1I50


Conserved Protein Domain Family
RNAP_II_RPB11
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cd06926: RNAP_II_RPB11 
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RPB11 subunit of Eukaryotic RNA polymerase II
The eukaryotic RPB11 subunit of RNA polymerase (RNAP) II is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. At least three distinct RNAP complexes are found in eukaryotic nuclei: RNAP I, RNAP II, and RNAP III. RNAP II is responsible for the synthesis of mRNA precursor. The RPB11 subunit heterodimerizes with the RPB3 subunit, and together with RPB10 and RPB12, anchors the two largest subunits, RPB1 and RPB2, and stabilizes their association.
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Statistics
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PSSM-Id: 132902
Aligned: 44 rows
Threshold Bit Score: 93.8109
Created: 14-Nov-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:RPB11 - RPB3 heterodimer interface [polypeptide binding site]
Evidence:
  • Comment:The yeast RNAP II RPB11/RPB3 heterodimer, together with RPB10 and RPB12, anchors the two largest subunits, RPB1 and RPB2, stabilizing their association.
  • Structure:1I50_K; Saccharomyces cerevisiae RNAP II RPB11 subunit heterodimerizes with RPB3 subunit (1I50_C), defined using 3.5A contacts
  • Comment:RPB11 interfaces with the RPB11-like subdomain of RPB3.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  # #                                 #   # ## #    #  #                
1I50_K        13 GEGES----KLKIDPD--------------------TKAPNAVVITFEKEDHTLGNLIRAELLNDRKVLFAAYKVEHPF- 67  baker's yeast
EEA25848      13 GEGEK----KIEEKAD--------------------TRTPSTSIFTINKEDHSVGNLLRGRLLQNRHVTFAAYKIPHPL- 67  Penicillium mar...
XP_001712456  14 PETLQ----KITFYKD--------------------EKNKNCGYFKIEKEDHTLGHLIHSKLLKEKSVIFSGYKRPHPL- 68  Hemiselmis ande...
XP_001713368  12 PSTSE----KIKILNF--------------------SNNKNTKEFLFENEDATMGEILVYKLENHKNVLFCGYKKLHPL- 66  Guillardia theta
XP_001794335  66 DDGQQ----KIEYKEEtrkstyhpalpsdtqanpttLGVPNTGIFTFNKEDHTLGNLISQRLLKYPYITFSAYKVPHPL- 140 Phaeosphaeria n...
CAQ41819      10 PENIDllvlPPGEKKVsc----------------eiSEKGDCNIFTIKLEDHTIGNLIKQALCQDPQVTFAAYRQPHPL- 72  Plasmodium know...
CAC28816      13 QDGEK----KIEEKVF--------------------TGMSNTSDFKILKEDHTLGNLLAEHLKQAPHVLMAGYKIAHPN- 67  Neurospora crassa
ACI66475      13 SEGEK----KIEEKVY--------------------SGMSNTSDFVLNKEDHTLGNLLAEHLKAHPNVYMAGYKLGHPN- 67  Atlantic salmon
XP_001593192  14 GDGEK----KCTEEAD--------------------TRTPNSSIFTFNKEDHTLANMLRAHLLKDPHVIFSGYKIPHPL- 68  Sclerotinia scl...
XP_001939084  88 DEGQQ----KVEEKAE--------------------TRVPNTAVFTFNKEDHTLGNLLSARLQKNPAILFAAYKEAVIRt 143 Pyrenophora tri...

Feature 1                                 ##    ### #####
1I50_K        68 --FARFKLRIQTTegYDPKDALKNACNSIINKLGALKTNF 105 baker's yeast
EEA25848      68 --VHKLELRVQTDgeITPKDALLAACHDTVRDLGTLSREF 105 Penicillium marneffei ATCC 18224
XP_001712456  69 --EHFIYLKIITDgvFSPKDAFDSVLKDLYIEFSYLEDGI 106 Hemiselmis andersenii
XP_001713368  67 --DNNIFLKIKTNsfTDPVLELEWAIKEIYVDLSYIQTNL 104 Guillardia theta
XP_001794335 141 --FATFELRVSTDgsITPKDAIIACCRQVVQDLEDLKRSF 178 Phaeosphaeria nodorum SN15
CAQ41819      73 --QNTIEITIKPKg-YAGVKLLSDNVNSLLSDVSQLRETF 109 Plasmodium knowlesi strain H
CAC28816      68 --VPELFIRIQTDgsITPREALVGACKQLVAMYGQLGREF 105 Neurospora crassa
ACI66475      68 --VPQLFIRLQTDgtKTPRDVFTSVCEKLINQLESLHQEF 105 Atlantic salmon
XP_001593192  69 --FSKFELRIQTDgeITPKEALVACCRNLVSELEVFSREF 106 Sclerotinia sclerotiorum 1980
XP_001939084 144 ctEVITELSKLNDsfQTEWLGKRIVSEGEAERLQREQNNF 183 Pyrenophora tritici-repentis Pt-1C-BFP

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