2E28,6K0K


Conserved Protein Domain Family
PykF

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COG0469: PykF 
Pyruvate kinase [Carbohydrate transport and metabolism]
Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Statistics
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PSSM-Id: 440237
Aligned: 898 rows
Threshold Bit Score: 454.492
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2E28_A         1 MK-R---KTKIVSTIGPASESVDKLVQLMEAGMNVARLNFSHGDHEEHGRRIANIREAAKRTGRTVAILLDTKGPEIRTH 76 
WP_013266798   1 -MkR---LAKIMVTMGPSTLDYAIVRRMMSAGADGFRINMSHGDEKQWATFLELIDKASQELGVHVAKVADLEGPRVRLG 76 
WP_012185641   1 MV-G---KVKIMATIGPSSEKPEVAGKLIKL-IDGARVNFSHGDLNTWVSRIELIRRINPS----IPILGDLPGPGVRTG 71 
WP_013335835   1 -M-G---KVKIIATIGPSSEKPEVLKELIKY-VDGIRINFSHGSAEEWRSRIMNARSLRSD----IAVLGDLRGPGVRTG 70 
WP_015232284   1 -M-R---LLKIVATVGPANYDYNVIRKMVASGTDAFRINMSHGDQKQWEDFIDLINKASNELGIKVTKIADLEGPRVRLG 75 
AFH42330       1 -MeN---KTKIIVTMGPSIEKYEVLLSLVKEGARGFRINFSHGDPSQWYNYINNLKSVEKELSIPLGIIGDLQGPNIRIG 76 
BAJ50662       1 -M-----RTKIACTLGPSLQEVVDIEKAISLGCRIYRINFSHGNPILWRQLADNAREAAEKRGEKIVLIGDLRGPSIRVS 74 
ADM28248       1 -M-----FVKIIASIGPSSGNIETICNMVKEGVRGFRINFAHGDQSEWKKYVEAVREVEAKLGKPIALIGDLEGPSLRLG 74 
BAA79454       1 -M-Rg--PVKIVATVGPSSSSASILAQMLSLGVDVARINASHGGVEQWNSMLESLRRAEEAVGKRVGVAVDLEGPRVRTG 76 
WP_082419589   1 -M-TgyvNTKIIATVGPSSSSFEVIEQLASLGVSGFRINFAHGEPSLWKSWIEIIRETEKSIGRPLAIIGDLVGPSIRIG 78 
2E28_A        77 NMENgAIELKEGSKLVISMSE--VLGTPEKISVTYPSLIDDVSVGAKILLDDGLISLEVNAVDKqaGEIVTTVLNGGVLK 154
WP_013266798  77 EFQ--GVDIAPGQQVRFKYKD----AQGEGIPVDNRAFFASLERGDRVLVDDGKVVLSVEDIER--DSATLRVISGQRLE 148
WP_012185641  72 EMVD--LPFSKGDSLTFKLAN--E-GK-GYVPVPVKEFFDIVDKGDVIIMDDGRIRLEVTGKGS--NEVTVVALTNGIIR 143
WP_013335835  71 SMK--PITLGVGDSVEFRFAD--K-SDGGFVPIPSPSFFRVITVDDIIVMNDGRLRLRVDKVSA--SNAVLTALTAGTIS 143
WP_015232284  76 NFE--PVKIQQGQNLVLRYEN----SKIDGIPVDNKVFFSSIEQGDKILIDDGKVSAEVEIVEK--DSAEVRIIEGDLLE 147
AFH42330      77 QLIN-QINLKKDDIVQFFYGN--K-SETNDIPLPYEEFFKTVERGDVIQLADGAIQLIVLETSP--KSFIAKTIAGGVIT 150
BAJ50662      75 GLET-SISLRAGERAKFSLD--------GPLSLPYPRFFETVEVGDTLLLDDGRGMLKVVAKDE--TSIAAEAIRPATIS 143
ADM28248      75 KISK-PIVLQKGEHIKIIYGNevSDSNEKNVPMPIPKFFEYIDVGDILIMDDGRTRLRIVDKGA--DSVEAIALTDSVIT 151
BAA79454      77 NSE--PVKLEKGDLVTLGFME-------GDVPVDARQFFETIDEGDIVLLDDGKIILQVESVEG--FRVKARVLEGGVLG 145
WP_082419589  79 VLEE-PITLSPGDVAEIVYGEkaKGGSERIIPLPLRRVFEVVEEGDILVMNDGRVKLRVIDVRG--LRIRVEALTPARIT 155
2E28_A       155 NKKGVNVPGVKVNLPGITEKDRADILFGIRQGIDFIAASFVRRASDVLEIRELLea-hD-AlHIQIIAKIENEEGVANID 232
WP_013266798 149 PRKGVVLAGKEYDLPPVTEKDLQNMKFIAANNFDYVMASFVRSARHVEIIRKALsd-aGaK-DVKLLAKIETPSGVNNID 226
WP_012185641 144 THKSITIMNKDYPLPILGDRDKEAIKVAAKYNLEYLGLSHVRSVEDIESTREYLrs-lN-Y-SPMIIVKVETASAIRSIK 220
WP_013335835 144 QEKAVVIKGKDYPLPILDDYDREALKFAVEVGMDYVGISHVRSSDDIEEVRTELrr-lGgD-WIKLMAKIEGPDAVRNMK 221
WP_015232284 148 PRKGVVLAGKEFDMPPITDKDLNDMKFIAAKDFDYVMVSFVRNSKHIDIVREALkk-qGaN-NIGLLAKIETPSGVKNID 225
AFH42330     151 SRKSISIKDKDIEIPYVTEKDERDIEFACNNDFSHLMASFVESKDNIFQLKELLnkkcN-K-QLNILAKIETKRGVYNVE 228
BAJ50662     144 PNKSIVIRGKEVQVPDYLATCREQLQAAADMELDYVGLSFVTKAADVDAAKTFLhe-kG-L-ATGVIAKIETPSGVKNVD 220
ADM28248     152 SRKAIAIQGKELDLPALSDRDINSIKFAIENDFDYIGLSYVRTAEDIDLLRDILrr-aGrE-DIGIISKIETKSAIRNLS 229
BAA79454     146 PRKGVVVRGKEPDLPPLSAKDRRALEFFADKGVSHVYVSFARSAEHVEKVRTVVrr-lGlR-QARIFAKIEGPSGVSRIG 223
WP_082419589 156 SRKAIVILNRDPGLPALTERDMQCLRFALDNELDYVALSYVRGGEDIAVLKTLIan-eG-G-DVGVAAKIETRSAVENLS 232
2E28_A       233 EILEAADGLMVARGDLGVEIPAEEVPLIQKLLIKKSNMLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAVML 312
WP_013266798 227 SILDVVDGIVVARGDLGMHFPLEDIPVIQRRIIEAARRKLKPVILATEIFMSMIERPLPTRGEISDVYAGIEEGVDGFLV 306
WP_012185641 221 DIACNADYVMVARGDLGMVFNLEEVPKIQEKIITAAHSCGKPVMVATQLLESMVNNPVPTRAEVVDIMTSVLQGVDSLLL 300
WP_013335835 222 DVICASDYVMVARGDLGMHFDLEEIPRIQSSIIREAQKCGVPTMVATQLLESMIEQPVPTRAEVVDITNAVMEGVDSLLL 301
WP_015232284 226 EISEAADGIVVARGDLGMHFPLEQLPMIQKKIIESARRKLKPVILATEIFMSMIERPVPSRGEISDVYKAVEEGVDGFLV 305
AFH42330     229 EILKVADGIVVARGDLGTHFPMETLPTIQKDLISKSIVQGKPSIVATQLLSSMLNSPIPTRSEIVDIYNAVQESANALML 308
BAJ50662     221 EISERSDAVLIARGDLGMHFPLEYVPRLQKTIIDAAYNACKPVIVATQLLGTMVNEPVPTRSEIVDVMTCVEDGVDVLML 300
ADM28248     230 SILEKSDIILVARGDLGMNFGLEEIHYHQRYIVEKALENRKPVIVATQLLESMTEKPVPTRAEVVDVSVAVEMGVDALML 309
BAA79454     224 EIAEASDGVIIARGDLGMHYSLEELPEIQELIVWEARKRYKTVVLATEFLSSMIEKPVPTRSEVVDIYQAVLQTADALML 303
WP_082419589 233 SIIEESDIVIVARGDLGMNYGLEEIPLLQEHIVYETRRRGKPVIVATQILESMIDNPVPTRAEVMDVATAVKQGVDALML 312
2E28_A       313 SGETAAGQYPVEAVKTMHQIALRTEQALEHRDIL--SQRtKESQTTITDAIGQSVAHTALNLDVAAIVTPTVSGKTPQMV 390
WP_013266798 307 TSETSIGKYPAEVVSWLSRVIEEANKNVRPRRV-------DQLTSSLESRISRGVVEMAQNVGAS-VVVYAHDFDVARLI 378
WP_012185641 301 TDETTMGNYPVEAVEWLRRIVSNYEDQVTPGFRA--DS----SVFDERMRFALGVAELADSIGAK-IVVFTKSGLTAVRL 373
WP_013335835 302 TGETAVGKYPVEAVQWLRRVATEYEDEVHVDRGV---------MANLTDRLALGIVQLAEDIGAK-IVIYSRGGRFVEAI 371
WP_015232284 306 TSETSIGKYPVQVIIWLSRVIQEAQKHITPNRI--------EISDISDARIAKGVVDLANDIGAE-IVSYATTIDMSRFI 376
AFH42330     309 TNETSIGNYPIDAVRWLKKVIIEAEKNSAIVYPV------KPIENSLAHRFALGISEFSRQLNAK-ISVYTKSGLTAQNI 381
BAJ50662     301 TAETAVGRYPLESIQWLVNIAETYEKGIEPRRAL-------PPSAEVVDRFALAVVNLAESLAAK-IAIFTINGNMARRI 372
ADM28248     310 TGETAVGKFPVEAVSWLNRIVVFVERHIMPKIIDrvSNKaREHLETIQLKFAKGVLELAEDLSAK-LFVFSIHGNTARRI 388
BAA79454     304 TGETAIGKYPVKSVQWMAKISSRAYKKLATSPPE------RPRPTSTPYKLALGLVELAESLDSP-LVVYSKTGRFAERL 376
WP_082419589 313 TGETAIGKYPVEAVKWLRKIIRRIEERYPPQKFP---------PSDHQWAYASSIVETAERLNASHILVYSIGGTLPPKI 383
2E28_A       391 AKYRPKAPIIAVTSNEAVSRRLALVWGVYTKEAPHVNTTDEMLDVAVDAAVRSGLVKHGDLVVITAGVPVGEtGSTN--L 468
WP_013266798 379 SAFRPGTSIYVGVPTTQLARQLSLLWGTVPVVVGPADSEEQGLEATEKELESKGITGPGSLLVELSWTP-D--RSTA--V 453
WP_012185641 374 SRYRPRVQILAGTPSEAVFRRLKLLWGVESRVIND-QDYDKGMVDTLNEYIKEGLIKHGDLVVLTYGLRPNVsEYEH--V 450
WP_013335835 372 SRYRPRVPTYVGVSDEKVLRRLRLYWGVEPILIDNVRDYDEGERETLNQLIRSGLVVKGDLVLLTHGVI-D---TYNdyS 447
WP_015232284 377 AGFRPSKPIYTGVSEESVAKKLNIFYGIKPLIVGQSNNEEEGLKVTESYLRKEGVLGAGDTVIETARSL-E--ENSF--I 451
AFH42330     382 SLYRPYGIIYAGVPDMHTARKLSIIWGVEPYVLAA-DSYENGLEKIRKVLISEGKLSKGDTLIETYRFK-E--GEVH--T 455
BAJ50662     373 ARFKPVSGIIAATPNHDVVPRLMLLWGVTPLLLEA-QSYAEGLEKLEKKLEEERLAEPGDTYVLTYGLV-KEp--IH--I 446
ADM28248     389 AALKPKIPVYVASQNIKVLRKLSILWGLSPFHINA-NSYEEGLQNMLSKAMDLKLISYGDLVVLTYGLK-E---PRQ--K 461
BAA79454     377 ASFKPLKTFYVGVPSREVERVVRHLWGAEPIVVGDY-PYEAGLAKTYEKLRRENIIHGDETVVEAAWSS-ER-G-IY--I 450
WP_082419589 384 AASRPLVKTIIGVGDVARARRLVIVWGLHLRHVVA-EGYEDGLHKLIKELCRDGEIHPGELIIKAYREA-H---NKH--V 456
2E28_A       469 MKVHVI 474
WP_013266798 454 VKVKQV 459
WP_012185641 451 IKLIRA 456
WP_013335835 448 IRILKV 453
WP_015232284 452 IKVKQL 457
AFH42330     456 IKLVTV 461
BAJ50662     447 VKMKKF 452
ADM28248     462 VEILRI 467
BAA79454     451 IRVRNL 456
WP_082419589 457 IIVEKM 462
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