Conserved Protein Domain Family
ETAA1

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pfam15350: ETAA1 
Ewing's tumour-associated antigen 1 homolog
This family of proteins is found in eukaryotes, where members are expressed at high levels in the brain, liver kidney and Ewing tumour cell lines. Proteins in this family are typically between 648 and 898 amino acids in length.
Statistics
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PSSM-Id: 464665
Aligned: 16 rows
Threshold Bit Score: 854.078
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007476791  75 YKTPKRLLKTGFRSPIFTSPyNDIDGQQEIFWDPNSPTTCQLDERRNKQHDRRCSVAISDIVNRIAPQGE-KPTTDSLLD 153 
XP_012395614  75 YKTPKRLLQSSFRSPVFSSPcNDNDGPQEIFWDPNSPTTCQLDERRNKQHDRRCSVAISDIVNRIAPQGE-KPTTDSLLD 153 
XP_007670265   6 YKTPKRSLKTRLRSSTFSSPyNDTDAQQEIFWDPTSPTTYKLDKRRKKQADRKSTVEISEIVNRIAPQDE-RPVRDTLLD 84  
XP_023613225  73 YETPKRVLKMELLSSTFNSP-NDPDGLNDIFWDQNSPMTKQLGKGRKKKIYNTDSDEISHIVNCIAPQDE-KPITDSMLG 150 
EFB28770      77 YETPKRVLKMDFLSSAFSSP-NDPDGQNDIFWDQNSPMTKQLGKGRKKQIYTTDSDEISHIVNRIAPQDE-KPTTNSMLG 154 
Q08DI1        77 YETPKRMLQMDLLSSTFSSP-NDPDGQNDIFWDQNSPMTKQLDKGRKKQLYTTDSDEISHIVNRIAPQDE-KPTTDSMLG 154  cattle
XP_005343087  77 HETPQRVLKMDLFSCTFSSP-NDPDGQNDIFWDQNSPMTKQLGKGRKKKIYTTGSDEISDIVNRIAPQDEkKPTTNSMLG 155 
Q5SVT3        79 KETPVQIVKMDLLSCTFSSP-NDPDGQTDIFWDQNSPMTKQLGKGRKKQISSAYSDEISHIVNRIAPQDE-KPVTNSMLG 156  house mouse
XP_007641188  14 YETPTRVLKTDLLSCAFSSP-NDPDGQTDIFWDQNSPITKQLGKGRKKQISSTYTDEISHIVNRIAPQDE-KPVTNSMLG 91  
XP_003468984  67 YETPTRMLKMDLLSCTFSSP-NDLDGQNDIFWDQNSPVTKQLGKGRKKQIYTTDTDVISHIVNRIAPQDD-KPAANPMLD 144 
XP_007476791 154 MWIGEGAIPCTPDITKIKSRTKTNYIRFKAQSSEEELIKLAKQFDKNMVELDVRQEQENETCGFVQTISEAETSNTCKEA 233 
XP_012395614 154 MWIGEGAIPCTPGITKIKSRTRTNYVKFKAQSSEEELIKLAKQFDKNMVELDVRQEQDSETYDFVQTVSEAETLNNYKDE 233 
XP_007670265  85 IWIGEDAIPSTPSVAKVRSRTKASCTRLKAQNGEEELMKLAKQFDKNMVAQEAIQEEDHESHDVIQTSLETETLNNYTDD 164 
XP_023613225 151 MWIGETAIPCTPHVAKGKSRAKISCTKLKTQNQEEELMKLAKQFDKNMEELDVIQEQNKRNHDFIQMISEAETLNNYKDN 230 
EFB28770     155 VWIGATAIPCTPSVAKGKSRAKISCTKLKTQNQEEELMKLAKQFDKNMEELDVIQEQNKRNHDFIQTISEAETLSNYKDN 234 
Q08DI1       155 VWIGDTAIPCTPSVAKGKSRTKLSCTKLKSQNQEEELMKLAKQFDKNMEELDVIQEQDKRNHDLIQMISEAETSLNCRDN 234  cattle
XP_005343087 156 MWIGAAAIPCTPNVAKEKSRVKVSRTKLKTQYREKELMKLAEQFDKNMEELDVAQEQNKRNHDFIQEISKAETSRSCNDY 235 
Q5SVT3       157 VWIGETAIPCTPGVAKEKSRVKASCTKLKTKNREKELMKLAQQFDKNMEELDVIQEQDGKNHDFIQMTSKMGHLDNHKDS 236  house mouse
XP_007641188  92 VWIGDTAIPCTPSVAKEKSRVKISCTKLKTQNREKELMKLAKQFDKNMEELDVIQEQDGRNNDFIQTTSEVGHLHIHKDS 171 
XP_003468984 145 IWIGETAIPCTPVVAKEKSRVKISCTKLKTQNREKELMKLAKQFDKNMEELDVIQEQTKKDHDFVQIISDTETLHNCKDC 224 
XP_007476791 234 AQIqdlQSASDKVPETDIAVR---VKENSNISREENdKNNSQTNFDPNAEAALTALFDGSTQKCSGQLSQgl-sHVSFTT 309 
XP_012395614 234 AQLqtlQSISDEVPEVNIAVT---VKGNSSISKEEHyKNSSLTNFDPSAEAALTALFDGSTQKCSGQLSQgl-sNASFTT 309 
XP_007670265 165 AQTqdlQSFPDEVPETSIALSlkaRKQSADNAAAERcPNTIQKAYDPNAEAALTALFDGSTQKCSGLLSQdl-pDVS-SS 242 
XP_023613225 231 VQM---QLLHEIVPEIDNGIIkkpMKENTKVSVVND-QYHSQKPFDQNAEAAFNAIFDGSTQKCSGQLSQdl-sDALWST 305 
EFB28770     235 VQM---QLLHDIVPEIDNSIIkkpMKENTRMSVVND-QNSIQKLFDQNAEAAFNAIFDGSTQKCSGQFSQdl-sDAFLNM 309 
Q08DI1       235 VQM---QLLCDTVPEIDKALLkkpVKENTKISVVND-QTSSQKPFDQNAEAAFIAMFDGSTQKCSGQLSQdl-sDSFLKT 309  cattle
XP_005343087 236 VQM---HPLHDVVPIIDNAIIkkpVKGNTRISVAND-QSSSQKPFDQNAEAAFNALFDDSTQKCSGQLSQdl-aDAFLNT 310 
Q5SVT3       237 VQK----PSGDVVPEITCTPVkkqMKGDSRISLAKA-QDSSQKPFDQNVEAAFNAIFDGSTQMCSGQLSQdl-lDAFLNN 310  house mouse
XP_007641188 172 VRM----ETDDKVPEISCALVkkqMEGNIGITVAEE-QDSNQKPFDHNVEAALNAIFDGSTQMCSGQLSQylssEAFLNN 246 
XP_003468984 225 VQM---HSSCEVVPEIDNATLnkpVRGNLVISVAND-QTSSQKPFDPNVEAAFNAIFDGSTQICSGQLSQdl-sDAFLYN 299 
XP_007476791 310 SHNIHGKNNTLKEEIENsTETVVTEKhvnkishQQNLTPLS--VTSASDSLLMAKSNVTSSFAKSEIFDKP-GKVDVSID 386 
XP_012395614 310 SHNICGKNDTLKEEIDNsIETVVTERqgskisgQQNLTSVA--VTSASDSFVMA----TSSIAKSEILTKP-GEIEAGMD 382 
XP_007670265 243 AGVSQRNNSTLIEEKQMnRGELADVD-------LPQKDSTTttVTSKMDT-VAKETPKISSTPKSSTSNKP-TQDQTNSD 313 
XP_023613225 306 VNTTFGKKSALKEEKIIsNETQVTEK-------LRNKPPTS--LSHQVDTPGMTKSYVTSSTKEPEAFNKH-TDVFTTGD 375 
EFB28770     310 SNTTFEKKSALKEEKIImNESLVPEK-------LPDKTPRS--LFCQVDTPGMTKSCVTSYTEKPEAFHKY-LDAFTTSD 379 
Q08DI1       310 SNTTFGKKNTLKEEKIItNESVVTEN-------LPSKTLGS--LSHQVDNPGMTKSYVTFCTKEPGTFNKH-IDTFTTSD 379  cattle
XP_005343087 311 R------KNTLKEEKIIiNGTLVTEK-------LPGKTQDS--LYPQVDPPILTKSCVTPYSKEPEASSKP-IGTFTTSD 374 
Q5SVT3       311 SKTSLRKKNALLQEEIItTETLLTEN-------LLNKTPIS--LSPQIDTTVILNSCVTPCPKTPAAPDTQ-LDELTAND 380  house mouse
XP_007641188 247 SKSTFVKKSSLIEEDIIiNETLLTEN-------LPNKTSLS--PSPQVDTPLLQKSCVTPCAKKPEASNKHaADGLTGSD 317 
XP_003468984 300 SNTTLGEKSPLTKESIItDKTLVTEK-------LPSKTPVP--LSPQVCVPTVTKSYLTPKTKEQEESNKH-VVAFPTND 369 
XP_007476791 387 FddDDDWEH-MLTDDAFVMPISQAPELLTTsETSQLILQKDICRLtTSKNDKAKVGLNGNLAISKSLSKNLQDLSSETNN 465 
XP_012395614 383 FddDDDWEH-MLTDDSFVMQISQAPELLIT-DSSQPTIQKDIFMLtASKSDEPKVGINGDLTIGKSVSKNLQVLPSETNN 460 
XP_007670265 314 F--DDDWEDcFLQHNSLELQTAENPELTTTpRRSRTAHPEANRTPtSNESKETKARISRTSVVGVT---NIQDVTSETNS 388 
XP_023613225 376 F--EDEWEN-LLNNEPFVMQNVERSELFSApETVQMVDQKDICIF-NSKNGKSNSRMNTSLDAEFRDSKIL-DVSSNTHT 450 
EFB28770     380 F--EDDWEN-LLSNEPFVMQNVNMCEPFPApKTAQIADQKGIYNF-NNKNDKNKSRMNTSLDTRLRDSKILQDLPSKTRN 455 
Q08DI1       380 F--EDDWEN-LLSNEPFVMQNIETSELFPApKTIQIADQKEMCSF-NSKEAKSKSGMNKSVDVKLRDSKILQGLPSNTWN 455  cattle
XP_005343087 375 L--EDDWEK-LLSNEPFVMQNVE-AELFPS-KTAQVTDHKGIYSF-TSEYGGNTSRTNKSLDAKLGDSEVLQDLPSKTHN 448 
Q5SVT3       381 F--EDDWES-LLGSEPFLMENAEMLEFVPS-TTAQDTCQKAICTS-VGENDTITSRTNMNLGGRLRDSKVTLDLPSKTRN 455  house mouse
XP_007641188 318 F--EDDWES-LLGNEPFLMENAEMLELFPS-TTAQVTGQKAICTV-AAKNDTITSRTNTDLGGKLRDSKITLDLPSKTCN 392 
XP_003468984 370 F--EDDWES-LLENEPFVVQNTEMLELFPS-KTAH---------------DNSISGTNTSLDTRLRDSKILQDLPSNTHN 430 
XP_007476791 466 KDfldptkSLFPPKPNNEAMEFVPPENDVTFERNLNKTS-FPNKIPDYpelSVASNIQKIKELNCPKFGPDIKVSAkESA 544 
XP_012395614 461 KNvfdptkALFPLKSNNEPMELIPTENEVKYEKNFSKTS-FPTKIPSYselSVASNIQKTKEAIYPKFGSNMKVSAkESA 539 
XP_007670265 389 RDvngiakSLFSKKPRDEENVVVPHGSNIKTDERTIHIGsVPDRVSHS---TPSGSKVNAKEESKPEAGQSRNASVrEST 465 
XP_023613225 451 NElidarkYRFLPNSNGKPNKLLSIGNKVKFEKSFNK-I-IQGKTQDG---AVASDPTKVKEDIQTKFISNVNTSQkKST 525 
EFB28770     456 KEsidsgkYGFSLNPNDKPSKLPSTGNKMKFEKSFSKTV-VQDEIQDC---AVASNLTKVKEDMHTKFTSDVNISE-KSA 530 
Q08DI1       456 NEltdaekYRFSPKPNDKPNKLSTTGNKMKLEKSFNIVV-NQDKIQDC---AVASNLTKVNEDTHTKFNCKVNASEkKSA 531  cattle
XP_005343087 449 RElidagkYRFSSNPNDKSSKLSSTRNKMK---SSSKIV-SQDKTQDC---ADTSNLTKVKEDICINYTSNVNNSEkKSA 521 
Q5SVT3       456 GElrnageHRFSSHPGDESRKVPFTGNKVSFEKSVTSIV-SKD--EDY---VAVSNLEKVKEDSRNKCILNKHSSNkSSS 529  house mouse
XP_007641188 393 KElrnsgsYRFLSRPSDESSKLPFTFSNVK--------------DEDC---VDVSNLTRVKEDSGSKCNFNVLASDsSGS 455 
XP_003468984 431 lrd--treYSFSPNPNRKTSNLPLTGNEMKFEKSFNKVV-IQDKTQNF---TVVSNLTKIKENIHTNFISNVNASEkK-P 503 
XP_007476791 545 LVKRHTNHQLqtggdreNWPNCYQSFNVPAKTnpnNSIRISSETNFHNLILKDAPQQCSAFDDWNDPKLATEVIEACHEL 624 
XP_012395614 540 LGRRPSNFQSqtrrdseNPPNCYQSFNVPTKInpnNSLRISNETTFCNLNKKDASKQCSLFDDWNDPKLASEVIEACHEL 619 
XP_007670265 466 --SASGQLQHggdrkstSTVFRNSSFNVSATVsayGSSRANKETLCPFTQSETQQQAPEGLEGSGEVTER------CHKP 537 
XP_023613225 526 LNTGYSNEQK-------NKSSFNQSFKTPANIvpfDSAALDIA------NQTNASNTDSFSDDWNDPSFANEIVKACHQL 592 
EFB28770     531 LNTGYSNEQK-------NKSIYNQSFKAPANIdpfGSATLGNETSVSNPNQTNASKLGSFFDDWNDPSFANEIVKACHQL 603 
Q08DI1       532 LKPGCS-----------NKSIFNQSLKVPANVkpfGSATLGSTTSVCNPDQTNGSKLGSFFDDWNDPSFTNEIVKACHQL 600  cattle
XP_005343087 522 LNTEHSIEQK-------NKPIFDQSFKAPVNIdpfGSSTLDCETVVNKPDQTNASKLGSFFDDWNDPSLANEIFETCHRL 594 
Q5SVT3       530 Y-TRYPSKQS-------SELGVNLPLQVP-TTdpfDSVFLGKENIVCSTNQSHGSKLNSSFDDWNDPLLASEMVEACHRL 600  house mouse
XP_007641188 456 Y-SRYPNEQK-------YGFSVNPPLKTPAVTapsGSVFLDKENSVCNTNQTNGLKFSSSIDDWNDPLVASEMIKACSEL 527 
XP_003468984 504 LNTKSSSEQK-------NKPILKHVFTAPVNIdsfGAAT-----GVSNLNQTNASKLDSFIDDWNDPLFASEIIKACHKL 571 
XP_007476791 625 EKSWDAdDDDDDDLLYQACDHVEKLTQQQDLRKDNKGSENKQMVNYNSSLGLETNSITSDKR-YQFQQHKHLNTDNVSAH 703 
XP_012395614 620 EKSWNA--DDDDDLLYQACDHVEKLTQQQDLEKDKQGSENQQKVNYNSYLGMETNNTVTSEKeYHLLQSKHLNRGDFSAH 697 
XP_007670265 538 ES-WEL-NDVDDDVLYQVCDNVEKLTKQQNCQQEGKESESMDKAGDISKTGSDSGLTSTKPGqPNHQSIDRLNVH---RN 612 
XP_023613225 593 ENTWE--DDVEDDLLYQACDDIERLTQQQDMRKDNKTSESILDINNSSKHGAKNTFTTSKQG-SQLVQSTYLNLSDISAQ 669 
EFB28770     604 EDTWEA-DDVDDDLLYQACDDIERLTQQQDIRKDSKISESKLDINNSSKHGAKTMFTTSKQE-SQLVQSKHLNLSSISGY 681 
Q08DI1       601 ENSWEA-DDVDDDILYQACDDIERLTQEQNIRVDSKTSESVLEINNSSKHGAKNVFTTPKQG-SQFMQSKHLNLNSISAQ 678  cattle
XP_005343087 595 ETSWEA-DNVDDDLLYQACDDIERLTQQQDILKDNKTSESILEINDSSKHGSKNISTTSKQG-SQLAQSNHLNLGSITVQ 672 
Q5SVT3       601 EATWDA-GEVDDDLFCQACDDIERLTQQE-----NKGSEESESVSYTSTRGSRSSSTASKQA-SQSAPSKHWNVVS-SAV 672  house mouse
XP_007641188 528 ETTWEA-DDVDDDLLYQACDDIEKLTQQE-----NKRSKQSESINNTSKQGSRNIYTASKQR-SQSVPSKHWNLVS-SSV 599 
XP_003468984 572 ETTWET-NDVDDDLLYQVCDDIERLTQQQDI----KDSKSTLEINNNTKHGHKSLPAVSKGG-SHLEQPKHLNLGSFSAQ 645 
XP_007476791 704 ETTFREVIQTDK-LAVKEGTNYGNSTNTTG-IKNLSEEYKYPNYHNSnqhASWNNSNVPAGMNK---------------- 765 
XP_012395614 698 GTSVREVIETGK-LTCKEGKNYRSSANSTD-TKNLSKNYQYPNYQNNnqhVSWNNSNVAVGVNK---------------- 759 
XP_007670265 613 VSSLLKSCQSESiSTSGNKVNCGKSVTTKGvSTDVGTQFENPRGQTQsqrVPGN---VPVKVNTscavpihrltphahmn 689 
XP_023613225 670 -SSSTGSSQINKsVKMQKGEICGNSPSFIGaTTNLTIYSKNSSCLINnlpVSWGNTGIPVEVNSs--------------- 733 
EFB28770     682 -TSFTNSSQLNKpVKMEK-EICGNSPSFLGaTTNLTIYSKNSNDQIDnlhYACNNTDVPIQVTSt--------------- 744 
Q08DI1       679 TSSLANSLQINKsVKMERGEMYGNSPGFLGaTTNLSIYSKNSDCQISnlhVSCNNPDVPKQVNSs--------------- 743  cattle
XP_005343087 673 TSSLTVGTQINKsVKMEKREMSGNSSEFWGtTTNLTTYSKNSNCQMNnlhVYRNNSDVLMQMPSs--------------- 737 
Q5SVT3       673 PLSLANKSQMSKpVTVQKRGRCGDGPNILDa-TNLSVCSKNSS----------DNKRGPVQVNSs--------------- 726  house mouse
XP_007641188 600 PPSLTDNSQIHKsVKVEKRDPCGDYPNILYaTTNLSVCSRNSI----------DNQYIPVQVNGs--------------- 654 
XP_003468984 646 TSFLTSNSQIGKpMKMKKREVCENSPQILGpTTNLTPCSKNSNCEINsvhVSWSNSDAPIHMTSs--------------- 710 
XP_007476791 766 ------------------------------------------SSTFTGNLSLGIR------------------------- 778 
XP_012395614 760 ------------------------------------------SSILTGNLSLAIS------------------------- 772 
XP_007670265 690 qngisssiniswserlspngtlshcgnsvntpwipkatraqcKNLQYQNFGQQISdtvpvrvnascsitsgrpiphlqes 769 
XP_023613225 734 ------------------------------------------KSVLIRSSSLNVN------------------------- 746 
EFB28770     745 ------------------------------------------ESVLIGNSSLNVR------------------------- 757 
Q08DI1       744 ------------------------------------------KSVLTGSSSLNVG------------------------- 756  cattle
XP_005343087 738 ------------------------------------------KSVFAGSSSLNVN------------------------- 750 
Q5SVT3       727 ------------------------------------------KFVLGGSSNLNVN------------------------- 739  house mouse
XP_007641188 655 ------------------------------------------KFILEGSSSLNDS------------------------- 667 
XP_003468984 711 ------------------------------------------RSFLSRSSDVNGS------------------------- 723 
XP_007476791 779 --SGHIHTDFPPDSRHLHNQKLSPSVITTQTHCHVNNTSipTSSGFSFTKIKNPQTL-HFSHNSISpGSKSDTKIL-QHS 854 
XP_012395614 773 --KDHKYTDTAS-SRNLHNQILSHSTVTTETH--VNKTSipTPSGYSFTKIKNPQTFpHLSHSSIPsRSISDSKIL-QHS 846 
XP_007670265 770 gnDHNVRTGVPGYDGQLQNQNLSRKRTTPHTTYG-NKTSv-APPKYTFTKIENTLVQv---------NSGSAIKMVpQTL 838 
XP_023613225 747 --SDRMSREIATCKKKSSSRPLFHGTITDEAQNDLNRTV--NFSKYRFTKIKNSQILsQINQNCIP-ESISDTKIT-KSL 820 
EFB28770     758 --SDHRNTETATDKKKLSTQHLSHRSTTDGPKSDLNRPV--RFPKYTFTKMKNSQILsQLNQNCIP-ARVSDTKIT-QGL 831 
Q08DI1       757 --SHHMSTEIAASKNRLSTLHLSKSTTRGKAQSDLNRAV--RLSEYVFTKMKNCPMLsPFNNSSVT-GSISDTKIA-QGL 830  cattle
XP_005343087 751 --SNYVSPVIASNKKKLITQQLFHRPQTDEAQSEFNKAV--RFSKYTFAKTKNPQILcQLNQNCIE-TSMSTTKIS-QDL 824 
Q5SVT3       740 --LGLMSTKIAT-NMKLSTQQLSHNSLADTAQND-NKIL--KLPKFTF-KKKNPQ----LNQNHLV-GSVPVGKIS-EDL 806  house mouse
XP_007641188 668 --LGRMSTEIAT-NTKFSTHQLSHKTLADRTQND-NKIL--RVSKFTF-KTKNPQVLsQLNQNCIA-GNMPVSKTL-QDL 738 
XP_003468984 724 --SNHIGMETVN-SKRLSTQRLSCVTTARETHSD-PKTG--RSSRYTFTKLKNSQTNpQFHQNHSA-EHMPATRIT-QSV 795 
XP_007476791 855 ERSKTQIvSSLPGETVPPQFLk--RQFSESHKQSTKEEEEKNRKYSPEEIQKKRQEALVRRMSKA 917 
XP_012395614 847 EKSKTQFvNSLLGETMPQQLLk--RQFSESCELPIKEEEEKNRKYSPEEIQRKRQEALVRRMSKT 909 
XP_007670265 839 KESTDQStESLPGKESVPRHHclkRQLSESSTRASSGTEEESKKYSEEQIQRKRQEALARRKSKL 903 
XP_023613225 821 EKNKIPV-NSLCGQAVQQQSL---MK-PESLKLPSKEEEEKNRKYSPEEIQRKRQEALVRRMAKA 880 
EFB28770     832 EKNKTVN--PFCGKTVQQQSL---AKRSESLKQPPKEEEEKNKKYSPEEIQRKRQEALVRRMAKA 891 
Q08DI1       831 EKNKTVN--PLPGKAVQQQPL---VKFSEPLKQPSKEEEEKNRKCSPEEIQRKRQAALIRRMAKA 890  cattle
XP_005343087 825 EKKKTVN--SIPREANQQMSL---VKISESLKQSSKEEEEKNRKYSPEEIQRKRQEALVRRMAKA 884 
Q5SVT3       807 GKRETVN--SLL-EANQQQSS---INYSESLKPSSPDEEERNRKYSPEEIQRKRQEALVRRKAKA 865  house mouse
XP_007641188 739 GKKETVN--SLL-EDNHQRSS---IKYSASLTPSSKDEEERNRKYSPEEIQRKRQEALVRRKAKA 797 
XP_003468984 796 EKKKTVN----LQEADRQQPS---VKLSESLRQSSKEEEEKYRKCSPEEIQRKRQEALVRRKAKV 853 
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