Conserved Protein Domain Family
PAP2_BcrC_like

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cd03385: PAP2_BcrC_like 
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.
Statistics
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PSSM-Id: 239480
Aligned: 19 rows
Threshold Bit Score: 111.196
Created: 29-Dec-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
P75806     23 MISLAIFIAKdlitVVPLLAVVLWLWGLTa---------------------QRQLVIKIAIALAVSlfvSWTMGHLFPHD 81  Escherichia coli
P94571     19 LDSIMVFITEyaivAYALILLAIWLFGNTq---------------------SRKHVLYAGITGIAGlviNYLITLVYFEP 77  Bacillus subtilis
CAA09858   26 LMAFATFCAQytlvIIPLTLLGHWFLGGKs---------------------GHRRALFSLVTILVAlglGFICTTLWFHP 84  Klebsiella pneumoniae
NP_279756  19 LNEAMVFLAEravfLVPLVLVVLWVAPGVdrpipvleaalaglgitthdgkQKSVFVFATIVVALAi--SYGMGTLHSHP 96  Halobacterium sp. ...
NP_635152  26 LDSTMIFAAKniiyIFAAYLACIWLTKSE----------------------YRQEALFAGYASVLGlgiNFIITLFYFHP 83  Methanosarcina maz...
YP_032131  25 LVLFSIFCAKfliyIIPIHLWVLWFCGGDr---------------------ERRVGLSVCVSICTSlfiGYLISLIYFHP 83  Bartonella quintan...
YP_036618  32 LDTFMIFISQktrfLYIFLLALMWFRNNS----------------------YKKIILFAGLSVGFAlfiNCFIQLFYFKP 89  Bacillus thuringie...
AAU17867   19 LDKVMIAITNsaayVAILFMLILWFHNGKken----------------airKQYTVLYTTLSVIIAllvNVFIHLVYYHP 82  Bacillus cereus ZK
AAY95084   22 MRALAVFLAQwvvlSVPLLLVVFWVFGERr---------------------QRMIVLLAGLSIVLAlvcNLLVRELWFHP 80  Pseudomonas fluore...
AAS41671   24 LNPAIVFLAEymvyIFALIILAYWFTGSRk---------------------SRMMVIQAMVAFVIAeviGKIAGKFHLNY 82  Bacillus cereus AT...
Feature 1     #                     ###                                  #     #   #          
P75806     82 RPFVENigynfl-hhaadDSFPSDHGTVIFTFALAFLCWHrl-wsGSLLMVLAVVIAWSRVYLGVHWPLDMLGGLLAGMI 159 Escherichia coli
P94571     78 RPFVAHtvhtli-phaadASFPSDHTTGALAISIAMLFRNrk--iGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAII 154 Bacillus subtilis
CAA09858   85 RPFMVPlghtwi-yhapeTSFPSDHATLFFSAGLSLLLSDar-vsGGLILLLSLFVAWSRVFLGVHFPLDMAGASLLAVL 162 Klebsiella pneumoniae
NP_279756  97 APYAAGyetll--agppeNSFPSQHTTVMFAFAWPLASLQdrwraVVVGVAVAALVGYSRVYVGVHYPVDIAGGIAASVL 174 Halobacterium sp. ...
NP_635152  84 RPFMVPtgtlli-thaaeSSFPSDHATVMFSVSIMLLAFNylryrGAIFLVLAFLSGLARVYSGLHFPMDIAGSFLVASL 162 Methanosarcina maz...
YP_032131  84 RPFVVGlttpli-khratASFPSNHALTVASYMACLYFYRyk-iaSQFAAIFLCLICWGRVFVGVHYPFDVLAGAVLGSL 161 Bartonella quintan...
YP_036618  90 HPFVIHrvrlli-plknnSSFPSKHTVLAFALASSVLLRErl--fGSIMWFLAILTGFSRIWLGHHYPFDIIGILTSIAI 166 Bacillus thuringie...
AAU17867   83 RPFVSYdvnqlv-phaenSSFVSDHSVLVLSIAFMFILRGek--lRYIALLWAVLVCISRLYVGVHFPLDVIGAAVITIL 159 Bacillus cereus ZK
AAY95084   81 RPFMIGlgqnfl-ahapgASFPSDHASGMFAMAFALILASlr-ktGLVMLGLALLVSWARVYLGVHFPFDILGGCLVGGL 158 Pseudomonas fluore...
AAS41671   83 QPFAVLpdvnklvdhavdNSFPSDHTILFFSICFSFWLVRkk--tGWLWLILALCIAISRIWVGVHYPFDVAVGALIGCI 160 Bacillus cereus AT...
Feature 1            
P75806    160 GCLSAQI 166 Escherichia coli
P94571    155 IGFLFFR 161 Bacillus subtilis
CAA09858  163 ACLLVRP 169 Klebsiella pneumoniae
NP_279756 175 GFGAVYA 181 Halobacterium sp. NRC-1
NP_635152 163 STGILLT 169 Methanosarcina mazei Go1
YP_032131 162 ISWGIVQ 168 Bartonella quintana str. Toulouse
YP_036618 167 GNATYIF 173 Bacillus thuringiensis serovar konkukian str. 97-27
AAU17867  160 TSCLLLQ 166 Bacillus cereus ZK
AAY95084  159 SAWLVRQ 165 Pseudomonas fluorescens Pf-5
AAS41671  161 SAVISYW 167 Bacillus cereus ATCC 10987

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