Conserved Protein Domain Family
LETM1_RBD

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pfam07766: LETM1_RBD 
LETM1-like, RBD
Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.
Statistics
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PSSM-Id: 462258
Aligned: 123 rows
Threshold Bit Score: 176.522
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCH63189      75 MKRRELIQLRKTADDLFRLLPFSAF-IIIPFAELLLPFCLKLFPN-LLPSTYETGDNKMLKL----IRLAENKSIISSLL 148
EFX69034     111 LGLKEIDIFYRMPREMLKVSPVLLI-SALPFANYIIFPLAYVLPKqLLSTHFWSLQQRRDFAlqdhKKSVQHFRPTFRCM 189
EFN87522     109 LTRKELQLMHMMPRDLRKLTPLFLL-SAIPFTNYIIFPLVLYFPRyLLTSHFWTLQQKLEFMlhdhKRRLRHNRPLFRCM 187
OXU25443     113 LNREELQLTFTFPKDLIKISPVLLI-SAVPFTNYIIFPLAFYFPHvLLTSHYWSIEDKLNFMlkehKKRLQHNKPLLRCV 191
EFA01050     116 LTRREIELYHQMPKDMRKVAPVLLI-SALPFANYVIFPLAYLFPRiFLSRHFWNLQQRAEFSiyylRGRLVNNRPLFRCV 194
Q7Q6P8       138 LTRKEIELYYQMPRDMRKVAPVLLI-SALPFANYVIFPLAYMYPRtLLTSHFWSAQQKLDFVqidlRNRLLYNRRVFRCM 216 Anopheles gambi...
XP_002084149 190 LNRQELELYMQMPRDMMKVAPALIG-CSLPMVGYAFFPLVFYYPRsFLTAHFWTPQQRSEFQsyymKRRLCNNKDVFRCL 268
XP_002431928  61 LTRKELEVYYELPKDILRTAPVIFIgAVVPFGG-IIFILGYYFPKhLLTHHFWSQQQQNEFSslkhKKTISSYTPVYNCL 139
EEC13321     109 LSRKELELYFQIPRDIIKVAPVLFV-IALPATNFFMFPLIYLFPKqLLTWHFWSLEQRVDFSvatqRKKVSNYLPVLRYM 187
XP_015784586  95 LSYQELLVYYQTPKDLLKVAPTLLV-SAAPFANYVVFPLALYFPKqLLSQHFWSKEIRFNYQlektKKRLKHNRPIFRYL 173
CCH63189     149 R---NTLndSKLniplynnhSKQiATNKEIFNKFFYRLKilKRnGYsLAItklsfhfteHEVLQVAKLFKDD-TLLISLT 224
EFX69034     190 QariPSV-------------NDTd--LTKKLSQILSKLA--SG-VH-PTV---------EEILEVKMLFQREpFHLNCLY 241
EFN87522     188 QaelKTI-------------GDQt--LRIKWRDVIACLG--SG-TH-PTT---------NDIIACSVLFSGPpYSLDVLK 239
OXU25443     192 QsqvKTI-------------QDTe--SRATFKNIIACLG--SG-TH-PTI---------DDILYCKKLFSGPpYSLKCMK 243
EFA01050     195 QgelDKI-------------RGHr--LYYKWAEVLGMMG--SG-VQ-PKV---------EQILQCKDLFTCEpYHLFYLK 246
Q7Q6P8       217 QsklDAL-------------KKThDPAYEKFAYMLGLLG--SG-LH-PTS---------EEILDVKEVFQRPpFHLNSLS 270 Anopheles gambi...
XP_002084149 269 QaklKAT-------------ASHp--KHSAFAEILGQLG--SG-TH-PTP---------EMLIDVKDIFADGpYSLLGMS 320
XP_002431928 140 EsrlSVI-------------KDTd--LCLKMCNLLENIK--SN-VH-PNA---------KSILSVKSLFKGVpFGLNHME 191
EEC13321     188 QanvPKG-------------EEGq-----KLLRIFHKLG--SG-TH-PTV---------EDILDAKQYFIAKpLALSKLS 236
XP_015784586 174 QfklSSIpkQLS--------NSPdIDFKEQCKLIYDKLG--SG-TH-PTV---------EELLKVSPVFDQQpYGLLHLS 232
CCH63189     225 KRQLSLLNQymslsLPSLGT-MNLLKYRLRHTLNKIKKDDILIARE-GVTHLTDEELYEACMSRGIQIQhetdllthkSV 302
EFX69034     242 PRHKNQLLK-----VHGMHT-LWSRRRRLSQRAEEIINKDKVLERE-GVTSLSLEELRSACYTRGLNPS---------NM 305
EFN87522     240 RKHMKELLA-----IYGMSSwRLFKRKRLMERGMLILRMDRAIVREgGVKAMSNDAMRWALSFRGVNPT---------NM 305
OXU25443     244 RKHVKELLK-----VHGMSRfSLGNRTRLLERGLLIKRMDTAIQREgGVTKLPYDAIRWALSFRGVNPV---------NM 309
EFA01050     247 GKHVKHLLK-----IHDLHM-GWFRRSRLIERAVILQEMDKAIVREgGVHNMPQDALKHACYIRGLNPM---------NM 311
Q7Q6P8       271 SSHLKYLCR-----LHDIHA-GLLRRFRLSERAYVVHHMDMAIKREgGVHNMPIESLKHACYLRGLNAN---------NL 335 Anopheles gambi...
XP_002084149 321 RKHVRNLVN-----LHGLPS-SIFKRHRLHEHAFLVHYMDQAITREgGVHNLTPDALRYSCYLRGLNPD---------SL 385
XP_002431928 192 SYHISKLLN-----LYNMHK-GWRRRERLYMRANLVKLMDLAIIKEgGPEILNLHDMRWHCFFRGLNPI---------NM 256
EEC13321     237 RKHLSSLCR-----IHGKSTfFLGRRSRLWRHGGFVHEMDLAMARE-GIDQMDVAELRWACFLRGLNPM---------GL 301
XP_015784586 233 KSHLSHLCK-----MHGITS-LPRKVPRLVNYCGLVHELDLAILRLgGSAKLSDNDLKLAANMRGLNPF---------GC 297
CCH63189     303 MRKEMIKALENWLLLRLKHHIPMVLLILATTAP 335
EFX69034     306 RTEDMVKYLEQWIAVSVHVDPATYSLVLHCPIL 338
EFN87522     306 STESMRSWLEQWLTVSASVDQKNISLLLHSPIL 338
OXU25443     310 STESMQAWLDQWLLISSQVDEGSISLLLHCPIL 342
EFA01050     312 RNEDMINWLNNWIKISSVVDRESWSLLLHCPIL 344
Q7Q6P8       336 SAESMIEWLQEWVKVSLVVDEDCISMLLHLPIF 368 Anopheles gambiae str. PEST
XP_002084149 386 SSEAMIEWLRKWVKVSTSIQGEHITLFLHLPIL 418
XP_002431928 257 NNDELLFWLRMWLEISREIDKNSYSLLLHCPVL 289
EEC13321     302 SKKDLIAWLQDWIKISSSIDSQSMSLLLHCPIL 334
XP_015784586 298 SREELTNWLDNWLYISKALNGTCPSLLLHCPIF 330
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