1MAT,1O0X,1QXW


Conserved Protein Domain Family
MetAP1

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cd01086: MetAP1 
Click on image for an interactive view with Cn3D
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
Statistics
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PSSM-Id: 238519
Aligned: 69 rows
Threshold Bit Score: 269.363
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1MAT; dinuclear cobalt center
  • Structure:1QXW; bound aminoketone inhibitor in the active site

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                         #           
1MAT       11 IEKMRVAGRLAAEVLEMIEPYVkpgvsTGELDRICNDYIVneqhavsaclgyhgypkSVCISINevVCHGIpddakLLKD 90  Escherichia coli
Q11132     10 VEQIRQACKIFQEAKAYFTIERllgksLTAIDQALKQFIEskgatcaf-hkyqnfpgFNCLSLNetVIHGIad-nrVFGV 87  Mycoplasma pneumoniae
P56102     11 IKALRKAGELTAQALALLEREVrpgvsLLELDKMAEDFIKssharpaf-kglygfpnSVCMSLNevVIHGIpt-dyVLQE 88  Helicobacter pylori
NP_078086  10 IAAIKEAVRIWKIAREAIYKQAkagvsLKELDLLAKEVIEanggiaaf-hnylgfkgHICISVNecVIHGVpt-dyVLKD 87  Ureaplasma urealyt...
NP_282779  10 IEKLRIANQIVAKTLNFLENEIkigmsLKQIDKMAEDYILslgakpsf-kglygfpgAICTSLNqvCIHGIpd-dkIIKE 87  Campylobacter jeju...
NP_326397  10 IELIKKSCQILAEVKKVIYDLIrpgvsLKELDSIAFKEIVkrgakpaf-kgymgfpaTICASLNeeLIHGIpn-erVLKE 87  Mycoplasma pulmonis
NP_758378  10 IEQIKKACSVWKKVRQALIENAaagksLIELDELAKKVTIendcttpf-hqyrgfpgYNCISVNdvVIHGVpt-nyKLKD 87  Mycoplasma penetrans
NP_860929  11 IESLRIPNKIVAQTLELLRLEAkegisLLELDRKAKDFIIsqggrpsf-yqlygfpqSICISVNqvIIHGIpt-dyILKN 88  Helicobacter hepat...
O52353     10 IQKIKNAAQIYKKIVKQFNFDYiknksLKEIDQMLRDFVSqhhanscy-hgylgfkgYHCLSLNqtIIHGLan-deIFTS 87  Mycoplasma gallise...
NP_907824  11 IKALASANRIVAQTLSLLREHAkpgisLLELDKIAEDFIRsqgarpsf-kglygfpgAICTSVNevIIHGIpn-gyQLKE 88  Wolinella succinog...
Feature 1           #          #                                                              
1MAT       91 GDIVNIDVTVIKdGFHGDTSKMFIVgkptimGERLCRITQESLYLALRMVKPGi-nLREIGAAIQKFVEAegfsvvREYC 169 Escherichia coli
Q11132     88 KDKLTLDIGINLnGYICDAAFTVLGpkapepMQTLLEVTEACFTAVVEPQLRPnnpTGNVSHAIQTYFESkgyyllKQFG 167 Mycoplasma pneumoniae
P56102     89 GDIIGLDLGVEVdGYYGDSALTLPIgaispqDEKLLACSKESLMHAINSIRVGm-hFKELSQILESTITErgfvplKGFC 167 Helicobacter pylori
NP_078086  88 GDKVTFDVGVKYdNHYCDAAFTIIInnsnveALKISEICKKSIDEAVAIIKPKv-tTHAISNAIQKFIEKngyfvlRDFA 166 Ureaplasma urealyt...
NP_282779  88 GDILGLDVGSLIdGYYGDAARTIAIgevspaDKALISCAKDALYHAIDIIRDGm-rFKELSAALGEFIHVrgfvplRGYC 166 Campylobacter jeju...
NP_326397  88 DDLISIDIGVIYkGYYSDSAFSKSLspeneeNAFLINVAKVAFEKGIKAIKKGa-tIGDIGYAIGKYLDSqkvftpREYS 166 Mycoplasma pulmonis
NP_758378  88 KDMVTFDVGVAYnGYICDAAFTVIIgen-veAQKINDVCYKSLIEGIKQIKPGn-rIGDISNAIEEYVVSngyyilEDFG 165 Mycoplasma penetrans
NP_860929  89 GDIVGIDIGVEYnGWYGDAAITIGIgdiqetDRILIDCAKDTLYEAISKVKIGm-rFKELSLILEQAINGrgfvplRGFC 167 Helicobacter hepat...
O52353     88 KDKLTIDIGIELdNYYCDSAFTILGpdvnprQKLLSEVTHNCIFELVKKIVPNqttTNDLGIWTEEYAKKygysviKDFG 167 Mycoplasma gallise...
NP_907824  89 GDILGVDIGTEYkGWFGDGAATFGIgavtqnDEALMACSRDALLYAIDSIRVDm-rFKELSHLIEQFILKrgmvplRGFC 167 Wolinella succinog...
Feature 1      #                                    #                                #        
1MAT      170 GHGIGRgfheepqvl----hydsretnvVLKPGMTFTIEPMVNAgkkeirtmkd--gwtvktkdrsLSAQYEHTIVVTDN 243 Escherichia coli
Q11132    168 GHGCGIkvheeplil----nygkpdtgtKLEPGMVLCIEPMVMTdsdamvmhnn--swnvltpksrYNCHVEQMYVITTS 241 Mycoplasma pneumoniae
P56102    168 GHGIGKkpheepeipnylekgvkpnsgpKIKEGMVFCLEPMVCQkqgepkilad--kwsvvsvdglNTSHHEHTIAIVGN 245 Helicobacter pylori
NP_078086 167 GHGCGNeihedplipn---yrsllyrnvTLEENMVICIEPMILSgsnayyidpnd-qwsvksknhqMTCHWEHMILITKD 242 Ureaplasma urealyt...
NP_282779 167 GHGIGRkphgepeilnylekgasaksgpKIKNGMVFCIEPMICQkdgtpkhyng--kwdagsidglNAAHYEHCVAVING 244 Campylobacter jeju...
NP_326397 167 GHGIGSalhespyvf----nraprgsgmKIRNNMVICIEPMILQkspqvytked--nwtvvaksglKSSHYEHTVLIQDW 240 Mycoplasma pulmonis
NP_758378 166 GHGCGRklhedpiil----nygvknsgpIIKPNMVLCIEPMILTedasyyidkd--kwsviasnhkLSCHWEHMVLVTNE 239 Mycoplasma penetrans
NP_860929 168 GHGIGRspheepeipny-lesphtnqgpKIKEGMVFCLEPMIAQhngepvilnd--nwsviakdglNGSHYEHTIAIVDG 244 Helicobacter hepat...
O52353    168 GHGCGIkihedpiil----nygtkksseLLTPNMVICIEPMFFEkdnryyidpddswsvkpvnknqYVCHWEHMVLIKED 243 Mycoplasma gallise...
NP_907824 168 GHGIGRkpheepeipny-leggnpkqgpKIREGMVFCIEPMICQksgeakilsd--kwavvshdglNGSHHEHTVAIVNG 244 Wolinella succinog...
Feature 1            
1MAT      244 GCEILTL 250 Escherichia coli
Q11132    242 GFECLTN 248 Mycoplasma pneumoniae
P56102    246 KAVILTE 252 Helicobacter pylori
NP_078086 243 GCEVLTD 249 Ureaplasma urealyticum
NP_282779 245 RAEILSM 251 Campylobacter jejuni subsp. jejuni NCTC 11168
NP_326397 241 KAIVLTK 247 Mycoplasma pulmonis
NP_758378 240 GYEILTE 246 Mycoplasma penetrans
NP_860929 245 KAEILTE 251 Helicobacter hepaticus ATCC 51449
O52353    244 QAEILTL 250 Mycoplasma gallisepticum
NP_907824 245 RAEILSK 251 Wolinella succinogenes

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