Conserved Protein Domain Family
AKR_unchar

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cd19752: AKR_unchar 
uncharacterized aldo-keto reductase (AKR) superfamily protein
This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Statistics
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PSSM-Id: 381391
Aligned: 13 rows
Threshold Bit Score: 424.437
Created: 16-Oct-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          ###                          #    #                                    #   
KXS49018   14 SQMGLGCLYFGardsKEKSFRRMDQYLAAGGNFLDTANMYshwisd-qtqggESEKMIGKWLKer-nnREDVIIASKVGF 91  Halanaerobium sp. ...
OFX31398   14 SCMGLGTMYFGtktdEQTSHAILDVYVSHGGSFLDTANKYaswip--gfkggESEQLIGRWMKqr-gnRQTLFVASKVGF 90  Bacteroidetes bact...
ARN19179   15 SELCLGTMYFGtridEPTSFAILDRFVEAGGNFIDTANCYcfwtd--ggrggESEALIGRWLRsr-glRDRVVIASKVGA 91  Methylibium sp. NS21
OHE70326   14 SAMSLGCLYFGardsREESFKRLDQYLGYGGNFLDTANMYshwisd-atrggESESLLGEWLKar-gcRSRVVIASKVGF 91  Treponema sp. GWC1...
OEK01344   14 SEMCLGTMYFGtktnQKQSESVIETFLDNGGNFLDSSNNYafwme--ggigdESEQTIGNWLQhq--qRDKIILATKCGA 89  Fabibacter sp. 4D4
PSQ03244   14 SELCLGPMYFGstvdRETSFGLLDRYYDAGGRFLDTANIYatwve--gyddpESEPLVGEWLDer-gvREEMTVATKLGF 90  Halobacteriales ar...
SDS99478   16 TVPCLGIMNLGvtvdDEASMAILDRFYQAGGRFVDTSNNYgswtp--gttagDSERLLGRWMAdr-kvADDMVIATKCGA 92  Microlunatus soli
OMF04787   14 SALGLGCLNFGsrtdKETSYRLLDQYVDAGGSFLDTSNNYafwne--gcsggESELLLGQWLKdr-gnREHIVLATKVGA 90  Paenibacillus sp. ...
OAM76977   16 SRLALGAMLFGgnveESLSRQLLDQYVAAGGNFIDTANNYsfwt----ayagSSEDLLGRWLKdr-grRDDLVIATKVGA 90  Devosia sp. S37
EKU96490   14 SCLCLGTLRFGtlntYEQSAQLLDIYLEAGGMFIDTGNSYnqwsa--ngkggESEVVVGRWLRer-gnRDDLFIASKVGF 90  Leptolyngbya sp. P...
NP_631148   6 PQIVLGTMDFGtrvdPGQAFAILDSFVAGGGVWLDTANCYsfwtdp-sgvggASERLIGEWLRarpsaRDAVRIATKVRQ 84  Streptomyces coeli...
AUX42399   14 SQLSLGCMQMGtltsEEESRQMLDRYVEQGGNFLDTANCYgwflrr-gshggESEAVLGRWLAqs-gkRGRVFLATKGAA 91  Sorangium cellulosum
EDY80808   23 SEICLGCMLMGsttsREESFRVMDDFLAAGGDFLDTANCYawwvgdgafvgdESELVVGEWMKlr-gaRDKVFLATKVGG 101 Verrucomicrobiae b...
Feature 1                                                          ##                         
KXS49018   92 pypg------------------teyGTSKKQIKEECHKSLERLgTDYIDLYYAHTDDFNTPlEETLEAFNELITEGKVRA 153 Halanaerobium sp. ...
OFX31398   91 pygn------------------iprSLKKEIILSECEKSLKRLdIETIDLYYVHAYDAGTPpEEFMEAFYQLKKSGKIRF 152 Bacteroidetes bact...
ARN19179   92 aprdpsqp----------ysafnreGLAASVIKAEAAASLKRLgVDRLDLYYAHVDDRATAfSQTLRALGTLVSDGDVRA 161 Methylibium sp. NS21
OHE70326   92 pypg------------------vpyGTSAKRIKEECDKSLKRMgTDYIDLYFAHSDDRGTPmEESLGAFNELIKEGKVRN 153 Treponema sp. GWC1...
OEK01344   90 rpksfdgn----------ldnisleGLSHDTIIQAVEGSLKRLkTDYIDLMYGHIDFPEYPiEERLNAFQKLKEQGKIRE 159 Fabibacter sp. 4D4
PSQ03244   91 gyrd------------------vptSLDPDLVAQEIDRSLDRLgTDTIDLLYAHVDDPDTPqTDVMGAFGEAVDAGKVRH 152 Halobacteriales ar...
SDS99478   93 gkldpngpil------ngtpptnyeGLAPEVVRNQLTVSLRNLgVERVGVYYGHVDDRDRDiTEVADTYSALAEEGLIAI 166 Microlunatus soli
OMF04787   91 qptipgg------------gfesmeGLSRKAIEQAIDGSLRRLgTDYVDLYYAHIDDVNTPlEETMEAFDRLVRAGKVRA 158 Paenibacillus sp. ...
OAM76977   91 lpnraga------------gledieGLGRTAIMRGIDSSLRRLgTDYIDLYYAHIDDRTTDlEETLAAFNALVQAGKVRA 158 Devosia sp. S37
EKU96490   91 gyge------------------vpdGLAASTIISECDNSLKRLgIDHLDLYYAHKDDPRTPlEETLEAFHSLVKAGKVRF 152 Leptolyngbya sp. P...
NP_631148  85 npliphs------------wpasaeGLSARAVHAGVEESLGRLgIDHVDLLWAHAEDRTVPlEETVGAFGELVAKGVALR 152 Streptomyces coeli...
AUX42399   92 mvrspdahwraegevdwttarrdfeGAGRETLERALEASLRRLqTDHVDLYYVHVDDRVTPlDETLEALARLVKAGKARF 171 Sorangium cellulosum
EDY80808  102 rlqdvasmrgadgmidwsrlpneyeLQTAGTIEREIDESLRRLqTDHVDLYYAHIMDPRVPlEETLEALNSIVMAGKARY 181 Verrucomicrobiae b...
Feature 1        ##                        #                                                  
KXS49018  154 IGASNFkaWRLERARQIAKQnhwqsYSAIQQRYSYLRPKSgwdfg------------dqvaaNQDLFEFVEDTg-ISLVA 220 Halanaerobium sp. ...
OFX31398  153 AGASNFhaWQLGEANQAAKNqgwegFSCIQQFHTYLQPALwadfg------------nqqilTPEIQEFCSVRk-LSIVA 219 Bacteroidetes bact...
ARN19179  162 VAASNYptWRLALARDHARQaglplFRAVQMRHSYLEARHlrtpape---------atqfpvTPELVDYAGTDgeLTVLG 232 Methylibium sp. NS21
OHE70326  154 IGASNFkaWRLERAARISRQngwaeYCCIQQRYSYLRPKAgwdfg------------vqvaaNDDLLEYVTDTg-MGLMA 220 Treponema sp. GWC1...
OEK01344  160 IGTSNTwsWRIEESNNLSKAqglpqYCAVQQKFSYLRPKYnadfw------------vqriiDEEMIDYVSYRpeLTLFA 227 Fabibacter sp. 4D4
PSQ03244  153 LGASNFpaWRVARANRIAEErglprFECVQPRFSYLIPDRdadfg------------gqlatTDELVDYCEQAd-LTLLP 219 Halobacteriales ar...
SDS99478  167 PGLSNTvsWRLAVARAHSRQhgraeFGAWQQQHSIYWPRPgyye--------------agpvTPDMIDYAASEpdLTIMS 232 Microlunatus soli
OMF04787  159 LGCSNHhtWRVEKARNISKShhwasYSCIQQRYTYLRPKPgadfg------------vqisaNDELLNYCQTHddFSLLA 226 Paenibacillus sp. ...
OAM76977  159 IACSNMavWRIERARQLSRQhgwaeYAGLQQHFSYFRPRPdsdlkrnavmglrggwgteaglRGQHLDYIRFNpdFRAVA 238 Devosia sp. S37
EKU96490  153 VGASNYdaWRLADADAIATAqgwhgFTCIEQRFTYLRPNPgadfg------------dqrliNQNLMSYGDARg-KTMLP 219 Leptolyngbya sp. P...
NP_631148 153 VGAANHaaWRVERARSLAREqgvepWTALQLRHSLVQPRPltplae----------sghrllADEDLDLAQSEg-LTMWS 221 Streptomyces coeli...
AUX42399  172 IGYSNVrtWRLERIRQRCAAegwpaPVALQQQHTYLRRRQgleh--------------tsivDDEQLDYLREHpdLTLVA 237 Sorangium cellulosum
EDY80808  182 LGCSNFttERLREAREICRRegwaePVAIQQQYSYLWPNSnanfg------------vmrnvDTELIDYLKENpeVALLG 249 Verrucomicrobiae b...
Feature 1     #######                                         #                               
KXS49018  221 YSPLLQGAYTNPNKEFKEqy-----qGPDTDKRLAVLDEIAAEtgatRNQLVYYWLMNrk-------------------- 275 Halanaerobium sp. ...
OFX31398  220 YSPLLAGAYTRNDIPLPEqf-----rGQNTGHKLEKLKTVAGElgvsANAVVLVWMMQtp-------------------- 274 Bacteroidetes bact...
ARN19179  233 YSALLSGAYARPDRPLPAdy-----dTPGADRRRAVLHEVARTlgatPNQVVLAWMLRgt-------------------- 287 Methylibium sp. NS21
OHE70326  221 YSPLLYGAYTDPKKAFQEqy-----lGPDSDARLGVLSEVAAEigatKNQVVYAWLMRgt-------------------- 275 Treponema sp. GWC1...
OEK01344  228 YSTLLSGAYSKDGNIELPqe----ydTKDNQLRMSTLEKIAKQlgcsKNQLVLAWIMNqr-------------------- 283 Fabibacter sp. 4D4
PSQ03244  220 YSPTLQGCYGRDDRPVPEgy-----aRSENRVKMRAIEDIADRkgvnGNTVALAWLLDrd-------------------- 274 Halobacteriales ar...
SDS99478  233 YSPQQGGQITRPWMAVRDpy-----dHPASLDRLRLAHRIAHDhdatANQVIMAWHLAgpesrlvyrdgsrthaldelpa 307 Microlunatus soli
OMF04787  227 YSPLLNGSYTRSDAPLQKqy-----eSEDAQARLRVLSEVAQEtggtLNQIVLAWLLQst-------------------- 281 Paenibacillus sp. ...
OAM76977  239 YTPMLRGAYADPSRLEPAy------rTEDNDKRRAALEAVAGEtgatPSQVVIAWLLHst-------------------- 292 Devosia sp. S37
EKU96490  220 YTPLLRGAYVRADRPISAay-----aGPDTEARIAALREVAQElnatANQVVLAWMMHrq-------------------- 274 Leptolyngbya sp. P...
NP_631148 222 YSSLMWGSYVRADKPLPQty-----dHPGTTRVLSVLDEVAGElaatRNQVVLAWLMRr--------------------- 275 Streptomyces coeli...
AUX42399  238 YSPILKGLYDATAEKRRGhwamqpylGSDSDARLAAVAEMARRldvlPHQLVLAWMLHqra------------------- 298 Sorangium cellulosum
EDY80808  250 YSPLLKGLYDSEEKRKAYyawd-qfeSEDSRVRLTRIRELAGElgvlPSQLVYAWLLHqr-------------------- 308 Verrucomicrobiae b...
Feature 1            ######  #  ##     
KXS49018  276 --pnAIPLIAATTDEQFKEALGSLE 298 Halanaerobium sp. T82-1
OFX31398  275 --pgIIPLLAGSTVSQVEENLQSLS 297 Bacteroidetes bacterium GWA2_42_15
ARN19179  288 --vpVLPVLGVSSVAQLDEALAAPT 310 Methylibium sp. NS21
OHE70326  276 --paAIPLVASTTDSQFGEAMGSLS 298 Treponema sp. GWC1_61_84
OEK01344  284 --vkIIPIISGSRPSQIEESTKAAG 306 Fabibacter sp. 4D4
PSQ03244  275 --qpTVPVLGVSTLEQVEQNLAATD 297 Halobacteriales archaeon QS_5_68_33
SDS99478  308 rraaMIPIFGASSVAQLDEAIGALD 332 Microlunatus soli
OMF04787  282 --ptTLSIIAASKPEQLQENLDSLN 304 Paenibacillus sp. FSL H7-0331
OAM76977  293 --paIIPLVAASTPAQLAENIAGAG 315 Devosia sp. S37
EKU96490  275 --ppLLPAFSGGRPEHMQENLGALD 297 Leptolyngbya sp. PCC 7375
NP_631148 276 ---gIDPIVGVSRVEQIEEALAARR 297 Streptomyces coelicolor
AUX42399  299 --prVVPLVGPRTREQLEQNLRAVS 321 Sorangium cellulosum
EDY80808  309 --prVIPLLGFSRFEQYRSNLESVE 331 Verrucomicrobiae bacterium DG1235

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