7NJ1


Conserved Protein Domain Family
Securin
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pfam04856: Securin 
Securin sister-chromatid separation inhibitor
Securin is also known as pituitary tumour-transforming gene product. Over-expression of securin is associated with a number of tumours, and it has been proposed that this may be due to erroneous chromatid separation leading to chromosome gain or loss.
Links
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Statistics
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PSSM-Id: 461456
Aligned: 8 rows
Threshold Bit Score: 111.523
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7NJ1_B   1 MATLIyvDKENG------EPGTRVVAKDGLK------------------------------------------------L 26 
Q24454   1 MDQIL--NKENTginlpaNPIKNGVPTNSVLkk---------------------------------------------pL 33  fruit fly
P21135   3 PRTMFsyGKENa------FPVTPISNRNGTKgags----------------------------------------krapL 36  Schizosaccharomyces p...
P97613   1 MATLIfvDKDNe------EPGSRLASKDGLK------------------------------------------------L 26  Norway rat
A1YF19   1 MATLIyvDKENg------EPGTRVAAKDGLK------------------------------------------------L 26  western lowland gorilla
Q6CJE7   6 KENIIsvQDPDNdlg-lrTPLNQMKRTDSLVrgn------------------------------------------rrpL 42  Kluyveromyces lactis
Q6FKE1   9 ENNVVgtLREKGp----aTPTQLLKRTRSTLlpkkn--------------------------------------gqrqpL 46  [Candida] glabrata
P40316   9 ENNIVytGNESSginfpqTPAHLLKRSHSNIlkppvrldqlkrdansnngntlkyiqggkevsptkrlhthaqqqgrlpL 88  Saccharomyces cerevis...

7NJ1_B  27 GSGPS--IKALD------------------------------------------------GRSQVSTPr---fGKTFdaP 53 
Q24454  34 GNLDNvmHQTPGit--------------------------------------------pfKSTSLKLE-----GSIA--K 62  fruit fly
P21135  37 GS-----TKQSN------------------------------------------------APSSVTVPrtvlgGKSTniS 63  Schizosaccharomyces p...
P97613  27 GSG----VKALD------------------------------------------------GKLQVSTPr---vGKVFgaP 51  Norway rat
A1YF19  27 GSAPS--IKALD------------------------------------------------GRSQVSTPr---fGKTFdaP 53  western lowland gorilla
Q6CJE7  43 ASKDN--NRTQSilsvknnaalgksd---------------------hplkrpassfmknMPEN-KLKk---yGSVL--G 93  Kluyveromyces lactis
Q6FKE1  47 ASKDKnyNRSSSylsl------------------------------------------krnSNQKKLKp---aVTRAgsT 81  [Candida] glabrata
P40316  89 AAKDN--NRSKSfifpetsnqskdadlpqlqntlsirkndqlrklsqisrsrsranhndlLSNSRKLQk---yGSVL--G 161 Saccharomyces cerevis...

7NJ1_B  54 PALpKATRKALGTVNrateKSVKTKGPL----------KQKQPSFSAKKMTEKTVKAKSS-------------------- 103
Q24454  63 LSLrKAPKQNVVSRDr---EEVRYKTNScflgayvlncEYRVVNLFNYTDFPNEKCLKNC-------------------- 119 fruit fly
P21135  64 KFIsAPSTKKMSPMD----ISMDSPTIL----------EPNSQGISRSAVQERSKRLSASprrsslt------------- 116 Schizosaccharomyces p...
P97613  52 -GLpKASRKALGTVNrvteKPVKSSKPL----------QSKQPTLSVKKITEKSTKTQGS-------------------- 100 Norway rat
A1YF19  54 PALpKATRKALGTVNrateKSVKTKGPL----------KQKQPSFSAKKMTEKTVKAKSS-------------------- 103 western lowland gorilla
Q6CJE7  94 MNTfMPRTKSLVLKD----TELNEKNDD----------EDEEDEEDDLPIFPSGKSLnlgfgngl--------------- 144 Kluyveromyces lactis
Q6FKE1  82 ANNaNRRVTSLILKD----IASGDEKES----------ASESDSEDDEESNPLALKIKQAlthsiasaegktgll----- 142 [Candida] glabrata
P40316 162 YNA-LPKMKSLVLKD----LADSGKNEE----------SSDDDEGNEDSESKLGKKLQSAllkqdssdgenelngglglf 226 Saccharomyces cerevis...

7NJ1_B 104 ----------------------------VPASDDAYPEIEKffpfnplDFE--SFDlp-------eEHQIAHLPLs---- 142
Q24454 120 ----------------------------SKPVTETWSENQE-------GYE--GLLdqlyldlrtlENNLENRCL----- 157 fruit fly
P21135 117 ---------------------dtplpneLEEDIEYMPPPVHldpiqslGFDdvAIDcetldpwpsmQNKATSVTIr---- 171 Schizosaccharomyces p...
P97613 101 ----------------------------APAPDDAYPEIEKffpfdplDFE--SFDlp-------eEHQISLLPLn---- 139 Norway rat
A1YF19 104 ----------------------------VPASDDAYPEIEKffpfnplDFE--SFDlp-------eEHQIAHLPLs---- 142 western lowland gorilla
Q6CJE7 145 --------------------kalirekeDELNIEYAPKRQKelpyipnGYD--PFD----------KESIEKLQHh---- 188 Kluyveromyces lactis
Q6FKE1 143 --------------ngksglrkifndrdLDREIEVASVREPekpyepeGYE--PLD----------DSDLEKLKLknain 196 [Candida] glabrata
P40316 227 neqgglqqliknstkneqktkndksdktDDYDIEIAPQRQEplpyvpeGYS--PFQ----------QDDIEKLKTf---- 290 Saccharomyces cerevis...

7NJ1_B 143 ------gVPLM-----I--LDEERELEKlfQLGPPSPvkmpsppwe---------------------------------- 175
Q24454 158 -------PPLDftdlpYiyNTENMEPAEpeYLLNLYPp------------------------------------------ 188 fruit fly
P21135 172 ------nTPASdfhvyKefSDDDPIQFPllSVDGDSPltekdtnlttpatlkasdqqrkvlekpsvskqsssrtrlstvy 245 Schizosaccharomyces p...
P97613 140 ------gVPLMi-------LNEERGLEKllHLDPPSPlqkpflpwe---------------------------------- 172 Norway rat
A1YF19 143 ------gVPLMi-------LDEERELEKlfQLGPPSPvrmpsppwe---------------------------------- 175 western lowland gorilla
Q6CJE7 189 ------rSPFQ-----VesITFDTEERDp----ELISlaatdedlvsptrynnhkhn----------------------- 230 Kluyveromyces lactis
Q6FKE1 197 rptfimdSPRA-----IsiVGDDSPQLLplDLEE-SKleegvlndknttdevitrantqa-------------------- 250 [Candida] glabrata
P40316 291 ------nSPYK-----L--DLEDEDDTP--DKVDLLPleqideegekdetecitr------------------------- 330 Saccharomyces cerevis...

7NJ1_B 176 ------------------------------snllqspsSILSTLDV 191
Q24454 189 -------------------------------------lPNLEGIDV 197 fruit fly
P21135 246 rtklasgksiprplshkltrprvtasgnsrrrplsrsiHSLSSSRI 291 Schizosaccharomyces pombe 972h-
P97613 173 ------------------------------sdplpsppSALSALDV 188 Norway rat
A1YF19 176 ------------------------------snllqspsSILSTLDV 191 western lowland gorilla
Q6CJE7 231 ------------------leldsdnesitielgeeyngQGLDTLEL 258 Kluyveromyces lactis
Q6FKE1 251 ---------------knanitesiddcssveidsiydgRGLDEQEL 281 [Candida] glabrata
P40316 331 --------------------nqeegaalpllsknfkevAAVPTMEL 356 Saccharomyces cerevisiae S288C
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