5SVA


Conserved Protein Domain Family
Med17

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pfam10156: Med17 
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Subunit 17 of Mediator complex
This Mediator complex subunit was formerly known as Srb4 in yeasts or Trap80 in Drosophila and human. The Med17 subunit is located within the head domain and is essential for cell viability to the extent that a mutant strain of cerevisiae lacking it shows all RNA polymerase II-dependent transcription ceasing at non-permissive temperatures.
Statistics
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PSSM-Id: 401965
Aligned: 26 rows
Threshold Bit Score: 294.211
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5SVA_P        11 LSSETGIKLALDPNLITLALssnpnsslhsptsdepvpesagkadtsirlegdelenktkkdndknlkflknkdslvsnp 90  baker's yeast
XP_002172173   5 SEKNDDFLLPIDPEALQDSL------------------------------------------------------------ 24 
P87306         8 DADISSLSLSLDPEIIGG-------------------------------------------------------------- 25  Schizosaccharom...
CCU77470       6 NTNEDDLLLSLGPDQTPS-------------------------------------------------------------- 23 
EPE26918       2 sTTTNSFPISLRSWPSSK-------------------------------------------------------------- 19 
Q7SI24        14 iiRTMDSPLNLRPRPPNS-------------------------------------------------------------- 31  Neurospora crassa
EHK45765      54 msSEGGPPLSLRPFPVAD-------------------------------------------------------------- 71 
EON65248       3 TTESSTIQLSLRPAIAEN-------------------------------------------------------------- 20 
CBX99790       2 ssMESLRDVKLRPWPASK-------------------------------------------------------------- 19 
EPB84714       4 EPTKKRIKLSLEPAIDNNVVditnagqe-------------------------------------------------ilk 34 
5SVA_P        91 HEIYGSMPLEQLIPIILRQRGPgfkFVDLNEKELQNEIKQlgsdssdghnsekkdtdgadeNVQIGEDFMEVDY----ED 166 baker's yeast
XP_002172173  25 LAVDSENSLATVIPKIVKKYGL---FRSLTESDLREKSEQeeqsqevq------ekakptpAKQPTAEEQGLD------- 88 
P87306        26 QNNFLENNLQQIFQKIIQERGP---FRDLKEEDLQKELQKesikde---------ssakssETENVLEFATLDSkrnvND 93  Schizosaccharom...
CCU77470      24 ---INENSLADKISRINFQRAEsggFRGLTEDNLREEILGerivtk----------ecsesDGESTEEEEEPDRi----- 85 
EPE26918      20 --NSDATSLSTLFQRINGERGG---IQGLTEESLRQEIAAeaetkm----------deddtSENEDEDEEQPDKl----- 79 
Q7SI24        32 ---RGPQTIADFIRRVNAEPGG---FRALNEEEVRRNVIAernglhh-------edvemvtDQEADDDSKKPD------- 91  Neurospora crassa
EHK45765      72 ---QKPKNLAEFIARVNAQPGG---FRSITEDKLREELRNsedpd-----------aaddqDEEVSEAAGEADVae---- 130
EON65248      21 ---NGAHTLAEQIWRINAERGH---FRSVTEEGLRREIEAqeag--------------lveTTEENDKEEEEDKvhtrE- 79 
CBX99790      20 QGTLSQQKLYAQIEQLTTERAH---LRDITKTALQEALGAgkdipd----------gvalkEKEDEEKKEKKEVvtqkVT 86 
EPB84714      35 tdtslPEKLMQSVDRIWFERGE---WKDISEKSLMASIKKrkqqpel-------kdeeeegEGEEEHELQTENA------ 98 
5SVA_P       167 KdnpvdsrnetdhktnengetddnietVMTQE-----QFVKRRRDMLEHINLAMNESSLALEFVSLLLSSVKESTGMSSM 241 baker's yeast
XP_002172173  89 -------------------------------------NLSAHKKELIDQIAMAQNECSLALDMVSLLLSKYRTN-SVDTI 130
P87306        94 Teve-------------------------------smDSQAYKKELIEQIMIAQTECSLALDMTSLLLSKFKEN-SIETI 141 Schizosaccharom...
CCU77470      86 ------------------------------------kELSIARQELLCQIDSAHQSAMFALDFISLALSKDAPTQAVSTI 129
EPE26918      80 ------------------------------------rELMEAKGEMLGLLESAYVSSAVTLDFLSLLQSKDNPVQAASTM 123
Q7SI24        92 --------------------------------------IIAARHNIIMSLGQAIQISSNFLDFISLLLSKEIPTQAAVSI 133 Neurospora crassa
EHK45765     131 ------------------------------------kDPGVARMEVLKNIDIAGNAALLTLDSMSLLLSKQNPTQAGLTL 174
EON65248      80 -------------------------------------GLAAARLELIRYVGQAYQEAAMALDMISLLLSKDAPAQGTQSM 122
CBX99790      87 Re-----------------------------------TIFNAQREMYSHLEWAKFAATNALDLLSLVLSQDPNKRVASSF 131
EPB84714      99 ---------------------------LPSQSlppgfDVAKLRESVINKLFHAKSEIDVALDVINILAAGNRGSSAA--- 148
5SVA_P       242 SPF-----LRK-VVKPSSLNSDKIPYV---APTK-----KEYIELDI-LNKGWKLQSLNESKDLLRASFNKLSSILQNEH 306 baker's yeast
XP_002172173 131 SPF-----LEN-AVSLGSLTMNRCEAP------------KAKSSDAL-VGKLWKDKALKNARTSFTAAAQRLRNVVEGEQ 191
P87306       142 SPF-----LKS-TVPPSSLQFSRSQPP------------ESKESDAT-LAKCWKEKSLTSSCKFLFEAKERLTSVVETEH 202 Schizosaccharom...
CCU77470     130 SSE-----LRE-FVGLGTLGFDKLNAT---RITD-----TKINENKQ-VVRGWQIQSLNKTVDSILAAATRLEKEIESET 194
EPE26918     124 SQD-----IKL-AVPTGTLGADKLNGP---QINR-----AQMLDNKR-IAKGWKVQNVDKTIDSILNAATRFKNEVESET 188
Q7SI24       134 SPW-----LRS-QVPIGSIGATQLDAPt--PLTQ-----SRVADNKL-ITIGKRLVALNEAADTALAAANRLRQEINSET 199 Neurospora crassa
EHK45765     175 SQQ-----LRD-MVGIGTLGADKLNDS---NVTP-----AKTKDKES-VAMGWTLLEINKTRDSSEEAASFLEKEINSES 239
EON65248     123 SPA-----LKS-LVPPGTIHYEKWPPT---QRTN-----AELRNEDV-VTKGWKMQSLNAAADSLLVGAARLEKEVKKET 187
CBX99790     132 SHTfreqgLEQ-GIPFGSFGISKESHEyfvPRPEeaerlEELAKKQLlVAKGSRMEALDSAADEILKAAKKLEKEVRRET 210
EPB84714     149 --------VKDlVLPAGSLTATYVTKP---KQTT-----KAQLESVQ-LNLGLKRKKQKQASDFLKKSAAALKHLVEKEH 211
5SVA_P       307 DYWNKImqsISNKDVIFKIRDRTSGQK--LLAIKYGYEDSGSTYKhDRGIANIRN----NIESQNLDLIPHsssvfkgtd 380 baker's yeast
XP_002172173 192 EKWNLF---ARFHEKGWPILRGKDG----ALCVQYSALGGQSV-----GVGTFDL----SSKKGKPTFVHG--------- 246
P87306       203 EYYTEL---VKVKEASWPLFNS-QGSN--HLSVQYSCLGGISL-----GLGLIRM----KPESKSFEVQSS--------- 258 Schizosaccharom...
CCU77470     195 RYWEQV---LDISNNGWAICCLPTEKQ--TLGVRVGISDASPAFK-SRSLAALRR----NHDGSIFLDQGI--------- 255
EPE26918     189 KYWEEV---VSVSEKGWSLCRLPSERH--TLGVRFGFLEASMTFR-NQSLAALRR----NADGSIFLDQGF--------- 249
Q7SI24       200 KYWQEV---LTVSQKGWSTARLPQEPH--DMGVKFGFSNAAPLFK-NNSVAPLKR----AEDGSVRLEYGR--------- 260 Neurospora crassa
EHK45765     240 KYWEDI---VGVKKAGWSISRVPQERH--TLGVRFGFSEAAAEFK-NNGLAPMRR----GDDGSADLDFGR--------- 300
EON65248     188 KYWEQV---LSLSREGWAIRRVPQQKN--VLGVQIGCVDAAPRFK-SRGFSALRS----NDEGDIILDEA---------- 247
CBX99790     211 KYWQEI---VSVSDKGWPIQRLRQNARhvPFGVRFGLPEASDHFK-ARGFAPLRM----SKDGSIILDPA---------- 272
EPB84714     212 VFWDEA---LDLRRNNWQMQANSNAGA--SFFVQYGYTEVGSDFN-EQSIGELKRssdeDDDGSNLLQMSL--------- 276
5SVA_P       381 fVHSVKKFLRVRIFTKie--------------------sEDDYILSGESVMDrd---------------sESEEAETKDI 425 baker's yeast
XP_002172173 247 -LQYEHASLKVDIHRR------------------------DEIVASNRWSWP------------------DEHKTEEDDV 283
P87306       259 -LLYSQAALKISILNK-----------------------DRDEIGSSTWSWP--------------------SQNCNSVL 294 Schizosaccharom...
CCU77470     256 -SGSDPQVIRVRI--------------------------ETNGSKTGSTTTP-------------------LLVPDNAPV 289
EPE26918     250 -TGSEPKILRVRV--------------------------QVGEIYTGTSQVP-------------------KATGEDASV 283
Q7SI24       261 -MGSKSERLQATL--------------------------LHNGEVVGRSSLP-------------------RPLPDDAPL 294 Neurospora crassa
EHK45765     301 -LGGVSEALVVTY--------------------------EKDGKVIGRSTTR--------------------PSSDDESL 333
EON65248     248 -LTQRPEAIRVRI--------------------------RHQDKIIGSSRLA------------------AIDTKAQAPV 282
CBX99790     273 -LALKPKTFRVRV--------------------------TLDGETTGTSQLS------------------VQQDMKDNSI 307
EPB84714     277 -PHGTCRKVAVRISKShmgklglggqnefsegilgileeQQGAYAADQDKERstfnqgkeggaavkvysnTMLGTSHSKI 355
5SVA_P       426 RKQIQLLKKIIFEKELMYQIKKECALLISYGVSIENeNKVIIEL---------PN------EKFEIELL---SLDDDSIV 487 baker's yeast
XP_002172173 284 EKQLHQARRTLFEMDVWNALLLEAQYCGNQGVIYTG-NSIEVTYd--------GT------YKTSISLS---PVDSGADE 345
P87306       295 LKDIYKLQEILFEMDIWNSLLQEAQSCGNQGVNFTG-DEILVPI-----------------SDDHVVRI---TLETSSKN 353 Schizosaccharom...
CCU77470     290 QALILQARNTLFAEELWQELQREARFLCSFGVSSTS-STVTLTLt--------PQ------KRALIDIV---PLCAQSIS 351
EPE26918     284 ESLIQQARNTIFFTELWQELNRESRNLGGADVKATE-DSLILPLn--------SE------KRIILDLVniaDLEAPAPQ 348
Q7SI24       295 DDRVKEARNTIFAQELWHEINREGRTLHGHHVRLEQ-SAVTCALd--------PN------RTISFELV---GLDDQDHS 356 Neurospora crassa
EHK45765     334 EARVLEARNTIFSQELWHELTKESRSLAAYDVKPEG-RKLACQId--------ET------TKITLELL---PLESCPSP 395
EON65248     283 EELVHRARDTLFEQELYQEMILEARQLHGYYIETRD-GVINVPAkspkasntiPDgskevtEHILIDKV---YLDETLDD 358
CBX99790     308 EKSIQLARDSLFEEELYHEMSMETRQLLAYGVEFRD-SVIQLDVprmgn--------tsqqLKLLIDCI---PRDEPIAE 375
EPB84714     356 QNQLAEAHSTVFDAELFSDILAEAQALNS-NVRFPD-DEIVINId--------GQ------IDLHVSKV---------PV 410
5SVA_P       488 NHEQDLPK---INDKRANLMLV------------MLRLLLVVIFKKTL-------------------------------- 520 baker's yeast
XP_002172173 346 HH---------KNDLSSDSMNVddkdvqlrelclVFNTLIHVLFVQYC-------------------------------- 384
P87306       354 TESGFTEDkksNEDTSTNFVTIkqekellkclcdTLNAIAHILFLKHC-------------------------------- 401 Schizosaccharom...
CCU77470     352 ESRG-------KDDFFASGIHT------------ALHLGLTWSHRLVR-------------------------------- 380
EPE26918     349 -----------EDDHIAQGLCL------------SLQLLLSYAHRQNH-------------------------------- 373
Q7SI24       357 RAPL-------PGDLDAETASI------------TLHLLLSNAHRQNQ-------------------------------- 385 Neurospora crassa
EHK45765     396 EQDM-------PENGLAEKISM------------ALHILLSYAHRYNE-------------------------------- 424
EON65248     359 YDGH-------TQDAFAERVAL------------ALRVLLAHGYRQRL-------------------------------- 387
CBX99790     376 SQSQ-------SHNWLAQNVAE------------GLRLLLAHEHSMRL-------------------------------- 404
EPB84714     411 VAANHTPAkltSQQIISRSIDL------------SFRLLLLQHQRFNLwktkakilssnhkihqllsdtavgsstassaa 478
5SVA_P       521 -----------------------------------------------------RSR---ISSPHg--LINLNVDDDILII 542 baker's yeast
XP_002172173 385 -----------------------------------------------------RET------QKfslKHLRQNPIPASIL 405
P87306       402 -----------------------------------------------------RKSdrrSQQPElymAIDANAP---LIL 425 Schizosaccharom...
CCU77470     381 -----------------------------------------------------RRRa-qPPQPVt----SNPLPEPCSLM 402
EPE26918     374 -----------------------------------------------------RRRt-lPPPPIsgqKRTNP---PYNLL 396
Q7SI24       386 -----------------------------------------------------LKR-----SERtaaNAMRGPPPPYNLL 407 Neurospora crassa
EHK45765     425 -----------------------------------------------------LMRirpIPPHIsrsTRQQS----YALL 447
EON65248     388 -----------------------------------------------------HLRs-qVPPPMtdkERK---PPVTAIL 410
CBX99790     405 -----------------------------------------------------YRRs-qVPPPLtarAQEKPPPP---LL 427
EPB84714     479 tpvnttattnaptptnsgngatgapaptpttatsgnvlpivgtsssvstasraRTR---LAATAttaTATRDLPSQIPIL 555
5SVA_P       543 RPILGKVRFANYKLLLKKIIKDYVLDI 569 baker's yeast
XP_002172173 406 RPLIFLFSTNRLAHSFQTWLQEHnipf 432
P87306       426 RPLIFYYNLNQESLEFQRWLKQRDISF 452 Schizosaccharomyces pombe 972h-
CCU77470     403 RPILTRLVHERTISEVIAFISPLTASL 429
EPE26918     397 RPIITRLGHQRTVNTLTTLLRDLTSLL 423
Q7SI24       408 LPIITYYRHEKTLEDCTTFLAAFCGAL 434 Neurospora crassa
EHK45765     448 RPVLARTMYLKNVEESMQNMGLLVRTL 474
EON65248     411 RPLLTVLQHWRDVGLLREYLKTTCTAR 437
CBX99790     428 RTLLAVFRHLESVDSLYVYLETLKRTL 454
EPB84714     556 SPIMSLTRFWVQFDRIRHVTNKTIREY 582
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