Conserved Protein Domain Family
SET_SETD9

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cd10537: SET_SETD9 
SET domain found in SET domain-containing protein 9 (SETD9) and similar proteins
SETD9 is an uncharacterized protein that belongs to the class V-like SAM-binding methyltransferase superfamily.
Statistics
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PSSM-Id: 380935
Aligned: 32 rows
Threshold Bit Score: 143.096
Created: 18-Jun-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
putative activeputativecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens SETD2 (5V21) binds H3K36M peptide and SAM.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      ###                      #                          #   #   #  
Q8NE22    119 TLGFSVAQATSsl--isAGKGVFVTk-----GLVPKGAVVSMYPGTVYqKYEPIFFQSi-----gNPFIFRCLDGVLIDG 186 human
ERN09431  158 KIGYTLELKPSeihheeAGTGVFIK------GEAEVGSVVAFYPGIIYsPDFYRYIPGypridanNPYLISRYDGTVIDA 231 Amborella trichopoda
PNR46367  184 HTGFTLCLQRSgipheeAGTGLFIK------GRAEPGTVVSMYPGVVYsPSQYRYIPGypkvdvdNGYLISRYDGLVIDG 257 Physcomitrella patens
EEY65817  126 LFGFTLNVEESsv--pgADEGVKLR------GSAPIGSLVALYPGIVYlPEHYKKKHHlgv-lsnNAYARARFDSVIIDA 196 Phytophthora infes...
EFJ33949  144 QLGFSLHLKDSevpghnAGQGLFLE------GIARTGTVVALYPGVIYsPAKYWYIPGypk--ldNPYLVSRYEGYVIDG 215 Selaginella moelle...
EAL66159  150 PRGFRLHVRKSdinheeAGYGVHIE------GECVPGTVIAIYPGDTYdGDNIPSNVIs-----dNDYMISRYDGTVIDG 218 Dictyostelium disc...
CAK91138  288 NLGFKLNLREStidhsdAGEGVFLEtlpankRLVPAGTLLGFVPGLIYdNYKSYSEKTp------PDMHFFRFDGPIFDF 361 Paramecium tetraur...
EDO39115   93 KQSFSLSIKPStiqhpeAGEGVFLD------GSAVPGTVVMFHPGLVYlPPYIRKMPNypwidkdNTYLMSRYDGCIVDP 166 starlet sea anemone
EIE19882   42 RMGFSLCLAPSavghadAGEGLWLR------GRAKTGAVVGLYPGIIYtRSHYREMPGypkvdreSDFLISRFDGAILDA 115 Coccomyxa subellip...
ACO67898  113 RAGFSAHVAESta--pnAGRGLFVN------GQVDPGEIVCVYPGVVYaPENLRHMPGypkiaadNPYLVARYDGSVVDA 184 Micromonas sp. RCC299
Feature 1                                                                                     
Q8NE22    187 ndkgiskvvyrscngrdr---------------------------------------------------------lgplk 209 human
ERN09431  232 qpwgpggearefwdgfasarigqnapess-----------------------------------gnsdrfwrilskplef 276 Amborella trichopoda
PNR46367  258 kpwgkgddirewwdghngisfeqaaeltgp--------------------------------arqslpsfwqfvgggkvm 305 Physcomitrella patens
EEY65817  197 knes---------------------------------------------------------------------------- 200 Phytophthora infes...
EFJ33949  216 kswgkggtsrefwdgydepeekeedled-------------------------------------rkeeqgeeamvdkas 258 Selaginella moelle...
EAL66159  219 rswnkradelilkekff-----------------------------------------------------------kklg 239 Dictyostelium disc...
CAK91138  362 tsriyypyvpgygfdeyeqkisdike-----------------------------------------ladrssrsyrnks 400 Paramecium tetraur...
EDO39115  167 kgldtdiq------------------------------------------------------------------------ 174 starlet sea anemone
EIE19882  116 kpwgrgaleepqsaeslg--------------------------------------------------------yrdgla 139 Coccomyxa subellip...
ACO67898  185 spwglgagwssaktsldgddgwtdgerrrvqgfgrwpgapigtddargdspggdspggdspggwlraaagetpldptqlt 264 Micromonas sp. RCC299
Feature 1                       ###                                                     #     
Q8NE22    210 msdstwltseihNPLAVGQYVnn-----------cSNDRAANVCYqEFDVPavf--------pieLKQYLPNIAYSYdkq 270 human
ERN09431  277 ggqkfgevlekrNPLARGHYVnh-----------pAKDFEPNVMVcPYDFPfge---------ngMRVYIPNLVFGGeeg 336 Amborella trichopoda
PNR46367  306 qgplegaelerrSPIALGHFAnh-----------pPEGVHPNVMIcPYTFSisg--------qqsMRAYIPNVMFGNdee 366 Physcomitrella patens
EEY65817  201 --------skprNPLAVAHKInh-----------pPSGTPPNVIGfAFEFPpeepf-----stkeYDELIPNSFVQEpsr 256 Phytophthora infes...
EFJ33949  259 egeaasqvierrNPLALAHFVnh-----------pPKGQLPNVMIcPYDFPehe---------edMRPYIPNLRFEDdtv 318 Selaginella moelle...
EAL66159  240 tkssgtdllcykNPFAIGNFInhppiitkdgdgdtDQTKEPNVIAySYNFRsnf--------pnhLSQYIPNKTVTEhsi 311 Dictyostelium disc...
CAK91138  401 kggyelvkgediNPYALGHKInh-----------tPRNKSTNVSLiDIFVPqtff-------peeLMKFWPTQYFSTtqd 462 Paramecium tetraur...
EDO39115  175 ----rsdgtmvaHPLAAGHKVnh-----------aPPGTKPNILPfSYDFAktf--------peeLLRLVPNKYVTRchv 231 starlet sea anemone
EIE19882  140 daltqlhvlerrHPFSLAHYAnh-----------pPAGRRPNIMIaAYDFQncr---------dgTRRYIPNAMFGSpra 199 Coccomyxa subellip...
ACO67898  265 dartaaesvdrrHPLALAHLAnh-----------pPKGTSPNVAVaSVDVVfdaeteeldkdvkaLRRYLPNVGLGRwrv 333 Micromonas sp. RCC299
Feature 1                                                                                     
Q8NE22        --------------------------------------------------------------------------------     human
ERN09431  337 enkrnmrrygsfw------------------------------------------------------------------- 349 Amborella trichopoda
PNR46367  367 fdmqrrgplwinegkkerpe-------------------------------------------------------dpadt 391 Physcomitrella patens
EEY65817  257 lsmf---------------------------------------------------------------------------- 260 Phytophthora infes...
EFJ33949  319 knmerrgkswskv------------------------------------------------------------------- 331 Selaginella moelle...
EAL66159  312 fnd----------------------------------------------------------------------------- 314 Dictyostelium disc...
CAK91138  463 flqtkss------------------------------------------------------------------------- 469 Paramecium tetraur...
EDO39115  232 lnacvngdistntvgtqehlhkkrmknifsniivygckqlndisqhhkgsvvkvvvvkvvvkglvvkrlvvkvvvvkglv 311 starlet sea anemone
EIE19882  200 spgltga------------------------------------------------------------------------- 206 Coccomyxa subellip...
ACO67898  334 plgtgeakrrggageakrarggfvgs--------------------------------------------larmfgedde 369 Micromonas sp. RCC299
Feature 1                              #          #####
Q8NE22    271 ---------------splRCVVLVALRDINqGEELFSNYYT 296 human
ERN09431  350 --lrmgkaedaeagvllfKTLVLVSTRRISdGEEVLLNYRL 388 Amborella trichopoda
PNR46367  392 rlstverseqpitlisdvHTLVLVTTREVD-NEELFLNYRL 431 Physcomitrella patens
EEY65817  261 ------------gkraivHGLAFIATADIAdEEELFLNYRY 289 Phytophthora infestans T30-4
EFJ33949  332 --plpevlsakdrdptylRGLVLVTTRNVC-NEELLLNYRL 369 Selaginella moellendorffii
EAL66159  315 -------------tsvlrRSLLLIAFKPIK-NQEVFLNYRF 341 Dictyostelium discoideum AX4
CAK91138  470 ---------ldqhyknhiRGLGFISVTEIRdGEELFLDYLE 501 Paramecium tetraurelia
EDO39115  312 vkryyrepnflfktpavlRSVVYVTTNHVH-NQELFVNYRL 351 starlet sea anemone
EIE19882  207 --------eeipmddrplLCLALVATREIE-DEELLLNYRL 238 Coccomyxa subellipsoidea C-169
ACO67898  370 dgdieeaeaeapngkvvvPTLVLVAKRFIL-DEEVFLNYRL 409 Micromonas sp. RCC299

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