Conserved Protein Domain Family
RXLR
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pfam16810: RXLR 
RXLR phytopathogen effector protein, Avirulence activity
RXLR is a family of phytopathogen avirulence or effector proteins. RXLR proteins are defined by a secretion signal peptide - not in this family - followed by a conserved N-terminal domain with the sequence motif RXLR (Arg-Xaa-Leu-Arg) consensus sequence. The RXLR part is required for translocation inside plant cells, although it appears to be dispensable for the biochemical activity of the effectors when expressed directly inside host cells. The effector activity resides in the C-terminal part of the family, which activate effector-triggered immunity in plants that carry a corresponding resistance (R) protein. The C-terminal region exhibits a fold appears to be able to evolve to outwit the host as the latter tries to acquire new immunity.
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Statistics
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PSSM-Id: 465277
Aligned: 18 rows
Threshold Bit Score: 70.9644
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002899701   1 MTL-----VVLATVLLLSGTAVSNADRASVLNVDAVHSsni----------ltAEEKRFLRSHQttdDEg--------eN 57 
7_pfamImport   1 MHLgfvslAIALVVLASCDAASVDQTKISMMTTAGVTKaes----------rpLVDARSLRGYKlseAEddertinvsaS 70 
6_pfamImport   1 M--------------------------------ATVGKidae--------grvLADNRSLRGYKrteAEdedr--aisaS 38 
XP_002904569   1 MQLryillLAAATLATASSTTSAASGTRDPKTPTVASNhhiek------tvtaQADHEFMRSLL---------------E 59 
KAH7499791     1 MHLryilmMVVATLAASSSIVSAASVSDDVKILSAGQAfr------------vHENKRFLRTTP---------------H 53 
D0NYP1         1 MRMhsvlmMVVATLAIANGSVSAAGGSNLRKAKATSSInsfnt------vqteAKNSRMLRNTDvatGEnghvyyypakK 74  Phytophthora in...
EEY53939       1 MHLhcvlmVLVAILAASNGAVSATIVKEDSEHVKINRAhsiqt------lqtdTRRKRFLRTED---KFntdyyydpakR 71 
XP_002894699   1 MRLylilsASMVISYFVTCNAATSS---DQTKLSRMEPsllvhsl-gaalnvdAVDRRFLR------------------E 58 
D0NPN8         1 MRLaimlsATAVAINFATSSAI------DQTKVLVYGTpahy--------ihdSAGRRLLRKNE---------------E 51  Phytophthora in...
EEY58095       1 MRVsyvllVAVATLLITCD--------------VVSAQpstlslpasdgamieDTNNQPLRLLEi--------------T 52 

XP_002899701  58 NEHVGEERAGGANLLA--------------------------------GLKLQKMGRDTSYRDKVFQRWKNYGKSVEDVS 105
7_pfamImport  71 IDDVIKRLNAGKIALDyvvnlkkldkkvlrafkrlptkensylnkvfvQPKLDKMLKDEKYAQKSFLEWYALGFSGETIK 150
6_pfamImport  39 LDDVILKLNAGKSSLQhvvdvkaldkavkkafkqisaqkksylekvftESNLDKMLTNEKHAEATFLEWYALGLTGKRIT 118
XP_002904569  60 DDDNSATQGQtf-----------------------------------mEHKLKKMLTNPKKAKQLYQHWHKKGYTAKQVA 104
KAH7499791    54 RKQTESEKEAGPvf---------------------------------mEHKLEKALSNPKKTKRLYQSWYTRGITAKEVS 100
D0NYP1        75 GERKPf-----------------------------------------iEVRLKKALSNSKKVNRLYEDWYKSGFSTKKVA 113 Phytophthora in...
EEY53939      72 DDHRSaf----------------------------------------iENKLEKSLTNPRKTTKLYEQWYKRGYTLKRVS 111
XP_002894699  59 RKESMEERGYhltl------------------------------kgevKALAKKIIADFDTADDVYKKWNENGHSLNKIA 108
D0NPN8        52 NEETSEERAPNFNLANlneemfnva---------------alteradaKKLAKQLMGNDKLADAAYMWWQHNRVTLDQID 116 Phytophthora in...
EEY58095      53 TADDGEERMAEARLMD--------------------------------SEILEKIVNDHAYAKQVFRSWLQNGQTKEDIE 100

XP_002899701 106 DHVPSSLTQaf-eiYLRMRKntGKVYTRPH 134
7_pfamImport 151 SRLGGVGAH-----FDTLFTq-YTVFVSRI 174
6_pfamImport 119 SSLAGVGAH-----YGTLFAq-YTTFINRF 142
XP_002904569 105 SDLGQTENRaldqtYKKIAKe-YAAFVKEQ 133
KAH7499791   101 HSLAQSENRelnktYKKLASg-YAAYVKEQ 129
D0NYP1       114 KELNQSENRelketYKTLAIg-YTAFVKGK 142 Phytophthora infestans T30-4
EEY53939     112 SGLNQDENRelqrvYQELAHg-YAAYIKKE 140
XP_002894699 109 NLLKVSEKEkyvpvYNG-----YLAYLNRI 133
D0NPN8       117 TFLKLASRKtqgakYNQIYNs-YMMHLGLT 145 Phytophthora infestans T30-4
EEY58095     101 NRLKTLGll---tkYGNVVKq-YAQYLTVL 126
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