Conserved Protein Domain Family
MAP7

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pfam05672: MAP7 
MAP7 (E-MAP-115) family
The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.
Statistics
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PSSM-Id: 461709
Aligned: 45 rows
Threshold Bit Score: 46.1871
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
A2AG50       438 KPTAGTTDAGEAAKILAEKRRQARLQKEQE-EQERLEKEER-----ER---LEKEELKRKAEEERLRI-E---------- 497  house mouse
EEN45793     568 KGKAVLTDEEAAKAALAERRRMVREQREREaELERQRQEEE-----KR---RAEEEEKRRLEEEA--RiEe--------- 628 
EFA11334     354 VTKIRINTEEEAKAALAERRRLAREEAERQaEQERLRIEME-----AQ---AELE--RQRREEEQIQR-Li--------- 413 
EFN71814     427 IAKIRITTEEEAKAALAERRRLAREQAEREaELERQRQEEE-----AR---LEAERLRAEEEEQR--RlEe--------- 487 
XP_026037625 421 KVAAGTSNAEEASRLLAERRRQARAQKELE-EKKREQQEEE-----GR---LPEE--RKQLAQEQQRQ-Ep--------- 479 
XP_023198537 414 KVGAGTTNAEEATRLLAERRRQARAQKELE-ERKQEKEQE------ER---LREEEQKKQLAQQLQGQ-Qa--------- 473 
9_pfamImport   1 RVAAGTINAEEATKLLAERRRQARAQKELE-DRKRELEEDErfkssERffrHREEQRQKKLAQERQQQ-Ea--------- 69  
XP_001342278 322 K--AGTTDAEEASRLLAERRRLARVLKEQE-EKQRLEDE--------R---LRVEELQRQQEEERQRQ-Ee--------- 377 
XP_015196643 114 KPIAGTTDAEEASRLLAERRRQARLQRELE-ERQQREQEEA-----ER---VRAEEERRKVAEERARQ-Ee--------- 174 
XP_016282663 472 KTGLETISAEETDKTLIEKQQSVPDQKDQE-EGGKDLKEEE-----ER---KVKEETEKKAIEAE----Eerdaghtqlg 538 
A2AG50       498 MAYKREQEKKRQEE-------EEKRKAEEKak--ekAEEELLSkekqekEKQEQ---EKkekamiekQKEAAEAKAQDAA 565  house mouse
EEN45793     629 EQRRLAEEYKKAEE-------ERLRKAIEEaekqkrEEEEKQK------ELER--------------QREEEERKAREEA 681 
EFA11334     414 EAQRLAEQERLEEA-------IRETKRREE--------EERLR------REEEQr-sKL--------LKEEAERKAREEA 463 
EFN71814     488 ETIRLANEARKAEE-------QRLQLAIEEak--rrEEEDRRK------REEEA---RQk------qEKEEAERKAREEA 543 
XP_026037625 480 VNQQVKERGRREAD-------AHLKQEEEK-------WKKEQQ------EKELQaqmDR--------EREKAKVLAQEDV 531 
XP_023198537 474 KVQQGEVRRNNVMD-------HHRLKLEED---------KRKE------EQQEVq-iVA--------EKDKAKVQAKEDT 522 
9_pfamImport  70 EALKLKERGKREEDlnrvkqeEDNRKKEDQ-------------------EKQLQsqmDK--------EKETAQVQAQGDA 122 
XP_001342278 378 ENRLAEEKRLRQEE-------QRCQREMED------RHQKEQR------WKELQddlER--------QREEAVQRVHREA 430 
XP_015196643 175 EARRAEEERLREEE-------EQRLREEAE------RQQRERQ------ARELQarlDR--------EREEAEARAQQEA 227 
XP_016282663 539 ETSPPEEQQQKTEE-------DQERLAae---------------------------lQQ--------QKEEAEVKAQEEA 576 
A2AG50       566 KQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDaSLE 605  house mouse
EEN45793     682 EKRQRELEERLAKEEQERQERKKRLEMIMSRTRKSG-TPG 720 
EFA11334     464 EKKFAEQQERLKNEEKEREARRKRVEAIMRRTRGVN-NAN 502 
EFN71814     544 EKQRIEMAERLKKEEEERNARRKRVEAIMLRTRGRN-QSN 582 
XP_026037625 532 ERQRQDRELQTQQEEEERQQRKKRIEEIMKRTRKGE--AE 569 
XP_023198537 523 ERQRQGREQQTQQEEEERQLRKKRIEEIMKRTRKSE-ADM 561 
9_pfamImport 123 ERQRQGRDLQAQQEEEERQLRKKRIEEIMKRTRKGE--AD 160 
XP_001342278 431 ERKRQERELLKIQEEQERLQRKKRIEEIMKRTRKPD--GE 468 
XP_015196643 228 ERLRQERELQQLQMEQERLQRKKRIEEIMKRTRKSD-TFE 266 
XP_016282663 577 ARQRRERERIMEQSVQERLERKKRIEEIMKRTRKVE-QNS 615 
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