytosis and the Mso1p-Sec1p interaction site depends on a functional Rab GTPase Sec4p and its GEF Sec2p. The C-terminal region of Mso1 (not built) assists in targetting Sec1 to the sites of polarised membrane transport.
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Statistics
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PSSM-Id: 433978
Aligned: 40 rows
Threshold Bit Score: 47.2172
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004196879  48 KFSNLSLSspmqhisnfSEHDG-NSDDDTLLHNAFVKYFDQKGEPYPDWL 96 
EEQ30303      20 SLRRVISS---------DETDDpENEDLSHISNVLRAYYNEKGRRLPPWL 60 
XP_003008428  18 SLQSRLLQ---------TENDG-DTEDDTHVCRVLRAYYTQEQRPFPGWL 57 
XP_007293586  18 SIRQNLLP---------TENDG-DTEDDTHVCRVLRAYYTEKGRAFPTWL 57 
XP_003848947  18 SLRRTLLS---------TEDDG-DTPDDTHICRVLRAYYTEKNRAFPDWL 57 
XP_006964488  18 NLRSTLLS---------SEADG-DTEDDTHVCRVLRNYYTEKGRPFPGWL 57 
KLU89944      18 NLRTTLLG---------GDADG-DTEDDTNVCRVLRAYYTEKGRPFPGWL 57 
XP_006672356  18 SLRSTLLA---------GDADG-DTDDDTHVCRVLRNYYADKGRPMPPWL 57 
ELR08757      18 SLRNLLPA---------GEADG-DTPDDTHICRVLRAYYIEKGGAFPPWL 57 
CAZ82452      13 SRYQTLRGi--------DEQDG-DSEDDSHISRVLRNYYQEQGQQLPDWL 53
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