2Z5B


Conserved Protein Domain Family
POC3_POC4

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pfam10448: POC3_POC4 
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20S proteasome chaperone assembly proteins 3 and 4
This family contains chaperones of the 20S proteasome which function in early 20S proteasome assembly. The structures of two of the proteins in this family (POC3 and POC4) have been solved, and they closely resemble those of the mammalian proteasome assembling chaperone PAC3, although there is little sequence similarity between them.
Statistics
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PSSM-Id: 402192
Aligned: 17 rows
Threshold Bit Score: 40.8817
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2Z5B_A         4 MLVKTISRTIESESGfl----------------qpTLDVIATLP---ADDRSKKIPISLVVGFKQEASLNSSSS------ 58  baker's yeast
EDO17157       1 MSVQTFSKTLEPSGSis----------------gkLLDVSVTIP---VDLSNNKIPITVTIGSKEGGINAGENDtgndin 61 
Q6FJZ1         1 MSQIVVD----------------------------GLSVRVDCD----VEDGVKSPISLNLCLSGDEELKSSR------- 41  [Candida] glabrata
XP_001383602   1 MIHRSR----EVNVD--------------------GVDCVVVASy--SQSDSSRTPVTVYVNELNNAAMGD--------- 45 
EDK36897       1 MQVARIKSPKQNLNSfalektvmntttaisklalfSGDYDVAITgcaARTSQHYPPIAVFITDVAAPRFGS--------- 71 
Q6BTU4         1 MIVTK-----QENIN--------------------GDDYQIVIS----IDKHDKSSINVYVNEMTNTSVGS--------- 42  Debaryomyces ha...
Q75BZ6         1 MTQTKTADYTVSTLG--------------------GDDVRLLVTmpvELTASKKVPVSIVVSGRCDGVNEE--------- 51  Eremothecium go...
XP_001387161   1 MT--EIQKDSTGLSSafsa------------yykdDRSTEIFFH---KIEYADRMVLNIQFNGVMDTTFEIPISsr---- 59 
EDK45431       1 MSNQLICVDPSGLSKsftvnlgstankekeekkegEEEVSFHFH---LLEFANKVIINISIDGILDSSFRAPVPtr---- 73 
XP_716296      1 MTTKLI-QDPTGFSKsfettyp-------ndtsssSSTNEFFFH---IINYSDKQILNISINGLMDTTFELPVStk---- 65 
2Z5B_A        59 ---LSCYYYAIplmr------drhiNLKSGGSNVVGIPLLDTKDDRIR-DM-ARHMATIISERFNRPC-YVTWSSLPSEd 126 baker's yeast
EDO17157      62 nlkLLCYYYSI--------------SRRSDKNDVVSTVLLDTSIDSVR-DT-TRQLSTLLCKKYRHPC-YVAWSSDASN- 123
Q6FJZ1        42 ---LECYYYTI----------------MGRKDDVLGIPLRDTSSDWIR-DL-ARLCATMITKKYNKPC-YVTISTVGEN- 98  [Candida] glabrata
XP_001383602  46 ------YVYAI--------------------GQSQTFLHHGTSSESGSgSGsIESLNLLLNKKLQRPV-YLNVSGA---- 94 
EDK36897      72 ------YVYTI---------------GDRKSGETFATVIHESDADT---EEmCRNMGRVLAKKFEVPV-YTNINGR---- 122
Q6BTU4        43 ------YVYSI---------------NDKKSGQIYSSVLQDHSSNIVT-EQ-ARNLGYLVVKKYCRPS-YTNINGQ---- 94  Debaryomyces ha...
Q75BZ6        52 ---LAATVYGV----------------PYKGSDVVTSVLLDTADNRIR-DF-GSTFCRVLVKKVGLPC-YVSVSSSVGR- 108 Eremothecium go...
XP_001387161  60 --aTINYSAAL--------------SNSDSDLGVEPVLLVGNHANMKI-SIvAAQIGKLILASANPKSaILSIGSKWFGk 122
EDK45431      74 --kVMNYESRIdldddneeeekndgSMGFVDTSGELELIVGNYSNMKI-SIvAAQVAKLV-QTKKPKEtIVTIGSRWFGn 149
XP_716296     66 --sAITYASALeipidqfddeheqeEIREREVIPEPILLIGDHSNMKL-SIvATQISKLI-SNNCPKPtILSIGSKWFGk 141
2Z5B_A       127 PSMLVANHLYILKKCLDLLK 146 baker's yeast
EDO17157     124 -TNDMFDQISIIKTCVQYIH 142
Q6FJZ1        99 --NFQASTIPLLAAVKEHVA 116 [Candida] glabrata
XP_001383602  95 ---AQVSTVSMFRAIVEVID 111
EDK36897     123 --LDPGSYQELLNHVIDRAS 140
Q6BTU4        95 ----ISDYPQVLKVVFNLLD 110 Debaryomyces hansenii
Q75BZ6       109 -MLDSGDQLAVIRKALEHLT 127 Eremothecium gossypii
XP_001387161 123 GDETEDSDFEKLMFILENTK 142
EDK45431     150 GEEVEDSDFERLMFVLENVK 169
XP_716296    142 GDEVDDNDFEKLMFILANVK 161
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