1BIH,1HXM,1BIH,1BIH,1BIH,1CDI,1CS6,1CS6,1CS6,1CS6,1DQT,1E07,1E07,1E07,1E0O,1E4K,1EPF,1EV2,1EV2,1F58,1F6A,1FYT,1FYT,1G1C,1GL4,1GSM,1GXE,1HCF,1HXM,1I85,1I8L,1I8L,1IJ9,1IJ9,1IRA,1IRA,1IRA,1KOA,1N26,1NBQ,1NBQ,1NCT,1NEU,1OLZ,1PD6,1PKO,1QZ1,1RHF,1RHF,1T0P,1TLK,1U2H,1WIO,1WIO,1WIO,1XED,1XIW,1XIW,1YA5,1YA5,1YJD,1Z7Z,1Z9M,2AVG,2AW2,2BK8,2C5D,2C5D,2CKN,2CQV,2CRY,2D3V,2DF3,2E9W,2EDJ,2FBO,2GK2,2GY5,2ICE,2ID5,2IEP,2IEP,2IFG,2IFG,2ILL,2ILL,2J12,2JJS,2KKQ,2MIM,2PKD,2R15,2V5S,2V5S,2V5S,2V9Q,2V9Q,2VA4,2YD8,2YR3,3BOV,3BP5,3DMK,3DMK,3DMK,3DMK,3DMK,3LAF,3LAF,3NOI,3O4O,3P40,3P40,3QR2,3RRQ,3V6B,4BFI,4BFI,4GOS,4JJH,4OFD,4U7M,4WRM,4ZSO,5IHB,5NOI,5OPE,5OYJ,5VKJ,5VKM,5VKM,5VKM,5X8L,5XWT,5ZO2,6ARQ,6DHB,6ISC,6NG9,6OIL,2DM2,2DM3


Conserved Protein Domain Family
Ig

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cd00096: Ig 
Immunoglobulin domain
The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.
Statistics
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PSSM-Id: 409353
Aligned: 586 rows
Threshold Bit Score: 28.0639
Created: 1-Nov-2000
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand B [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      #####                                                                           
1BIH_A     230 TMIYCmygs-npmgYPNYFkngkdvngnpe--------------dritrhnrtsgKRLLFkttlp-edegVYTCEVdngv 293  cecropia moth
1E07_A     221 LNLSChaas-nppaQYSWFvngtfq------------------------qstqelFIPNItvn----nsgSYTCQAhnsd 271  human
2GK2_A      21 VLLLVhnlp-qqlfGYSWYkgervdgnrqivgyaigtqqatpgpansgretiypnASLLIqnvtq-ndtgFYTLQViksd 98   human
4OFD_A     127 YNLTCrafnakpaaTIIWFrdgtqqegavtst-----------ellkdgkrettiSQLLIeptdl-digrVFTCRSmnea 194  house mouse
6ARQ_D     237 ATLTCdarsnpeptGYNWSttmgplp----------------------pfavaqgAQLLIrpvdk-pintTLICNVtnal 293  human
O75326     562 YYLSCpmes--rhaTYSWRhkenveqsc-------------------epghqspnCILFIenlta-qqygHYFCEAqegs 619  human
O60500     563 LNLTCvsvssnppvNLSWDkegerlegvaapp-----------rrapfkgsaaarSVLLQvssr--dhgqRVTCRAhsae 629  human
CAF97406    46 VELRCtvpdhmstwQYRWFkgsee---------------------------lhyhGQIFVlwkarvddtgKYSCQGvrdt 98   Tetraodon nigrov...
A1YIY0     131 VEFLCeahqgslpiFYSFYingeilgk---------------------plapsgrAASLLasvkaewstkNYSCEAknni 189  house mouse
6166019    349 VEFLCmslanplptNYTWYhngkemq----------------------grteekvHIPKIlpw----hagTYSCVAenil 402  human
Feature 1                          
1BIH_A     294 ------------gkpqKHSL 301  cecropia moth
1E07_A     272 t-----------glnrTTVT 280  human
2GK2_A      99 ------------lvneEATG 106  human
4OFD_A     195 i-----------pngkETSI 203  house mouse
6ARQ_D     294 g-----------arqaELTV 302  human
O75326     620 -------------yfrEAQH 626  human
O60500     630 ------------lretVSSF 637  human
CAF97406    99 vvgdirtlqsvpveiiVDGG 118  Tetraodon nigroviridis
A1YIY0     190 s-----------reisELKK 198  house mouse
6166019    403 -------------gtgQRGP 409  human

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