Conserved Protein Domain Family
DUF6345

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pfam19872: DUF6345 
Family of unknown function (DUF6345)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000703) is described by MIBiG as an example of the following biosynthetic class, saccharide, in particular the kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus. This family appears to be predominantly found in bacteria and archaea.
Statistics
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PSSM-Id: 437704
Aligned: 27 rows
Threshold Bit Score: 171.389
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
RQO59837                6 IDGIRYFNharaagvsTASDLSYTFNRCNGFDAKLRSA-GHARNFYW----ANTDCWETDIRDSDRGGDDVHY---VDNV 77 
WP_056025402            7 TEWINAYN--------NLNVLTHEHEDAGGFYDELRVHdGATGKFNW----GDGNAFEDDFKANARGGHADQW---VEQA 71  Cellul...
KNZ34153                6 IEWINDFPtp-----cTQNQLSNCDETSVGFQDGMASR-GHVRAFNW----GNGNAFERDFRDPANGGDDSNW---ADDV 72 
PVX25764                6 TEWINKFPap-----cNQKQLSHCDETSQGFGSAMRSR-GHTWKFDW----GNSNAWETDWRDSAFGGADNNTqggADSV 75 
WP_015206344            6 IEGIRSFSnaraagvsTAGDLTYTFNICNGFDSKLRSA-GHTRSFYF----ANTDCWETDIRDSDKGGDDVNW---VDNV 77  Cylind...
PIL45240                6 VEGIRYFNharaagvsTAGDLTYTFNRANGIDGKLRSA-GHARAFYW----SNTNAWETDIRDADKGGDDVNW---VDDV 77 
OON64188                6 VEAIRYFNharaagvsTAGDLSYTFNRSNGFDAKLRSA-GHSRAFYW----ANTDVWENDIRDVDQGGDDRAW---VDNV 77 
KGF80322                6 VEAIRYFSharaahvdTAGDLTYTFNRSNGLDNKLRGA-GHTRAFYW----ANTDVWETDIRDSDQGGDDRHW---VDDV 77 
Prokka:IMCC3135_33405   7 SWWIKD-------------GLVGRRIEAQSFASTF----DLIPGFDWtedhGDSNVKEKDFVVTTN------YdekTDNV 63 
WP_035947430            7 SWWIKD-------------GIDGRRLEAEGFASTL----GGLAEFDWtqnhGESDVKESDFVTTAS------TmqrSDQV 63  Knoell...
RQO59837               78 DIFWIETHG------------GHESNGQARmlfdaqqtawRTYSgswQLGENwNAEWIMAYSCDTV--------DRGNVA 137
WP_056025402           72 DIVYFTGHGspsgf---yfrsDVPDDSQVRgdftstsagnDGDL---RLGHG-DLEWLGLEVCNTLqmdafqqgANRDVF 144 Cellul...
KNZ34153               73 DFVHFSSHGgtsgnvfsgnfgRRVDRCTWR----------SDEA---RFGNK-ELEYLCLDACNSLd-------LSGDIV 131
PVX25764               76 DFAYLSSHGgagsnnfvaafgIQHDKCLWN----------NREG---RLGNW-NLEWVVMDTCESL--------QLPSPQ 133
WP_015206344           78 DIFWISTHG------------NHTSDGQARllydiprknwRTFSgqwQLGENwNAEWVMAFSCETV--------DRNNVS 137 Cylind...
PIL45240               78 DLFWIETHG------------NHEADGRARllydtaqtnwRTFSdqwQLGENwNAEWVMAYSRDTV--------DLNRVT 137
OON64188               78 DLFWIETHG------------GHEADGRARmlydiarsnwRTYSntwQLGEDwNNEWVMAYSCETV--------NLERVT 137
KGF80322               78 DLFWIETHG------------NHDDAGHVVllydtpvtewLANSarwQLGEDwNNEWVMAYSCDTA--------ALPTVT 137
Prokka:IMCC3135_33405  64 DCLMMSSHGspgrfsvwdgsvSTSDSV--------------------AFGAG-DLEVWASHACQVLk------hDSNNRV 116
WP_035947430           64 DAMQMSSHGwqdgflvwggsvDTSEAV--------------------DFGKN-DLEIFATHACDLLh------hGSDNSV 116 Knoell...
RQO59837              138 GLW-NIFAGLHIYCGAWDNMYDgitTDECGEDVGDNLI-----------------HGHTVCHAWHDGVSdwwvDNHPITV 199
WP_056025402          145 DRWaDAFEGLHALLSFTTTSLD---LANPGRAFASALDgrwltamygipeflvgrRPMRVVDAWFWMAQ----FTQPDWV 217 Cellul...
KNZ34153              132 ATWrGTFHGLRMIFGFTDLVSDswwTAGRGHAFGRRAG-----------------NNERLTNAWLDEGYsfwcDDNP--V 192
PVX25764              134 NRWhHCFHGLHMVLGFTGGASDswwTDDRGWDFGRRAG-----------------AGAKLSDAWLDEAYswwcDDDP--V 194
WP_015206344          138 GLW-NIFAGMHIYCGAWGKMYDgitTDECGEDVAENLI-----------------NGHTISEAWIDGVSdwwvDNHPITV 199 Cylind...
PIL45240              138 GLW-NIFARLHIYCDAWGTMWDgttTDECGEDVGDSLI-----------------HGDSVSHAWHDGVSdwwvENHPITV 199
OON64188              138 GLW-NIFARMHIYCGAWGNMWDgvtTDECGEDVADNLV-----------------DGDTVCQAWHDGVAdwwvDNHPITV 199
KGF80322              138 GLW-NIFARMHIYCGAWDLMWDgitTDECGEDVGDNLV-----------------HGDTVAHAWHDGVSdwwvDNHPITV 199
Prokka:IMCC3135_33405 117 WDWiPAFEGLHYMCGFHTNSYSgggRDQRGFWFAWYGGvahal-------msgffTHYPIRTAWKKANR----MVEGSNV 185
WP_035947430          117 GRWiPAFSRLHYMLGFHNSSYSgggQNARGQWFAMYAAwffygp-----lswlfkIDMPVREAWAEANE----IVEGSNV 187 Knoell...
RQO59837              200 CVGDSATWNNGniqwgrSYLNRDHLWGHGNVDPDLPpsrqacilfmwTE 248
WP_056025402          218 ESAVLYANSSG------TNTGADFLHGHGFVSSDPQ-----------RG 249 Cellulomonas sp. Leaf395
KNZ34153              193 AMAAGRNQADAl-----NRRDNERLGGGFGDIPNsqvg-----wfawRW 231
PVX25764              195 AMACGRNKEDAk-----NRLYNERITSYFNDIPNseir-----wywwRW 233
WP_015206344          200 CVGDADTWNGGnikwerSYLNRDHLWGHGNVDPDLPpakqscilcrwAE 248 Cylindrospermum stagnale
PIL45240              200 CVGDAATWNKGnirwdrSTLNRDHFWGHGSVDPDRApaqqacilwywTE 248
OON64188              200 CVGDAATWNGGairwdrSYLNRDHLWGEGGVLPDLSlaeqacilwywTE 248
KGF80322              200 CVGDAATWNNGairwnlSAINRDHLWGHGTVTPDLApaqqacllwywTE 248
Prokka:IMCC3135_33405 186 EWAYLRASGTSdsg-vtANTYNEKFTSGEPTDPDrsrt-----fhwtRG 228
WP_035947430          188 QWAYLRAEAPG------APTYNERLRVAETTDPVsnrs-----fwtaRG 225 Knoellia flava
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