Conserved Protein Domain Family
bHLH_TS_ASCL3
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cd19745: bHLH_TS_ASCL3 
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 3 (ASCL-3) and similar proteins
ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is a bHLH transcription factor specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis.
Links
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Statistics
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PSSM-Id: 381588
Aligned: 7 rows
Threshold Bit Score: 97.2387
Created: 28-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #   # ### #    #                 ####                  
Q9NQ33        90 GPAFTRKRNERERQRVKCVNEGYAQLRHHLPEEYlEKRLSKVETLRAAIKYINYLQSLL 148 human
KFQ31051      71 GPAFIRKRNERERQRVKCVNEGYAKLRHHLPKEYlEKRLSKVETLRAAIKYISYLQSVL 129 brown roatelo
XP_018115309  80 GPSYVRKRNERERKRVKCVNEGYTKLRRHLPQEYvEKRLSKVQTLRAAICYIRHLQEVL 138 African clawed frog
XP_005989731  85 EPAFIRKRNERERQRVKCVNEGYAKLRNHLPDEYsEKRLSKVETLRAAIKYIKHLQSLL 143 coelacanth
XP_007886043  19 PAAFIRKRNERERQRVKCVNEGYALLRRHLPQELsHRRLSKVETLRAAIRYIGELQALL 77  elephant shark
XP_019620848  87 EPAFIRKRNERERQRVKCVNEGYARLREHLPSDIsDKRLSKVETLRAAIKYIKKLQKVL 145 Belcher's lancelet
NP_001071656  92 EPAFIRKRNERERQRVKCVNEGYARLREHLPDEYaEKRLSKVETLRGAIQYIKQLQDML 150 vase tunicate

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