1OYB,1GWJ,1ICP,1VJI,1VYP,2G5W,2GOU


Conserved Protein Domain Family
OYE_like_FMN

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cd02933: OYE_like_FMN 
Click on image for an interactive view with Cn3D
Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Members of OYE family include 12-oxophytodienoate reductase, pentaerythritol tetranitrate reductase, morphinone reductase, and related enzymes.
Statistics
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PSSM-Id: 239243
Aligned: 164 rows
Threshold Bit Score: 390.295
Created: 30-Aug-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1OYB; Saccharomyces pastorianus OYE binds FMN and P-Hydroxybenzaldehyde
  • Citation:PMID 7881908
  • Structure:1ICP; Solanum lycopersicum OPR binds FMN, a sulfate ion, and nonaethylene glycol

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                           # #                                  #                      
1OYB         16 NLFKPIKIGnNELLHRAVIPPLTRmralhpgnipNRDWAVEYYTQRAQrpgTMIITEGAFISpQAGGYdnaPGVWSEEQM 95  lager yeast
1VJI_A       11 PLLTPYKMGrFNLSHRVVLAPLTRqrsy---gnvPQPHAAIYYSQRTTp-gGFLITEATGVSdTAQGYqdtPGIWTKEHV 86  thale cress
2G5W_B       11 TLFSSYKMGrFDLSHRVVLAPMTRcral---ngvPNAALAEYYAQRTTp-gGFLISEGTMVSpGSAGFphvPGIYSDEQV 86  thale cress
NP_774246     5 ALFKPLQVGpYELAHRVAMAPLTRmraer-dsfsPRPLNAEYYGQRATp-gGLLIAEASPVLsHGRGNpatPGIYSEAQI 82  Bradyrhizobium j...
Q9FEX0       10 PLCTPYKLGrFKLTHRIVFPALTRnrsq---nntPQSHLTEYYSQRATn-gGLIISEAAAASdISKECpnlPGIWNEEQV 85  tomato
AAY26527     20 SLFSPYQMPrFRLAHRVVLAPMTRcrap---davPGPALAEYYAQRSTd-gGLLISEGTIISpSGPGFprvPGIYNQEQT 95  maize
ABB11356      4 ALFSPLRLGpFALAHRVVMAPLTRmraae-pgntPHALNVEYYRQRATy-gGLIITEGSQISpTGQGMpatPGIHSPEQV 81  Burkholderia sp....
YP_554039     8 KLLSPARVGpLSLAHRVVLAPMTRlrsd--addsPSAMMVEYYRQRASq-gGLLITESAHPSyDSRGYigaPGIYTNAHV 84  Burkholderia xen...
ZP_01506607   3 HLFTTKKVGaYTLAHRVVLAPMTRlrtiq-pgdiPSPMMADFYGQRASq-gGLEIVEGVSISiPARSYlgaASFYHDGQM 80  Burkholderia phy...
ZP_01508396  62 KLFTSVKVGpYEFAHRVVLAPLTRmrae--dgarPGRLMAEYYAQRTSa-gALLIGEATIAAvEGNGYlgaPGLYDDSQI 138 Burkholderia phy...
Feature 1                          # #      #                                                   
1OYB         96 VEWTKIFNAIHEKKSFVWVQLWVLGWAAFpdnlardglRYDSASDnvfmdaeqe----akakkannpQHSLtkDEIKQYI 171 lager yeast
1VJI_A       87 EAWKPIVDAVHAKGGIFFCQIWHVGRVSNsgfq-pngkAPISCSDkplmpqirsn---gidealftpPRRLgiEEIPGIV 162 thale cress
2G5W_B       87 EAWKQVVEAVHAKGGFIFCQLWHVGRASHavyq-pnggSPISSTNkpisenrwrvllpdgshvkypkPRALeaSEIPRVV 165 thale cress
NP_774246    83 AGWRKVTDAVHAKGGIIFLQLWHVGRVSHssfh--ggeLPVSASAiaikaegmkamtaegkiadyetPRALetDEVKGIV 160 Bradyrhizobium j...
Q9FEX0       86 EAWKPVVNGVHEKGGVFFCQIWHSGRLSVptvsalffsIGIGWSTrpddkv-----------yakptPLPLesDKIPCIV 154 tomato
AAY26527     96 DAWRKVVDAVHAKGAIFFCQLWHVGRASHqvyq-pgaaAPISSTDkpissrwrilm-pdgsygkyptPRRLatSEIPEIV 173 maize
ABB11356     82 EGWKAVTQAVHAKGGLVFMQLWHVGRISHssll--ngeQPVAPSAiaapgnafts---tfervpfeiPRALgtKEIASLV 156 Burkholderia sp....
YP_554039    85 EAWRKITDAVHARGARIFMQIAHDGRQSHvdls--wgnAPVAPSVvpyettvft----qngwvpnspHRALelDEIPALI 158 Burkholderia xen...
ZP_01506607  81 EGWKAIANAVHAKGGRVFMQLIHGGRQSHvemt--ggvAPLAPSVvpfegvalt----kdgfvpaspHRALgiEEIPGIV 154 Burkholderia phy...
ZP_01508396 139 AGWREVTDAVHAKGGKIFLQLYHAGRQSNaelq-pegrRPVGPSEvlhggvayt----kagwipntpNRALeiDEIAAIV 213 Burkholderia phy...
Feature 1                           #  # #                                               #      
1OYB        172 KEYVQAAKNSIAAGADGVEIHSANGYLLNQFLDPHs-NTRTDEYGGSIENRaRFTLEVVDALVEAIGheKVGLRLSPYGV 250 lager yeast
1VJI_A      163 NDFRLAARNAMEAGFDGVEIHGANGYLIDQFMKDTv-NDRTDEYGGSLQNRcKFPLEIVDAVAKEIGpdRVGIRLSPFAD 241 thale cress
2G5W_B      166 EDYCLSALNAIRAGFDGIEIHGAHGYLIDQFLKDGi-NDRTDQYGGSIANRcRFLKQVVEGVVSAIGasKVGVRVSPAID 244 thale cress
NP_774246   161 EAFRQGAKNALAAGFDGVEIHGANGYLLEQFLQSRs-NQRTDQYGGGIENRaRLLLDVTQAAIDVWGanRVAVRLSPHGI 239 Bradyrhizobium j...
Q9FEX0      155 NDFRIAARNAIKAGFDGIEINASSGGYLIDEFMNDqvHGWTDEYDESIKDRcRLALEIVEAVANEIGadKIGIKLSPFDG 234 tomato
AAY26527    174 EQYRQAAVNAIKAGFDGIEIHGAHGYLIDQFLKGGi-NDRTDEYGGSLSNRcRFLLEVTRAVVSAIGadRVAVRVSPAID 252 maize
ABB11356    157 DDYAQAARNALEAGFDGVEIHGANGYLLEQFLQSRs-NHRTDEYGGSIENRcRIVLEVAEAVSAVYGpdRVGIRLSPFGV 235 Burkholderia sp....
YP_554039   159 RSFRDAAARAKDSGFDGVELHNANGYLADTFLQDGt-NKRTDAYGGSVEKRaRFSLEAVEAFASVWGadRVGVRVSPSGR 237 Burkholderia xen...
ZP_01506607 155 EEFRVAAQRALDAGFDGVELHGANGYLVDQFIQDGt-NHRTDAYGGPIENRvRFLRETVEALISVWGadRVGVRISPSGE 233 Burkholderia phy...
ZP_01508396 214 ESFRTAAERGVKAGFDGVELHAANGYLFDQFLQDGs-NKRTDIYGGSFENRaRLLMEATRAVISVWGsnKVAVRLGPSGS 292 Burkholderia phy...
Feature 1       #                                                                              #
1OYB        251 FnsmsggaetgivaQYAYVAGELEKraka-gkrLAFVHLVEprvtnpflte----gegeyeggsNDFVYSiwkGPVIRAG 325 lager yeast
1VJI_A      242 Ymesgd---tnpgaLGLYMAESLNKy------gILYCHVIEarmktmge--------vhacphtLMPMRKafkGTFISAG 304 thale cress
2G5W_B      245 Hldatd---sdplsLGLAVVGMLNKlqgvngskLAYLHVTQpryhaygqtesgrqgsdeeeaklMKSLRMaynGTFMSSG 321 thale cress
NP_774246   240 Andsge---pdpmpLYTHVVKALDKl------gLAYLHFIEprssgagrad----vhwenvpsaMVLFRPlysGVLMTAG 306 Bradyrhizobium j...
Q9FEX0      235 Kkdsn------seaLATYMANELSKl------gVLYLHVMEpret---------------vnrsLLPIRKafkGTLIASG 287 tomato
AAY26527    253 Hldayd---snplqLGLAVVERLNAlqqe-agrLAYLHVTQprytaygqtesgqhgsaeeesrlMRAVRGayrGTFMCSG 328 maize
ABB11356    236 Angsge---daplpLYSHLIERLARl------dLAYLHLIEprasgagqad----vdhqnvpfaSELFRPhwpNVLIAAG 302 Burkholderia sp....
YP_554039   238 Wgaisd---nhpeaTFGYFAQRLNEy------gLAYLHVIEprvmgtetl------tegeapvaSAFLRKvftGPIIAAG 302 Burkholderia xen...
ZP_01506607 234 Wggisd---sdpeaTFSHVARVLDGy------gIAYLHVIEprvkgddtl------heghapvaVKYLRPhfsGPIIAAG 298 Burkholderia phy...
ZP_01508396 293 Wgdmsd---sdpvgLFSYVADELAKl------dLAYLHLIEpriagnved-----esrnpdpvaAQTIRKhyaGTIIAAG 358 Burkholderia phy...
Feature 1                            # ##                       
1OYB        326 NFalhPEVVREEVkd-kRTLIGYGRFFISNPDLVDRLEKGlPLNKYDR 372 lager yeast
1VJI_A      305 GFt--REDGNEAVskgrTDLVAYGRWFLANPDLPKRFQVDaPLNKYDR 350 thale cress
2G5W_B      322 GFn--KELGMQAVqqgdADLVSYGRLFIANPDLVSRFKIDgELNKYNR 367 thale cress
NP_774246   307 GFt--GETANAAIadghADIIAFGRIFISNPDLPRRLRHDyPITPYNR 352 Bradyrhizobium japonicum USDA 110
Q9FEX0      288 GYg--KSDGEKAIdenyADLISFGRMFLANPDLPKRFEVNaPLNKYNR 333 tomato
AAY26527    329 GYt--RELGVEAIesgdADLVSYGRLFIANPDLVERFRRDaPLNKYVR 374 maize
ABB11356    303 NYt--PATAGAVIgagrADAVAFGRLFIANPDLPERVRLGaSLNAYNR 348 Burkholderia sp. 383
YP_554039   303 GFd--RDGAEQILqrgdADLVAFGRWFSSNPDLPERFRLGhALAPYNR 348 Burkholderia xenovorans LB400
ZP_01506607 299 GFd--GDSAEAIVasgdADLVAFGRHFSSNPDLPYRLQHKlPLTPYVR 344 Burkholderia phytofirmans PsJN
ZP_01508396 359 GFk--GDSAEAILvdgdADLVAFGRDFIANPDLPERLRRNlPLNAYDR 404 Burkholderia phytofirmans PsJN

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