Conserved Protein Domain Family
GHBP
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pfam12772: GHBP 
Growth hormone receptor binding
Growth hormone receptor binding protein is produced either by proteolysis of the GHR (growth hormone receptor) at the cell surface thereby releasing its extracellular domain, the GHBP (growth hormone-binding protein), or, in rodents, by alternative processing of the GHR transcript. The sheddase proteolytic enzyme responsible for the cleavage is TACE (tumour necrosis factor-alpha-converting enzyme). Growth hormone (GH) binding to GH receptor (GHR) is the initial step that leads to the physiological functions of the hormone. The biological effects of GHBP are determined by the serum levels of growth hormone (GH), which can vary. Low levels of GH can result in a dwarf phenotype and have been positively correlated with an increased life expectancy. High levels of GH can lead to gigantism or a clinical syndrome termed acromegaly and have been implicated in diabetic eye and kidney damage.
Links
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Statistics
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PSSM-Id: 463696
Aligned: 10 rows
Threshold Bit Score: 298.331
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_008101044 291 KGKLDEVNSILASHG-----SYMPQLYGEDSWVEFIELDI-E--ENEER--TEGSDTDRLLG-------DDHLKTHGCLA 353
XP_015128166 289 KGKLDEVNSILASHD-----NYKTQLYNDDLWVEFIELDI-D--DSDEK--NRVSDTDRLLS-------DDHLKSHSCLG 351
XP_005060638 292 KGKLDEVNSILACHD-----IYKTQLYSDDLWVEFIELDI-E--DPDEK--NRASDTDRLLS-------EDDLKSHNCLG 354
XP_028916116 304 KGKLEEVNMILASHN-----SYKPEFYNDDSWVEFIELDI-D--DSEEK--TEGSDTDRLLN-------DDHLKSLNCLG 366
XP_007487298 314 KGKLEEVNTILASHD-----SYKPQFYNDDSWVEFIELDI-D--DPDEK--AEESDTDRLLS-------SERQKSLNYLG 376
XP_019666893 316 EGKLEEVNTILAIHD-----NYKPEFYNDDSWVEFIELDI-D--DPDEK--TEGSDTDRLLS-------NDHEKSLNILG 378
Q3UP14       325 EGKLEEVNTILGIHD-----NYKPDFYNDDSWVEFIELDI-DeaDVDEK--TEGSDTDRLLS-------NDHEKSAGILG 389 house mouse
XP_005794966 303 KGKLEELNFILNGGGvdglpAYATDFYQEEPWVEFIEVDE-EdaEGGDKedNYNSDTQRLIGl-----pHRNVEGFRAIS 376
NP_001266530 304 KGKLDELNFMLSGRGmdglpIYAPDFYQDEPWVELMEVDEtEdvDNGEKkdNRGSDTQKLLGqsqpvsqHININCSNSVS 383
NP_001098560 303 KGKLEELNFILNGGSigglqTFSPDFYQDEPWVEFIEVDE-EdaDSREKedDQASDTQKLLGppqpisdHRTIRCSETIR 381

XP_008101044 354 VRDDDSGRASCCEPDIPETDFSVSDTCDGTSDIDQSKKTsDKEKDLLCLEQKDSEKPSSSFDESpTQLSPDNPAKTQQPK 433
XP_015128166 352 AKDDDSGRASCYEPDIPETDFSASDTCDAISDIDQFKKVtEKEEDLLCLHRKDDVEALQSLANT-DTQQPHTSTQSESRE 430
XP_005060638 355 AKDDDSGRASCCEPDIPETDFSASDTCDATSDSDQFKKAaEKEEDLLCLDRQDNDESLPSLANT-DPQGRHRNTQSENSL 433
XP_028916116 367 AKDDDSGRTSCYEPDILEVDFSAIDISDLSSEVAQMPKA-KEEGDLLCLNRK-TDDAPPSDLSTpDSPEPHDPLSPVGTK 444
XP_007487298 377 AKDDDSGRTSCYEPDILETDLSAPASCDSTSDIAHSQRL-PGTADLFCLEPK--NEASPS-----TTPPPSGGLLSEGGQ 448
XP_019666893 379 AKDDDSGRTSCYEPDILETDFNASDMCDGTSEVAQPQRL-KGEVDLLCLDQK-NQNNSPSTDATpTTQQPSV-ILAKENK 455
Q3UP14       390 AKDDDSGRTSCYDPDILDTDFHTSDMCDGTLKFAQSQKL-NMEADLLCLDQK-NLKNLPY-DASlGSLHPSITQTVEENK 466 house mouse
XP_005794966 377 HPDDDSGRASCYDTDLP-----------------------EHLASLLPGQPEDNKTCLD----ApATEMGEK-------- 421
NP_001266530 384 GPDAESSQATCYNTDLPEEETL------------------MLMATLLPGQPDEEETSLDTVERSsASETGER-------- 437
NP_001098560 382 HPEEVFGHGSCYNADRPEEDSK------------------VQMDAPPPGQAGDKESSTEFAERTpALDRCRA-------- 435

XP_008101044 434 AHASATDSNEMTSPPVQTQLSNQSSVANIDFYTQVSDITPGGSVVLSPGQKMKMAKIQSEAGKEpvtqcqPS-------- 505
XP_015128166 431 SWPPFADSTDSANPSVQTQLSNQNSLTNTDFYAQVSDITPAGSVVLSPGQKSKVGRAQCESCTE------QN-------- 496
XP_005060638 434 LWAPFGDSLESPRPSVHTQMSNQNSLTSTDFYAQVSDITPAGRVVLSPGQKSKLGRAQREGCTE------QN-------- 499
XP_028916116 445 PRPLLIDGVESKIPPVHSQLSNHSSLANIDFYTQVSDITPAGSVVLSPG-RNKASRTQCDALPEstslglPN-------- 515
XP_007487298 449 PRPLLPNGMESSSLAVHAHLSNQSSLANIDFYAQVSDITPAGSVVLSPGQKSKAGISQCDGHREasp-crGN-------- 519
XP_019666893 456 PRPLLTSGTESTHQAAHTQLSNPSSLANIDFYAQVSDITPAGSVVLSPGQKNKAGISPCDMHPEavslcqAN-------- 527
Q3UP14       467 PQPLLSSETEATHQLASTPMSNPTSLANIDFYAQVSDITPAGGVVLSPGQKIKAGIAQGNTQREvatpcqEN-------- 538 house mouse
XP_005794966 422 -------------PLIQTQIGGPQTWINTDLYAQVSNVMPSGGVVLSPGQQPKIQENTSGSEREtqkggkQNedvegike 488
NP_001266530 438 -------------QLIQTQTRGPQTWVNTDFYAQVTNVMPTGGVVLSPGQQLRIQESISAAEKEtkkkrkESedseesee 504
NP_001098560 436 -------------PPVQTQTGTPQTWVNTDFYAQVSNVMPSGGVVLSPGQQLRTQESTPASEHGaqtkgkQRdesgdmdg 502

XP_008101044 506 ----------IAMD---SAYFCETDVKKCVIVPPHKEAEPEVQDQS---------------FSEGAYIVTESLTTSAVnp 557
XP_015128166 497 ----------FTMD---NAYFCEADVKKCIAVISQEEDEPRVQEQS---------------CNEDTYFTTESLTTTGIn- 547
XP_005060638 500 ----------FAVD---NTYFCEADVKKCIAVTSHEENEPRVQEQG---------------YNEDGYFTTESLTTTVAn- 550
XP_028916116 516 ----------PTTD---NAYFCEADVKKSIAAAPPKGAEPHVAPKC---------------PEEDVYFTTESLTTTSV-- 565
XP_007487298 520 ----------FILD---NTYFCEADAKKCVSVAPHAEPEPRTEPRF---------------SPEDVYITTESLTTTAG-- 569
XP_019666893 528 ----------FIMD---NAYFCEADAKKCIAVAPHVEAESRVEPNF---------------NQEDIYITTESLTTTAG-- 577
Q3UP14       539 ----------YSMN---SAYFCESDAKKCIAVAPRMEATSCIKPSF---------------NQEDIYITTESLTTTAQ-- 588 house mouse
XP_005794966 489 qkrnepqfqlFVLVpegSGYTAENNTQQ--TSTPPSTSVPGVGYQTiqpqpmetkpaatgdTNESPYILPEPSQSQLF-- 564
NP_001266530 505 rkqkepqfqlLVVDpegSAYSTESSIQQ-ISTPPPSSPMPGEGYHIihpqpveprpaatmeLNQSPYIIPD--SPQFF-- 579
NP_001098560 503 qrqkepqfhlLVVDpegSGYTTESNCWQ--NSTPSNSPNPGAGYQTippppvdikpaasadANQLPYILPD--CPQLV-- 576

XP_008101044 558 vtAAEDEELPeSSEMPVADYTSIHVVQSPQGLVLSATSLPVP 599
XP_015128166 548 -lGASMAETP-SMEMPVPDYTSIHIVHSPQGLVLNATALPVP 587
XP_005060638 551 -fGASTAAAP-SSETPVADYTSIHIVQSPQGLVLNATALPLP 590
XP_028916116 566 --SSRMPAEAsNPDTPVPDYTSIHIIQSPQGLVLNATTLPVP 605
XP_007487298 570 --SSGIAGGPsGAEMPVPDYTSIHIVQSPQGLVLNATALPVP 609
XP_019666893 578 --QSGTAERApGSEMPVPDYTSIHIVQSPQGLVLNATALPLP 617
Q3UP14       589 --MSETADIApDAEMSVPDYTTVHTVQSPRGLILNATALPLP 628 house mouse
XP_005794966 565 --------------TPVADYTVVQELDTHRSLLLNPPPSQSP 592
NP_001266530 580 --------------APVADYTVVQELDSHHSLLLNPPCHQTP 607
NP_001098560 577 --------------APVADYTVVQELDTHHSLLLDPTPIQSP 604
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