Conserved Protein Domain Family
Collectrin
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pfam16959: Collectrin 
Renal amino acid transporter
Collectrin is a single-pass transmembrane protein that is homologous to the C-terminal region of human angiotensin-converting enzyme 2, ACE2, SwissProt:Q9BYF1, found in Peptidase_M2 pfam01401. Collectrin is critical for normal amino acid reabsorption in the kidney.
Links
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Statistics
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PSSM-Id: 465322
Aligned: 35 rows
Threshold Bit Score: 200.559
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002194303 617 AIKVRISLKSALGDQAYEWDESELF-LFKSSVAYAMRKYFAEVKkqkaaFDITDIHVGEETQRISFYITVSMPGNISDMV 695
XP_003439995  27 GYKVRFSIKTALGDQAYPWSKNEMF-LFRAALAFAMRDYTNGEE-----FGVSDIHPCDETKRVSFWFVVTRPNTT-DLV 99 
NP_001132930  38 GFKVRISLKTALGNDAYEWNESEKF-LFRSTLAYAMRKKTGEDT-----YNIENILVCNDTKRVSFIFVVTLPADPTQLI 111
XP_011472761  27 GHKVRLSIKTALGDEAYDWNENELF-LFQSTMAYAMRRLKGQQ------FIVSNIVVCNETPRVSFWFVVTSPQDPSQLV 99 
XP_005997909  27 AYKVRLSIKTALGDKAYNWNENEQY-LFRATIAFAMRQYLKNEI-----FRASNVLTCNETQRVSFWFVVTSPENPSVTI 100
XP_003218941  27 AFKVRLSIKTALGDNAYSWDATEEY-LFKAVVAFAMRRSFSQEA-----TQVSNVLLCNVTERVSFWFVVTDSSTNKTTV 100
XP_005037421  27 AFKVRISIKTALGDNAYAWDANEEY-LFKAMVAFAMRRYSSKST-----TQISNVLLCNVTDRVSFWFVVTDSSKNVTTV 100
2_pfamImport   1 AFKVRLSIRTALGDKAVSGEPAKEYrINKVVFLWSVKISPNRRT-----RKISHVLLCNITQRVSFWFVVTDPTKN-YTL 74 
XP_014584253   7 AFKVRLSIRTALGDKAYAWDTNEEY-LFKAMVAFSMRKVANREK-----TEISHVLLCNVTQRVSFWFVVTDPSEKH-TL 79 
XP_007500934  27 AFKVRLSLKTALGDKAYTWNENEEY-LFKAMVAFSIRTFSSREK-----IEISNVLLCNVTKRVSFWFVVTDPSEN-QTV 99 

XP_002194303 696 PKADVENAIRMSRGRMNEAFRLDDSTLEFVGILPTLAAPYEPPVTIWLIVFGVVISLVVIGIIALIVTGL--RDR 768
XP_003439995 100 DKGTVEMAIKKSRNRINGAFLLTDQTLEFDGIYPTLAAPVSPDTPPWLIVFGVVMGAVSVGIIALLAYPLvqRKL 174
NP_001132930 112 PKEEVERAVRQSKHRINNAFLLSDMTLEFVGVPPTLAVPIQYNTPPWLIVFGVVIGIVAVGIVALLMSTVskRRR 186
XP_011472761 100 PKGEVEEAVRKSRNRINQAFMLSDSTLEFIGILPTLAAPVEPPTPTWLIVFGVVMGLVVAGIFILLVLSSvqKKR 174
XP_005997909 101 PENDVAEAIRLNRHRINNAFLLSDKTLQFIGIPPTLSPPVESSLPVWLILFGVVLGLVVIGIIFMIVTGIrqRKR 175
XP_003218941 101 PKSVVEAAIRLNRNRINSAFLLDDSTLQFLQISATLAPRVEPPVPTWLIVFGVSFCLVAVGIVLLIISGIhkNRR 175
XP_005037421 101 PGSEVEAAIRMNRNRINNAFLLSDKTLQFLKITSTLSPPVEPSTPVWLIVFGVVLCLIVAGIVFLIISGIrkHKK 175
2_pfamImport  75 PADEIQSAIRMNRNRINSAFSLNDQTLEFLKIPSTLAPPTDPSVPIWIIIFGVVFCIVIVAITLLVLSGIrqRRR 149
XP_014584253  80 PAVEVQEAIRMNRNRINNAFFLNDQTLEFLKIPSTLIPPTDPPVPIWIIIFGVIFCIVIVAIILLILSGIrqRRR 154
XP_007500934 100 PAGEVQGAIRMNRNRINNAFILNDQTLEFLEIPATLGPPTEPSTPIWVIIFSVVFCLVIVGIVLLIVSGIrqRRR 174
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