Conserved Protein Domain Family
DUF4487

?
pfam14868: DUF4487 
Domain of unknown function (DUF4487)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 209 and 938 amino acids in length. There is a conserved WCF sequence motif. There is a single completely conserved residue W that may be functionally important.
Statistics
?
PSSM-Id: 464352
Aligned: 21 rows
Threshold Bit Score: 520.4
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_018677001  198 VTLLNVSWKGVVSLLQL--GKGFLTKKVNVADIILNLVSLAIESLRSASEA--W----CMTLQETLTGAEAK---RFFLP 266 
XP_023810320  228 IALHANTWKFLIKQSLK--HRPLVEEHLRHGDLSSSLCDNLLTSFHNCVEL--AeqiqHAGLQDSTQSTEYKlfqKTAKM 303 
XP_003440085  228 VALHANTWKFLIKTSLK--YQSLVEEHLHHSEISNSLVDNLLTSFHNCVEL--AeqikHAGLQEATQSPEYKlfqKSAKM 303 
XP_004348155  210 MSMLNATWKALIRLVSRa-APTALRSNIPIGAIVDALSAPLLRNLKDCVTAtpYtvtgQTPDEPATSFGDSKnftRCFRV 288 
XP_006854270  262 VSILNVSWKGVVTLLQLevGKAILANKINVEDIILTLVSLARESLKCTAEA--W----ALPFKGSLSVTEAK---RSFLP 332 
XP_019075832  160 VTILNLSWKGVVTLLQL--GKGALAVKVNVPDIILTLISLANESLRCAAEA--W-----SSRTETITAAEAK---RTFLP 227 
XP_009111092  257 VTILNTSWKGVITLLQI--DKQTLASKVDVGEIILKLISLIKESLRFSAVA--W----SCSVKENISATEAR---RVFLP 325 
EFH68493      222 VAILNTSWKGVITLLQI--DKQTLVSKVDVGEIILKLISLIKESLRFAAEA--W----SCSVKENISATEAR---RVFLP 290 
EEF44288      154 VTVLNVSWKGVVTLLQQ--GKEVLTEGVSVQDIIVTLISLVNEPLKCAAVA--W-----SSLEETISMTEAR---RIFLP 221 
3_pfamImport    1 IALHANTWKFLIKHSLK--YQSLVEEHLHHGDISNSLCENLLVSFNNCVEL--AeqikHAGLQESTQSPEYKlfqKTAKM 76  
XP_018677001  267 IKFYLINAVRISSEYPYEAIDVYRELTRCALLISSLgi--lFSKETKLRAASEALAEFLEPTSSL---LLHTLLNTANIN 341 
XP_023810320  304 CRFFANTLIHYIKEFKYFLTKYCSRFHQLYLQIITK-----FPPSLCAPALPAALSGELSAAAAV---PMDAFLLQLLPL 375 
XP_003440085  304 CRFFANTLIHYIKEFKFFLTKSCSCFHQLYLQIMSK-----FPPSLCTPELPIALSQELNAAALV---PMDAFLLQVLPL 375 
XP_004348155  289 CRFYLSHLFHTVKALASSLESCYAKVIDIVLSVKGLildalTSKNVTAVTFSELRSLVINADTIVkclAINPLFCACLGS 368 
XP_006854270  333 IKFYLINAVRICSRYPCEASKVFKDIMFCVLRISTLgl--eLRKETNLGTASDALAEFLEPTSFL---LIHTLLNSLELE 407 
XP_019075832  228 VKFYLINAVRISSQYPCQAYLVYREIILCVLMILTLgi--sLSIEKHLKTASEVLAELLEPTYFH---LLNALLNSAQVK 302 
XP_009111092  326 VKFYLINAVKVAALFPNQVSMVFKEISLCILMISAFkv--sLSQQTHGKYASEVMTDLLEKTTVD---LLNALLNAGEIT 400 
EFH68493      291 VKFYLINAVKVVALFPSQASMVFKEIALCILMVSAFkv--sLSQQTLGKSAGEVMTDLLEKTTVD---LLGALLNAAELT 365 
EEF44288      222 AKFYLINAVKISSFYPCQAYLVYREVSHCVLMISTFri--lLSFQKLLNTASEVFSELLEKTSID---LLTSLLNSTEVN 296 
3_pfamImport   77 CRFFANTLVHYIKEFKFFLTKYCNCYHRLYLHIISK-----FPPSLSAPTLPSALSEELSAAALV---PMGALLLQLLAV 148 
XP_018677001  342 LESRLLILDWLLsyendskstvvvenadsssg-stslgsiflvncddvpmaraV-----LLGRLMLFLNLLKTSPVLREE 415 
XP_023810320  376 GQFADVVLQVDL-----------------------------------------QlnpdqELPHCLLLASIMGQLTSQPEE 414 
XP_003440085  376 RPFAEAVLQQDL-----------------------------------------RlspehELPHCLLLVSVMGQLAGQPEE 414 
XP_004348155  369 SCQSDAIAGRPL-----------------------------------------------RLAQLTTVLALCTFSTDTRDP 401 
XP_006854270  408 NECKLQILDSLFpidvakqsmksegdicsidnekiapdealasncedipsmrnL-----ILGRVFVLVNLLKNSPDLGEE 482 
XP_019075832  303 QELKFQILDWLFidehnsnssvgdpstsywt---asmdtiftvsceampgaqiL-----LLSRVALFLNILKSSRDLEED 374 
XP_009111092  401 QELRLSLLDSLFideqcfptqvcnkqghgsqt-epslvdilslsvesaasargL-----LLARVVLFQAVMRYSSELEED 474 
EFH68493      366 QEFRLTLLDSLFvdeqgfsnqickkqshdsht-ktslvdilslsvesatsardL-----LLARVILFQSVMRYSSELDKD 439 
EEF44288      297 QEQKLELLDWIFadeccsnsfhgdlssfyhl---nsmveifsvssesipqerlL-----LLGRIALFHTLLRYSIYVEED 368 
3_pfamImport  149 RPFAEFVLQNDL-----------------------------------------RlspehELPQCLLLLSVLGQIHSQPEE 187 
XP_018677001  416 I------------------VIGISGKLDSLLHMMMHEEvyslALGLEIPVNCVVGPNSGVAwqLMFYFILHSLKTFMIva 477 
XP_023810320  415 Vlqlwfags---qfpeetpRLPLYKAIFDSFRRCDVER----KVPVLLPGVMLKGQAQARV--SLHRHICVQLCASIA-- 483 
XP_003440085  415 Vlqlwyagn---qfseeniRLPLFQAIFTSFRRCYTER----KVPVLLPGVMLKGQAQVQV--TLHQHICVHLCASVA-- 483 
XP_004348155  402 LpatvldllfpnaaadqqsALPLLDMVFAQVAEARAEIllpcTLYVEVPGAVPSSEQAQLLrvSLYQHTWESLCDLAV-- 479 
XP_006854270  483 V------------------VFMLSKKLDWLLDAFINENvysfTLLTQIPQVSGLTTSPEIAvqPMFYYILNSLKTFMIv- 543 
XP_019075832  375 V------------------RLGIARKLGWLLDVLVHEEvyssVLVLQVPILYGSGQTLELVwqPMFSSLILSLKTFMIv- 435 
XP_009111092  475 A------------------KLAITRKLQWLLDVLTDEKvytsVLSSQLPMADGSGKT--IVweSMFSALLLSLKTLMIt- 533 
EFH68493      440 A------------------KLAITTKLQWFLDILADKEiyssVLSSQLPMADGSGKI--IIweSMYSALLLSLKTLVIi- 498 
EEF44288      369 V------------------RNKLTRKLGWLLDILVDEEvyssFLDLQILVSYGCGKTIELVwqPIFSSLLDALKTFMIl- 429 
3_pfamImport  188 Vlqlwhtgs---qfseeepRLPLYQALFTSFRRCCAER----RVPVLLPGVMMKGQAQVLV--TLHSNICVQLCASVA-- 256 
XP_018677001  478 ASSGPAWMEVEFFLLRNICHPHFLCLEIITEMYCFLLRHGETNMTNYILDKLCSVLKFVASSEPDLrplDTLRKTSRLVC 557 
XP_023810320  484 ALPPKHFPMLERCLIDAVLQADTQTALLATDAWCFTARYGSAELCFHHVLLVAQLVKTCPTECYRM---SHLGILLKRLV 560 
XP_003440085  484 WLPPEYFRVLECCLVEAVLQADTQTALLAADVWCFTARYGTAELCLHHVLLIAQLVKACATDCYQS---FHLGMLLKRMV 560 
XP_004348155  480 ALPAAKFSVLERALMRQVLSPNSLCATLAADVWSFLAPRLPAHTLCAHLRLLGQLIVCTPRDQPLH---VTLGHLISRLS 556 
XP_006854270  544 ASSSLAWLEVEKFLLCNVVHPHPLCSEIVTELWCFLAQHAERDLLNDTVDKLSSLIWTLASSGQGPipsSALRKMARSVC 623 
XP_019075832  436 VSPSPMWSEFEFFLLQNFFHPHFLCWEIVMELWCFMVRHAEIEMVVGIIDKLCSLLKSVASIQPVLapsCPLRKMARSIC 515 
XP_009111092  534 LSSSPAWEELETLLLKNLLHPHFLCWQIVMELWCFWARHATDVTVANVIDKLCIFMLSMSTSEAPLcpdSVLRRTAKSIC 613 
EFH68493      499 LSSTPAWEELETFILQNLLHPHFLCWQIVMELWCFWVRHATEDLVVDMINQLCTFMMSMPSSETPLcpdSMLRRTTKSIC 578 
EEF44288      430 VSSSSGWVEMEAFLLENLFHPHFLCWEMIRELWCFWSRHAESDMVNGILDKFLSLMKLLASPESVLihaSPLRKIARIIC 509 
3_pfamImport  257 ALPPVFVPVLERCLLNTVLQSDTQTALLATDVWCFTARYGTAELCLHHVLLVAQLVKCCPAECYQS---SQLGLLLRRMV 333 
XP_018677001  558 VSLSYVCPAAVDRFYNLVESEDepnls--qimylALLVEGFPL--ESLPDESKMLAIRKLVTSFYHFTENKAKE-QELVL 632 
XP_023810320  561 FLMTPKHQEQLVEHFPPSELEN------------RAVWDNILF--GALSQDTRLRVEADMISLAQNALTDWRNGgYKMVQ 626 
XP_003440085  561 FLMTPNHQMELVSHFPPSEVEN------------LPVWHHVLL--RALSQDICRQVVTEVTGLTQKMLTDWQNGgYKLGQ 626 
XP_004348155  557 SELPDDQYIALVEAFSPAANLAn-----------LAFWRYFAAsgQAMSEQEIAVVQAGVSSIVSGVVapatqalvq--- 622 
XP_006854270  624 IVLNCTPQSAIDRIYGSFFGEDnarngasvalhlALLMEGFPL--DSLSENLRKLAVRRVLTAFCGFIESNSKN-----L 696 
XP_019075832  516 KILSSGTESIVDQVYSSIVGDDrsqls--lvmhiALLMEGFPL--NLLSDSMKSIATRRIMTDYFGFIDSFDDK-----T 586 
XP_009111092  614 FLLTHSPKSLTAQVYKNISTESrsesa--pdaylALLLEGFPL--NFLPDRMISDAKKQIVAEFFHFIENFTEK-----T 684 
EFH68493      579 FLLTHSPKSLTVQVYKNISTESrsdsa--pgvylALLLDGFPL--NFLPDRIKNDAKRQIFADFFNFIEKFIEK-----P 649 
EEF44288      510 SLLMNGSSSIVDHVYSSVIGDGkshws--svmyiALLLEGFPL--NSLSDNLRSIAKQKIVTDYFSFTATSSHK-----L 580 
3_pfamImport  334 FLMTPDHQTELVERFPPSEVGN------------LPVWRHVLL--RALSQEARRRVEADITDLTEKALSDWRSGgYKLGQ 399 
XP_018677001  633 lkstefgyssfvglpvhalssalqcrqvkdsdiagDKNMAHVVNFAVVVIHGYKsavdRK-KDIFATL------------ 699 
XP_023810320  627 -----------------------------------VDQVNVALSALLSVVRGQL----SPtAQPAVEMitevwlrmspa- 666 
XP_003440085  627 -----------------------------------VGKVNAVLMSLLSVVRGQSap-eEQcVLSSMRIvtqlwlrmspd- 669 
XP_004348155  623 --------------------------scqpnqgasVHEIQTLACGAIATLFTSHaiasTIaRRDLTTLidtivrcsasvf 676 
XP_006854270  697 vdrsstsipglhgepvy-alsslfshnqikgheidNKYIWPILRFTMTVIHGFKsitdTSkKDQYIQF------------ 763 
XP_019075832  587 lqacssgvfglpvfal----saalqsievktsdidTK----TLRFLVAIIQKYRssmdNLmKDHCRKL------------ 646 
XP_009111092  685 snssryfvqggpvval----saclgilkmsipeidSR----TLKFGVALIQKLRkskdEMtRDRYTEI------------ 744 
EFH68493      650 syssrdtvlgapvftl----saclrilktsiseidAK----TLNFVVALIQKYRnskdETtKDRYSEI------------ 709 
EEF44288      581 sttcssgvfgfpvftl----saslqsqqvsisdvdMK----SLNFLVTTIRNFKnavhKLmKEHYHKL------------ 640 
3_pfamImport  400 -----------------------------------VEKVNKVLFALLAVVRVQSsp-eEPcVLSATGVitqlwlrmspd- 442 
XP_018677001  700 -------------LSATLVIISNMRNFYGSAEMEKLIVELHTLFMQCPTDaDgmLyqcKPSLAYFMASLSHMEIAEGEGQ 766 
XP_023810320  667 --qvqscpvlqdtLQLLLSVTAALVKNAEPHVLCQALSCLDAVVSGTCPD-H--L---LLAALDFLSSMGKVFVPPESQS 738 
XP_003440085  670 --qlrthpvlqwtLQLLLSLSAILVKHIEPHIICQALVCLDDVVSQKCAD-W--L---LLAALEFLCSLGKIFVPPDSQS 741 
XP_004348155  677 paagsgeapaqacCALLNAVHA-LYPGLSVDHLTSIFTALAASIERQPLGv-------KLIVCKLLGRCAHFSVEGLRQP 748 
XP_006854270  764 -------------LGQTLEIISHIKQAYACDQMHELVSELLSLFTAYTTIsDgqLhlcKPALAAFLAGLSHMEISEGEEC 830 
XP_019075832  647 -------------LSETLGIVSNMKHLYASDAMEEVILELQNLFISGQAAsDtqLyecKPDLASFLAGLAYMKIVESDKN 713 
XP_009111092  745 -------------LSETLSIISRSEQLYTCQEMDNVITELQRLFITETDNsQhhLhklKPSLALFLSGLSNYEMSETETC 811 
EFH68493      710 -------------LSETLSIISRSDQLYTCQEMDNVITELQKLFISETDHhHnhLrksKPNLALFLSGLSKYEMSETETC 776 
EEF44288      641 -------------LNETLGIISNLKHLYKSDEIEEVILELQNLFISGPAAsDplLyqcKPYLLLFMGGLGDMDMSESDNC 707 
3_pfamImport  443 --qvqthpvlqwtLQLLLSITAILVKSLDPQVIYQALLCVDKVVSQKCAD-Q--L---LLAALEFLSSLGKIFFPPDSQN 514 
XP_018677001  767 TLCTAVWD----LYHMLLRERHWAIVHLVIVAFGYFAARTSCTQL 807 
XP_023810320  739 PVLPKLSG----LFGVLLADKSWLVQQHALEAFSFFAENTNHEEV 779 
XP_003440085  742 QILPRLSS----LFGVLLAEESWLLHQHTLEAFSQFAENTNHEEV 782 
XP_004348155  749 HASPELLQawihLFNVVLSEQHWLVLTPACVAWQEFAQFTPFKDI 793 
XP_006854270  831 PSSRAIWE----LYHNMLREKHWALVHLGLAAFGNFAARTSCNQL 871 
XP_019075832  714 AKSSAVWE----LYRMLLSERHWAFVHLAITAFGYFSERTSCDQL 754 
XP_009111092  812 PKSRAVWE----LYHLLLRKRHWALVHHAVTAFGYFCARTGCAQL 852 
EFH68493      777 PKSRAVWE----LYHLLLKKRHWALVHHAVTAFGYFCARTSCNQL 817 
EEF44288      708 AKSCAVWE----LYHMLFKERHWALVHLAIAAFGYFAARTSCNQL 748 
3_pfamImport  515 PILPKLSS----LFAVLLADGVWLLQQHALEAFSQFAEITNHEEV 555 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap