Conserved Protein Domain Family
RNA_3prim_cycl

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TIGR03399: RNA_3prim_cycl 
RNA 3'-phosphate cyclase
Members of this protein family are RNA 3'-phosphate cyclase (6.5.1.4), an enzyme whose function is conserved from E. coli to human. The modification this enzyme performs enables certain RNA ligations to occur, although the full biological roll for this enzyme is not fully described. This model separates this enzyme from a related protein, present only in eukaryotes, localized to the nucleolus, and involved in ribosomal modification. [Transcription, RNA processing]
Statistics
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PSSM-Id: 274563
Aligned: 15 rows
Threshold Bit Score: 433.239
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q609M1   4 LRIDGSYGEGGGQIIRTALSLAALTGTAVRLENIRARRRKPGLAAQHLTAVKAVALLCDARIGGAELGSQTLEFIPGRPv 83  Methylococcus capsula...
Q1IS76  11 IVIDGSQGEGGGQILRTALSLSMVTGQPFTIEKIRANRERGGLLRQHLTAVLAAAEISGANVTGAELGSRTLTFAPQRV- 89  Candidatus Koribacter...
Q8ZST4   3 VRIDGSYGEGGGQILRTSIALSALLGRPVEIVNIRAKRANPGLQPQHLTGVKVAALLTDAEVKGAEKGSTRLYFEPKTL- 81  Pyrobaculum aerophilu...
O77264   7 LEIDGSYLEGGGQALRNALSLSCILGKPVRVVKIRASRPSPGLSHQHLHGLNLLRDITNADVVGNYLLSSTVEFTPRTI- 85  fruit fly
O00442   6 VEVDGSIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIRDLCDGQLEGAEIGSTEITFTPEKI- 84  human
Q8TZC9   4 IEIDGSYGEGGGQILRTAVGMSALTGEPVRIYNIRANRPRPGLSHQHLHAVKAVAEICDAECEGLEIGSTEIVFEPGKV- 82  Methanopyrus kandleri...
Q8U0N7   2 IIIDGSYGEGGGQILRTSIALSAITGEPVKIINIRANRPNPGLRPQHLNAILALKKLANAKVEGAEVGSREVTFIPGEL- 80  Pyrococcus furiosus D...
O28837   2 IEIDGSFGEGGGQILRTAVALSCVTGKAVRIRNIRANRPKPGLAAQHLKGIEAAKIISNAEVEGLRIGSTEIVFNPGSV- 80  Archaeoglobus fulgidu...
Q60335   4 IVIDGSYLEGGGQIIRTAVSLSALTQKPVKIINIRKKRKNKGLAPQHVSAVKAVKKLCNAEVFGLNVGSEELTFIPSKL- 82  Methanocaldococcus ja...
Q974U1   2 IEIDGSFGEGGGQILRTSLTLSALTKKPFRIYKIRANRPKPGLQRQHLTAVEAVKKLTNAKVKGDFVGSTELVFEPEDIv 81  Sulfolobus tokodaii s...
Q609M1  84 RAGDYTLDVgearegGSAGAVMLVLQTVLPPLALAEGASTVSLRGGTHVPMSPPFDYVREVWLPTLARMGVRAELSLVRS 163 Methylococcus capsula...
Q1IS76  90 TPGDYSFAV------GTAGSATLVLQTLLPALMLANKPSNVVVEGGTHNMAAPPFDFLAKTFAPIIESMGPKLKLTLDRY 163 Candidatus Koribacter...
Q8ZST4  82 KCGNFSIDI------GTAGSISLIVQTLAPILLYAPCPTQITVTGGTDVAWAPPIDYMRFVFTKVLERFGAKLSIELIRR 155 Pyrobaculum aerophilu...
O77264  86 LDNTYRVET------HTAASITLIYQMALPVLLFAGRPSRLIVSGGTNVDFAPPVEYMQEVLLPNLKHFGVSFDLKVQRY 159 fruit fly
O00442  85 KGGIHTADT------KTAGSVCLLMQVSMPCVLFAASPSELHLKGGTNAEMAPQIDYTVMVFKPIVEKFGFIFNCDIKTR 158 human
Q8TZC9  83 KGGEYEVDI------GTAGSVTLLLQAVKLAAIAADGPVEMEVRGGTDVKWSPPVDYEINVNAHYLDRLGYRYELEVLRR 156 Methanopyrus kandleri...
Q8U0N7  81 KGGEIRVDI------GTAGSITLVLQALLPAMVFAKDTVEFKITGGTDVSWSPPVDYLINVTMFALRKIGIEGEIKLLRR 154 Pyrococcus furiosus D...
O28837  81 RGGNFRVDI------GTAGSVTLIFQTVLLPLLFADRDSTLTVTGGTDVAWAPPVDYFKNVTLRALREMGAECELEVLKR 154 Archaeoglobus fulgidu...
Q60335  83 SPKDFTIDI------GTAGSISLVIQTLLPLSLGINKKFTVKIKGGTDVKRAPPIDYVKNVTLKILRNFGVLTELKVLKR 156 Methanocaldococcus ja...
Q974U1  82 EKGDFEFDV------GTAGSVTLILQTILPLLI--NRNIKVTIKGGTDVPKSPSIDYIRLTFLSLLEKIGIRVNLILIRR 153 Sulfolobus tokodaii s...
Q609M1 164 GWYPVGKGEVRLVVAGGRRsLEALKARHRGTLQAVTGRALAAN-LPAHIPERMAARARAVLad-agIAAAIEPAV----- 236 Methylococcus capsula...
Q1IS76 164 GFYPAGGGKITAEIEPVEK-LKQLELLDRGEVLQQNAVALLAH-LPRHIADRELETASNILg----LAPESTRILg---t 234 Candidatus Koribacter...
Q8ZST4 156 GHYPRGGGRAVVRAEPVKR-LKAVESEEFGNVVKISGISHAVN-LPPHVAERQAKAAREELsk-mgLDADIAIEVr---- 228 Pyrobaculum aerophilu...
O77264 160 GFYPRGQGRCQLDVQPVTK-LNSGKLVAFGRIKSVSGVAYCAGrLPVNIAIDMQQTAQREIhr-lwPSQQCSIEPikhsr 237 fruit fly
O00442 159 GYYPKGGGEVIVRMSPVKQ-LNPINLTERGCVTKIYGRAFVAGvLPFKVAKDMAAAAVRCIrk-eiRDLYVNIQPvqepk 236 human
Q8TZC9 157 GHYPRGGGIVRARMEPPKR-LKPLEAVKFGELESVRGISHCVR-LPPHVAERQAKAASEIIerelgIRPEIEIETypkgr 234 Methanopyrus kandleri...
Q8U0N7 155 GHYPKGGGIVAGYVKPWIE-RKELIAEEFENIYKVSGISHATN-LPAHVAERQAKAAMEELkv-lgVPIEIKKEV----- 226 Pyrococcus furiosus D...
O28837 155 GYYPKGGGMVRLTVRP-AE-MKGVVYERIDEI--VRGVSHCQN-LPGHVAERQASSARNFLee-rgIRAEIRTEV----- 223 Archaeoglobus fulgidu...
Q60335 157 GFYPEGGGEVIFEVKP-SK-IKKFDLIEHSKSNLVEGISYVQN-LDESIARRMRKKAVDLLnk-ekLLPNIKIEC----- 227 Methanocaldococcus ja...
Q974U1 154 GHYPEGGGEIKITEVKGNP--SSFSLMERGELLMIKGISHVSS-LPSHIAERQAKSAKEFLlskikIPVEIEIDVr---- 226 Sulfolobus tokodaii s...
Q609M1 237 LQAACAGAGLFLTARYD-HCLAGFTALGRRGKSAERVAEEACGALLAHHRSGAALDQHLADQIVLPAALCrEESLFSVER 315 Methylococcus capsula...
Q1IS76 235 KNSAGPGNALMIEVQTE-RHTEIFTAFGKVGISAEKVAEEAAVAAAQYVASSAFACEHLADQLLLPIALA-GGGSFTAVR 312 Candidatus Koribacter...
Q8ZST4 229 NDGLGPGSGVVIWAVSDaGNVIGGDSLGERGKPAETVGKEAAQKLIAVLKTRASVDPHMADMAVLYMALAeGRSRISTSE 308 Pyrobaculum aerophilu...
O77264 238 QKAFHNGAGILMTVNTTsDVVLGASALGKKRIDGHVLGSEASCQLGDYMRKQVCVDDYMQDQLIIYMALAvGRSTMRTGK 317 fruit fly
O00442 237 DQAFGNGNGIIIIAETStGCLFAGSSLGKRGVNADKVGIEAAEMLLANLRHGGTVDEYLQDQLIVFMALAnGVSRIKTGP 316 human
Q8TZC9 235 DPHLGPGSGIVLWAEDDqGNRIGADALGEKGKPAEVVGREAAEQLVQRLRTGMALDEHMGDQILPFLAIAdGESVFGVTG 314 Methanopyrus kandleri...
Q8U0N7 227 SHSLGPGSGIVVWAETE-CLRLGGDALGKKGKPAEEVGREAAQELLSQVKTKACVDKFLGDQIIPFLAISgGK--IKVAE 303 Pyrococcus furiosus D...
O28837 224 LKGLSTGSGIVLWSGYK-----GGSALGERGKRAEVVGQEAAESLYRELMSDAAFDAHLADQVMPFAAMArGRTEYTTSE 298 Archaeoglobus fulgidu...
Q60335 228 SKGISTGAGIVLWNDT-----LGGSCLGEKGLRAEIVAERAVNELLKERESGMALDKYMGDQIIPFLAF--GKGIVGVSE 300 Methanocaldococcus ja...
Q974U1 227 ENERSKGSGIALTAIFE-KTFLGSDSLGEKGKRAEIVGEEAAKSIYEEIISNATVDRHMSDMLMLYASLYyGE--YIGSE 303 Sulfolobus tokodaii s...
Q609M1 316 ITPHLTTNAWVVDRFGLARVD 336 Methylococcus capsulatus str. Bath
Q1IS76 313 QTMHARTNIEIIRLFLPVSFE 333 Candidatus Koribacter versatilis Ellin345
Q8ZST4 309 ETMHLKTNMYIIEQFLRVKFS 329 Pyrobaculum aerophilum str. IM2
O77264 318 LTNHTRTAINVAEQMTGVKFD 338 fruit fly
O00442 317 VTLHTQTAIHFAEQIAKAKFI 337 human
Q8TZC9 315 VDPHLPTNAWVVEKFLPVSVE 335 Methanopyrus kandleri AV19
Q8U0N7 304 ITKHLITNVWVVEQFFGKVFE 324 Pyrococcus furiosus DSM 3638
O28837 299 VTMHQKSNAYVINTFLGKVVK 319 Archaeoglobus fulgidus DSM 4304
Q60335 301 ITNHTKTNMWVVKHFLDVDFE 321 Methanocaldococcus jannaschii DSM 2661
Q974U1 304 LTSHARTNSEIIKKFLNVNIQ 324 Sulfolobus tokodaii str. 7
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