1GL2


Conserved Protein Domain Family
SNARE_Syntaxin8

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cd15852: SNARE_Syntaxin8 
Click on image for an interactive view with Cn3D
SNARE motif of syntaxin 8
Syntaxin 8 forms a complex with syntaxin 7 (Qa), Vti1b (Qb) and either VAMP7 or VAMP8 (R-SNARE) and is involved in the transport from early endosomes to the lysosome. Syntaxin 8 is a member of the Qc subgroup of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins, which consist of coiled-coil helices (called SNARE motifs) that mediate the interactions between SNARE proteins, and a transmembrane domain. The SNARE complexes mediate membrane fusion, important for trafficking of newly synthesized proteins, recycling of pre-existing proteins and organelle formation. SNARE proteins are classified into four groups, Qa-, Qb-, Qc- and R-SNAREs, depending on whether the residue in the hydrophilic center layer of the four-helical bundle is a glutamine (Q) or arginine (R). Qa-, as well as Qb- and Qc-SNAREs, are localized to target organelle membranes, while R-SNARE is localized to vesicle membranes. They form unique complexes consisting of one member of each subgroup, that mediate fusion between a specific type of vesicles and their target organelle.
Statistics
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PSSM-Id: 277205
Aligned: 24 rows
Threshold Bit Score: 69.1816
Created: 4-Apr-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
heterotetramerzero layer
Conserved site includes 40 residues -Click on image for an interactive view with Cn3D
Feature 1:heterotetramer interface [polypeptide binding site]
Evidence:
  • Structure:1GL2, Rattus norvegicus endosomal SNARE complex, contacts 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              ## ### ## ### ###### ###### ## ### ### ## ### ## ### 
1GL2_D         4 MQEQDAGLDALSSIISRQKQMGQEIGNELDEQNEIIDDLANLVENTDEKLRTEARRVTL 62  Norway rat
EFX79879     152 MADQDRGLDELSRIIGRQRQIAQTIGDEVESQNDLIENIADNVDRTRDRMAQQTSTITV 210 common water flea
CBY24816      16 INQQDQALDDLATIIRRQRDIGITIGNEVDDQNVVIDNITDMTENSRGRLNRNTENIDN 74  Oikopleura dioica
XP_001750756 145 MDEQDRGLSTISASAQRLKQVGMAIGDELDDQNEMLDELGQGMDITDRRLKRETEHVVY 203 Monosiga brevicollis MX1
XP_002431297 161 LKEQDQGLENLLKIVSAQKQIATSINDEVEHHNEILVDIADGMERVDGRINRATDMVQV 219 human body louse
XP_003426427 161 LQEQEQGLEQLSKIISRQKQIAQAIHSEVDNHNEIIDDLADHIDRTDERLIDGTRQVRT 219 jewel wasp
NP_524113    147 LAQQNEGLEVLSATLSRQRQLATQLGNEVEDQNNILDNLANAMDRVETGVQRETQSIGQ 205 fruit fly
EDS36549     150 LEDQNEGLDALSKVISRQKELASRIGGEVDRHNDILDDLATTMETTDARLDRETRQIGV 208 southern house mosquito
AEE62423     148 LSDQEKGLENLSKIISRQKDIAHTIANEVDFHNEIIGDIGIQIDRTDQRVRVETERVGT 206 mountain pine beetle
EGD83556      41 IGQQDQALGRIADTAKVLQHYGRQIGDEVDDQLDMMEDLEDGMHHTSKRLKRETQHVEY 99  Salpingoeca sp. ATCC50818

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