Conserved Protein Domain Family
viperin_w_prok

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NF038283: viperin_w_prok 
viperin family antiviral radical SAM protein
Homologs of a viral defense radical SAM enzyme found in Homo sapiens, viperin (RSAD2), occur in prokaryotes with a strong bias toward placement in phage defense islands, encoded next to CRISPR system and restriction enzyme genes. Further investigation shows members indeed perform the anti-viral function of synthesizing modified ribonucleotides such as ddhCTP, ddh-guanosine triphosphate (ddhGTP) and ddh-uridine triphosphate (ddhUTP). Those non-standard ribonucleotides can interfere with viral replication machinery.
Statistics
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PSSM-Id: 468450
Aligned: 123 rows
Threshold Bit Score: -1
Created: 24-Apr-2023
Updated: 3-May-2023
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_012852367      11 VETVNFHLWQPCNMSCLFCFATFRDVrrtvlpqgHLDRRD-AERVVRLLAEAGFSKITFAGGEPLLCPW---LPDLVEL- 85  Thermomonos...
5_ncbifamImport    1 KLKVNLHLIEACNYRCRHCFAHFDKhn------vLTPETWiNIIDNAVA-SGMVTSFNFAGGEPLLYPHltsLAEYANS- 72 
93_ncbifamImport   1 KYKVNLHVLEACNFRCFHCFSRFGSnk------iMGLKDWkQIVDNCME-SQVVSEFNIAGGEPLLYKDligLTKYIRE- 72 
9_ncbifamImport    1 ASIINLHLLDACNYRCGHCFAHFNMpk------vLPLEQWkRVIDNIIA-NSDVKRFNLAGGEPLLYPEidnLIRYIAS- 72 
10_ncbifamImport   1 AYKVNLHITQKCNYACKYCFAHFDNnn------dLSLDQWkHIIDNLKN-SGIVDAINFAGGEPVLHKDfpaIVSYAYN- 72 
78_ncbifamImport   1 AYKVNLHITQKCNYACKYCFAHFDHhn------dLTLGQWkHIIDNLKT-SGLVDAINFAGGEPVLHRDfaaIVNYAYD- 72 
95_ncbifamImport   1 NKIFNLHFTDFCNFNCRCCYAKKDKNcls---fdDIQKIIeNIAGYFEKHGITDGRVNIAGGEPTTSKDlqkIIDAVVS- 76 
WP_008725214       6 SLKLNWHFINNCNMHCKFCYASk----------dICNIDLfKIASILK----PFKYINLVGGEPTIYKN---YIPLLYY- 67  Brachyspira...
6_ncbifamImport    1 -LTVNWHFTAACNFKCRYCFMHNSl--------sLTRKDYmVVLKKLTG---SFQRINFVGGEPTVSPL---LIPLVRD- 64 
8_ncbifamImport    1 SIKLNFHFSMFCNMRCKFCFYAPLIAk------aKREDNLnNWLEIIKK-VAFFKAINFAGGEPTLYWNq---LKQMAKl 70 
WP_012852367      86 ACDLGVTTALVTNGSLLDEA---MLDRLAGTLEWITVSIDSLRPRTLRSLGRATAGr--VMDEAGYLALCRRIRQRG--F 158 Thermomonos...
5_ncbifamImport   73 ---LGCKCSVITNGSCIDEEw-iK--NNVSLFTTIGFSLDSFFPDTLRKIGRCDTNg-rVLDLDRIKEIFTLIKKYNpsI 145
93_ncbifamImport  73 ---KGAKVSMITNGFLMNEEw-iQ--KYGQLFNTIGFSVDSVNDETNQKIGRCINTg-sVISASRVTKLCELIRKYApdC 145
9_ncbifamImport   73 ---KHIETSIITNGLLLNENr-iN--FFSGMVSMVGISIDSLNDETLRRIGRCTYKd-eLLNHSHCVSICKSIKTHD--I 143
10_ncbifamImport  73 ---QGFRLSLITNGSLMLNPn-lMPPELFKRVDTLGISVDSINPQTLIALGACNKSq-eVLTFDKLTQLIALALSVNpnI 147
78_ncbifamImport  73 ---QGFKLSIITNGSLMLNPk-lMPPELFAKFDTLGISVDSINPKTLIALGACNNSq-eVLSYDKLSHLITLARSVNptI 147
95_ncbifamImport  77 ---KGIKASLITNGILLTEE---FVRENAGKLTMIGLSIDSLNDGTNRILGRCEGVggrVFDYGRLVAICRCIKECG--I 148
WP_008725214      68 LKSQNHILSIVSNGSMLLKDk-sILNATLECCDVIGLSIDSLDKETCLKIGRSIGNs-sTITEKEYLYLTSKIKESG--K 143 Brachyspira...
6_ncbifamImport   65 AYHAGFDCSIVTNGFNLIHHt-qQFEAIYPLLSCIGISVDSLNKETNAAIGRCCKGh--VITRTEYEQLCAAIKSHG--I 139
8_ncbifamImport   71 CKELGLKVTLITNGTVIKNKsqnEVNDLLQYFNSVGISMDSIDLNINQNSGRAIGNk-sALSEDDYLEVGAKIKKAG--C 147
WP_012852367     159 RLKVNTVVTSRNWREDLSGFIVAAGP--ERWKVFQVLPVEGQNsrkvdpLLITPEQFESFISRHLhvel----------- 225 Thermomonos...
5_ncbifamImport  146 KIKVNTVVSAINKDETPGELIRKHDLpvDRWKILRMSPFENDRfsn-kdITVTDEEYTEYITRNLsafgintisekvlyn 224
93_ncbifamImport 146 KIKINTVVTTRNRDEQLSDFIDTIKP--DRWKILKMKTFVYGTfsn-msLQVSAAEFDEFVRQNKivne----------- 211
9_ncbifamImport  144 KLKINTLVSTLNKNEDFHSFIKEVQP--DRWKILKMKHFENAQynn-kiFIPNNYDYESFVARHSd-------------- 206
10_ncbifamImport 148 RIKLNTVITKLNEKEDLTIIGKQLNI--ARWKFLRMKLFIHNNfnn-spLLSNQGEFDNFVARHTkv------------- 211
78_ncbifamImport 148 RIKLNTVITNLNADEDLTIIGQELDI--ARWKMLRMKLFIHEGfnn-apLLVSQADFDGFVERHAev------------- 211
95_ncbifamImport 149 TLKINVVASKLNFNEDIKRLLDDVRP--KRFKILQMLPTTPFAee----nALSESEFDKYVQKYDgy------------- 209
WP_008725214     144 ELKINTVVNRYNYKENLNSFIEKTLP--NKWKIFQVLPIENlns--ckeLLISDEEFNYFLNTHAane------------ 207 Brachyspira...
6_ncbifamImport  140 RLKINTVVSKLNVHEDFTHFYEAVQP--DRIKLFQVLKPNTQLkndygdLLITKADFNSFVLRHKtags----------- 206
8_ncbifamImport  148 QLKINSVVHSLNKNTRMIDFIEKIDP--YKWKIMQVSSVGQEFhk---dFIISKSDFDKFLEINDiknk----------- 211
WP_012852367     226 agiaLIPEDNDAMTGSYAMVDPAGRFFD-AVEPGgYRYSEPILRVGVHRALSQVTVSRAKFLARGG 290 Thermomonospora curvata
5_ncbifamImport  225 tdagMEIVCESNLNGTYIMIDAGGYLVDdTKNSN-YVRVINCADTPFSDGISKLTFDSEIYEARYK 289
93_ncbifamImport 212 ---ktrIVVEPDMKASYILIGPNGWLLDnAANEMtPVEICDCKKEKLKEGLKKLTLDEKRYCNRYA 274
9_ncbifamImport  207 ----MPLIAEREMKNAYIMVDAWGNLVDtGTENN--AIVASLLEIDFAESFSRLNFNYDVYNQRYV 266
10_ncbifamImport 212 ---sRDVVPENDLTRSYIMIDNQGQLLDdETENY--NVVGSLLTEDFTKVFARYSFDESTYASRYA 272
78_ncbifamImport 212 ---sHDIVPENDLTRSYIMVDNQGRLLDdETEEY--KVVGSLLAEDFGTVFDRYHFDEATYASRYA 272
95_ncbifamImport 210 ---nPVTEKQENIKKAYLIIDSSGFVTTnNLHFD---KKHNALEKSLDEILDDIDFDFESEAARYK 269
WP_008725214     208 --riIYSENNNNMTSSYIMLDAKARFFNnIDNKYiYSKSLLEDDADLYEEFFKMNYSIDKYYNRYK 271 Brachyspira hampsonii
6_ncbifamImport  207 fgenIVAEDNAAMTNAYYILDSECRFIDnKTGK--KSPSLANDGMTVEKALSYIEVDAAKYQARYI 270
8_ncbifamImport  212 hsfvKSIEDETTVTSTYVMIDGEGYFYNsDQIYNkNNKSILKENVDVLEEFNKCNFDINSQLDRYK 277
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