Conserved Protein Domain Family
Hop

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COG1372: Hop 
Intein/homing endonuclease [Replication, recombination and repair, Mobilome: prophages, transposons]
Statistics
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PSSM-Id: 440983
Aligned: 163 rows
Threshold Bit Score: 129.243
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_012843018    1 MAELRFVKIHDYLWEIPRTGGMRVPARIYASEKILRELKEDQAPQQAVNVAHLPGIVKYSLAMPDIHWGYGFPIGGVAAF 80  
WP_011249425  864 VLGWIIERYKEFTESEVYFLGLTLENGLQVTIELGKDGKDVEPPEYVTVEEVQLEERELNPAPPYTTDAMLKDASTFLKL 943 
WP_012675738  604 HKLPIDDQNVYRLLQSGKTTGVFQLESKGMQDLLVRLKPDKFDEIIAILALFRPGPLMSGMVDDFIDRKHGRKPVEYPFE 683 
WP_010870567  165 LGFENLNNKKPIEIMEEVYKYFKDKNIPFVITNWETAELIKYASNAFLATKISFINELAKLSDKVKADIKTISYAMGLDP 244 
WP_010870940  522 QEIEKLEEIRKTELKLVKEILNDEKLIDSIGYVLFLASNEIYWDEIVEIEQLNGEFTIYDLHVPRYHNFIGGNLPTILHN 601 
WP_064496538  302 WAYEKGKFYMLQARPITTLKKGKKEKKAKEEDIEAKILLKGIGASPGIATGVVKIIHDVSEIDKVKEGDILVTEMTTPDM 381 
WP_013413127  302 GTRLRGDIHVLMIGDPGIGKSQMLKYVSKLAPRGIYTSGKGTTGVGLTAAAIRDEFGGWSLEAGALVLGDKGVVCIDELD 381 
WP_013799845    1 -------------------------MEKPWVEKYRPKTLDEIVGHEEIVKRLKKYVEKKSMPHLLFSGPPGVGKTTAALC 55  
WP_014797554  509 EIVNKTEVIKLKRDILLPKYDIPKEFDNEDDYLRHLTYEGAKTRYKEVTPAITERIDHELKIMKNMGFPGYFLIVQDFIN 588 
WP_015327798  261 LNVPTRVGFQTPFTNITMDLNVPQMMKDEPVIIGGEYQDETYGEFEVELDMFNKAFAEVMLEGDKKGRVFSFPIPTYNIT 340 
WP_012843018   81 DLDEGVISPGGVGYDINC--------LTGEARVLHAH-G---YYRTIAEIVea---------------------gTNDPL 127 
WP_011249425  944 SAPETMRLAQDLFEAGLC--------VTPDTLVSLAD-G---RIMEIKDAVeks----------------------egNL 989 
WP_012675738  684 EVKEILEETYGLCLTGDT-------------LITMAD-G---SRKTIKEIVen--------------------dlIDEEI 726 
WP_010870567  245 RIGNKFLNAGIGYGGSCF---------HPDEVLFIDR-GrglECITFKELFele-------------------dkDNVKI 295 
WP_010870940  602 TTAALCLARDLFGENWRDnflelnasVSKDTPILVKIdGk-vKRTTFEELDkiyfetnd--------enemykkvDNLEV 672 
WP_064496538  382 VPAMKKAAAIVTDEGGLTc-------IEGDAKILTDR-G----FLKMKEVYklv------------------kngEKLKV 431 
WP_013413127  382 KMREEDRSAIHEALEQQS--------YHKDFEILLAN-G---RKMKIGNFVdelmeknknkiiygkdteilmtddLDLKV 449 
WP_013799845   56 LARDLFGENWRDNFLELNa------sVAKDTPILVKIdGv-iKRTTFEELDklyfnngnie----klfdgeyvetKNLEV 124 
WP_014797554  589 EARRIGVAVGPGRGCLTA-----------DAKVVLYN-G---TTKNICDIQig--------------------------- 626 
WP_015327798  341 DDFNWDNEVLEPVWEMTAkygipyfcLDEDTNIITNN-G----IKKVKDLNidt-------------------------- 389 
WP_012843018  128 CSYRFAvrrPESA-----RIIY--RFGEt--PRT-RVWRVWTRGGD--TVEATEDHPFW----------------TP-Qg 178 
WP_011249425  990 LSVNgl--kPKEA-----KALK--FWEId--WNG-PLKVIKLKNGH--EIKATPDHGLL----------------VM-Re 1038
WP_012675738  727 LTLDLSdngLKKG-----KITH--CFDN---GIK-DVYKITLQNGL--EIKATADHKFL----------------TPfg- 776 
WP_010870567  296 LSFDge--kLSLK-----KLKL--ASKRy--YND-DLITLRFNLGR--EIKITKDHPVV----------------IL-Ed 344 
WP_010870940  673 LTVDENf-rVRWR-----KVST--IIRH---KVD-KILRIKFEGGY---IELTGNHSIM----------------ML-De 720 
WP_064496538  432 LGLNAEtlkTEWK-----EIID--AQKRearRYEiGVYRKNKNTKD--TIKITPDHKFP----------------VF-Vn 485 
WP_013413127  450 MAYDLKnlkIIPA-----NVNR--ISRHk--APD-KFVKIKFENGR--NVTVTPEHPFV----------------VW-Dk 500 
WP_013799845  125 LTVEnn--kVVWK-----PVKY--LIRH---KVD-KILEVRFEGGK---IKLTGNHSVM----------------VF-Ne 171 
WP_014797554  627 -------dkVITEsgtvrKVKNtfVYPTn--NKE-ELLKIKTYYGEtdGITLTKDHKILtekqifptnyenwaesTKkSr 696 
WP_015327798  390 -------dkVLGEdnkfyEVTN--YFKN---EHS-EYIKIETKNNN--TIKSSKNHKFP----------------TN-Ng 437 
WP_012843018  179 ----------mVPLREL-RPG------DRVA-FcPFE-GVp----------YEAPSsetilspeafwealrqlgipdrg- 228 
WP_011249425 1039 gk------lgwVSAKNV-REG------DYVA-F-AYN-TGh----------RGRDEytllklmiklgitdvmveldeeyf 1092
WP_012675738  777 ----------wKTVREL-QAEk-----DLLA-V-PVN-VDv----------EGE-------------------------- 801 
WP_010870567  345 ge------lkiKLTSDV-KEG------DKVI-L-PYGn-------------FGEEReieidileelsktdliekvwihnk 396 
WP_010870940  721 ng------lvaKKASDI-KVG------DCFL-Sf----VAni--------eGEKDRldlkefepkdi------------- 761 
WP_064496538  486 ge------lskVQLCDIiDNNlsvlsiDYIP-Miee-------------------------------------------- 514 
WP_013413127  501 di-------kiVRADEI-KEG------MVVLgVn---nYEisg------------------------------------- 526 
WP_013799845  172 nge-----lttKHAKDL-KVG------DYII-Sf----VStl--------eGKRNElelnskivnt-------------- 212 
WP_014797554  697 skprptgnlewKEAQDI-SEN------DWLF-V-PKPkVEikeikefdladLSENStlndlrfdeetiyhdvq------- 760 
WP_015327798  438 ----------lKKAIDL-SLN------DKLYe--HKTelvfen---gfklsYKNQSyfdiydkndnkitfeninkeniqe 495 
WP_012843018  229 -----------------------------------------rryrqlvryltrrgllplrydsPALPLLCKLLGYLLGDG 267 
WP_011249425 1093 nekvapivreriststky----kylrrrvlplyllqewglddyeahvkslyrqragskpipnfKLDGRFwYVFGLVLGDG 1168
WP_012675738  802 ---------------------------------------------------------------ESDEDKLRVLAYLLADG 818 
WP_010870567  397 dlatnefniikpylsnkyphdvkrngtirakdilpikeildkygsknrlftaksksttipykiKIDKDFARLIGYYLSEG 476 
WP_010870940  762 -----------------------------------------------------tsrvkiindfDIDEDTAWMLGLYVAEG 788 
WP_064496538  515 -------------------------------------------------------------kyESLAEVMYLGGAVLSDG 533 
WP_013413127  527 -------------------------------------------------------------nsSIDPNIAKFLGFILSGE 545 
WP_013799845  213 ------------------------------------------------------krtvkieklEMDELTSYVLGLYTAEG 238 
WP_014797554  761 ----------------------------------------------ntlcntiqrtktqerkiVLDKDWYKIFGIFTGDG 794 
WP_015327798  496 fyylkp----------------------------tvremkslsdfnypknryqttlkeidipkELDTDIFEIIGELLGDG 547 
WP_012843018  268 TC-YRERNGrir----lvAYg----rAE---DLEAMRHDLEALGVRAARlrrrrrrhrvqtvyrpyafEREEVSLHITSR 335 
WP_011249425 1169 TL-RDSKv---------lIS------QTp---LKDVKSVLEDVFPFLRV-------------------FETTNQVGFSNS 1210
WP_012675738  819 YL-AKSSi---------sFVnk---dKT---LIEAFKVSVERAFDNVSFkeflrard------vwniyivSKERNRYHSN 876 
WP_010870567  477 WI-SKDYGRngvvrkrigLCfgi-heEE---YINDVKNILNKLGIKYie-----------------kiKDGSHSILISSK 534 
WP_010870940  789 AV-GFKGKTsgq----viYTlgs-heHD---LINKLNDIVDKKGFSkyenftg---------sgfdrkRLSAKQIRILNT 850 
WP_064496538  534 HIvRRNGKPir-----vrFTqk--dtEEkkdFIEKVKgdVKLIGGNFIEis----------------nRNNVIEYQTSRK 590 
WP_013413127  546 CT-YKDGFYei------vFSna---nKK---LLEEFETIVKKLGIKYNIskk--------------keGHKTFTVKIASK 598 
WP_013799845  239 AL-GFKNNTsgq----iiFTfgypkeKY---LLNTVKSWAKNVNMPyyinlts---------sgfnrnRYSAIQIRLLTT 301 
WP_014797554  795 CF-RKNERPmi------sFAfhq-deKEs---LNFVKNKFEEIGCQVSEqh---------------skTRKLIQLSINSK 848 
WP_015327798  548 YL-PKNKNSi-------rLTsn---dDE---IINFFSETIKykfgldt-------------kicqagnSDTCLEANVNSA 600 
WP_012843018  336 AFALLL--V--ALGmp-igDRTAQDf---EA-PawLERAPRWQKRLFLAGLFGAELSApr-lmSghartfatpvltlTKR 405 
WP_011249425 1211 IIAEVF--R--RLGa--------rKg---KLhPl-VFGLREEYINAMIAGYFDTDGTFsilndRk------------GPN 1262
WP_012675738  877 PLINWF--K--ELGlf--hKKSEEK----FI-PefVFKLNKESISKFLAYYWDCDGYIg------------------EKL 927 
WP_010870567  535 ILAYVF--E--NILnc--gINCYNK----NI-PpqMFNAKEEIKWEFLKGLFRGDGGIvrlnnNk------------NLN 591 
WP_010870940  851 QLARFV--E--ENFydgngRRARNK----RI-PdiIFELKENLRVEFLKGLADGDSSGn-----------------wREV 904 
WP_064496538  591 IPSEILgf--iEVNi---------N----TI-P---LYATKDEIADLIAGFVDGDGCLs-----------------gKRR 634 
WP_013413127  599 EFYHDLitEfpELSl----QSQSQRfthvKV-PnkILMSSKSVKKAFLNAYFKRSGFVd------------------NCR 655 
WP_013799845  302 KLAREF--S--RYFykngrKIARNK----RI-PefIYESQITSRLAYLKGLADGDGCGs-----------------wGEV 355 
WP_014797554  849 PIYLLF--K--KLYde-yeFNSATK----YV-PnfVLSASEENVASFLAGYCAADGHEg------------------EGK 900 
WP_015327798  601 MLKSYL--Q--HLGlk--fGIGSEK----EI-PsiVYHRSDAEISALLRGLFDTDGSIti-nnNg------------NPN 656 
WP_012843018  406 APF--AESGRRF--LETLARWAAELGVRTQAI-EARre-----------------------------llA-TGERV--RW 448 
WP_011249425 1263 FRGilTSKRGDV--LRMLSVYLYQIGIMNYLR-RDEr---------------------------------tG------VW 1300
WP_012675738  928 AHI--KTISKDL--AYGLYYLLLRLGIKANIY-KSYy-------------------------------dD----KT--SY 965 
WP_010870567  592 IEF--ATVSKKM--AHSLLILLQLLGIVASVK-KCY---------------------------------NnKST-Tm-AY 631 
WP_010870940  905 VRI--SSKSDNL--LIDTVWLARISGIESSIF-ENEarliwkggmkwkksnllpaepiikmikklenkiN-GNWryilRH 978 
WP_064496538  635 VEI--YQNSSHIkkIEGLIVGLYRLGIIPRLR-YKRssta-------------------------tiyfN----NN--LE 680 
WP_013413127  656 VGY--STPSIKM--AEDLQDLLLMMGIYSYIS-KDE--------------------------------------R---TY 689 
WP_013799845  356 VRI--SSVSEDL--LVDIVWLSRISGIESSIF-KDEvrliwngsmkykksdllpakmfikffekisdriK-INWryilRH 429 
WP_014797554  901 FRF--TTVSRKL--ADQVRFLCWRINIPASLGiDKRee-----------------------------fkNt---KT--AY 942 
WP_015327798  657 ISL--VLKNHKL--LQQVLELLMFLGIVASYK-DTDd----------------------------------------kYG 691 
WP_012843018  449 QW-----RM-ASDPAsLRALWGRIGYe-YNFRRQHE---AACALQYVK-Y----KE--------QVVRqrqeavrllrrw 505 
WP_011249425 1301 DL-----II--SNRS-LEKFREKIYPy-LRIRRAQF---DEAYSVYRAsrrafeGDllpvapvfGKLKfkngtknrilke 1368
WP_012675738  966 QV-----TV-YDLKN-FKKYIlp---hmISQKARNL---TREVSDNSFyL----KDia-----lEKVKafceengisqre 1023
WP_010870567  632 II-----RI-NGLEQ-VKKIGELFGK-----KWENY---KDIAESYKRniep---------------------------- 668 
WP_010870940  979 QLyegkkRV--SKDK-IKQILEMVNVekLSDKEKEV---YDLlk------------------------------------ 1016
WP_064496538  681 TIlqrtrRI--KLDK-LKEFK-------KPVEDKKLidiSQIlpelkefd------------------------------ 720 
WP_013413127  690 KV-----II-DGEEN-IKKFAKIIKD------DFRI---GRIn---------------------DLIEtsgn-------- 724 
WP_013799845  430 QLyenknRV--SKNK-VMTILNNIEVdkLTEDERKIyenl---------------------------------------- 466 
WP_014797554  943 YI-----TIpQd---------KRIGK--TKAKANYIy---------------------------EPIKne---------- 969 
WP_015327798  692 KI-----NI-HGSKN-INLFKEKIGFr-INRKNNRL---QKNk------K----KQtvl---gdKIITkeqsfemf---- 743 
WP_012843018  506 raagvsvgeatrrladqdINRRFV----ERTYyeqrgdtprigdavcsyaafrrerQNGqeplGCV-----------WEE 570 
WP_011249425 1369 tg---idvwnwlkrpegeIPRDKL----SKVLeyaeespe---------keflkslVEA----GVT-----------WVK 1417
WP_012675738 1024 fsrltgiqrnnffngkqqFIKSSVi---EKIApviede-------------ellklMDG----DIG-----------FVP 1072
WP_010870567  669 -----------------------------------------------------lgyKKSd---NFA-----------ILE 681 
WP_010870940 1017 ------------------------------------------------------klSKT----ELY-----------ALV 1027
WP_064496538  721 -----------ykgylykTYKEKLfigiNKLEeylskidkdgi---erikqkikllKES----DIY-----------SIR 771 
WP_013413127  725 ---------------knnQDQNILe---NEIVqdiedd------------eksvkiSNNerqrNIR-----------FIK 763 
WP_013799845  467 -----------------------------------------------------rniASS----DLH-----------VVR 478 
WP_014797554  970 -------------------------------------------------------------thDGF-----------LVK 977 
WP_015327798  744 -----------gndhrqyYDKEMF-----RIK------------------------ENGn---GIYlftaefnkyknKVD 780 
WP_012843018  571 IVRIEpV-ERPELr--VYDLTVDh---PDHNFIA-NG-FVVSN-CGVRLLASRLTYEEVEPHLERLVEMLFRRVPTGVGA 641 
WP_011249425 1418 VKGVE-EeLYTGK---LYDFTTT-----TENFLS-NG-AVSH--NCTYHRTDSTHVSNTGIEVAKEYITQELGEKYFKPR 1484
WP_012675738 1073 IREIE-Y-AGKEH---VYDIEVE----GTHNFIA-NN-IISHNcIYQEQIMFMANILSGFTMAEADTLRKAIGKKKADVM 1141
WP_010870567  682 VKEII-K-EHYSGy--VYSVETE----NSLLITSy-G-ILIHN-CFPKDVKALIKQFENNNIEPILIKATDIVNEEQIKW 750 
WP_010870940 1028 VKEIE-I-IDYNDf--VYDVSVP----NNEMFFAgNvp-----iLLHNSDERGIDVIRTKVKDFARTKPIGDVPFKIIFL 1094
WP_064496538  772 IKKVG---EDYGE---VYNITVKaeneFNHNYVV----WTKH--YTPIVVFNCHAAIVSRELGTPCVVGTKKATKVLKDG 839 
WP_013413127  764 VKNVKf--VENSDskwVYDITVE----PHHLFVS-HG-IVLH--NSISIAKAGIMATLNSRCSVLAAANPKFGRFDRYKS 833 
WP_013799845  479 IKEIK-L-LDYNDy--VYDISVP----NNEMFFAgEtpILLHNsDERGIDVIRTKVKDFARTKPIGDAPFKIIFLDESDA 550 
WP_014797554  978 IRSIE-T-VPNQTf--VYDFEVE----EEHNYLTsS--FLVHN-SAAGSVVAYCIGITNIDPILYNLLFERFLNPERVSM 1046
WP_015327798  781 ISNLKl--INNTLk--SVDITVNs---NSHLFTLsNG-I-----ITHNSNMVNSDVNPEDVRSMCCRLRLSNKELRKRGG 847 
WP_012843018  642 SGALRVSKQELRRVAVEGAHWAVRHGFGSEVDLEFIEENGRIEGADPAAVSERAYERGADQLGTLGSGNHFLEVGYVAQI 721 
WP_011249425 1485 PWGEEGAHEAIRPTRPIDTGRLMQLIRDGIIQLPRNLTRNHYRLYDMIFRRFMTSQMTPAKILYEKAVINAGVGKAELEG 1564
WP_012675738 1142 AKMKDRFISGAVERGFDKVKIEKLWDDIEKFASYSFNKSHSTAYAYLTYWTAYIKTYYPEEFFAVKLSIENNDNKFLNLL 1221
WP_010870567  751 FFEKIKNYYGNLNGKTFAVLGLAFKPNTDDLRESRAIKLIDMLLESGAIVKGFDYVEKARENTINMYKLDKSKGFYGYNL 830 
WP_010870940 1095 DESDALTADAQNALRRTMEKYSDVCRFILSCLTGDAKITLPDEREIKIEDFIKMFEERKLKHVLNRNGEDLVLAGVKFNS 1174
WP_064496538  840 MIVTVDGEKGIVYEGEIKKVEEKEKKQEVVVQQAPIITATEVKVNVSMPEVAERAAATGADGVGLLRAEHMILGLGKHPR 919 
WP_013413127  834 ISEQINLPSTILSRFDLIFVIEDLPNKDRDRRLAEHVLKIHQARDIKPEIDPELLRKYIAYARKYIKPKLTKDAREVIED 913 
WP_013799845  551 LTSDAQNALRRTMEKYSDVCRFILSCNYPSKIIPPIQSRCAIFRFSPLKKEDVVKKLKEIAEKEGLTLTPEGIEAIIYVS 630 
WP_014797554 1047 PDIDVDFDDVGRQRVIEYVVEKYGRNQVAQIVTYGTMAAKMSIKDVARVMELPLDESNRMAKLVPEKPGTNLDKAFEEVE 1126
WP_015327798  848 ALFGSNPMTGSIGVVTINMPRIGYLAEDKEEFIKRVYELMDIAQESLEIKRKVLERLTDNGLYPYSKFYLRGIKERFDEY 927 
WP_012843018  722 FDDEAARVMGLFPGQVTVIIHTGSRGFGYQICDDYLAVMDRALARYHIRLPDRQLACAPLRSPEGQQYLAAMRCGINFAF 801 
WP_011249425 1565 YVEIIEDGWTRLRSPPLRELPKLEKGMKLKVVEAKKWKAPKVSLYTQGDIIALMKERKIGRPSTYAKIVETLMRRGYVVE 1644
WP_012675738 1222 LDMEDFGIKLLPPDINRSRSNFSIEDKGKIRFGLSRIKNVGEQSAKLIVEERERNGDYKDIFDIAERMDSKALNKRVLEA 1301
WP_010870567  831 YVLDDLYETVKNVDGIIITVEYDFNKEDWEKIGNLVKEKVVFDGRNILDVEKIKKLGFKYYGVGR--------------- 895 
WP_010870940 1175 KIVNHKVYRLVLESGREIEATGDHKFLTRDGWKEVYELKEDDEVLVYPALEGVGFEVDERRIIGLNEFYEFLTNYEIKLG 1254
WP_064496538  920 KILEEEGEEALIEALMEGIRKVADAFYPRPVTYRTLDAPTDEFRGLEGGENEPIEHNPMLGWRGIRRDLDEVDILKCELK 999 
WP_013413127  914 FYVSMRSKGLEEDSPVPITVRQLESIVRLAEASARMKLKDKVEVEDAKRAIRLVEACLKQLGYDPETGKIDIDKVEGRTP 993 
WP_013799845  631 EGDMRKAINVLQTAASVSKEINDEVVYKVSSRARPEEIKKMIELALEGKFIEARELLYKLMIDWGMSGEDVILQIFREIP 710 
WP_014797554 1127 ELRQIYRAKDLQGEVLQNAKVLEGSVRNTGTHAAGVIIAPDDITEYIPVCTAKDAELFITQFDGKVVEDAGMLKMDFLGL 1206
WP_015327798  928 WKNHFNTIGLNGMNEALLNFMGQDIASEEGRQFAIEVMEAMRERLVDYQEETGNIYNLEATPAEGTSYRFANLDKQKFGA 1007
WP_012843018  802 ANRQIIAHNTRKAFAEALGMREEDI 826 
WP_011249425 1645 TKGRKKLLPTEKGIKVYHYLVSKYR 1669
WP_012675738 1302 LIKAGAFDFSGVDRGVMLASVDRAL 1326
WP_010870567      -------------------------     
WP_010870940 1255 YKPLGKAKSYKELITRDKEKILSRV 1279
WP_064496538 1000 AIKRLREEGYKNIEIMIPLVTHPDE 1024
WP_013413127  994 KSKRDKYNAALELIKELEDEYESVP 1018
WP_013799845  711 SLNIDERKKVELVEALGECDYRIVE 735 
WP_014797554 1207 KTLTIIKDAIDLIEKNHGVKIDPDE 1231
WP_015327798 1008 DIICANQERVRNEDADPYYTNSTQL 1032
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