Conserved Protein Domain Family
Caveolin
?
pfam01146: Caveolin 
Caveolin
All three known Caveolin forms have the FEDVIAEP caveolin 'signature motif' within their hydrophilic N-terminal domain. Caveolin 2 (Cav-2) is co-localized and co-expressed with Cav-1/VIP21, forms heterodimers with it and needs Cav-1 for proper membrane localization. Cav-3 has greater protein sequence similarity to Cav-1 than to Cav-2. Cellular processes caveolins are involved in include vesicular transport, cholesterol homeostasis, signal transduction, and tumour suppression.
Links
?
Statistics
?
PSSM-Id: 460081
Aligned: 33 rows
Threshold Bit Score: 173.155
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_007234243  16 EDLFSRSIEPIltkkeklytpepdrDRDPRDINAHL-KVEFEDIIAEPSSTHSFDSVWIWSHAVFELLKYIFYRLLTTLL 94 
NP_001096498  19 KDLLTKEIDLV--------------DRDPKRINDSViKVDFEDVIAEPQGTHSFDGVWKASYTTFTVTKFWCYRILSAAI 84 
OCA24586      17 TEALTKEIDLV--------------QRDPKKINQEVvQVDFEDVIAEPDGTHSFDGVWKASSTTFTVTKYWCYRVFSAIF 82 
XP_003498141  15 KDIHCKEIDLV--------------NRDPKNINEDIvKVDFEDVIAEPEGTYSFDGVWKVSYTTFTVSKYWCYRLLSTLL 80 
EFX82628     107 VQTFTVGLNVL--------------DRDEKHINDTI-NLNFEDVLAEPDVAHGFDPIWRAAFILFTGSRFWIYRLLSAIL 171
KRX73430      93 QSQMTIGINML--------------DRDEKQLNEHI-KLNFEDILAEPDGYHSWDWVWRGTYHTFNTLRRFIYRFLALLF 157
PDM72941      84 KQEMTIGIDMQ--------------MRDEKQINNHV-NIQFDDVFAEPETFHSVDCIWRINHRIFESTRTFFYKVFG-IL 147
EGT60057      92 DRDQRMGINFV--------------DRDRNNLATNL-DFSFENVFGENKAQHSWEWSYRINHYVYSAFKEIFYKLFQ-WC 155
Q94051        93 EENIAIGVDLV--------------NRDANSMNNHV-QLNFEDIFGEADSQHSWDCVWRLNHTVFTAVRLFIYRLVS-LL 156 Caenorhabditis ...
CAP33397      97 EDHIAIGMDFV--------------NRDHNGLNNHV-QHNFDDIFGEADSQHTWEFMWRLNASVFNWVRLFVYRFFT-IL 160

XP_007234243  95 AIPMAFVAGIVFGLLSCVHIWVVMPLVHSCMMALPSVQVVWASLMDMFTGPFFHSFGKSLSSINIKTV 162
NP_001096498  85 GIPLSIVWGFIFALISFCHIWAVVPCIKSYQIETHCLGRIFSLCTHTFCDPLFEALGKIFSSIKVTLQ 152
OCA24586      83 GLPLALLWGFLFACLSFCHIWAVVPCVKSYLMEVQCLGQFYALCVRTFCDPIFEAIGKVLSGIKVSLR 150
XP_003498141  81 GVPLALIWGFLFACISFCHIWAVVPCIKSYLIEIQCISHIYSLCIRTFCNPLFAALGQVCSNIKVVLR 148
EFX82628     172 ALPLALVWGITFSLITFFSVWLATPLLRIMDVFLFYIRRVWVALVQTTLEPVANAVGGCFSNVKLTHN 239
KRX73430     158 AVPCAIVWAMLFALLTSINVWILTPLAIAISIPAVWLAKTWNFIIRSLLDPFFKSCGLMRAAHSESPT 225
PDM72941     148 SIPIVFIFAILFAFASAVNNFLVMPLAALFTIPLTWIAKTWTFLVSNIFDPVANSIGLCFSKINVRKY 215
EGT60057     156 VLPFTVFFAIFVALFVTLYSWILLPLGKLLIIPGTVVAAVWSWLIHAIFDPIFSSLGLLFSNFNIRKY 223
Q94051       157 ALPFTIIFAIFFGLLASINVFIIVPLGKLLSIPGTLLAKLWNWLIHAIFDPIASAVGLIFSNFNIRKY 224 Caenorhabditis elegans
CAP33397     161 ALPFTLLFAIFFGFFAAVNVFVIVPFGKLISIPGNLLAKLWNWLVHAVFDPVASAVGLIFSNFNIRKY 228
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap